candoxatril has been researched along with Cardiac Failure in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (76.47) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lang, CC; Singh, JS | 1 |
| Carretero, OA; Liu, YH; Oja-Tebbe, N; Shesely, EG; Xu, J; Yang, F; Yang, XP | 1 |
| Berezin, AE | 1 |
| Borgeson, DD; Burnett, JC; Cataliotti, A; Luchner, A; Martin, FL; Redfield, MM; Schirger, JA; Stevens, TL | 1 |
| Barclay, PL; Burnett, JC; Margulies, KB | 1 |
| Wilkins, MR | 1 |
| Drummer, C; Gerzer, R; Kentsch, M; Müller-Esch, G; Nötges, A; Otter, W | 1 |
| Buchanan, KD; Coutie, W; McDowell, G; Nicholls, DP; Shaw, C; Struthers, AD | 1 |
| Boon, NA; Currie, PF; Dargie, HJ; McDonagh, T; Newby, DE; Northridge, DB | 1 |
| Coodley, E | 1 |
| Dargie, HJ; Newby, DE; Norrie, J; Northridge, DB; Rooney, E | 1 |
| Bostrøm, P; Christensen, CC; Parikka, H; Rykke, EO; Toivonen, L; Westheim, AS | 1 |
| Boon, NA; Currie, PF; Dargie, HJ; Ford, M; McMurray, JJ; Newby, DE; Northridge, DB | 1 |
| Coutie, WJ; Lang, CC; Motwani, JG; Struthers, AD | 1 |
| Elsner, D; Kromer, EP; Müntze, A; Riegger, GA | 1 |
| Coutie, WJ; Lang, CC; Motwani, J; Struthers, AD | 1 |
| Elsner, D; Kahles, HW; Kromer, EP; Riegger, GA | 1 |
4 review(s) available for candoxatril and Cardiac Failure
| Article | Year |
|---|---|
Angiotensin receptor-neprilysin inhibitors: clinical potential in heart failure and beyond.
Topics: Aminobutyrates; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Clinical Trials as Topic; Drug Combinations; Heart Failure; Humans; Hypertension; Indans; Natriuretic Peptide, Brain; Neprilysin; Propionates; Pyridines; Receptors, Angiotensin; Renin-Angiotensin System; Risk Factors; Stroke Volume; Tetrazoles; Thiazepines; Valsartan | 2015 |
[The new class of drugs-- metalloprotease inhibitors -- in the treatment of heart failure].
Topics: Glycopeptides; Heart Failure; Hemodynamics; Humans; Indans; Metalloproteases; Propionates; Protease Inhibitors; Pyridines; Thiazepines; Thiorphan | 2004 |
Clinical potential of endopeptidase-24.11 inhibitors in cardiovascular disease.
Topics: Animals; Antihypertensive Agents; Cardiovascular Diseases; Cyclohexanecarboxylic Acids; Diuretics; Drug Design; Heart Failure; Humans; Hypertension; Indans; Neprilysin; Propionates; Protease Inhibitors; Thiorphan | 1993 |
Newer drug therapy for congestive heart failure.
Topics: Adrenergic beta-Antagonists; Algorithms; Amiodarone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Calcium Channel Blockers; Cardiotonic Agents; Diagnosis, Differential; Heart Failure; Humans; Indans; Magnesium Compounds; Mineralocorticoid Receptor Antagonists; Natriuretic Peptide, Brain; Propionates | 1999 |
10 trial(s) available for candoxatril and Cardiac Failure
| Article | Year |
|---|---|
Neutral endopeptidase 24.11 inhibition may not exhibit beneficial haemodynamic effects in patients with congestive heart failure.
Topics: Aldosterone; Atrial Natriuretic Factor; Cyclic AMP; Double-Blind Method; Heart Failure; Hemodynamics; Humans; Indans; Middle Aged; Neprilysin; Propionates; Protease Inhibitors | 1996 |
The effect of the neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides.
Topics: Aged; Analysis of Variance; Atrial Natriuretic Factor; Calcitonin Gene-Related Peptide; Cross-Over Studies; Double-Blind Method; Endothelins; Heart Failure; Humans; Indans; Male; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Prodrugs; Propionates; Protease Inhibitors | 1997 |
Candoxatril improves exercise capacity in patients with chronic heart failure receiving angiotensin converting enzyme inhibition.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Double-Blind Method; Exercise Test; Exercise Tolerance; Female; Heart Failure; Humans; Indans; Male; Middle Aged; Neprilysin; Propionates; Protease Inhibitors; Time Factors | 1998 |
Comparison of the short-term effects of candoxatril, an orally active neutral endopeptidase inhibitor, and frusemide in the treatment of patients with chronic heart failure.
Topics: Atrial Natriuretic Factor; Chronic Disease; Diuretics; Double-Blind Method; Exercise Test; Furosemide; Heart Failure; Humans; Indans; Male; Middle Aged; Propionates; Protease Inhibitors; Renin; Severity of Illness Index; Time Factors | 1999 |
Hemodynamic and neuroendocrine effects for candoxatril and frusemide in mild stable chronic heart failure.
Topics: Adolescent; Adult; Aged; Aldosterone; Antihypertensive Agents; Chronic Disease; Diuretics; Double-Blind Method; Enzyme Inhibitors; Exercise Test; Furosemide; Heart Failure; Hemodynamics; Humans; Indans; Middle Aged; Neprilysin; Propionates; Pulmonary Wedge Pressure; Renin | 1999 |
Placebo-controlled comparison of candoxatril, an orally active neutral endopeptidase inhibitor, and captopril in patients with chronic heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Double-Blind Method; Exercise Test; Exercise Tolerance; Female; Heart Failure; Humans; Indans; Male; Middle Aged; Propionates; Protease Inhibitors | 1999 |
Clearance of brain natriuretic peptide in patients with chronic heart failure: indirect evidence for a neutral endopeptidase mechanism but against an atrial natriuretic peptide clearance receptor mechanism.
Topics: Aged; Atrial Natriuretic Factor; Dose-Response Relationship, Drug; Heart Failure; Humans; Indans; Male; Middle Aged; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Propionates; Protease Inhibitors; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface | 1992 |
Effectiveness of endopeptidase inhibition (candoxatril) in congestive heart failure.
Topics: Adult; Aged; Aldosterone; Atrial Natriuretic Factor; Double-Blind Method; Female; Heart Failure; Hemodynamics; Humans; Indans; Male; Middle Aged; Neprilysin; Propionates; Renin | 1992 |
Influence of candoxatril on plasma brain natriuretic peptide in heart failure.
Topics: Atrial Natriuretic Factor; Brain; Heart Failure; Humans; Indans; Middle Aged; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Propionates | 1991 |
Effects of atriopeptidase inhibitor UK 79300 on left ventricular hydraulic load in patients with congestive heart failure.
Topics: Aorta; Atrial Natriuretic Factor; Heart Failure; Humans; Indans; Middle Aged; Neprilysin; Propionates; Regional Blood Flow; Ventricular Function, Left | 1991 |
3 other study(ies) available for candoxatril and Cardiac Failure
| Article | Year |
|---|---|
Dual inhibition of ACE and NEP provides greater cardioprotection in mice with heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Collagen; Disease Models, Animal; Echocardiography; Heart; Heart Failure; Indans; Liver; Lung; Mice; Mice, Knockout; Muscle Cells; Neprilysin; Organ Size; Propionates; Pyridines; Ramipril; Thiazepines; Treatment Outcome; Ventricular Function, Left; Ventricular Remodeling | 2004 |
Natriuretic and antialdosterone actions of chronic oral NEP inhibition during progressive congestive heart failure.
Topics: Administration, Oral; Aldosterone; Animals; Atrial Natriuretic Factor; Cyclic GMP; Disease Models, Animal; Dogs; Heart; Heart Failure; Indans; Kidney; Male; Mineralocorticoid Receptor Antagonists; Natriuresis; Neprilysin; Propionates; Protease Inhibitors | 2005 |
The role of neutral endopeptidase in dogs with evolving congestive heart failure.
Topics: Animals; Atrial Natriuretic Factor; Cyclic GMP; Dogs; Heart Failure; Hemodynamics; Indans; Kidney; Male; Natriuresis; Neprilysin; Propionates; Sodium; Time Factors | 1995 |