candesartan cilexetil has been researched along with Glomerulosclerosis, Focal Segmental in 5 studies
candesartan cilexetil: a prodrug which is metabolized to an active form candesartan to exert its biological effects
Glomerulosclerosis, Focal Segmental: A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with candesartan cilexetil lowered systemic blood pressure, normalized PGC at 10 weeks and greatly reduced proteinuria and allograft glomerulosclerosis at 24 weeks." | 3.69 | Candesartan cilexetil reduces chronic renal allograft injury in Fisher-->Lewis rats. ( Azuma, H; Brenner, BM; Mackenzie, HS; Nagano, H; Rennke, HG; Tilney, NL; Troy, JL; Ziai, F, 1997) |
| "In vehicle-treated rats, proteinuria, glomerulosclerosis, interstitial mononuclear cell (MNC) infiltration and interstitial fibrosis developed." | 1.30 | Effects of candesartan cilexetil (TCV-116) and enalapril in 5/6 nephrectomized rats. ( Fukuda, R; Imura, Y; Matsuo, T; Nagano, H; Nishikawa, K; Noda, M; Ohta, M; Shibouta, Y, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hamaguchi, A | 1 |
| Kim, S | 1 |
| Wanibuchi, H | 1 |
| Iwao, H | 1 |
| Noda, M | 1 |
| Fukuda, R | 1 |
| Matsuo, T | 2 |
| Ohta, M | 2 |
| Nagano, H | 2 |
| Imura, Y | 2 |
| Nishikawa, K | 1 |
| Shibouta, Y | 2 |
| Obata, J | 1 |
| Nakamura, T | 1 |
| Kuroyanagi, R | 1 |
| Yoshida, Y | 1 |
| Guo, DF | 1 |
| Inagami, T | 1 |
| Mackenzie, HS | 1 |
| Ziai, F | 1 |
| Azuma, H | 1 |
| Troy, JL | 1 |
| Rennke, HG | 1 |
| Tilney, NL | 1 |
| Brenner, BM | 1 |
| Ishikawa, E | 1 |
| Ishimura, Y | 1 |
| Sugiyama, Y | 1 |
5 other studies available for candesartan cilexetil and Glomerulosclerosis, Focal Segmental
| Article | Year |
|---|---|
Angiotensin II and calcium blockers prevent glomerular phenotypic changes in remnant kidney model.
Topics: Actins; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biomarke | 1996 |
Effects of candesartan cilexetil (TCV-116) and enalapril in 5/6 nephrectomized rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; | 1997 |
Candesartan prevents the progression of glomerulosclerosis in genetic hypertensive rats.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; | 1997 |
Candesartan cilexetil reduces chronic renal allograft injury in Fisher-->Lewis rats.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compoun | 1997 |
Renal protective effect of candesartan cilexetil in spontaneously hypercholesterolemic rats.
Topics: Albuminuria; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Be | 2002 |