cantharidin has been researched along with Acute Liver Injury, Drug-Induced in 11 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cantharidin (CTD) is a promising anticancer drug; however, its dosage is limited by hepatotoxicity." | 1.62 | Protective mechanism of Astragalus Polysaccharides against Cantharidin-induced liver injury determined in vivo by liquid chromatography/mass spectrometry metabolomics. ( Chen, Y; Huang, X; Li, W; Lin, C; Liu, J; Sa, Z; Tang, W; Wang, L; Xu, M; Yang, C, 2021) |
| " In the present study, the hepatotoxicity of CTD in the rat was investigated using a metabolomic approach combined with conventional pathology methods." | 1.56 | Study on the mechanism of cantharidin-induced hepatotoxicity in rat using serum and liver metabolomics combined with conventional pathology methods. ( Chen, K; Chen, Q; Duan, C; Li, X; Mu, W; Wang, L; Zhang, J, 2020) |
| " However, clinical application of cantharidin is relatively restricted due to its potential toxic effects, especially hepatotoxicity." | 1.51 | UPLC-Q-TOF/MS Based Metabolomics Approach to Study the Hepatotoxicity of Cantharidin on Mice. ( Dai, YL; Liu, SW; Long, R; Song, T; Zhang, L; Zhang, P; Zhu, SS, 2019) |
| " Concurrently, the growth curve of photosynthetic bacteria was used to determine the inoculation amount of the photosynthetic bacteria and the safe concentration of cantharis." | 1.43 | Cantharis by photosynthetic bacteria biotransformation: Reduced toxicity and improved antitumor efficacy. ( Yu, M; Zhao, Y, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 6 (54.55) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, W | 1 |
| Wang, Y | 1 |
| Liu, J | 2 |
| Li, X | 4 |
| Yu, M | 2 |
| Duan, C | 4 |
| Liu, L | 2 |
| Zhang, J | 5 |
| Zhu, SS | 1 |
| Long, R | 1 |
| Song, T | 1 |
| Zhang, L | 1 |
| Dai, YL | 1 |
| Liu, SW | 1 |
| Zhang, P | 1 |
| Chen, Q | 1 |
| Wang, L | 2 |
| Chen, K | 1 |
| Mu, W | 1 |
| Yu, Y | 1 |
| Zhang, Y | 1 |
| Guan, C | 1 |
| Ren, L | 1 |
| Liu, F | 2 |
| Wang, X | 1 |
| Huang, X | 1 |
| Tang, W | 1 |
| Lin, C | 1 |
| Sa, Z | 1 |
| Xu, M | 1 |
| Li, W | 1 |
| Chen, Y | 1 |
| Yang, C | 1 |
| Wu, W | 1 |
| Su, M | 1 |
| Li, T | 1 |
| Wu, K | 1 |
| Wu, X | 1 |
| Tang, Z | 1 |
| Zhao, Y | 1 |
| Till, JS | 1 |
| Majmudar, BN | 1 |
| Bagatell, FK | 1 |
| Ferendeci, S | 1 |
| Laronge, T | 1 |
11 other studies available for cantharidin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Hepatotoxicity of cantharidin is associated with the altered bile acid metabolism.
Topics: Animals; Bile Acids and Salts; Biomarkers; Cantharidin; Chemical and Drug Induced Liver Injury; Chro | 2022 |
UPLC-Q-TOF/MS Based Metabolomics Approach to Study the Hepatotoxicity of Cantharidin on Mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cantharidin; Cell Line; Chemical and Drug Induced Liver I | 2019 |
Study on the mechanism of cantharidin-induced hepatotoxicity in rat using serum and liver metabolomics combined with conventional pathology methods.
Topics: Animals; Biomarkers; Cantharidin; Chemical and Drug Induced Liver Injury; Chromatography, High Press | 2020 |
Cantharidin-induced acute hepatotoxicity: the role of TNF-α, IKK-α, Bcl-2, Bax and caspase3.
Topics: Animals; Cantharidin; Caspase 3; Chemical and Drug Induced Liver Injury; I-kappa B Kinase; Liver; Ma | 2020 |
Cantharidin-induced LO2 cell autophagy and apoptosis via endoplasmic reticulum stress pathway in vitro.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Proteins; Cantharidin; Cell L | 2020 |
Hepatoxicity mechanism of cantharidin-induced liver LO2 cells by LC-MS metabolomics combined traditional approaches.
Topics: Biomarkers; Cantharidin; Cell Culture Techniques; Cell Line; Cell Survival; Chemical and Drug Induce | 2020 |
Protective mechanism of Astragalus Polysaccharides against Cantharidin-induced liver injury determined in vivo by liquid chromatography/mass spectrometry metabolomics.
Topics: Animals; Antineoplastic Agents; Astragalus Plant; ATP-Binding Cassette Transporters; Cantharidin; Ch | 2021 |
Cantharidin-induced liver injuries in mice and the protective effect of vitamin C supplementation.
Topics: Animals; Antioxidants; Ascorbic Acid; Cantharidin; Chemical and Drug Induced Liver Injury; Dietary S | 2015 |
Cantharis by photosynthetic bacteria biotransformation: Reduced toxicity and improved antitumor efficacy.
Topics: Animals; Antineoplastic Agents; Bacterial Proteins; Biotransformation; Cantharidin; Chemical and Dru | 2016 |
Cantharidin poisoning.
Topics: Cantharidin; Chemical and Drug Induced Liver Injury; Digestive System Diseases; Female; Genital Dise | 1981 |
The determination of cantharidin in tissues and its subcellular location.
Topics: Animals; Cantharidin; Chemical and Drug Induced Liver Injury; Chromatography, Gas; In Vitro Techniqu | 1966 |