Page last updated: 2024-09-03

candoxatril and Hypertension

candoxatril has been researched along with Hypertension in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (71.43)	18.2507
2000's	3 (21.43)	29.6817
2010's	1 (7.14)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lang, CC; Singh, JS	1
Hercule, H; Newaz, MA; Oyekan, A; Truong, L; Yousefipour, Z	1
Jakovski, K; Jovanoska, E; Kostova, E; Maleska, V; Slaninka-Miceska, M; Zafirov, D	1
Hayakawa, H; Hirata, Y; Kangawa, K; Matsuo, H; Matsuoka, H; Sugimoto, T; Suzuki, E	1
Goto, A; Hayakawa, H; Hirata, Y; Kangawa, K; Kimura, K; Matsuo, H; Minamino, N; Omata, M; Suzuki, E; Suzuki, Y	1
Armstrong, R; Finn, WL; Gordon, RD; Klemm, SA; Stowasser, M; Tunny, TJ; Ziesak, MD	1
Wilkins, MR	1
Crozier, IG; Espiner, EA; Nicholls, MG; Richards, AM; Yandle, TG	1
Crozier, IG; Espiner, EA; Frampton, C; Ikram, H; Richards, AM; Wittert, GA; Yandle, TG	1
Ikuse, T; Kuro, T; Matsumura, Y; Nose, M; Okahara, A	1
Connell, JM; Davidson, G; Jardine, AG; O'Connell, JE	1
Buckley, MG; MacGregor, GA; Markandu, ND; Sagnella, GA; Singer, DR	1
Bevan, EG; Carmichael, HA; Connell, JM; Davies, DL; Doyle, J; Lorimer, AR; McInnes, GT	1
Buckley, MG; MacGregor, GA; Markandu, ND; Miller, MA; Sagnella, GA; Singer, DR	1

Reviews

2 review(s) available for candoxatril and Hypertension

Article	Year
Angiotensin receptor-neprilysin inhibitors: clinical potential in heart failure and beyond. Vascular health and risk management, 2015, Volume: 11 Topics: Aminobutyrates; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Clinical Trials as Topic; Drug Combinations; Heart Failure; Humans; Hypertension; Indans; Natriuretic Peptide, Brain; Neprilysin; Propionates; Pyridines; Receptors, Angiotensin; Renin-Angiotensin System; Risk Factors; Stroke Volume; Tetrazoles; Thiazepines; Valsartan	2015
Clinical potential of endopeptidase-24.11 inhibitors in cardiovascular disease. Biochemical Society transactions, 1993, Volume: 21 ( Pt 3), Issue:3 Topics: Animals; Antihypertensive Agents; Cardiovascular Diseases; Cyclohexanecarboxylic Acids; Diuretics; Drug Design; Heart Failure; Humans; Hypertension; Indans; Neprilysin; Propionates; Protease Inhibitors; Thiorphan	1993

Article

Year

Angiotensin receptor-neprilysin inhibitors: clinical potential in heart failure and beyond.

Vascular health and risk management, 2015, Volume: 11

Topics: Aminobutyrates; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Clinical Trials as Topic; Drug Combinations; Heart Failure; Humans; Hypertension; Indans; Natriuretic Peptide, Brain; Neprilysin; Propionates; Pyridines; Receptors, Angiotensin; Renin-Angiotensin System; Risk Factors; Stroke Volume; Tetrazoles; Thiazepines; Valsartan

2015

Clinical potential of endopeptidase-24.11 inhibitors in cardiovascular disease.

Biochemical Society transactions, 1993, Volume: 21 ( Pt 3), Issue:3

Topics: Animals; Antihypertensive Agents; Cardiovascular Diseases; Cyclohexanecarboxylic Acids; Diuretics; Drug Design; Heart Failure; Humans; Hypertension; Indans; Neprilysin; Propionates; Protease Inhibitors; Thiorphan

1993

Trials

7 trial(s) available for candoxatril and Hypertension

Article	Year
Inhibition of endopeptidase EC 3.4.24.11 by candoxatril lowered blood pressure and increased urinary but not plasma atrial natriuretic peptide in essential hypertension. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1993, Volume: 11, Issue:5 Topics: Adult; Aged; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Double-Blind Method; Female; Humans; Hypertension; Indans; Male; Middle Aged; Neprilysin; Propionates	1993
Plasma brain natriuretic peptide and endopeptidase 24.11 inhibition in hypertension. Hypertension (Dallas, Tex. : 1979), 1993, Volume: 22, Issue:2 Topics: Adult; Aged; Angiotensin II; Atrial Natriuretic Factor; Double-Blind Method; Humans; Hypertension; Indans; Male; Methionine; Middle Aged; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Posture; Propionates; Time Factors	1993
Chronic inhibition of endopeptidase 24.11 in essential hypertension: evidence for enhanced atrial natriuretic peptide and angiotensin II. Journal of hypertension, 1993, Volume: 11, Issue:4 Topics: Adult; Angiotensin II; Atrial Natriuretic Factor; Blood Pressure; Double-Blind Method; Heart Rate; Humans; Hypertension; Indans; Kidney; Male; Middle Aged; Natriuresis; Neprilysin; Propionates; Time Factors	1993
Candoxatril, an orally active neutral endopeptidase inhibitor, raises plasma atrial natriuretic factor and is natriuretic in essential hypertension. Journal of hypertension, 1992, Volume: 10, Issue:3 Topics: Administration, Oral; Adult; Analysis of Variance; Antihypertensive Agents; Atrial Natriuretic Factor; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypertension; Indans; Male; Natriuresis; Neprilysin; Propionates	1992
Is atrial natriuretic peptide-guanosine 3',5' cyclic monophosphate coupling a determinant of urinary sodium excretion in essential hypertension? Journal of hypertension, 1992, Volume: 10, Issue:4 Topics: Atrial Natriuretic Factor; Cyclic GMP; Female; Humans; Hypertension; Indans; Male; Middle Aged; Natriuresis; Neprilysin; Propionates; Sodium, Dietary	1992
Candoxatril, a neutral endopeptidase inhibitor: efficacy and tolerability in essential hypertension. Journal of hypertension, 1992, Volume: 10, Issue:7 Topics: Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Double-Blind Method; Female; Humans; Hypertension; Indans; Male; Middle Aged; Neprilysin; Propionates	1992
Dietary sodium and inhibition of neutral endopeptidase 24.11 in essential hypertension. Hypertension (Dallas, Tex. : 1979), 1991, Volume: 18, Issue:6 Topics: Adult; Aldosterone; Analysis of Variance; Atrial Natriuretic Factor; Blood Pressure; Creatine; Heart Rate; Hematocrit; Humans; Hypertension; Indans; Middle Aged; Neprilysin; Potassium; Propionates; Renin; Sodium; Sodium, Dietary	1991

Other Studies

5 other study(ies) available for candoxatril and Hypertension

Article	Year
Chronic endopeptidase inhibition in DOCA-salt hypertension: mechanism of cardiovascular protection. Clinical and experimental hypertension (New York, N.Y. : 1993), 2003, Volume: 25, Issue:6 Topics: Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Endothelin-1; Hypertension; Indans; Kidney; Male; Models, Animal; Neprilysin; Nitric Oxide; Propionates; Rats; Rats, Sprague-Dawley; Sodium	2003
Dual inhibition of angiotensin converting enzyme and neutral endopeptidase produces effective blood pressure control in spontaneously hypertensive rats. Bratislavske lekarske listy, 2005, Volume: 106, Issue:12 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Drug Combinations; Enalapril; Hypertension; Indans; Male; Neprilysin; Propionates; Pyridines; Rats; Rats, Inbred SHR; Thiazepines	2005
Mechanisms of the natriuretic effects of neutral endopeptidase inhibition in Dahl salt-sensitive and salt-resistant rats. Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:2 Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Dose-Response Relationship, Drug; Hypertension; Indans; Natriuresis; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Peptide Fragments; Propionates; Rats; Rats, Inbred Strains; Sodium, Dietary	1994
Mechanisms underlying the augmented responses of deoxycorticosterone acetate-salt hypertensive rats to neutral endopeptidase inhibitors. Journal of hypertension, 1994, Volume: 12, Issue:4 Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Base Sequence; Blood Pressure; Desoxycorticosterone; Hypertension; Indans; Male; Molecular Sequence Data; Neprilysin; Polysaccharides; Propionates; Rats; Rats, Wistar; Sodium Chloride; Thiorphan	1994
Effects of SA7060, a novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme, on deoxycorticosterone acetate-salt-induced hypertension in rats. Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:7 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Blood Pressure; Body Weight; Cardiomegaly; Desoxycorticosterone; Enalapril; Heart; Hypertension; Hypertrophy; Indans; Kidney; Kidney Function Tests; Male; Naphthalenes; Neprilysin; Organ Size; Peptidyl-Dipeptidase A; Propionates; Rats; Rats, Sprague-Dawley; Urea	2000