candicidin and Fatty-Liver

The effect of the sodium salts of levorin, isolevorin, nystatin and amphotericin B prepared with the use of sodium desoxycholate and amphoglucamine on the development of fatty degeneration of the liver was studied in rats. Fatty degeneration of the liver was induced in the animals by the diet deficient in choline and administration of alcohol (10 g/kg). Most of the studied antibiotics inhibited the development of the liver fatty degeneration. The only exclusion was amphotericin B prepared with the use of sodium desoxycholate which did not influence the level of the liver fatty degeneration. Sodium levorin (10 mg/kg) produced the most pronounced normalizing effect on the lipid metabolism in the liver. Complication of mycoses with fatty degeneration of the liver should not be considered as a contraindication to their treatment with polyenic antibiotics.

Topics: Amphotericin B; Animals; Anti-Bacterial Agents; Candicidin; Choline Deficiency; Drug Evaluation, Preclinical; Fatty Liver; Fatty Liver, Alcoholic; Male; Nystatin; Rats

Activity of Na+, K+-ATP- ase and 5'-nucleotidase, the lipid composition of the liver plasmic membranes with toxic and alimentary-alcohol fat dystrophy were studied on rats exposed to water-soluble sodium levorin. It was found that the above forms of the liver fat dystrophy did not change the activity of the enzymes in the membranes but caused significant shifts in the composition of the membrane lipids. The shifts were evident from an increased level of phospholipids in the plasmic membranes. Administration of levorin at the very beginning of the development of both the toxic and the alimentary-alcohol liver fat dystrophy aggravated the increase in the phospholipid level in the membranes. It was supposed that the increase in the phospholipid level due to levorin in the membranes of the liver with fat dystrophy was one of the mechanisms of the drug therapeutic effect in case of such pathology type. Levorin increased the amount of phospholipids in the dystrophic membranes and thus changed the membrane permeability resulting in decreased accumulation of neutral lipids in the hepacytes and subsequently in decreased levels of the liver fat dystrophy.

Topics: Animals; Antifungal Agents; Candicidin; Carbon Tetrachloride Poisoning; Cell Membrane; Drug Evaluation, Preclinical; Fatty Liver; Fatty Liver, Alcoholic; Liver; Rats