candicidin and Orthomyxoviridae-Infections

It was shown experimentally that polyenic antibiotics, i. e. amphotericin B and sodium levorin markedly increased the specific immunogenic properties and interferonogenic activity of inactivated influenza virus vaccine prepared with various methods from highly reproductive recombinants. The rate of pneumonia and death from influenza among the vaccinated mice treated with inactivated influenza virus vaccine and one of the polyenic antibiotics was lower than that among the animals treated with the vaccine alone (P less than 0.05). Correlation between the increase in the immunological response, the decrease in the virus reproduction rate in the lungs and addition of the antibiotics into the vaccine was also observed. It is recommended that inactivated influenza virus vaccine be used in conjunction with polyenic antibiotics.

Topics: Amphotericin B; Animals; Antifungal Agents; Candicidin; Chick Embryo; Drug Synergism; Immunization; Immunization, Secondary; Influenza A virus; Influenza Vaccines; Interferon Inducers; Mice; Orthomyxoviridae Infections; Vaccines, Attenuated; Virus Replication