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cantharidin and Acute Liver Injury, Drug-Induced

cantharidin has been researched along with Acute Liver Injury, Drug-Induced in 11 studies

Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.

Research Excerpts

ExcerptRelevanceReference
"Cantharidin (CTD) is a promising anticancer drug; however, its dosage is limited by hepatotoxicity."1.62Protective mechanism of Astragalus Polysaccharides against Cantharidin-induced liver injury determined in vivo by liquid chromatography/mass spectrometry metabolomics. ( Chen, Y; Huang, X; Li, W; Lin, C; Liu, J; Sa, Z; Tang, W; Wang, L; Xu, M; Yang, C, 2021)
" In the present study, the hepatotoxicity of CTD in the rat was investigated using a metabolomic approach combined with conventional pathology methods."1.56Study on the mechanism of cantharidin-induced hepatotoxicity in rat using serum and liver metabolomics combined with conventional pathology methods. ( Chen, K; Chen, Q; Duan, C; Li, X; Mu, W; Wang, L; Zhang, J, 2020)
" However, clinical application of cantharidin is relatively restricted due to its potential toxic effects, especially hepatotoxicity."1.51UPLC-Q-TOF/MS Based Metabolomics Approach to Study the Hepatotoxicity of Cantharidin on Mice. ( Dai, YL; Liu, SW; Long, R; Song, T; Zhang, L; Zhang, P; Zhu, SS, 2019)
" Concurrently, the growth curve of photosynthetic bacteria was used to determine the inoculation amount of the photosynthetic bacteria and the safe concentration of cantharis."1.43Cantharis by photosynthetic bacteria biotransformation: Reduced toxicity and improved antitumor efficacy. ( Yu, M; Zhao, Y, 2016)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19902 (18.18)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (27.27)24.3611
2020's6 (54.55)2.80

Authors

AuthorsStudies
Cheng, W1
Wang, Y1
Liu, J2
Li, X4
Yu, M2
Duan, C4
Liu, L2
Zhang, J5
Zhu, SS1
Long, R1
Song, T1
Zhang, L1
Dai, YL1
Liu, SW1
Zhang, P1
Chen, Q1
Wang, L2
Chen, K1
Mu, W1
Yu, Y1
Zhang, Y1
Guan, C1
Ren, L1
Liu, F2
Wang, X1
Huang, X1
Tang, W1
Lin, C1
Sa, Z1
Xu, M1
Li, W1
Chen, Y1
Yang, C1
Wu, W1
Su, M1
Li, T1
Wu, K1
Wu, X1
Tang, Z1
Zhao, Y1
Till, JS1
Majmudar, BN1
Bagatell, FK1
Ferendeci, S1
Laronge, T1

Other Studies

11 other studies available for cantharidin and Acute Liver Injury, Drug-Induced

ArticleYear
Hepatotoxicity of cantharidin is associated with the altered bile acid metabolism.
    Journal of applied toxicology : JAT, 2022, Volume: 42, Issue:6

    Topics: Animals; Bile Acids and Salts; Biomarkers; Cantharidin; Chemical and Drug Induced Liver Injury; Chro

2022
UPLC-Q-TOF/MS Based Metabolomics Approach to Study the Hepatotoxicity of Cantharidin on Mice.
    Chemical research in toxicology, 2019, 11-18, Volume: 32, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cantharidin; Cell Line; Chemical and Drug Induced Liver I

2019
Study on the mechanism of cantharidin-induced hepatotoxicity in rat using serum and liver metabolomics combined with conventional pathology methods.
    Journal of applied toxicology : JAT, 2020, Volume: 40, Issue:9

    Topics: Animals; Biomarkers; Cantharidin; Chemical and Drug Induced Liver Injury; Chromatography, High Press

2020
Cantharidin-induced acute hepatotoxicity: the role of TNF-α, IKK-α, Bcl-2, Bax and caspase3.
    Journal of applied toxicology : JAT, 2020, Volume: 40, Issue:11

    Topics: Animals; Cantharidin; Caspase 3; Chemical and Drug Induced Liver Injury; I-kappa B Kinase; Liver; Ma

2020
Cantharidin-induced LO2 cell autophagy and apoptosis via endoplasmic reticulum stress pathway in vitro.
    Journal of applied toxicology : JAT, 2020, Volume: 40, Issue:12

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Proteins; Cantharidin; Cell L

2020
Hepatoxicity mechanism of cantharidin-induced liver LO2 cells by LC-MS metabolomics combined traditional approaches.
    Toxicology letters, 2020, Oct-15, Volume: 333

    Topics: Biomarkers; Cantharidin; Cell Culture Techniques; Cell Line; Cell Survival; Chemical and Drug Induce

2020
Protective mechanism of Astragalus Polysaccharides against Cantharidin-induced liver injury determined in vivo by liquid chromatography/mass spectrometry metabolomics.
    Basic & clinical pharmacology & toxicology, 2021, Volume: 129, Issue:1

    Topics: Animals; Antineoplastic Agents; Astragalus Plant; ATP-Binding Cassette Transporters; Cantharidin; Ch

2021
Cantharidin-induced liver injuries in mice and the protective effect of vitamin C supplementation.
    International immunopharmacology, 2015, Volume: 28, Issue:1

    Topics: Animals; Antioxidants; Ascorbic Acid; Cantharidin; Chemical and Drug Induced Liver Injury; Dietary S

2015
Cantharis by photosynthetic bacteria biotransformation: Reduced toxicity and improved antitumor efficacy.
    Journal of ethnopharmacology, 2016, Jun-20, Volume: 186

    Topics: Animals; Antineoplastic Agents; Bacterial Proteins; Biotransformation; Cantharidin; Chemical and Dru

2016
Cantharidin poisoning.
    Southern medical journal, 1981, Volume: 74, Issue:4

    Topics: Cantharidin; Chemical and Drug Induced Liver Injury; Digestive System Diseases; Female; Genital Dise

1981
The determination of cantharidin in tissues and its subcellular location.
    The Journal of laboratory and clinical medicine, 1966, Volume: 67, Issue:1

    Topics: Animals; Cantharidin; Chemical and Drug Induced Liver Injury; Chromatography, Gas; In Vitro Techniqu

1966