candesartan has been researched along with Ureteral Obstruction in 12 studies
candesartan: a nonpeptide angiotensin II receptor antagonist
candesartan : A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.
Ureteral Obstruction: Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed to investigate whether withaferin A treatment ameliorates the development of renal fibrosis and its related mechanisms in a CKD mouse model." | 7.96 | Withaferin A protects against endoplasmic reticulum stress-associated apoptosis, inflammation, and fibrosis in the kidney of a mouse model of unilateral ureteral obstruction. ( Chen, CM; Chiang, CK; Chung, YP; Guan, SS; Huang, KT; Liu, CH; Liu, SH; Wu, CT, 2020) |
| "To examine the additive protective effects of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone (Pio) and the angiotensin II receptor blocker candesartan (Cand) in a murine model of renal fibrosis: mice with unilateral ureteral obstruction (UUO)." | 7.76 | Additive antifibrotic effects of pioglitazone and candesartan on experimental renal fibrosis in mice. ( Higashi, K; Hyodo, T; Kumagai, H; Kushiyama, T; Miura, S; Oda, T; Sakurai, Y; Suzuki, S; Yamada, M, 2010) |
| " Here, we examined the effects of the ANG II receptor type 1 (AT1R) blockade using candesartan on long-term renal molecular and functional changes in response to partial unilateral ureteral obstruction (PUUO)." | 7.74 | Candesartan prevents long-term impairment of renal function in response to neonatal partial unilateral ureteral obstruction. ( Djurhuus, JC; Frøkiaer, J; Jørgensen, TM; Knepper, M; Nielsen, S; Nørregaard, R; Pedersen, M; Topcu, SO; Wang, G, 2007) |
| "We aimed to investigate whether withaferin A treatment ameliorates the development of renal fibrosis and its related mechanisms in a CKD mouse model." | 3.96 | Withaferin A protects against endoplasmic reticulum stress-associated apoptosis, inflammation, and fibrosis in the kidney of a mouse model of unilateral ureteral obstruction. ( Chen, CM; Chiang, CK; Chung, YP; Guan, SS; Huang, KT; Liu, CH; Liu, SH; Wu, CT, 2020) |
| "To examine the additive protective effects of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone (Pio) and the angiotensin II receptor blocker candesartan (Cand) in a murine model of renal fibrosis: mice with unilateral ureteral obstruction (UUO)." | 3.76 | Additive antifibrotic effects of pioglitazone and candesartan on experimental renal fibrosis in mice. ( Higashi, K; Hyodo, T; Kumagai, H; Kushiyama, T; Miura, S; Oda, T; Sakurai, Y; Suzuki, S; Yamada, M, 2010) |
| " Here, we examined the effects of the ANG II receptor type 1 (AT1R) blockade using candesartan on long-term renal molecular and functional changes in response to partial unilateral ureteral obstruction (PUUO)." | 3.74 | Candesartan prevents long-term impairment of renal function in response to neonatal partial unilateral ureteral obstruction. ( Djurhuus, JC; Frøkiaer, J; Jørgensen, TM; Knepper, M; Nielsen, S; Nørregaard, R; Pedersen, M; Topcu, SO; Wang, G, 2007) |
| "Candesartan was associated with maintenance of XBP-1 expression and attenuated ATF4, cATF6 and CHOP protein expression." | 1.37 | Endoplasmic reticulum stress implicated in the development of renal fibrosis. ( Chang, YW; Cheng, HT; Chiang, CK; Hsu, SP; Huang, JW; Hung, KY; Liu, SH; Wu, CT; Wu, KD, 2011) |
| "In candesartan-treated piglets, the l-NAME-induced GFR reduction seen in normal and nonobstructed kidneys was absent in the partial obstructed kidneys." | 1.34 | Glomerular and tubular function during AT1 receptor blockade in pigs with neonatal induced partial ureteropelvic obstruction. ( Djurhuus, JC; Eskild-Jensen, A; Ferreira, LS; Frøkiaer, J; Nielsen, S; Nyengaard, JR; Paulsen, LF; Rawashdeh, YF; Rungø, C; Thomsen, K, 2007) |
| "Obstruction-induced fibrosis is a leading cause of end-stage renal failure in children." | 1.34 | AT1 receptor blockade prevents interstitial and glomerular apoptosis but not fibrosis in pigs with neonatal induced partial unilateral ureteral obstruction. ( Eskild-Jensen, A; Frøkiaer, J; Nyengaard, JR; Olesen, P; Paulsen, LF; Pedersen, L; Wogensen, L, 2007) |
| "Candesartan treatment from the onset of obstruction attenuated the reduction in GFR (3." | 1.33 | Angiotensin II mediates downregulation of aquaporin water channels and key renal sodium transporters in response to urinary tract obstruction. ( Frische, S; Frøkiaer, J; Jensen, AM; Knepper, MA; Li, C; Nielsen, S; Nørregaard, R; Praetorius, HA, 2006) |
| "Candesartan treatment, however, attenuated the chronic tubulointerstitial injury in obstructed kidneys and was associated with significant preservation of kidney tissue mass." | 1.32 | AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan. ( Padda, R; Sheikh-Hamad, D; Truong, LD; Tsao, CC; Wamsley-Davis, A; Zhang, P, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (66.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CM | 1 |
| Chung, YP | 1 |
| Liu, CH | 1 |
| Huang, KT | 1 |
| Guan, SS | 1 |
| Chiang, CK | 2 |
| Wu, CT | 2 |
| Liu, SH | 2 |
| Wang, Y | 1 |
| Huang, J | 1 |
| Liu, X | 1 |
| Niu, Y | 1 |
| Zhao, L | 1 |
| Yu, Y | 1 |
| Zhou, L | 1 |
| Lu, L | 1 |
| Yu, C | 1 |
| Jensen, AM | 2 |
| Bae, EH | 1 |
| Fenton, RA | 1 |
| Nørregaard, R | 3 |
| Nielsen, S | 4 |
| Kim, SW | 1 |
| Frøkiaer, J | 5 |
| Kuwabara, T | 1 |
| Mori, K | 1 |
| Mukoyama, M | 1 |
| Kasahara, M | 1 |
| Yokoi, H | 1 |
| Saito, Y | 1 |
| Yoshioka, T | 1 |
| Ogawa, Y | 1 |
| Imamaki, H | 1 |
| Kusakabe, T | 1 |
| Ebihara, K | 1 |
| Omata, M | 1 |
| Satoh, N | 1 |
| Sugawara, A | 1 |
| Barasch, J | 1 |
| Nakao, K | 1 |
| Higashi, K | 1 |
| Oda, T | 1 |
| Kushiyama, T | 1 |
| Hyodo, T | 1 |
| Yamada, M | 1 |
| Suzuki, S | 1 |
| Sakurai, Y | 1 |
| Miura, S | 1 |
| Kumagai, H | 1 |
| Hsu, SP | 1 |
| Huang, JW | 1 |
| Cheng, HT | 1 |
| Chang, YW | 1 |
| Hung, KY | 1 |
| Wu, KD | 1 |
| Nakatani, T | 1 |
| Tamada, S | 1 |
| Asai, T | 1 |
| Iwai, Y | 1 |
| Kim, T | 1 |
| Tsujino, T | 1 |
| Kumata, N | 1 |
| Uchida, J | 1 |
| Tashiro, K | 1 |
| Kuwabara, N | 1 |
| Komiya, T | 1 |
| Sumi, T | 1 |
| Okamura, M | 1 |
| Miura, K | 1 |
| Wamsley-Davis, A | 1 |
| Padda, R | 1 |
| Truong, LD | 1 |
| Tsao, CC | 1 |
| Zhang, P | 1 |
| Sheikh-Hamad, D | 1 |
| Li, C | 1 |
| Praetorius, HA | 1 |
| Frische, S | 1 |
| Knepper, MA | 1 |
| Topcu, SO | 1 |
| Pedersen, M | 1 |
| Wang, G | 1 |
| Knepper, M | 1 |
| Djurhuus, JC | 2 |
| Jørgensen, TM | 1 |
| Eskild-Jensen, A | 2 |
| Thomsen, K | 1 |
| Rungø, C | 1 |
| Ferreira, LS | 1 |
| Paulsen, LF | 2 |
| Rawashdeh, YF | 1 |
| Nyengaard, JR | 2 |
| Wogensen, L | 1 |
| Olesen, P | 1 |
| Pedersen, L | 1 |
12 other studies available for candesartan and Ureteral Obstruction
| Article | Year |
|---|---|
Withaferin A protects against endoplasmic reticulum stress-associated apoptosis, inflammation, and fibrosis in the kidney of a mouse model of unilateral ureteral obstruction.
Topics: Animals; Apoptosis; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Endoplasmic Reticulu | 2020 |
β-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; beta-Arrestin 1; b | 2017 |
Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction.
Topics: Adenylyl Cyclases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aquaporin 2; Be | 2009 |
Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Albumins; Angiotensin II Type 1 Receptor Blockers; Animal | 2009 |
Additive antifibrotic effects of pioglitazone and candesartan on experimental renal fibrosis in mice.
Topics: Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biomarkers; Biphenyl | 2010 |
Endoplasmic reticulum stress implicated in the development of renal fibrosis.
Topics: Angiotensin II Type 2 Receptor Blockers; Animals; Apoptosis; Benzimidazoles; Biphenyl Compounds; Blo | 2011 |
Role of renin-angiotensin system and nuclear factor-kappaB in the obstructed kidney of rats with unilateral ureteral obstruction.
Topics: Angiotensin Receptor Antagonists; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Fibrosi | 2002 |
AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan.
Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; DNA-Binding Proteins; Down-Reg | 2004 |
Angiotensin II mediates downregulation of aquaporin water channels and key renal sodium transporters in response to urinary tract obstruction.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aquaporin 1; Aquaporin 2; Aquapori | 2006 |
Candesartan prevents long-term impairment of renal function in response to neonatal partial unilateral ureteral obstruction.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Aquaporin 2; Benzim | 2007 |
Glomerular and tubular function during AT1 receptor blockade in pigs with neonatal induced partial ureteropelvic obstruction.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Aquaporin 2; Benzimidazoles; Bip | 2007 |
AT1 receptor blockade prevents interstitial and glomerular apoptosis but not fibrosis in pigs with neonatal induced partial unilateral ureteral obstruction.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Apoptosis; Benzi | 2007 |