Page last updated: 2024-10-24

candesartan and Renal Artery Stenosis

candesartan has been researched along with Renal Artery Stenosis in 2 studies

candesartan: a nonpeptide angiotensin II receptor antagonist
candesartan : A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.

Research Excerpts

ExcerptRelevanceReference
"Atherosclerotic renal artery stenosis is a problem with no consensus on diagnosis or therapy."1.33Stent revascularization for the prevention of cardiovascular and renal events among patients with renal artery stenosis and systolic hypertension: rationale and design of the CORAL trial. ( Cohen, DJ; Cooper, CJ; D'Agostino, R; Dworkin, L; Henrich, W; Jaff, M; Jamerson, K; Kuntz, R; Matsumoto, A; Murphy, TP; Reid, D; Rosenfield, K; Rundback, J; Steffes, M, 2006)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hoshide, S1
Kario, K1
Shimada, K1
Cooper, CJ1
Murphy, TP1
Matsumoto, A1
Steffes, M1
Cohen, DJ1
Jaff, M1
Kuntz, R1
Jamerson, K1
Reid, D1
Rosenfield, K1
Rundback, J1
D'Agostino, R1
Henrich, W1
Dworkin, L1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL)[NCT00081731]Phase 3947 participants (Actual)Interventional2004-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

30% Reduction of eGFR From Baseline, Persisting for Greater Than or Equal to 60 Days

(NCT00081731)
Timeframe: Measured at every 3 months for the first year and annually thereafter

Interventionparticipants (Number)
Optimal Medical Therapy77
Stenting68

Cardiovascular or Renal Death

(NCT00081731)
Timeframe: Measured at every 3 months for the first year and annually thereafter

Interventionparticipants (Number)
Optimal Medical Therapy20
Stenting20

Composite Endpoint: Death From Cardiovascular or Renal Causes, Stroke, Myocardial Infarction, Hospitalization for CHF, Progressive Renal Insufficiency, or Permanent Renal Replacement Therapy

Only the first event per participant is included in the composite (NCT00081731)
Timeframe: Measured at every 3 months for the first year and annually thereafter

Interventionparticipants (Number)
Optimal Medical Therapy169
Stenting161

Hospitalization for Congestive Heart Failure

(NCT00081731)
Timeframe: Measured at every 3 months for the first year and annually thereafter

Interventionparticipants (Number)
Optimal Medical Therapy26
Stenting27

Myocardial Infarction

(NCT00081731)
Timeframe: Measured at every 3 months for the first year and annually thereafter

Interventionparticipants (Number)
Optimal Medical Therapy27
Stenting30

Need for Renal Replacement Therapy

(NCT00081731)
Timeframe: Measured at every 3 months for the first year and annually thereafter

Interventionparticipants (Number)
Optimal Medical Therapy3
Stenting4

Stroke

(NCT00081731)
Timeframe: Measured at every 3 months for the first year and annually thereafter

Interventionparticipants (Number)
Optimal Medical Therapy16
Stenting12

Other Studies

2 other studies available for candesartan and Renal Artery Stenosis

ArticleYear
Ischemic nephropathy in an elderly patient.
    Geriatrics & gerontology international, 2008, Volume: 8, Issue:2

    Topics: Aged; Antihypertensive Agents; Atherosclerosis; Benzimidazoles; Biphenyl Compounds; Female; Humans;

2008
Stent revascularization for the prevention of cardiovascular and renal events among patients with renal artery stenosis and systolic hypertension: rationale and design of the CORAL trial.
    American heart journal, 2006, Volume: 152, Issue:1

    Topics: Angioplasty, Balloon; Angiotensin II Type 1 Receptor Blockers; Atherosclerosis; Benzimidazoles; Biph

2006