Page last updated: 2024-09-03

candoxatril and Cardiac Failure

candoxatril has been researched along with Cardiac Failure in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's13 (76.47)18.2507
2000's3 (17.65)29.6817
2010's1 (5.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lang, CC; Singh, JS1
Carretero, OA; Liu, YH; Oja-Tebbe, N; Shesely, EG; Xu, J; Yang, F; Yang, XP1
Berezin, AE1
Borgeson, DD; Burnett, JC; Cataliotti, A; Luchner, A; Martin, FL; Redfield, MM; Schirger, JA; Stevens, TL1
Barclay, PL; Burnett, JC; Margulies, KB1
Wilkins, MR1
Drummer, C; Gerzer, R; Kentsch, M; Müller-Esch, G; Nötges, A; Otter, W1
Buchanan, KD; Coutie, W; McDowell, G; Nicholls, DP; Shaw, C; Struthers, AD1
Boon, NA; Currie, PF; Dargie, HJ; McDonagh, T; Newby, DE; Northridge, DB1
Coodley, E1
Dargie, HJ; Newby, DE; Norrie, J; Northridge, DB; Rooney, E1
Bostrøm, P; Christensen, CC; Parikka, H; Rykke, EO; Toivonen, L; Westheim, AS1
Boon, NA; Currie, PF; Dargie, HJ; Ford, M; McMurray, JJ; Newby, DE; Northridge, DB1
Coutie, WJ; Lang, CC; Motwani, JG; Struthers, AD1
Elsner, D; Kromer, EP; Müntze, A; Riegger, GA1
Coutie, WJ; Lang, CC; Motwani, J; Struthers, AD1
Elsner, D; Kahles, HW; Kromer, EP; Riegger, GA1

Reviews

4 review(s) available for candoxatril and Cardiac Failure

ArticleYear
Angiotensin receptor-neprilysin inhibitors: clinical potential in heart failure and beyond.
    Vascular health and risk management, 2015, Volume: 11

    Topics: Aminobutyrates; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Clinical Trials as Topic; Drug Combinations; Heart Failure; Humans; Hypertension; Indans; Natriuretic Peptide, Brain; Neprilysin; Propionates; Pyridines; Receptors, Angiotensin; Renin-Angiotensin System; Risk Factors; Stroke Volume; Tetrazoles; Thiazepines; Valsartan

2015
[The new class of drugs-- metalloprotease inhibitors -- in the treatment of heart failure].
    Klinicheskaia meditsina, 2004, Volume: 82, Issue:5

    Topics: Glycopeptides; Heart Failure; Hemodynamics; Humans; Indans; Metalloproteases; Propionates; Protease Inhibitors; Pyridines; Thiazepines; Thiorphan

2004
Clinical potential of endopeptidase-24.11 inhibitors in cardiovascular disease.
    Biochemical Society transactions, 1993, Volume: 21 ( Pt 3), Issue:3

    Topics: Animals; Antihypertensive Agents; Cardiovascular Diseases; Cyclohexanecarboxylic Acids; Diuretics; Drug Design; Heart Failure; Humans; Hypertension; Indans; Neprilysin; Propionates; Protease Inhibitors; Thiorphan

1993
Newer drug therapy for congestive heart failure.
    Archives of internal medicine, 1999, Jun-14, Volume: 159, Issue:11

    Topics: Adrenergic beta-Antagonists; Algorithms; Amiodarone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Calcium Channel Blockers; Cardiotonic Agents; Diagnosis, Differential; Heart Failure; Humans; Indans; Magnesium Compounds; Mineralocorticoid Receptor Antagonists; Natriuretic Peptide, Brain; Propionates

1999

Trials

10 trial(s) available for candoxatril and Cardiac Failure

ArticleYear
Neutral endopeptidase 24.11 inhibition may not exhibit beneficial haemodynamic effects in patients with congestive heart failure.
    European journal of clinical pharmacology, 1996, Volume: 51, Issue:3-4

    Topics: Aldosterone; Atrial Natriuretic Factor; Cyclic AMP; Double-Blind Method; Heart Failure; Hemodynamics; Humans; Indans; Middle Aged; Neprilysin; Propionates; Protease Inhibitors

1996
The effect of the neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides.
    British journal of clinical pharmacology, 1997, Volume: 43, Issue:3

    Topics: Aged; Analysis of Variance; Atrial Natriuretic Factor; Calcitonin Gene-Related Peptide; Cross-Over Studies; Double-Blind Method; Endothelins; Heart Failure; Humans; Indans; Male; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Prodrugs; Propionates; Protease Inhibitors

1997
Candoxatril improves exercise capacity in patients with chronic heart failure receiving angiotensin converting enzyme inhibition.
    European heart journal, 1998, Volume: 19, Issue:12

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Double-Blind Method; Exercise Test; Exercise Tolerance; Female; Heart Failure; Humans; Indans; Male; Middle Aged; Neprilysin; Propionates; Protease Inhibitors; Time Factors

1998
Comparison of the short-term effects of candoxatril, an orally active neutral endopeptidase inhibitor, and frusemide in the treatment of patients with chronic heart failure.
    American heart journal, 1999, Volume: 138, Issue:6 Pt 1

    Topics: Atrial Natriuretic Factor; Chronic Disease; Diuretics; Double-Blind Method; Exercise Test; Furosemide; Heart Failure; Humans; Indans; Male; Middle Aged; Propionates; Protease Inhibitors; Renin; Severity of Illness Index; Time Factors

1999
Hemodynamic and neuroendocrine effects for candoxatril and frusemide in mild stable chronic heart failure.
    Journal of the American College of Cardiology, 1999, Nov-15, Volume: 34, Issue:6

    Topics: Adolescent; Adult; Aged; Aldosterone; Antihypertensive Agents; Chronic Disease; Diuretics; Double-Blind Method; Enzyme Inhibitors; Exercise Test; Furosemide; Heart Failure; Hemodynamics; Humans; Indans; Middle Aged; Neprilysin; Propionates; Pulmonary Wedge Pressure; Renin

1999
Placebo-controlled comparison of candoxatril, an orally active neutral endopeptidase inhibitor, and captopril in patients with chronic heart failure.
    European journal of heart failure, 1999, Volume: 1, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Double-Blind Method; Exercise Test; Exercise Tolerance; Female; Heart Failure; Humans; Indans; Male; Middle Aged; Propionates; Protease Inhibitors

1999
Clearance of brain natriuretic peptide in patients with chronic heart failure: indirect evidence for a neutral endopeptidase mechanism but against an atrial natriuretic peptide clearance receptor mechanism.
    Clinical science (London, England : 1979), 1992, Volume: 82, Issue:6

    Topics: Aged; Atrial Natriuretic Factor; Dose-Response Relationship, Drug; Heart Failure; Humans; Indans; Male; Middle Aged; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Propionates; Protease Inhibitors; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface

1992
Effectiveness of endopeptidase inhibition (candoxatril) in congestive heart failure.
    The American journal of cardiology, 1992, Aug-15, Volume: 70, Issue:4

    Topics: Adult; Aged; Aldosterone; Atrial Natriuretic Factor; Double-Blind Method; Female; Heart Failure; Hemodynamics; Humans; Indans; Male; Middle Aged; Neprilysin; Propionates; Renin

1992
Influence of candoxatril on plasma brain natriuretic peptide in heart failure.
    Lancet (London, England), 1991, Jul-27, Volume: 338, Issue:8761

    Topics: Atrial Natriuretic Factor; Brain; Heart Failure; Humans; Indans; Middle Aged; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Propionates

1991
Effects of atriopeptidase inhibitor UK 79300 on left ventricular hydraulic load in patients with congestive heart failure.
    American journal of hypertension, 1991, Volume: 4, Issue:5 Pt 1

    Topics: Aorta; Atrial Natriuretic Factor; Heart Failure; Humans; Indans; Middle Aged; Neprilysin; Propionates; Regional Blood Flow; Ventricular Function, Left

1991

Other Studies

3 other study(ies) available for candoxatril and Cardiac Failure

ArticleYear
Dual inhibition of ACE and NEP provides greater cardioprotection in mice with heart failure.
    Journal of cardiac failure, 2004, Volume: 10, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Collagen; Disease Models, Animal; Echocardiography; Heart; Heart Failure; Indans; Liver; Lung; Mice; Mice, Knockout; Muscle Cells; Neprilysin; Organ Size; Propionates; Pyridines; Ramipril; Thiazepines; Treatment Outcome; Ventricular Function, Left; Ventricular Remodeling

2004
Natriuretic and antialdosterone actions of chronic oral NEP inhibition during progressive congestive heart failure.
    Kidney international, 2005, Volume: 67, Issue:5

    Topics: Administration, Oral; Aldosterone; Animals; Atrial Natriuretic Factor; Cyclic GMP; Disease Models, Animal; Dogs; Heart; Heart Failure; Indans; Kidney; Male; Mineralocorticoid Receptor Antagonists; Natriuresis; Neprilysin; Propionates; Protease Inhibitors

2005
The role of neutral endopeptidase in dogs with evolving congestive heart failure.
    Circulation, 1995, Apr-01, Volume: 91, Issue:7

    Topics: Animals; Atrial Natriuretic Factor; Cyclic GMP; Dogs; Heart Failure; Hemodynamics; Indans; Kidney; Male; Natriuresis; Neprilysin; Propionates; Sodium; Time Factors

1995