cannabidiol and Asphyxia

Topics: Asphyxia; Cannabidiol; Child, Preschool; Drug Resistant Epilepsy; Epilepsy; Female; Humans; Infant; Quality of Life; Seizures; Treatment Outcome

Hypothermia, the gold standard after a hypoxic-ischemic insult, is not beneficial in all treated newborns. Cannabidiol is neuroprotective in animal models of newborn hypoxic-ischemic encephalopathy. This study compared the relative efficacies of cannabidiol and hypothermia in newborn hypoxic-ischemic piglets and assessed whether addition of cannabidiol augments hypothermic neuroprotection.. HI led to sustained depressed brain activity and increased microglial activation, which was significantly improved by cannabidiol alone or with hypothermia but not by hypothermia alone. Hypoxic-ischemic-induced increases in Lac/NAA, Glu/NAA, TNFα or apoptosis were not reversed by either hypothermia or cannabidiol alone, but combination of the therapies did. No treatment modified the effects of HI on oxidative stress or astroglial activation. Cannabidiol treatment was well tolerated.. cannabidiol administration after hypoxia-ischemia in piglets offers some neuroprotective effects but the combination of cannabidiol and hypothermia shows some additive effect leading to more complete neuroprotection than cannabidiol or hypothermia alone.

Topics: Animals; Animals, Newborn; Apoptosis; Asphyxia; Brain; Brain Injuries; Cannabidiol; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Hypothermia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Inflammation; Microglia; Neuroprotection; Neuroprotective Agents; Respiratory Physiological Phenomena; Swine