cannogenin-thevetoside and Leukemia--Myeloid

cannogenin-thevetoside has been researched along with Leukemia--Myeloid* in 1 studies

Other Studies

1 other study(ies) available for cannogenin-thevetoside and Leukemia--Myeloid

Article	Year
Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death. Molecules (Basel, Switzerland), 2016, Apr-22, Volume: 21, Issue:4 Despite the available chemotherapy and treatment, leukemia remains a difficult disease to cure due to frequent relapses after treatment. Among the heterogeneous leukemic cells, a rare population referred as the leukemic stem cell (LSC), is thought to be responsible for relapses and drug resistance. Cardiac glycosides (CGs) have been used in treating heart failure despite its toxicity. Recently, increasing evidence has demonstrated its new usage as a potential anti-cancer drug. Ouabain, one of the CGs, specifically targeted CD34⁺CD38(-) leukemic stem-like cells, but not the more mature CD34⁺CD38⁺ leukemic cells, making this type of compounds a potential treatment for leukemia. In search of other potential anti-leukemia CGs, we found that Peruvoside, a less studied CG, is more effective than Ouabain and Digitoxin at inducing cell death in primitive myeloid leukemia cells without obvious cytotoxicity on normal blood cells. Similar to Ouabain and Digitoxin, Peruvoside also caused cell cycle arrest at G₂/M stage. It up-regulates CDKN1A expression and activated the cleavage of Caspase 3, 8 and PARP, resulting in apoptosis. Thus, Peruvoside showed potent anti-leukemia effect, which may serve as a new anti-leukemia agent in the future. Topics: Antineoplastic Agents; Apoptosis; Cardenolides; Cardiac Glycosides; Caspase 3; Caspase 8; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Digitoxin; Gene Expression Regulation, Neoplastic; Humans; K562 Cells; Leukemia, Myeloid; Neoplastic Stem Cells; Ouabain; Poly(ADP-ribose) Polymerases	2016

Article

Year

Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death.

Molecules (Basel, Switzerland), 2016, Apr-22, Volume: 21, Issue:4

Despite the available chemotherapy and treatment, leukemia remains a difficult disease to cure due to frequent relapses after treatment. Among the heterogeneous leukemic cells, a rare population referred as the leukemic stem cell (LSC), is thought to be responsible for relapses and drug resistance. Cardiac glycosides (CGs) have been used in treating heart failure despite its toxicity. Recently, increasing evidence has demonstrated its new usage as a potential anti-cancer drug. Ouabain, one of the CGs, specifically targeted CD34⁺CD38(-) leukemic stem-like cells, but not the more mature CD34⁺CD38⁺ leukemic cells, making this type of compounds a potential treatment for leukemia. In search of other potential anti-leukemia CGs, we found that Peruvoside, a less studied CG, is more effective than Ouabain and Digitoxin at inducing cell death in primitive myeloid leukemia cells without obvious cytotoxicity on normal blood cells. Similar to Ouabain and Digitoxin, Peruvoside also caused cell cycle arrest at G₂/M stage. It up-regulates CDKN1A expression and activated the cleavage of Caspase 3, 8 and PARP, resulting in apoptosis. Thus, Peruvoside showed potent anti-leukemia effect, which may serve as a new anti-leukemia agent in the future.

Topics: Antineoplastic Agents; Apoptosis; Cardenolides; Cardiac Glycosides; Caspase 3; Caspase 8; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Digitoxin; Gene Expression Regulation, Neoplastic; Humans; K562 Cells; Leukemia, Myeloid; Neoplastic Stem Cells; Ouabain; Poly(ADP-ribose) Polymerases

2016