cangrelor has been researched along with Sepsis* in 2 studies
2 other study(ies) available for cangrelor and Sepsis
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Cangrelor ameliorates CLP-induced pulmonary injury in sepsis by inhibiting GPR17.
Sepsis is a common complication of severe wound injury and infection, with a very high mortality rate. The P2Y12 receptor inhibitor, cangrelor, is an antagonist anti-platelet drug.. In our study, we investigated the protective mechanisms of cangrelor in CLP-induced pulmonary injury in sepsis, using C57BL/6 mouse models.. TdT-mediated dUTP Nick-End Labeling (TUNEL) and Masson staining showed that apoptosis and fibrosis in lungs were alleviated by cangrelor treatment. Cangrelor significantly promoted surface expression of CD40L on platelets and inhibited CLP-induced neutrophils in Bronchoalveolar lavage fluid (BALF) (p < 0.001). We also found that cangrelor decreased the inflammatory response in the CLP mouse model and inhibited the expression of inflammatory cytokines, IL-1β (p < 0.01), IL-6 (p < 0.05), and TNF-α (p < 0.001). Western blotting and RT-PCR showed that cangrelor inhibited the increased levels of G-protein-coupled receptor 17 (GPR17) induced by CLP (p < 0.001).. Our study indicated that cangrelor repressed the levels of GPR17, followed by a decrease in the inflammatory response and a rise of neutrophils in BALF, potentially reversing CLP-mediated pulmonary injury during sepsis. Topics: Acute Lung Injury; Adenosine Monophosphate; Animals; Cecum; Disease Models, Animal; Ligation; Mice; Mice, Inbred C57BL; Punctures; Purinergic P2Y Receptor Antagonists; Sepsis | 2021 |
Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in A Murine Model of Urosepsis.
Urosepsis is a potentially life-threatening, systemic reaction to uropathogenic bacteria entering the bloodstream of the host. One of the hallmarks of sepsis is early thrombocyte activation with a following fall in circulating thrombocytes as a result of intravascular aggregation and sequestering of thrombocytes in the major organs. Development of a thrombocytopenic state is associated with a poorer outcome of sepsis. Uropathogenic Topics: Adenosine Monophosphate; Animals; Bacterial Toxins; Blood Platelets; Deoxyadenine Nucleotides; Disease Models, Animal; Escherichia coli Proteins; Hemolysin Proteins; Humans; Male; Mice, Inbred BALB C; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Sepsis; Treatment Outcome; Urinary Tract Infections; Uropathogenic Escherichia coli | 2020 |