candidin has been researched along with Hypersensitivity* in 2 studies
2 other study(ies) available for candidin and Hypersensitivity
| Article | Year |
|---|---|
Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy.
This study's objective was to investigate whether candidin or trichophytin elicit recall immune responses that could potentially inhibit a Th2 response.. Peripheral blood mononuclear cells from nine allergic and seven nonallergic individuals were cultivated in vitro in the presence or absence of these fungal extracts.. Trichophytin or candidin, or both, stimulated the production of regulatory cytokines (TGF-β and/or IL-10), accompanied or not by stimulation of production of cytokines associated with the Th1 response (TNF-α, IL-12 and IFN-γ), but without stimulation of Th2 cytokines (IL-5 and IL-13) and IL-17, by peripheral blood mononuclear cells of most allergic and nonallergic individuals.. These results indicate that these fungal extracts could be used as adjuvants in personalized therapeutic vaccines in a fair proportion of individuals. In addition, they justify the carrying out of investigations aimed at identifying molecules in these extracts that might exclusively induce Treg and/or Th1 immune responses. Topics: Adjuvants, Pharmaceutic; Adult; Allergens; Animals; Cells, Cultured; Cockroaches; Cytokines; Drug Therapy, Combination; Female; Humans; Hypersensitivity; Immunomodulation; Immunotherapy; Insect Proteins; Macrolides; Male; Mites; Precision Medicine; Th1 Cells; Th2 Cells; Trichophytin; Young Adult | 2014 |
[On the biological and clinical value of the cutaneous reactivity to candidin in adults].
Topics: Adult; Candidiasis; Dermatomycoses; Humans; Hypersensitivity; Immune System Diseases; Macrolides | 1961 |