cannabidiol and Hypoxia

Topics: Animals; Cannabidiol; Cell Proliferation; Disease Models, Animal; Glycolysis; Hypoxia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Reactive Oxygen Species; Vascular Remodeling

Electronic cigarettes, pens, cartridges and other devices were developed as nicotine delivery systems not requiring combustion of tobacco leaves. This technology was subsequently employed to deliver the cannabis component tetrahydrocannabinol (THC) via products often manufactured without adequate quality oversight and sold illegally. Recently, five patients presenting within a 2-month period with acute respiratory failure due to acute lipoid pneumonia after inhaling THC-containing concentrates or oils have been described. We report a 28-year-old previously healthy man who presented in acute respiratory failure 2 weeks after initiating use of a street-purchased THC-containing vape cartridge. Bronchoalveolar lavage cytology with oil red O staining confirmed the diagnosis of acute lipoid pneumonia. Diffuse alveolar hemorrhage and eosinophilic pneumonia were excluded. Evolving evidence supports a clinical entity of acute respiratory failure due to acute, exogenous lipoid pneumonia induced by THC-containing concentrates or oils inhaled through a variety of vaping products. All six patients reported to date received intravenous corticosteroids and survived to hospital discharge.

Topics: Administration, Inhalation; Adult; Bronchoscopy; Cannabidiol; Cannabis; Dronabinol; Electronic Nicotine Delivery Systems; Glucocorticoids; Humans; Hypoxia; Intubation, Intratracheal; Macrophages, Alveolar; Male; Methylprednisolone; Plant Oils; Pneumonia, Lipid; Respiration, Artificial; Respiratory Insufficiency; Tomography, X-Ray Computed; Vaping

BackgroundBrain hypoxic-ischemic (HI) damage induces distant inflammatory lung damage in newborn pigs. We aimed to investigate the effects of cannabidiol (CBD) on lung damage in this scenario.MethodsNewborn piglets received intravenous vehicle, CBD, or CBD+WAY100635 (5-HT

Topics: Animals; Animals, Newborn; Brain; Bronchoalveolar Lavage Fluid; Cannabidiol; Disease Models, Animal; Hemodynamics; Hypoxia; Hypoxia-Ischemia, Brain; Inflammation; Interleukin-1beta; Lung; Lung Injury; Male; Oxidative Stress; Oxygen; Swine