candicidin and Candidiasis--Vulvovaginal

A combination of 5-fluorocytosine (1000 mg) and candicidin (5 mg) was compared with clotrimazole (100 mg) in the treatment of 112 non-pregnant volunteers with vulvovaginal candidiasis. Seventy-two (75%) of the 96 patients treated with 1 or 2 vaginal tablets of the combination product and 10 (62%) of the 16 women treated with clotrimazole for 6 days were cured. The efficacy of the treatments was assessed mycologically and clinically 1 week and 1 month after the therapy. Both treatments were well tolerated and no side-effects could be detected. It is concluded that a short-term vaginal treatment with a 5-fluorocytosine and candicidin combination is effective in vaginal moniliasis, and the brevity of the treatment is an advantage compared with others now available.

Topics: Administration, Topical; Adult; Antifungal Agents; Candicidin; Candidiasis, Vulvovaginal; Cytosine; Drug Combinations; Drug Resistance; Female; Flucytosine; Humans

Topics: Adolescent; Adult; Antifungal Agents; Candicidin; Candidiasis, Vulvovaginal; Drug Evaluation; Female; Humans; Middle Aged; Ointments; Pregnancy; Tablets

Topics: Adolescent; Adult; Aged; Antifungal Agents; Candicidin; Candida albicans; Candidiasis, Vulvovaginal; Child; Female; Humans; Middle Aged; Ointments; Vaginitis

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antifungal Agents; Candicidin; Candidiasis, Vulvovaginal; Dermatologic Agents; Drug Therapy; Female; Humans

Candicidin vaginal ointment, 0.14 mg per gm of petrolatum base, was used in the treatment of 25 patients with monilial vaginitis. Ten of these patients were pregnant. All 15 of the non-gravid patients were cured, as proved by repeated cultures, after a maximum of three weeks of therapy. Eight of the 10 gravid patients were cured. Of the two patients with resistant cases, one had severe diabetes and the other had endocervicitis. Of 50 patients treated by insertion of Candeptin vaginal tablets, 42 became free of vaginal moniliasis after one or two 14-day courses of home treatment. All 42 remained free of infection for one month following treatment, as proven by culture. There were no instances of sensitivity to the preparation.

Topics: Antifungal Agents; Candicidin; Candidiasis, Vulvovaginal; Female; Humans; Ointments; Petrolatum; Pregnancy; Tablets; Uterine Cervicitis