candicidin and Candidiasis--Oral

Lymphotropic and endolymphatic therapy was carried out in 52 patients with candidiasis of the buccal mucosa. After preliminary injection of lidase, levorin was injected subcutaneously in the middle third of the shin to patients in a standing posture, after which a cuff with 45-50 mm Hg pressure was placed on the femur for 2-2.5 hours. Immunocorrector thymogen was injected in the submaxillary and chin lymph nodes. A course consisted of 5-6 sessions. The status of the buccal mucosa normalized after treatment. Contamination of the mucosa with yeast cells appreciably decreased, the content of substances with medium-molecular mass in the saliva reduced, and cellular and humoral immunity parameters normalized.

Topics: Adjuvants, Immunologic; Antifungal Agents; B-Lymphocytes; Candicidin; Candidiasis, Oral; Dipeptides; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hyaluronoglucosaminidase; Immunity, Cellular; Injections, Intralymphatic; Male; Peptides; T-Lymphocytes

Sensitivity of 146 clinical strains of Candida albicans to nystatin, levorin and amphoglucamine was studied on solid media with the replica method. The strains were isolated from 79 patients with candidiasis of the oral mucosa. It was found that sensitivity of the fungi to the polyenic antibiotics was different which should be considered in treatment of candidiasis. On the basis of the mean MICs for the clinical strains and their distribution by the MICs it was shown that the activity level of levorin and amphoglucamine was higher than that of nystatin. During the treatment resistance of the Candida strains to the polyenic antibiotics increased and cross resistance developed which required application of other treatment means.

Topics: Amphotericin B; Antifungal Agents; Candicidin; Candida albicans; Candidiasis, Oral; Drug Resistance, Microbial; Humans; Nystatin