candesartan has been researched along with Disease Models, Animal in 155 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (5.16) | 18.2507 |
| 2000's | 71 (45.81) | 29.6817 |
| 2010's | 69 (44.52) | 24.3611 |
| 2020's | 7 (4.52) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Araújo Filho, EAF; Carmona, MJC; Lima, LGCA; Maia, DRR; Otsuki, DA; Vane, MF | 1 |
| Abd El-Salam, DM; Hussein, RM; Rizk, SM; Shehata, NI | 1 |
| Bhandari, RK; Bhatia, A; Kaur, N; Malhotra, S; Pandey, AK; Rather, IIG; Shafiq, N; Sharma, S | 1 |
| Chen, MJ; Chen, QY; Dong, XX; Liu, JY; Wei, YJ; Zhang, GX | 1 |
| Chen, CM; Chiang, CK; Chung, YP; Guan, SS; Huang, KT; Liu, CH; Liu, SH; Wu, CT | 1 |
| da Silva, FER; de Lucena, DF; Dos Santos Júnior, MA; Lima, CNC; Macedo, DS; Medeiros, IDS; Monte, AS; Moreira Lima Neto, AB; Teixeira, AL; Vasconcelos, GS; Vasconcelos, SMM | 1 |
| Brolund, L; Brolund-Spaether, K; Cascorbi, I; Culman, J; Gohlke, P; Jacob, T; Schuster, SO; Zhao, Y | 1 |
| Jie, L; Osei-Owusu, P; Owens, EA; Reyes, BAS; Van Bockstaele, EJ | 1 |
| Bhat, SA; Goel, R; Hanif, K; Shukla, R; Shukla, S | 1 |
| Ali, SS; Gazzaz, ZJ; Ibraheem, MS; Murad, HA | 1 |
| Cechova, S; Chan, F; Dong, F; Kelley, MJ; Le, TH; Ruiz, P | 1 |
| Chen, Y; Kietzman, WE; Lai, EY; Li, L; Ray, PE; Riegel, AT; Solis, G; Tassi, E; Welch, WJ; Wellstein, A; Wilcox, CS | 1 |
| Basbugan, Y; Demir, CY; Ersoz, ME; Erten, R; Kocak, OF; Sultanoglu, Y | 1 |
| Apte, RN; Asraf, K; Fleisher-Berkovich, S; Torika, N | 1 |
| Garrido-Gil, P; Kulisevsky, J; Labandeira-Garcia, JL; Lanciego, JL; Pedrosa, MA; Rodriguez-Perez, AI; Sucunza, D | 1 |
| Fukuda, S; Kayano, R; Matsuo, T; Morofuji, Y; Nakagawa, S; Niwa, M; Ozawa, H; Watanabe, D | 1 |
| Bessaguet, F; Bouchenaki, H; Danigo, A; Demiot, C; Desmoulière, A; Duchesne, M; Magy, L; Richard, L; Sturtz, F | 1 |
| Eldahshan, W; Ergul, A; Fagan, SC; Ishrat, T; Pillai, B; Soliman, S | 1 |
| Ahmed, HA; Eldahshan, W; Ergul, A; Fagan, SC; Fouda, AY; Ishrat, T; Pillai, B; Sayed, MA; Waller, JL | 1 |
| Hu, G; Ito, O; Kohzuki, M; Miura, T; Muroya, Y; Ogawa, Y; Rong, R; Wang, W | 1 |
| Hamel, E; Lacalle-Aurioles, M; Royea, J; Tong, XK; Trigiani, LJ | 1 |
| Kitajima, K; Kuwano, T; Matsuo, Y; Miura, SI; Suematsu, Y; Tashiro, K; Tomita, S | 1 |
| Chappell, MC; Diz, DI; Nautiyal, M; Shaltout, HA | 1 |
| Gabor, A; Leenen, FH | 1 |
| Inamdar, MN; Kulkarni, C; Kulkarni, KS; Moinuddin, G | 1 |
| Dominguez-Meijide, A; Guerra, MJ; Labandeira-Garcia, JL; Lanciego, JL; Rodriguez-Perez, AI | 2 |
| Inoue, T; Ito, H; Takemori, K | 1 |
| Dominguez-Meijide, A; Garrido-Gil, P; Guerra, MJ; Labandeira-Garcia, JL; Sierrra-Paredes, G; Villar-Cheda, B | 1 |
| Luchini, A; Nagashima, S; Noronha, Ld; Olandoski, M; Oliveira, LR; Precoma, DB; Torres, CL; Torres, RA; Torres, Rdo R; Torres, RJ | 1 |
| Harris, RA; Sullivan, JC; Zimmerman, MA | 1 |
| El-Remessy, AB; Ergul, A; Fagan, SC; Ishrat, T; Pillai, A; Soliman, S; Somanath, PR | 1 |
| Cao, Y; Chui, D; Guo, X; Li, L; Li, M; Li, Z; Liang, Y; Liu, Y; Mo, N; Tian, X | 1 |
| Daida, H; Inoue, H; Konishi, M; Kurebayashi, N; Morimoto, S; Murayama, T; Nakazato, Y; Odagiri, F; Sakurai, T; Shioya, T; Sugihara, M; Suzuki, T | 1 |
| Ergul, A; Fagan, SC; Fouda, AY; Ishrat, T; Johnson, MH; Kozak, A; Pillai, B; Soliman, S | 1 |
| Dominguez-Meijide, A; Garrido-Gil, P; Labandeira-Garcia, JL; Muñoz, A | 1 |
| Chehade, H; Courbebaisse, M; Daryadel, A; de Seigneux, S; Dizin, E; Feraille, E; Girardin, E; Hasler, U; Houillier, P; Khodo, SN; Martin, PY; Metzger, M; Prié, D; Rutkowski, JM; Scherer, PE; Stengel, B; Wagner, CA; Wilhelm-Bals, A | 1 |
| Chen, C; Li, C; Luo, H; Shi, W; Wang, J; Wang, X; Xu, Z; Yang, X; Zeng, C; Zou, X | 1 |
| Bostanci, H; Dikmen, AU; Dikmen, K; Gulbahar, O; Poyraz, A; Sahin, TT; Tekin, E; Yuksel, O | 1 |
| Fagan, SC; Fouda, AY; Ishrat, T; Patel, A; Pillai, B; Soliman, S | 1 |
| Byrne, M; Chu, PY; Horlock, D; Jandeleit-Dahm, K; Kaye, DM; Nelson, E; Walder, K; Williams, D; Zimmet, P | 1 |
| Berk, M; Budni, J; Carvalho, AF; Cavalcante, LM; de Lucena, DF; de Sousa, FC; de Souza Gomes, JA; de Souza, GC; Macêdo, D; Quevedo, J | 1 |
| Armando, I; Asico, LD; Chen, SY; Eisner, GM; Felder, RA; Jones, JE; Jose, PA; Konkalmatt, P; Sanada, H; Villar, VA; Wang, X; Wang, Z; Weir, MR; Yang, Y; Zeng, C | 1 |
| Elkahloun, AG; Hafko, R; Saavedra, JM | 1 |
| Funamoto, M; Hasegawa, K; Katanasaka, Y; Miyazaki, Y; Morimoto, T; Sunagawa, Y; Suzuki, H; Wada, H | 1 |
| Huang, J; Liu, X; Lu, L; Niu, Y; Wang, Y; Yu, C; Yu, Y; Zhao, L; Zhou, L | 1 |
| Frohlich, ED; Krousel-Wood, M; Susic, D; Zhou, X | 1 |
| Boolell, V; Calkin, AC; Chew, C; Cooper, ME; Giunti, S; Jandeleit-Dahm, KA; Rajaram, YS; Sheehy, KJ | 1 |
| Anzai, T; Kohno, T; Maekawa, Y; Naito, K; Ogawa, S; Sugano, Y; Takahashi, T; Yoshikawa, T | 1 |
| Achard, JM; Bureau, A; Faure, S; Fournier, A; Javellaud, J; Oudart, N | 1 |
| Fukumoto, M; Ikeda, T; Ishizaki, E; Jin, D; Miyazaki, M; Oku, H; Sakaguchi, M; Sakonjo, H; Sugiyama, T; Takai, S | 1 |
| Bae, EH; Fenton, RA; Frøkiaer, J; Jensen, AM; Kim, SW; Nielsen, S; Nørregaard, R | 1 |
| Higashikuni, Y; Hirata, Y; Koibuchi, N; Kugiyama, K; Nagai, R; Nakamura, K; Nishimatsu, H; Sata, M | 1 |
| Hayashi, K; Ishiguro, K; Itoh, H; Sakamaki, Y; Sasamura, H | 1 |
| Hashimoto, T; Hirawa, N; Imai, N; Ishigami, T; Kihara, M; Kitamura, H; Kiuchi, Y; Nomura, K; Tamura, K; Toya, Y; Umemura, S; Yasuzaki, H; Yoshida, S | 1 |
| Carey, RM; Gildea, JJ; Howell, NL; Keller, SR; Kemp, BA; Padia, SH | 1 |
| Bursell, SE; Chilcote, TJ; Clermont, AC; Feener, EP; Phipps, JA; Sinha, S | 1 |
| Barasch, J; Ebihara, K; Imamaki, H; Kasahara, M; Kusakabe, T; Kuwabara, T; Mori, K; Mukoyama, M; Nakao, K; Ogawa, Y; Omata, M; Saito, Y; Satoh, N; Sugawara, A; Yokoi, H; Yoshioka, T | 1 |
| Raij, L; Schulman, IH; Zhou, MS | 1 |
| Horiguchi, Y; Kikuchi, E; Kosaka, T; Kosugi, M; Miyajima, A; Murai, M; Oya, M | 1 |
| Ecelbarger, CM; Hu, J; Hu, X; Riazi, S; Tiwari, S; Wang, X | 1 |
| Baliova, M; Benicky, J; Larrayoz, IM; Nishioku, T; Pavel, J; Saavedra, JM; Sánchez-Lemus, E; Zhou, J | 1 |
| Katovich, MJ; Mecca, AP; O'Connor, TE; Sumners, C | 1 |
| Fukuda, K; Hirooka, K; Shiraga, F; Yang, H | 1 |
| Anegawa, T; Hirooka, Y; Ikeda, A; Imaizumi, T; Kai, H; Kajimoto, H; Kato, S; Koga, M; Kudo, H; Mifune, H; Mori, T; Takayama, N; Yasuoka, S | 1 |
| Carey, RM; Fournie-Zaluski, MC; Howell, NL; Kemp, BA; Padia, SH; Roques, BP | 1 |
| Onozato, M; Palm, F; Welch, WJ; Wilcox, CS | 1 |
| Higashi, K; Hyodo, T; Kumagai, H; Kushiyama, T; Miura, S; Oda, T; Sakurai, Y; Suzuki, S; Yamada, M | 1 |
| Abidin, N; Choudhury, R; Garratt, CJ; Hall, MC; Kirubakaran, S; Peters, NS | 1 |
| Abbas, AM; Boshra, V; El Aal, IA; Elkhateeb, M; Saad, MA | 1 |
| Allen, TJ; Calkin, AC; Cooper, ME; Forbes, JM; Giunti, S; Jandeleit-Dahm, KA; Thomas, MC | 1 |
| Hatano, Y; Kimoto, Y; Mizumoto, K; Ogawa, K; Tange, K; Tokinaga, Y | 1 |
| Idikio, H; Jelani, A; Jugdutt, BI; Jugdutt, CE; Menon, V; Palaniyappan, A; Uweira, RE | 1 |
| Awad, AS | 1 |
| Furukata, S; Honda, T; Ishimitsu, T; Matsuoka, H; Nakano, N; Ohno, E; Ono, H; Sudo, Y; Takahashi, T | 1 |
| Akanae, W; Nonomura, N; Okuyama, A; Tsujihata, M; Yoshioka, I | 1 |
| Kohyama, K; Kozawa, E; Sugiura, H; Taguchi, O; Wasa, J; Yamada, K | 1 |
| Bailey, E; Delucia, AL; Dodd, T; Jadhav, R; Jo, H; Madison, R; Potter, B; Rocic, P; Russell, JC; Smith, E; Walsh, K | 1 |
| Fagan, SC; Guan, W; Kozak, A | 1 |
| Hida, N; Kimura, T; Miyoshi, S; Nishiyama, N; Numasawa, Y; Ogawa, S; Segawa, K; Tsuji, H; Tsuruta, H; Umezawa, A | 1 |
| Fujisawa, Y; Fukui, T; Hitomi, H; Lei, B; Masaki, T; Mori, H; Nagai, Y; Nakano, D; Nishiyama, A | 1 |
| Chang, YW; Cheng, HT; Chiang, CK; Hsu, SP; Huang, JW; Hung, KY; Liu, SH; Wu, CT; Wu, KD | 1 |
| Fukui, A; Hara, M; Murozono, Y; Nagano-Torigoe, Y; Nakagawa, M; Ooie, T; Saikawa, T; Shinohara, T; Takahashi, N; Taniguchi, Y; Teshima, Y; Thuc, LC; Wakisaka, O; Yoshimatsu, H; Yufu, K | 1 |
| Berr, SS; Carey, RM; Dimaria, JM; Epstein, FH; French, BA; Jehle, AB; Kemp, BA; Kramer, CM; Roy, RJ; Xu, Y | 1 |
| Chappell, MC; Diz, DI; Rose, JC; Shaltout, HA | 1 |
| Akazawa, H; Ito, K; Komuro, I; Kudo-Sakamoto, Y; Minamino, T; Naito, AT; Nemer, M; Oka, T; Ozasa, Y; Paradis, P; Shimizu, I; Shiojima, I; Tamura, K; Umemura, S; Yabumoto, C; Yamamoto, R; Yano, M; Yasuda, N | 1 |
| Dong, YF; Kataoka, K; Kim-Mitsuyama, S; Koibuchi, N; Nakamura, T; Ogawa, H; Sueta, D; Toyama, K; Yamamoto, E; Yasuda, O | 1 |
| Ishiguro, H; Komiya, M; Kubota, Y; Long, N; Seeni, A; Shirai, T; Takahashi, S; Tang, M; Uemura, H | 1 |
| Hirooka, Y; Kishi, T; Ogawa, K; Shinohara, K; Sunagawa, K; Utsumi, H; Yasukawa, K | 1 |
| Briones, AM; Burger, D; Burns, KD; Callera, GE; Corrêa, JW; Gagnon, AM; Gomez-Sanchez, CE; Gomez-Sanchez, EP; He, Y; Nguyen Dinh Cat, A; Ooi, TC; Ruzicka, M; Sorisky, A; Touyz, RM; Yogi, A | 1 |
| Fukumoto, T; Kitada, K; Matsumura, Y; Ohkita, M; Okamura, T; Tawa, M; Yamashita, N | 1 |
| Hara, H; Nakamura, S; Shimazawa, M; Tsuruma, K | 1 |
| Fujita, T; Hirooka, K; Itano, T; Nagai, Y; Nakamura, T; Nishiyama, A; Shiraga, F | 1 |
| Hashikawa, N | 1 |
| Bregonzio, C; Falcón-Neri, A; Ito, T; Saavedra, JM; Terrón, JA; Yamakawa, H | 1 |
| Hattori, Y; Jesmin, S; Kitabatake, A; Mowa, CN; Sakuma, I | 1 |
| Jugdutt, BI; Kumar, D; Moudgil, R; Musat-Marcu, S; Xu, Y | 1 |
| Itoh, M; Kubota, I; Miyamoto, T; Nakada, S; Takahashi, H; Takeishi, Y; Tomoike, H; Tsunoda, Y | 1 |
| Fujita, T; Kaname, S; Nagase, M; Onozato, ML; Takaichi, K; Tojo, A; Ueno, T | 1 |
| Goette, A; Klein, HU | 1 |
| Arakawa, K; Gondo, N; Kumagai, K; Nakashima, H; Saku, K; Urata, H | 1 |
| Buikema, H; de Zeeuw, D; Gschwend, S; Henning, RH; Pinto, YM; van Gilst, WH | 1 |
| Johnsson, C; Lindström, P; Ollerstam, A; Persson, AE; Wadström, J | 1 |
| Bayram, I; Ozbek, H; Tuncer, I; Ugras, S | 1 |
| Aburatani, H; Hasegawa, H; Kohro, T; Komuro, I; Kudoh, S; Mizukami, M; Toko, H; Zou, Y | 1 |
| Imaizumi, T; Kai, H; Kuwahara, F; Tokuda, K | 1 |
| Doerfler, A; Engelhorn, T; Forsting, M; Goerike, S; Heusch, G; Okorn, C; Schulz, R | 1 |
| Addicks, K; Beirowski, B; Bloch, W; Gross, O; Koepke, ML; Schulze-Lohoff, E; Smyth, N; Weber, M | 1 |
| Granger, DN; Ishikawa, M; Kusaka, G; Kusaka, I; Nanda, A; Tang, J; Zhang, JH; Zhou, C | 1 |
| Ferder, L; Inserra, F; Néstor Mazza, O; Stella, I; Toblli, J | 1 |
| Boomsma, F; de Boer, RA; Flesch, M; Pinto, YM; Pokharel, S; Suurmeijer, AJ; van Gilst, WH; van Kampen, DA; van Veldhuisen, DJ | 1 |
| Forslund, T; Iversen, BM; Leh, S; Margolin, SB; Vaagnes, Ø | 1 |
| Fan, Q; Gohda, T; Gu, L; Horikoshi, S; Kobayashi, M; Liao, J; Suzuki, Y; Tomino, Y; Wang, LN; Yamashita, M | 1 |
| Duke, LM; Evans, RG; Kett, MM; Widdop, RE | 1 |
| Fukui, H; Ikenaka, Y; Kitade, M; Kuriyama, S; Namisaki, T; Noguchi, R; Tsujinoue, H; Yamazaki, M; Yanase, K; Yoshii, J; Yoshiji, H | 1 |
| Ioroi, T; Iwao, H; Izumi, Y; Izumiya, Y; Kim-Mitsuyama, S; Tanaka, T; Wanibuchi, H; Yamamoto, E; Zhan, Y | 1 |
| Chen, J; Li, D; Mehta, JL; Schaefer, R | 1 |
| Adams, V; Dorenkamp, M; Du, J; Noutsias, M; Pauschinger, M; Riad, A; Schultheiss, HP; Spillmann, F; Stiehl, S; Tschöpe, C; Westermann, D | 1 |
| Hayashi, T; Horimoto, H; Inamoto, S; Kitaura, Y; Mieno, S; Mori, T; Okabe, M; Okuda, N | 1 |
| Armando, I; Bregonzio, C; Juorio, A; Macova, M; Pavel, J; Saavedra, JM; Sanchez-Lemus, E | 1 |
| Dalbeth, N; Hall, FC | 1 |
| Aizawa, Y; Kamal, FA; Kodama, M; Kunisaki, M; Ma, M; Mito, S; Palaniyandi, S; Prakash, P; Soga, M; Tachikawa, H; Veeraveedu, P; Watanabe, K | 1 |
| Chen, YY; Miao, CY; Shen, FM; Su, DF; Xie, HH | 1 |
| Bachmann, S; Bouby, N; Debiec, H; Nafz, B; Nüsing, R; Pavenstädt, H; Ronco, P; Seyberth, HW; Theilig, F | 1 |
| Angerosa, M; Becher, E; Mazza, ON; Toblli, JE | 1 |
| Cesolari, JA; Laudanno, OM | 1 |
| Doerfler, A; Engelhorn, T; Heusch, G; Schulz, R | 1 |
| Brdon, J; Culman, J; Gohlke, P; Hagemann, F; Kaiser, S; Zhao, Y | 1 |
| Doran, DE; Griendling, KK; Taylor, WR; Weiss, D; Zhang, Y | 1 |
| Elewa, HF; Ergul, A; Fagan, SC; Johnson, MH; Kozak, A | 1 |
| Nishimura, M; Takahashi, H; Yoshimura, M | 1 |
| Fei, Y; Itoh, T; Iwai, K; Kanda, T; Kawaura, K; Matsumoto, M; Morimoto, S; Moriya, J; Nakahashi, T; Saegusa, S; Sumino, H; Takahashi, T; Yamakawa, J | 1 |
| Miura, S; Oda, T; Omasu, F; Sakurai, Y; Yamada, M; Yamakami, K; Yoshizawa, N | 1 |
| Chlouverakis, GI; Chrysostomakis, SI; Karalis, IK; Koutsopoulos, AV; Mavrakis, HE; Simantirakis, EN; Vardas, PE | 1 |
| Grimberg, E; Guron, G; Nitescu, N | 1 |
| Fukuda, N; Kobayashi, N; Matsumoto, K; Matsumoto, T; Suzuki, R; Tahira, Y; Ueno, T; Yao, EH; Yu, Y | 1 |
| Kawachi, H; Khadzhynov, D; Krämer, S; Kron, S; Loof, T; Martini, S; Morgera, S; Neumayer, HH; Peters, H; Shimizu, F; Wang-Rosenke, Y | 1 |
| Krikov, M; Müller, S; Thone-Reineke, C; Unger, T; Villringer, A | 1 |
| Harata, S; Inden, Y; Kitamura, K; Murohara, T; Nattel, S; Shimano, M; Tsuji, Y; Uchikawa, T | 1 |
| Tsai, CT; Wilson, LD | 1 |
| Kintscher, U; Krikov, M; Müller, S; Schefe, JH; Schmerbach, K; Thoene-Reineke, C; Unger, T; Villringer, A | 1 |
| Akasaka, T; Goto, M; Ikejima, H; Imanishi, T; Kobayashi, K; Kuroi, A; Mochizuki, S; Muragaki, Y; Shiomi, M; Tsujioka, H; Yoshida, K | 1 |
| Brimijoin, S; Pavel, J; Saavedra, JM; Tang, H | 1 |
| Inada, Y; Kubo, K; Naka, T; Nishikawa, K; Ojima, M; Shibouta, Y; Wada, T | 1 |
| Inada, Y; Nishikawa, K; Shibouta, Y; Wada, T | 1 |
| Miura, T; Nakano, A; Shimamoto, K; Suzuki, K; Ura, N | 1 |
| Hamar, P; Heemann, U; Kovács, G; Peti-Peterdi, J; Rázga, Z; Rosivall, L | 1 |
| Morsing, P | 1 |
| Kawachi, H; Kimura, H; Nakamura, T; Obata, J; Ohno, S; Shimizu, F; Yoshida, Y | 1 |
| Brenner, BM; Taal, MW | 1 |
| Kanmatsuse, K; Kushiro, T; Nakagawa, S; Sasaki, K | 1 |
| Derebail, VK; Pollock, DM; Pollock, JS; Yamamoto, T | 1 |
| Achard, JM; Allard, J; Dalmay, F; Fournier, A; Mazouz, H; Pesteil, F | 1 |
| Durie, M; Levy, BI; Silvestre, JS; Tamarat, R | 1 |
4 review(s) available for candesartan and Disease Models, Animal
| Article | Year |
|---|---|
[Hyperinsulinemia as a risk factor for peripheral nervous system disorders].
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Disease Models, Animal; Humans; Hyperinsulinism; Mesenteric Arteries; Peripheral Nervous System Diseases; Rats; Risk Factors; Sensory Receptor Cells; Tetrazoles | 2012 |
[Nonpeptide angiotensin II-receptor antagonists].
Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Cardiovascular Diseases; Disease Models, Animal; Prodrugs; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles | 1994 |
Candesartan: a new-generation angiotensin II AT1 receptor blocker: pharmacology, antihypertensive efficacy, renal function, and renoprotection.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Hemodynamics; Humans; Hypertension; Irbesartan; Kidney; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 1999 |
ACE-I vs angiotensin II receptor antagonists: prevention of renal injury in chronic rat models.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Bradykinin; Chronic Disease; Disease Models, Animal; Enalapril; Follow-Up Studies; Glomerulosclerosis, Focal Segmental; Hypertension, Renal; Peptidyl-Dipeptidase A; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Treatment Outcome | 1999 |
1 trial(s) available for candesartan and Disease Models, Animal
| Article | Year |
|---|---|
RAS modulation prevents progressive cognitive impairment after experimental stroke: a randomized, blinded preclinical trial.
Topics: Amyloid beta-Peptides; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cell Hypoxia; Cells, Cultured; Cognitive Dysfunction; Disease Models, Animal; Double-Blind Method; Endothelial Cells; Epoetin Alfa; Hippocampus; Humans; Infarction, Middle Cerebral Artery; Locomotion; Male; Peptide Fragments; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Sensory Gating; Sulfonamides; Tetrazoles; Thiophenes | 2018 |
150 other study(ies) available for candesartan and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Effect of AT1 receptor blockade on cardiovascular outcome after cardiac arrest: an experimental study in rats.
Topics: Animals; Cardiopulmonary Resuscitation; Dimethyl Sulfoxide; Disease Models, Animal; Epinephrine; Heart Arrest; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1 | 2023 |
Effect of safranal or candesartan on 3-nitropropionicacid-induced biochemical, behavioral and histological alterations in a rat model of Huntington's disease.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Corpus Striatum; Disease Models, Animal; Huntington Disease; Motor Activity; Neuroprotective Agents; Nitro Compounds; Propionates; Rats; Rats, Wistar | 2023 |
Pharmacokinetic and pharmacodynamic evaluation of nano-fixed dose combination for hypertension.
Topics: Amlodipine; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Drug Combinations; Hydrochlorothiazide; Hypertension; Male; Nanoparticles; Rats; Rats, Wistar; Tetrazoles | 2020 |
The effect of candesartan on chronic stress induced imbalance of glucose homeostasis.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Glucose; Chronic Disease; Disease Models, Animal; Glucose Transporter Type 2; Hemodynamics; Homeostasis; Liver; Male; Muscle, Skeletal; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Renin-Angiotensin System; Restraint, Physical; Stress, Physiological; Stress, Psychological; Tetrazoles | 2020 |
Withaferin A protects against endoplasmic reticulum stress-associated apoptosis, inflammation, and fibrosis in the kidney of a mouse model of unilateral ureteral obstruction.
Topics: Animals; Apoptosis; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Fibrosis; Kidney; Male; Mice, Inbred C57BL; Nephritis; Protective Agents; Renal Insufficiency, Chronic; Signal Transduction; Tetrazoles; Ureteral Obstruction; Withanolides | 2020 |
Low-dose candesartan prevents schizophrenia-like behavioral alterations in a neurodevelopmental two-hit model of schizophrenia.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Female; Hippocampus; Interleukin-1beta; Lipid Peroxidation; Male; Mice; Neuroprotective Agents; Poly I-C; Pregnancy; Receptor, Angiotensin, Type 1; Schizophrenia; Sex Factors; Tetrazoles; Tumor Necrosis Factor-alpha | 2021 |
Neuroprotective effects of AT1 receptor antagonists after experimental ischemic stroke: what is important?
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Irbesartan; Losartan; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Stroke; Tetrazoles; Tissue Distribution | 2017 |
Elastin insufficiency causes hypertension, structural defects and abnormal remodeling of renal vascular signaling.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Elastin; Female; Humans; Hypertension; Kidney; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptor, Angiotensin, Type 1; Renal Elimination; Renal Insufficiency, Chronic; Signal Transduction; Sodium Chloride, Dietary; Tetrazoles; Vascular Resistance | 2017 |
Angiotensin Receptor Blockade by Inhibiting Glial Activation Promotes Hippocampal Neurogenesis Via Activation of Wnt/β-Catenin Signaling in Hypertension.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Astrocytes; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cell Nucleus; Cytokines; Disease Models, Animal; Gliosis; Hemodynamics; Hippocampus; Hypertension; Inflammation Mediators; Male; MAP Kinase Signaling System; Microglia; NADPH Oxidases; Neurogenesis; Neuroglia; NF-KappaB Inhibitor alpha; Proteolysis; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Tetrazoles; Wnt Signaling Pathway | 2018 |
Candesartan, rather than losartan, improves motor dysfunction in thioacetamide-induced chronic liver failure in rats.
Topics: Alanine Transaminase; Ammonia; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; End Stage Liver Disease; Enzyme-Linked Immunosorbent Assay; gamma-Glutamyltransferase; Glutathione; Liver; Liver Cirrhosis; Locomotion; Losartan; Male; Malondialdehyde; Motor Disorders; Random Allocation; Rats, Sprague-Dawley; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Tetrazoles; Thioacetamide; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Topics: Actins; Albuminuria; Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cell Movement; Cells, Cultured; Disease Models, Animal; Genotype; Hypertension; Male; Mice; Mutation, Missense; Myosin Heavy Chains; Nephrectomy; Nonmuscle Myosin Type IIA; Podocytes; Primary Cell Culture; Renal Insufficiency, Chronic; Sodium Chloride, Dietary; Stress Fibers; Tetrazoles | 2018 |
Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein).
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Carrier Proteins; Cyclic N-Oxides; Disease Models, Animal; Fibroblast Growth Factors; Humans; Hypertension; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Protein Synthesis Inhibitors; Signal Transduction; Spin Labels; Tetrazoles; Vasoconstriction | 2018 |
Comparison of Enalapril, Candesartan and Intralesional Triamcinolone in Reducing Hypertrophic Scar Development: An Experimental Study.
Topics: Administration, Oral; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biopsy, Needle; Biphenyl Compounds; Chi-Square Distribution; Cicatrix, Hypertrophic; Disease Models, Animal; Enalapril; Follow-Up Studies; Immunohistochemistry; Injections, Intralesional; Male; Rabbits; Random Allocation; Risk Assessment; Tetrazoles; Treatment Outcome; Triamcinolone | 2018 |
Candesartan ameliorates brain inflammation associated with Alzheimer's disease.
Topics: Alzheimer Disease; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Biphenyl Compounds; Cell Line; Disease Models, Animal; Encephalitis; Hippocampus; Humans; Mice, Transgenic; Microglia; Neuroprotective Agents; Phagocytosis; Rats; Tetrazoles | 2018 |
Angiotensin Type 1 Receptor Antagonists Protect Against Alpha-Synuclein-Induced Neuroinflammation and Dopaminergic Neuron Death.
Topics: alpha-Synuclein; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Calcium-Binding Proteins; Cell Death; Cytokines; Dependovirus; Disease Models, Animal; Dopaminergic Neurons; Encephalitis; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Humans; Male; Microfilament Proteins; Microscopy, Confocal; Mutation; Rats; Rats, Sprague-Dawley; Synapsins; Telmisartan; Tetrazoles; Transduction, Genetic; Tyrosine 3-Monooxygenase | 2018 |
In vitro analysis of drugs that improve hyperglycemia-induced blood-brain barrier dysfunction.
Topics: Animals; Benzimidazoles; Biphenyl Compounds; Blood-Brain Barrier; Cilostazol; Disease Models, Animal; Eicosapentaenoic Acid; Electric Impedance; Hyperglycemia; Propranolol; Quinolines; Rats; Rats, Wistar; Reactive Oxygen Species; Tetrazoles | 2018 |
Neuroprotective effect of angiotensin II type 2 receptor stimulation in vincristine-induced mechanical allodynia.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Antineoplastic Agents, Phytogenic; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Diterpenes; Ganglia, Spinal; Hyperalgesia; Imidazoles; Male; Mice; Motor Activity; Neural Conduction; Neurons; Neuroprotective Agents; Neurotoxins; Nociception; Pyridines; Sciatic Nerve; Skin; Tetrazoles; Vincristine | 2018 |
Silencing VEGF-B Diminishes the Neuroprotective Effect of Candesartan Treatment After Experimental Focal Cerebral Ischemia.
Topics: Animals; Benzimidazoles; Biphenyl Compounds; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Tetrazoles; Vascular Endothelial Growth Factor B | 2018 |
Angiotensin II upregulates CYP4A isoform expression in the rat kidney through angiotensin II type 1 receptor.
Topics: Angiotensin II; Animals; Arachidonic Acid; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cytochrome P-450 CYP4A; Disease Models, Animal; Gene Expression Regulation; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Protein Isoforms; Rats; Receptor, Angiotensin, Type 1; RNA, Messenger; Tetrazoles | 2018 |
Pleiotropic Benefits of the Angiotensin Receptor Blocker Candesartan in a Mouse Model of Alzheimer Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Brain; Cell Proliferation; Cognition; Disease Models, Animal; Doublecortin Protein; Male; Mice; Mice, Transgenic; Muscle, Smooth; Tetrazoles | 2018 |
Unique mode of binding between angiotensin II type 1 receptor and its blockers.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Disease Models, Animal; DNA; DNA Mutational Analysis; Hypertension; Mutation; Rats; Receptor, Angiotensin, Type 1; Tetrazoles | 2019 |
Comparison of Candesartan and Angiotensin-(1-7) Combination to Mito-TEMPO Treatment for Normalizing Blood Pressure and Sympathovagal Balance in (mREN2)27 Rats.
Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arterial Pressure; Baroreflex; Benzimidazoles; Biphenyl Compounds; Brain; Disease Models, Animal; Drug Combinations; Free Radical Scavengers; Heart; Heart Rate; Hypertension; Male; Mitochondria; Organophosphorus Compounds; Peptide Fragments; Piperidines; Rats, Transgenic; Reactive Oxygen Species; Renin; Sympathetic Nervous System; Tetrazoles; Vagus Nerve | 2019 |
Central mineralocorticoid receptors and the role of angiotensin II and glutamate in the paraventricular nucleus of rats with angiotensin II-induced hypertension.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Eplerenone; Glutamic Acid; Heart Rate; Hypertension; Infusions, Intravenous; Infusions, Intraventricular; Kynurenic Acid; Male; Mineralocorticoid Receptor Antagonists; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Glutamate; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; Tetrazoles | 2013 |
Modulation of haemodynamics, endogeneous antioxidant enzymes, and pathophysiological changes by selective inhibition of angiotensin II type 1 receptors in pressureoverload rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Catalase; Disease Models, Animal; Hypertension; Irbesartan; Losartan; Male; Myocardium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Superoxide Dismutase; Tetrazoles; Time Factors | 2013 |
Inhibition of Rho kinase mediates the neuroprotective effects of estrogen in the MPTP model of Parkinson's disease.
Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Enzyme Inhibitors; Estradiol; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Ovariectomy; Pyridines; Receptor, Angiotensin, Type 1; rho-Associated Kinases; Tetrazoles; Tyrosine 3-Monooxygenase | 2013 |
Effects of angiotensin II type 1 receptor blocker and adiponectin on adipocyte dysfunction in stroke-prone spontaneously hypertensive rats.
Topics: Adipocytes; Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Gene Expression Regulation; Hypertension; Kidney; Male; Rats; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Stroke; Tetrazoles | 2013 |
Effect of chronic treatment with angiotensin type 1 receptor antagonists on striatal dopamine levels in normal rats and in a rat model of Parkinson's disease treated with L-DOPA.
Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Corpus Striatum; Disease Models, Animal; Dopamine; Levodopa; Male; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Rats; Receptor, Serotonin, 5-HT1B; Receptors, Dopamine; Serotonin; Tetrazoles | 2014 |
Effect of candesartan on the expression of sclera-choroidal intercellular adhesion molecule-1 in hypercholesterolemic models.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Choroid; Disease Models, Animal; Hypercholesterolemia; Immunohistochemistry; Intercellular Adhesion Molecule-1; Macrophages; Macular Degeneration; Male; Rabbits; Reference Values; Sclera; Tetrazoles | 2014 |
Female spontaneously hypertensive rats are more dependent on ANG (1-7) to mediate effects of low-dose AT1 receptor blockade than males.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cell Adhesion Molecules; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hypertension; Male; Membrane Proteins; Peptide Fragments; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Sex Factors; Tetrazoles | 2014 |
Candesartan induces a prolonged proangiogenic effect and augments endothelium-mediated neuroprotection after oxygen and glucose deprivation: role of vascular endothelial growth factors A and B.
Topics: Angiopoietin-1; Animals; Benzimidazoles; Biphenyl Compounds; Cell Culture Techniques; Cell Line; Cell Movement; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Glucose; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Neovascularization, Physiologic; Neuroprotective Agents; Oxygen; Rats; Rats, Wistar; Stroke; Tetrazoles; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor B | 2014 |
Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood-Brain Barrier; Cognition Disorders; Disease Models, Animal; Hippocampus; Humans; Male; Neuroprotective Agents; Postoperative Complications; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles; Treatment Outcome | 2014 |
Effects of candesartan on electrical remodeling in the hearts of inherited dilated cardiomyopathy model mice.
Topics: Angiotensin Receptor Antagonists; Animals; Atrial Remodeling; Benzimidazoles; Biphenyl Compounds; Cardiomyopathy, Dilated; Disease Models, Animal; Electrocardiography; Electrophysiological Phenomena; Gene Expression Regulation; Gene Knock-In Techniques; Heart; Heart Ventricles; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Potassium; Potassium Channels; Survival Analysis; Tetrazoles | 2014 |
Low-dose candesartan enhances molecular mediators of neuroplasticity and subsequent functional recovery after ischemic stroke in rats.
Topics: Animals; Benzimidazoles; Biphenyl Compounds; Brain Ischemia; Disease Models, Animal; Male; Neuronal Plasticity; Rats, Wistar; Recovery of Function; Stroke; Tetrazoles; Vascular Endothelial Growth Factor A | 2015 |
Angiotensin type 1 receptor blockage reduces l-dopa-induced dyskinesia in the 6-OHDA model of Parkinson's disease. Involvement of vascular endothelial growth factor and interleukin-1β.
Topics: Adrenergic Agents; Angiotensin II Type 1 Receptor Blockers; Animals; Antiparkinson Agents; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Dyskinesia, Drug-Induced; In Vitro Techniques; Interleukin-1beta; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; Oxidopamine; Parkinson Disease; Tetrazoles; Vascular Endothelial Growth Factor A | 2014 |
Proteinuria Increases Plasma Phosphate by Altering Its Tubular Handling.
Topics: Adult; Albuminuria; Analysis of Variance; Animals; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Child; Disease Models, Animal; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Humans; Kidney Tubules, Proximal; Male; Mice; Mice, Transgenic; Nephrotic Syndrome; Parathyroid Hormone; Phosphates; Prospective Studies; Proteinuria; Rats; Rats, Wistar; Sensitivity and Specificity; Sodium-Phosphate Cotransporter Proteins, Type IIa; Tetrazoles; Urinalysis | 2015 |
Oxidative stress causes imbalance of renal renin angiotensin system (RAS) components and hypertension in obese Zucker rats.
Topics: Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cyclic N-Oxides; Disease Models, Animal; Drinking; Hypertension; Kidney; Male; Obesity; Oligopeptides; Oxidative Stress; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Zucker; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Spin Labels; Tetrazoles | 2015 |
Candesartan mediates microcirculation in acute necrotizing pancreatitis.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Female; Microcirculation; Pancreas; Pancreatitis, Acute Necrotizing; Rats; Rats, Sprague-Dawley; Tetrazoles | 2015 |
Sequential Therapy with Minocycline and Candesartan Improves Long-Term Recovery After Experimental Stroke.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Brain Infarction; Cell Movement; Cell Proliferation; Cerebrovascular Trauma; Disease Models, Animal; Endothelium, Vascular; Epithelial Cells; Humans; Hydro-Lyases; Infarction, Middle Cerebral Artery; Male; Matrix Metalloproteinases; Minocycline; Motor Activity; Muscle Strength; Psychomotor Performance; Rats; Rats, Wistar; Recovery of Function; Tetrazoles; Time Factors; Vascular Endothelial Growth Factor A | 2015 |
CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzylamines; Biphenyl Compounds; Bone Marrow Transplantation; Chemokine CXCL12; Cyclams; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Heart Ventricles; Hemodynamics; Heterocyclic Compounds; Humans; Mice; Mice, Transgenic; Myofibroblasts; Receptors, CXCR4; Tetrazoles | 2015 |
Antimanic-like activity of candesartan in mice: Possible involvement of antioxidant, anti-inflammatory and neurotrophic mechanisms.
Topics: Amphetamine; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Antimanic Agents; Antioxidants; Benzimidazoles; Biphenyl Compounds; Bipolar Disorder; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Lithium Compounds; Male; Memory Disorders; Memory, Short-Term; Motor Activity; Nerve Growth Factors; Random Allocation; Tetrazoles | 2015 |
Human GRK4γ142V Variant Promotes Angiotensin II Type I Receptor-Mediated Hypertension via Renal Histone Deacetylase Type 1 Inhibition.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Essential Hypertension; Female; G-Protein-Coupled Receptor Kinase 4; Gene Expression Regulation; HEK293 Cells; Histone Deacetylase 1; Humans; Hypertension; Immunoblotting; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Real-Time Polymerase Chain Reaction; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tetrazoles | 2016 |
An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Cerebellum; Databases, Factual; Disease Models, Animal; Gene Expression Profiling; Glutamic Acid; Hippocampus; Humans; Inflammation Mediators; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Signal Transduction; Tetrazoles; Transcriptome | 2016 |
Tyrosine phosphorylation of RACK1 triggers cardiomyocyte hypertrophy by regulating the interaction between p300 and GATA4.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Cardiomegaly; Cell Enlargement; Cells, Cultured; Disease Models, Animal; E1A-Associated p300 Protein; GATA4 Transcription Factor; Gene Knockdown Techniques; HEK293 Cells; Humans; Male; Myocytes, Cardiac; Neoplasm Proteins; Phenylephrine; Phosphorylation; Protein Binding; Rats; Rats, Inbred Dahl; Receptors for Activated C Kinase; Tetrazoles; Transcription, Genetic; Tyrosine | 2016 |
β-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; beta-Arrestin 1; beta-Arrestin 2; Biphenyl Compounds; Cell Line; Collagen Type I; Disease Models, Animal; Extracellular Matrix; Fibroblasts; Fibronectins; Fibrosis; Kidney; Kidney Diseases; Male; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Rats; Receptor, Angiotensin, Type 1; RNA Interference; Signal Transduction; Tetrazoles; Time Factors; Transfection; Ureteral Obstruction | 2017 |
Partial adherence to antihypertensive therapy fails to achieve full cardiovascular benefits in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Body Weight; Disease Models, Animal; Drug Administration Schedule; Hemodynamics; Hypertension; Male; Organ Size; Patient Compliance; Rats; Rats, Inbred SHR; Tetrazoles; Treatment Outcome; Ventricular Function, Left | 2008 |
The HMG-CoA reductase inhibitor rosuvastatin and the angiotensin receptor antagonist candesartan attenuate atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes via effects on advanced glycation, oxidative stress and inflammation.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apolipoproteins E; Benzimidazoles; Biphenyl Compounds; Blood Vessels; Diabetes Mellitus; Disease Models, Animal; Fluorobenzenes; Glycation End Products, Advanced; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Pyrimidines; Rosuvastatin Calcium; Sulfonamides; Tetrazoles | 2008 |
Angiotensin-receptor blockade reduces border zone myocardial monocyte chemoattractant protein-1 expression and macrophage infiltration in post-infarction ventricular remodeling.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Chemokine CCL2; Collagen; Disease Models, Animal; DNA Primers; Male; Myocardial Infarction; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Tetrazoles; Ventricular Remodeling | 2008 |
Protective effect of candesartan in experimental ischemic stroke in the rat mediated by AT2 and AT4 receptors.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Brain Ischemia; Disease Models, Animal; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles | 2008 |
Involvement of angiotensin II-dependent vascular endothelial growth factor gene expression via NADPH oxidase in the retina in a type 2 diabetic rat model.
Topics: Administration, Oral; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Benzimidazoles; Biphenyl Compounds; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expression Regulation; NADPH Oxidases; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Retina; RNA, Messenger; Tetrazoles; Vascular Endothelial Growth Factor A | 2008 |
Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction.
Topics: Adenylyl Cyclases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aquaporin 2; Benzimidazoles; Biphenyl Compounds; Colforsin; Cyclic AMP; Disease Models, Animal; GTP-Binding Protein alpha Subunits, Gs; Kidney Medulla; Male; Rats; Rats, Wistar; Receptors, Vasopressin; RNA, Messenger; Sodium Fluoride; Tetrazoles; Ureteral Obstruction | 2009 |
Candesartan ameliorates cardiac dysfunction observed in angiotensin-converting enzyme 2-deficient mice.
Topics: Age Factors; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Benzimidazoles; Biphenyl Compounds; Cardiomegaly; Disease Models, Animal; Echocardiography; Female; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myocardium; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Tetrazoles | 2008 |
"Pulse" treatment with high-dose angiotensin blocker reverses renal arteriolar hypertrophy and regresses hypertension.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arterioles; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Enalapril; Hydralazine; Hypertension; Hypertrophy; Kidney; Male; Matrix Metalloproteinase 13; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Tetrazoles; Vasodilator Agents | 2009 |
Urinary oxidative stress markers closely reflect the efficacy of candesartan treatment for diabetic nephropathy.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Biomarkers; Biphenyl Compounds; Deoxyguanosine; Diabetes Mellitus; Diabetic Nephropathies; Dinoprost; Disease Models, Animal; Hydralazine; Kidney Glomerulus; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Tetrazoles; Treatment Outcome; Tyrosine | 2009 |
Intrarenal angiotensin III infusion induces natriuresis and angiotensin type 2 receptor translocation in Wistar-Kyoto but not in spontaneously hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin III; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cell Membrane; Disease Models, Animal; Female; Hypertension; Imidazoles; Kidney Tubules, Proximal; Natriuresis; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sodium; Tetrazoles | 2009 |
Plasma kallikrein mediates angiotensin II type 1 receptor-stimulated retinal vascular permeability.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood-Retinal Barrier; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Hypertension; Kallikreins; Kinins; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Retinal Artery; Streptozocin; Tetrazoles | 2009 |
Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Albumins; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biomarkers; Biphenyl Compounds; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Humans; Kidney Glomerulus; Kidney Tubules, Proximal; Lipocalin-2; Lipocalins; Loop of Henle; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nephritis, Interstitial; Nephrons; Nephrotic Syndrome; Proto-Oncogene Proteins; RNA, Messenger; Sensitivity and Specificity; Tetrazoles; Time Factors; Ureteral Obstruction | 2009 |
Role of angiotensin II and oxidative stress in vascular insulin resistance linked to hypertension.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; C-Reactive Protein; Cyclic N-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension; Insulin; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred Dahl; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Signal Transduction; Sodium Chloride, Dietary; Spin Labels; Superoxide Dismutase; Tetrazoles; Vasodilation; Vasodilator Agents | 2009 |
Angiotensin II type 1 receptor antagonist enhances cis-dichlorodiammineplatinum-induced cytotoxicity in mouse xenograft model of bladder cancer.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antineoplastic Agents; Benzimidazoles; Biphenyl Compounds; Cisplatin; Disease Models, Animal; Drug Synergism; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Tetrazoles; Transplantation, Heterologous; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2009 |
Regulation of angiotensin II type I receptor (AT1R) protein levels in the obese Zucker rat kidney and urine.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Biomarkers; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Humans; Hypertension; Hypoglycemic Agents; Kidney; Metabolic Syndrome; Obesity; PPAR gamma; Rats; Rats, Zucker; Receptor, Angiotensin, Type 1; Rosiglitazone; Sodium Chloride, Dietary; Tetrazoles; Thiazolidinediones; Thinness | 2009 |
Angiotensin II AT1 blockade reduces the lipopolysaccharide-induced innate immune response in rat spleen.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cyclooxygenase 2; Cytokines; Dinoprostone; Disease Models, Animal; Immunity, Innate; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; NF-kappa B; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Spleen; Tetrazoles; Toll-Like Receptor 4 | 2009 |
Candesartan pretreatment is cerebroprotective in a rat model of endothelin-1-induced middle cerebral artery occlusion.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Endothelin-1; Infarction, Middle Cerebral Artery; Male; Rats; Rats, Sprague-Dawley; Stroke; Tetrazoles | 2009 |
Neuroprotective effects of angiotensin II type 1 receptor blocker in a rat model of chronic glaucoma.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cell Survival; Chronic Disease; Disease Models, Animal; Female; Glaucoma; Immunoenzyme Techniques; Intraocular Pressure; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Retinal Ganglion Cells; Tetrazoles; Up-Regulation | 2009 |
Exaggerated blood pressure variability superimposed on hypertension aggravates cardiac remodeling in rats via angiotensin II system-mediated chronic inflammation.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Chemokine CCL2; Chronic Disease; Disease Models, Animal; Heart Diseases; Heart Ventricles; Hypertension; Hypertrophy; Inflammation; Macrophages; Male; Myocytes, Cardiac; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles; Transforming Growth Factor beta; Ventricular Remodeling | 2009 |
Intrarenal aminopeptidase N inhibition restores defective angiontesin II type 2-mediated natriuresis in spontaneously hypertensive rats.
Topics: Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; CD13 Antigens; Disease Models, Animal; Female; Glomerular Filtration Rate; Hypertension; Imidazoles; Lithium; Natriuresis; Probability; Pyridines; Random Allocation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 2; Sodium; Tetrazoles | 2010 |
Blood pressure, blood flow, and oxygenation in the clipped kidney of chronic 2-kidney, 1-clip rats: effects of tempol and Angiotensin blockade.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cyclic N-Oxides; Disease Models, Animal; Enalaprilat; Glomerular Filtration Rate; Hypertension, Renovascular; Male; Organ Size; Oxygen Consumption; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Renal Circulation; Spin Labels; Tetrazoles; Vascular Resistance | 2010 |
Additive antifibrotic effects of pioglitazone and candesartan on experimental renal fibrosis in mice.
Topics: Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biomarkers; Biphenyl Compounds; Chemokine CCL2; Collagen Type I; Collagen Type III; Disease Models, Animal; Drug Therapy, Combination; Fibrosis; Kidney; Kidney Diseases; Macrophages; Male; Mice; Mice, Inbred C57BL; Pioglitazone; Plasminogen Activator Inhibitor 1; PPAR gamma; RNA, Messenger; Severity of Illness Index; Tetrazoles; Thiazolidinediones; Transforming Growth Factor beta; Ureteral Obstruction | 2010 |
Effects of angiotensin receptor blockade on atrial electrical remodelling and the 'second factor' in a goat burst-paced model of atrial fibrillation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Fibrillation; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Electrophysiological Phenomena; Female; Goats; Heart Atria; Receptors, Angiotensin; Tetrazoles; Time Factors; Ventricular Function | 2010 |
Effect of angiotensin II type 1 receptor blocker, candesartan, and beta 1 adrenoceptor blocker, atenolol, on brain damage in ischemic stroke.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Atenolol; Behavior, Animal; Benzimidazoles; Biomarkers; Biphenyl Compounds; Brain Ischemia; Case-Control Studies; Creatinine; Disease Models, Animal; Glomerular Filtration Rate; Hemodynamics; Humans; Hypoxia, Brain; Kidney; Male; Plasminogen Inactivators; Rats; Rats, Wistar; Renin; Renin-Angiotensin System; Stroke; Tetrazoles; Time Factors | 2010 |
The pleiotropic actions of rosuvastatin confer renal benefits in the diabetic Apo-E knockout mouse.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apolipoproteins E; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Drug Therapy, Combination; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Lipid Metabolism; Male; Mice; Mice, Knockout; Oxidative Stress; Pyrimidines; Rosuvastatin Calcium; Streptozocin; Sulfonamides; Tetrazoles | 2010 |
Reduction of adhesion formation by an angiotensin type 1 receptor antagonist.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Gene Expression; Male; Plasminogen Activator Inhibitor 1; Rats; RNA, Messenger; Tetrazoles; Tissue Adhesions | 2011 |
Aging-related early changes in markers of ventricular and matrix remodeling after reperfused ST-segment elevation myocardial infarction in the canine model: effect of early therapy with an angiotensin II type 1 receptor blocker.
Topics: Aging; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Apoptosis; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Dogs; Echocardiography; Immunoblotting; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Myocardial Infarction; Myocardial Reperfusion; Placebos; Polymerase Chain Reaction; Reperfusion Injury; RNA; Systole; Tetrazoles | 2010 |
Effect of combined treatment with curcumin and candesartan on ischemic brain damage in mice.
Topics: Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Curcumin; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Glutathione Transferase; Heart Rate; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Male; Mice; Neuroprotective Agents; Regional Blood Flow; Superoxide Dismutase; Tetrazoles; Time Factors | 2011 |
Year-long antihypertensive therapy with candesartan completely prevents development of cardiovascular organ injuries in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; Disease Models, Animal; Echocardiography, Doppler, Pulsed; Heart; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Kidney Glomerulus; Male; Myocardial Contraction; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sclerosis; Tetrazoles | 2010 |
Angiotensin type-1 receptor blocker candesartan inhibits calcium oxalate crystal deposition in ethylene glycol-treated rat kidneys.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Calcium Oxalate; Deoxyguanosine; Disease Models, Animal; In Vitro Techniques; Kidney Calculi; Kidney Cortex; Male; NADPH Oxidases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tetrazoles; Transforming Growth Factor beta | 2011 |
The tumor suppressive effect of angiotensin II type 1 receptor antagonist in a murine osteosarcoma model.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Neovascularization, Pathologic; Osteosarcoma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazoles | 2011 |
Angiotensin type I receptor blockade in conjunction with enhanced Akt activation restores coronary collateral growth in the metabolic syndrome.
Topics: Adenoviridae; Angiotensin II Type 2 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Collateral Circulation; Coronary Vessels; Disease Models, Animal; Male; Metabolic Syndrome; Myocardium; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Regional Blood Flow; Tetrazoles | 2011 |
Drug repurposing for vascular protection after acute ischemic stroke.
Topics: Animals; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Benzimidazoles; Biphenyl Compounds; Brain Infarction; Diabetes Mellitus, Type 2; Disease Models, Animal; Enalapril; Enzyme-Linked Immunosorbent Assay; Functional Laterality; Hemoglobins; Hemorrhage; Heptanoic Acids; Male; Matrix Metalloproteinase 9; Pyrroles; Rats; Rats, Inbred SHR; Rats, Wistar; Reperfusion; Stroke; Tetrazoles; Vascular System Injuries | 2011 |
Treatment of human mesenchymal stem cells with angiotensin receptor blocker improved efficiency of cardiomyogenic transdifferentiation and improved cardiac function via angiogenesis.
Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Cell Differentiation; Cell Transdifferentiation; Disease Models, Animal; Echocardiography; Female; Humans; Immunohistochemistry; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Microscopy, Confocal; Myocardial Infarction; Myocytes, Cardiac; Neovascularization, Physiologic; Rats; Rats, Inbred F344; Rats, Nude; Tetrazoles | 2011 |
Roles of central renin-angiotensin system and afferent renal nerve in the control of systemic hemodynamics in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Central Nervous System; Disease Models, Animal; Heart Rate; Hemodynamics; Hypertension; Injections, Intraventricular; Kidney; Male; Neurons, Afferent; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin-Angiotensin System; Signal Transduction; Sympathetic Nervous System; Tetrazoles | 2011 |
Endoplasmic reticulum stress implicated in the development of renal fibrosis.
Topics: Angiotensin II Type 2 Receptor Blockers; Animals; Apoptosis; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blotting, Western; Collagen; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Fibrosis; Fluorescent Antibody Technique; Kidney; Kidney Function Tests; Kidney Tubules; Male; Molecular Chaperones; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Signal Transduction; Tetrazoles; Unfolded Protein Response; Ureteral Obstruction | 2011 |
Candesartan restored cardiac Hsp72 expression and tolerance against reperfusion injury in hereditary insulin-resistant rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cells, Cultured; Dietary Fats; Disease Models, Animal; Genetic Predisposition to Disease; Glucose Tolerance Test; Glucose Transporter Type 4; Heredity; HSP72 Heat-Shock Proteins; Hyperthermia, Induced; Insulin Resistance; Male; Myocardial Reperfusion Injury; Myocardium; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Recovery of Function; Tetrazoles; Time Factors; Ventricular Function, Left; Ventricular Pressure | 2011 |
A nonpeptide angiotensin II type 2 receptor agonist does not attenuate postmyocardial infarction left ventricular remodeling in mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Coronary Occlusion; Disease Models, Animal; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Receptor, Angiotensin, Type 2; Tetrazoles; Time Factors; Ventricular Remodeling | 2012 |
Angiotensin-(1-7) deficiency and baroreflex impairment precede the antenatal Betamethasone exposure-induced elevation in blood pressure.
Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Baroreflex; Benzimidazoles; Betamethasone; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Female; Glucocorticoids; Heart Rate; Hypertension; Peptide Fragments; Pregnancy; Prenatal Exposure Delayed Effects; Receptor, Angiotensin, Type 1; Sheep; Tetrazoles | 2012 |
Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Myocardium; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tetrazoles; Ventricular Dysfunction; Ventricular Remodeling | 2012 |
Amlodipine enhances amelioration of vascular insulin resistance, oxidative stress, and metabolic disorders by candesartan in metabolic syndrome rats.
Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; Calcium Channel Blockers; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Heart Rate; Insulin Resistance; Male; Metabolic Syndrome; NADPH Oxidases; Oxidative Stress; Rats; Rats, Inbred WKY; Superoxides; Tetrazoles; Vasodilation | 2012 |
Therapeutic targeting of angiotensin II receptor type 1 to regulate androgen receptor in prostate cancer.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Benzimidazoles; Benzoates; Biphenyl Compounds; Cell Line, Tumor; Disease Models, Animal; Estrogen Receptor beta; Gene Expression Regulation, Neoplastic; Humans; Male; Molecular Targeted Therapy; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Receptors, Androgen; Telmisartan; Tetrazoles | 2012 |
Combination therapy of olmesartan and azelnidipine inhibits sympathetic activity associated with reducing oxidative stress in the brain of hypertensive rats.
Topics: Animals; Antihypertensive Agents; Azetidinecarboxylic Acid; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Brain; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Drug Therapy, Combination; Hypertension; Imidazoles; Male; Olmesartan Medoxomil; Oxidative Stress; Rats; Rats, Inbred SHR; Tetrazoles | 2012 |
Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction.
Topics: Adipocytes; Aldosterone; Animals; Benzimidazoles; Biphenyl Compounds; Calcineurin; Cells, Cultured; Diabetes Complications; Diabetic Angiopathies; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Obesity; Random Allocation; Sensitivity and Specificity; Signal Transduction; Tetrazoles | 2012 |
Different effects of AT1 receptor antagonist and ET(A) receptor antagonist on ischemia-induced norepinephrine release in rat hearts.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Atrasentan; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Norepinephrine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Tetrazoles; Time Factors | 2012 |
Candesartan, an angiotensin II type 1 receptor antagonist, inhibits pathological retinal neovascularization by downregulating VEGF receptor-2 expression.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Humans; Mice; Mice, Inbred C57BL; Oxygen; Polymerase Chain Reaction; Retinal Diseases; Retinal Neovascularization; Tetrazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
Neuroprotective effects of angiotensin II type 1 receptor (AT1-R) blocker via modulating AT1-R signaling and decreased extracellular glutamate levels.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Cell Survival; Disease Models, Animal; Electroretinography; Extracellular Fluid; Gene Expression Regulation; Glutamine; Immunohistochemistry; Male; NADPH Oxidases; Phosphoproteins; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Reperfusion Injury; Retina; Retinal Diseases; Retinal Ganglion Cells; RNA, Messenger; Signal Transduction; Tetrazoles; Vitreous Body | 2012 |
Dopaminergic degeneration is enhanced by chronic brain hypoperfusion and inhibited by angiotensin receptor blockage.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Brain; Brain Ischemia; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Immunohistochemistry; Male; Rats; Rats, Sprague-Dawley; Tetrazoles | 2013 |
Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Flow Velocity; Blood Pressure; Brain; Brain Ischemia; Calcium Channel Blockers; Captopril; Cerebrovascular Circulation; Disease Models, Animal; Drug Administration Schedule; Hypertension; Infarction, Middle Cerebral Artery; Male; Nicardipine; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Tetrazoles | 2002 |
Role of ANG II in coronary capillary angiogenesis at the insulin-resistant stage of a NIDDM rat model.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Capillaries; Coronary Circulation; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelial Growth Factors; Extracellular Matrix Proteins; Gene Expression; Glycation End Products, Advanced; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin Resistance; Lymphokines; Male; Neovascularization, Physiologic; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Receptor Protein-Tyrosine Kinases; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; RNA, Messenger; Tetrazoles; Transcription Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Increased AT(2)R protein expression but not increased apoptosis during cardioprotection induced by AT(1)R blockade.
Topics: Analysis of Variance; Animals; Apoptosis; Benzimidazoles; Biphenyl Compounds; Culture Techniques; Disease Models, Animal; Hemodynamics; Male; Myocardial Reperfusion Injury; Myocardium; Primary Prevention; Probability; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reference Values; Tetrazoles; Ventricular Dysfunction, Left | 2002 |
Long-term treatment with angiotensin II type 1 receptor antagonist, CV-11974, restores beta-catenin mRNA expression in volume-overloaded rabbit hearts.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; beta Catenin; Biphenyl Compounds; Blood Pressure; Connexin 43; Cytoskeletal Proteins; Disease Models, Animal; DNA, Complementary; Heart Rate; Hypertrophy, Left Ventricular; Hypertrophy, Right Ventricular; Japan; Male; Models, Cardiovascular; Myocardial Contraction; Rabbits; Receptor, Angiotensin, Type 1; RNA, Messenger; Stroke Volume; Tetrazoles; Time; Trans-Activators; Ventricular Pressure | 2002 |
LOX-1, an oxidized low-density lipoprotein receptor, was upregulated in the kidneys of chronic renal failure rats.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Collagen Type I; Disease Models, Animal; Gene Expression; Hypertension, Renal; Kidney; Kidney Failure, Chronic; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, LDL; Receptors, Oxidized LDL; Scavenger Receptors, Class E; Tetrazoles; Up-Regulation | 2003 |
Blockade of atrial angiotensin II type 1 receptors: a novel antiarrhythmic strategy to prevent atrial fibrillation?
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Atrial Fibrillation; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Dogs; Heart Conduction System; Humans; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles; Ventricular Remodeling | 2003 |
Effects of angiotensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Atrial Fibrillation; Benzimidazoles; Biphenyl Compounds; Cardiac Pacing, Artificial; Chronic Disease; Disease Models, Animal; Dogs; Electrophysiology; Female; Heart Conduction System; Hemodynamics; Male; Random Allocation; Receptors, Angiotensin; Tetrazoles; Time Factors; Ventricular Remodeling | 2003 |
Myogenic constriction is increased in mesenteric resistance arteries from rats with chronic heart failure: instantaneous counteraction by acute AT1 receptor blockade.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Captopril; Chronic Disease; Coronary Vessels; Disease Models, Animal; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Fatty Acids, Unsaturated; Heart; Heart Failure; Hydrazines; Imidazoles; Indomethacin; Lisinopril; Losartan; Male; Mesenteric Arteries; Nitric Oxide; omega-N-Methylarginine; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Superoxide Dismutase; Sympathetic Nervous System; Tetrazoles; Tetrodotoxin; Vascular Resistance | 2003 |
Effects of increased intra-abdominal pressure and volume expansion on renal function in the rat.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Disease Models, Animal; Kidney; Male; Pneumoperitoneum, Artificial; Pressure; Rats; Rats, Inbred Strains; Renin-Angiotensin System; Tetrazoles | 2003 |
Anti-fibrogenic effects of captopril and candesartan cilexetil on the hepatic fibrosis development in rat. The effect of AT1-R blocker on the hepatic fibrosis.
Topics: Actins; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Carbon Tetrachloride; Cell Count; Disease Models, Animal; Immunohistochemistry; Liver; Liver Cirrhosis, Experimental; Male; Rats; Rats, Sprague-Dawley; Tetrazoles; Treatment Outcome | 2003 |
Gene expression profile revealed different effects of angiotensin II receptor blockade and angiotensin-converting enzyme inhibitor on heart failure.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Echocardiography; Fibrosis; Gene Expression; Gene Expression Profiling; Heart Failure; Hypertension; Hypertrophy, Left Ventricular; Infusions, Parenteral; Male; Oligonucleotide Array Sequence Analysis; Organ Size; Rats; Rats, Inbred Dahl; Receptors, Angiotensin; Sodium Chloride, Dietary; Subcutaneous Tissue; Tetrazoles; Time Factors; Ventricular Function, Left | 2003 |
Sub-depressor dose of angiotensin type-1 receptor blocker inhibits transforming growth factor-beta-mediated perivascular fibrosis in hypertensive rat hearts.
Topics: Administration, Oral; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Benzimidazoles; Biphenyl Compounds; Collagen; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; Endomyocardial Fibrosis; Fibroblasts; Hypertension; Male; Myocytes, Cardiac; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Tetrazoles; Time Factors; Transforming Growth Factor beta; Ventricular Remodeling | 2003 |
The angiotensin II type 1-receptor blocker candesartan increases cerebral blood flow, reduces infarct size, and improves neurologic outcome after transient cerebral ischemia in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cerebrovascular Circulation; Disease Models, Animal; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Laser-Doppler Flowmetry; Male; Middle Cerebral Artery; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Tetrazoles | 2004 |
Antifibrotic, nephroprotective potential of ACE inhibitor vs AT1 antagonist in a murine model of renal fibrosis.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Fibrosis; Hypertension, Renal; Kidney; Mice; Ramipril; Tetrazoles; Time Factors | 2004 |
Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury.
Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Glucose; Blood Pressure; Body Weight; Brain Edema; Brain Infarction; Brain Ischemia; Carbon Dioxide; Diabetic Angiopathies; Disease Models, Animal; Immunohistochemistry; Lipid Peroxidation; Male; Membrane Glycoproteins; Membrane Transport Proteins; NADPH Dehydrogenase; NADPH Oxidase 2; NADPH Oxidases; Oxygen; Phosphoproteins; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; RNA, Messenger; Tetrazoles | 2004 |
Protection of cavernous tissue in male spontaneously hypertensive rats. Beyond blood pressure control.
Topics: Actins; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Atenolol; Benzimidazoles; Biomarkers; Biphenyl Compounds; Blood Pressure; Collagen Type III; Creatinine; Disease Models, Animal; Male; Models, Cardiovascular; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Systole; Tetrazoles | 2004 |
Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Genetically Modified; Atrial Natriuretic Factor; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Collagen Type I; Disease Models, Animal; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Fibrosis; Heart Failure; Homozygote; Hypertrophy, Left Ventricular; Imidazoles; Immunohistochemistry; Male; Mitogen-Activated Protein Kinases; Myocardium; Protein-Tyrosine Kinases; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin; Smad Proteins; Tetrazoles; Time Factors; Trans-Activators; Tyrphostins | 2004 |
Pirfenidone and candesartan ameliorate morphological damage in mild chronic anti-GBM nephritis in rats.
Topics: Analysis of Variance; Animals; Antibodies; Autoantibodies; Base Sequence; Benzimidazoles; Biopsy, Needle; Biphenyl Compounds; Blood Chemical Analysis; Blood Pressure Determination; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Glomerulonephritis; Immunohistochemistry; Kidney Function Tests; Male; Molecular Sequence Data; Probability; Pyridones; Random Allocation; Rats; Rats, Wistar; Reference Values; Renal Circulation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Statistics, Nonparametric; Tetrazoles | 2005 |
Candesartan reduced advanced glycation end-products accumulation and diminished nitro-oxidative stress in type 2 diabetic KK/Ta mice.
Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; DNA Primers; Glomerular Mesangium; Glycation End Products, Advanced; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Tetrazoles | 2004 |
AT(2) receptors mediate tonic renal medullary vasoconstriction in renovascular hypertension.
Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Renovascular; Imidazoles; Kidney Medulla; Laser-Doppler Flowmetry; Male; Pyridines; Rats; Rats, Sprague-Dawley; Renal Artery; Renal Circulation; Tetrazoles; Time Factors; Vasoconstriction | 2005 |
Combination of interferon-beta and angiotensin-converting enzyme inhibitor, perindopril, attenuates the murine liver fibrosis development.
Topics: Actins; Angiotensin-Converting Enzyme Inhibitors; Animals; Antiviral Agents; Benzimidazoles; Biomarkers; Biphenyl Compounds; Cell Proliferation; Collagen Type I; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Hydroxyproline; Interferon-beta; Kupffer Cells; Liver; Liver Cirrhosis, Experimental; Male; Mice; Mice, Inbred BALB C; Perindopril; Rats; Rats, Inbred F344; RNA, Messenger; Tetrazoles | 2005 |
Critical role of angiotensin II in excess salt-induced brain oxidative stress of stroke-prone spontaneously hypertensive rats.
Topics: Amlodipine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood-Brain Barrier; Calcium Channel Blockers; Cell Proliferation; Cerebral Arteries; Cerebral Cortex; Disease Models, Animal; Hippocampus; Hypertensive Encephalopathy; Male; Neurons; Oxidative Stress; Rats; Rats, Inbred SHR; Sodium Chloride; Stroke; Superoxides; Tetrazoles | 2005 |
Cross-talk between dyslipidemia and renin-angiotensin system and the role of LOX-1 and MAPK in atherogenesis studies with the combined use of rosuvastatin and candesartan.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Atherosclerosis; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Dyslipidemias; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Phosphorylation; Pyrimidines; Renin-Angiotensin System; Rosuvastatin Calcium; Scavenger Receptors, Class E; Sulfonamides; Tetrazoles | 2006 |
Protection against oxidative stress in diabetic rats: role of angiotensin AT(1) receptor and beta 1-adrenoceptor antagonism.
Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Diabetes Mellitus, Experimental; Disease Models, Animal; Hindlimb; Intercellular Adhesion Molecule-1; Male; Membrane Transport Proteins; Metoprolol; Muscle, Skeletal; NADPH Oxidases; Oxidative Stress; Phosphoproteins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Regional Blood Flow; RNA, Messenger; Tetrazoles; Vascular Cell Adhesion Molecule-1; Vasodilation | 2005 |
Nifedipine enhances the cardioprotective effect of an angiotensin-II receptor blocker in an experimental animal model of heart failure.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Body Weight; Calcium Channel Blockers; Capillaries; Cardiotonic Agents; Coronary Circulation; Disease Models, Animal; Drug Synergism; Heart Failure; Hypertension; Male; Microscopy, Electron; Myocardium; Nifedipine; Organ Size; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tetrazoles; Thiobarbituric Acid Reactive Substances; Ventricular Pressure | 2005 |
A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding.
Topics: Amphibian Proteins; Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Autoradiography; Behavior, Animal; Benzimidazoles; Benzodiazepines; Biphenyl Compounds; Cerebral Cortex; Disease Models, Animal; Flunitrazepam; GABA Modulators; In Situ Hybridization; Male; Maze Learning; Peptide Hormones; Peptides; Protein Binding; Pyrimidines; Pyrroles; Rats; Receptor, Angiotensin, Type 2; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Social Isolation; Stress, Physiological; Tetrazoles; Tyrosine 3-Monooxygenase | 2006 |
Angiotensin receptor blockers ameliorate collagen-induced arthritis in mice: comment on the article by Sagawa et al.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arthritis, Experimental; Benzimidazoles; Biphenyl Compounds; Cell Proliferation; Collagen Type II; Disease Models, Animal; Imidazoles; Joints; Male; Mice; Mice, Inbred DBA; Olmesartan Medoxomil; Ovalbumin; Quinapril; T-Lymphocytes; Tetrahydroisoquinolines; Tetrazoles | 2005 |
Effects of angiotensin II receptor blocker (candesartan) in daunorubicin-induced cardiomyopathic rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Apoptosis; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; Calcium-Transporting ATPases; Cardiomyopathies; Cytoprotection; Daunorubicin; Disease Models, Animal; Electrocardiography; Fas Ligand Protein; Male; Membrane Glycoproteins; Organ Size; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; RNA, Messenger; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Survival Rate; Tetrazoles; Tumor Necrosis Factors | 2006 |
Effects of long-term treatment with candesartan on hemodynamics and organ damage in spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Aorta; Baroreflex; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Hypertrophy, Left Ventricular; Kidney; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Regression Analysis; Tetrazoles; Time | 2005 |
Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat).
Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Bradykinin; Cyclic GMP; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Hypertension, Renovascular; Kidney Cortex; Kidney Tubules, Collecting; Kidney Tubules, Distal; Loop of Henle; Male; Membrane Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Surgical Instruments; Tetrazoles | 2006 |
Differences between Candesartan and Hydralazine in the protection of penile structures in spontaneously hypertensive rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Hydralazine; Immunohistochemistry; Impotence, Vasculogenic; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Penis; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles | 2006 |
[Angiotensin II AT1 receptor antagonists as antiinflammatory and gastric protection drugs].
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Benzimidazoles; Biphenyl Compounds; Carrageenan; Disease Models, Animal; Edema; Female; Gastric Mucosa; Indomethacin; Losartan; Rats; Rats, Wistar; Stomach Ulcer; Tetrazoles; Valine; Valsartan | 2006 |
Reduction of cerebral infarct size by the AT1-receptor blocker candesartan, the HMG-CoA reductase inhibitor rosuvastatin and their combination. An experimental study in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Brain; Cerebral Infarction; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Activation; Enzyme Inhibitors; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Reperfusion Injury; Rosuvastatin Calcium; Sulfonamides; Tetrazoles; Treatment Outcome | 2006 |
Comparison between early and delayed systemic treatment with candesartan of rats after ischaemic stroke.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart Rate; Infarction, Middle Cerebral Artery; Male; Motor Activity; Neuroprotective Agents; Psychomotor Performance; Rats; Rats, Wistar; Reflex; Reperfusion Injury; Stroke; Tetrazoles; Time Factors | 2007 |
Differential effects of AT1 receptor and Ca2+ channel blockade on atherosclerosis, inflammatory gene expression, and production of reactive oxygen species.
Topics: Amlodipine; Angiotensin Receptor Antagonists; Animals; Aorta; Atherosclerosis; Benzimidazoles; Biphenyl Compounds; Calcium Channels; Disease Models, Animal; Gene Expression Regulation; Hydrogen Peroxide; Inflammation; Mice; Oxidative Stress; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Tetrazoles | 2007 |
Blood pressure lowering after experimental cerebral ischemia provides neurovascular protection.
Topics: Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Area Under Curve; Benzimidazoles; Biomarkers; Biphenyl Compounds; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Circadian Rhythm; Disease Models, Animal; Dose-Response Relationship, Drug; Enalapril; Hemoglobins; Hydralazine; Infarction, Middle Cerebral Artery; Male; Rats; Rats, Wistar; Reperfusion; Telemetry; Tetrazoles | 2007 |
Upregulation of the brain renin-angiotensin system in rats with chronic renal failure.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Brain; Brain Stem; Disease Models, Animal; Heart Rate; Hypothalamus; Infusions, Parenteral; Kidney; Kidney Failure, Chronic; Male; Nephrectomy; Norepinephrine; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Rhizotomy; RNA, Messenger; Tetrazoles; Up-Regulation | 2007 |
Oral administration of candesartan improves the survival of mice with viral myocarditis through modification of cardiac adiponectin expression.
Topics: Adiponectin; Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Female; Gene Expression; Heart; Immunohistochemistry; In Situ Hybridization; Male; Mice; Mice, Inbred C3H; Myocarditis; Myocardium; Organ Size; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Tetrazoles; Time Factors; Tumor Necrosis Factor-alpha; Virus Diseases; Weight Gain | 2007 |
Effects of pioglitazone and candesartan on renal fibrosis and the intrarenal plasmin cascade in spontaneously hypercholesterolemic rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Fibrinolysin; Fibrosis; Hypercholesterolemia; Hypoglycemic Agents; Kidney; Macrophages; Male; Pioglitazone; Plasminogen Activator Inhibitor 1; Proteinuria; Random Allocation; Rats; Rats, Mutant Strains; Tetrazoles; Thiazolidinediones | 2007 |
Angiotensin II type 1 receptor inhibition is associated with reduced tachyarrhythmia-induced ventricular interstitial fibrosis in a goat atrial fibrillation model.
Topics: Animals; Atrial Fibrillation; Benzimidazoles; Biphenyl Compounds; Cardiac Pacing, Artificial; Disease Models, Animal; Female; Fibrosis; Goats; Male; Myocardium; Receptor, Angiotensin, Type 1; Tachycardia; Tetrazoles; Ventricular Remodeling | 2007 |
Low-dose candesartan improves renal blood flow and kidney oxygen tension in rats with endotoxin-induced acute kidney dysfunction.
Topics: Acute Kidney Injury; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Lipopolysaccharides; Male; Oxygen; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Renal Circulation; Tetrazoles | 2008 |
Effects of an ARB on endothelial progenitor cell function and cardiovascular oxidation in hypertension.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Antioxidants; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cell Movement; Cell Proliferation; Cells, Cultured; Chemokine CXCL12; Cyclic N-Oxides; Disease Models, Animal; Diuretics; Endothelial Cells; Hypertension; Male; Myocardium; NADPH Oxidases; Oxidative Stress; Proto-Oncogene Proteins c-kit; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin-Angiotensin System; RNA, Messenger; Sodium Chloride, Dietary; Spin Labels; Stem Cells; Tetrazoles; Thiobarbituric Acid Reactive Substances; Trichlormethiazide; Vascular Endothelial Growth Factor A | 2008 |
Rosuvastatin is additive to high-dose candesartan in slowing progression of experimental mesangioproliferative glomerulosclerosis.
Topics: Animals; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Fluorobenzenes; Glomerulosclerosis, Focal Segmental; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Glomerulus; Male; Proteinuria; Pyrimidines; Rats; Rats, Wistar; Rosuvastatin Calcium; Sulfonamides; Tetrazoles | 2008 |
Candesartan but not ramipril pretreatment improves outcome after stroke and stimulates neurotrophin BNDF/TrkB system in rats.
Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Brain Ischemia; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Incidence; Male; Pilot Projects; Ramipril; Rats; Rats, Wistar; Receptor, trkB; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; Stroke; Tetrazoles | 2008 |
Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation promotion in rabbits with congestive heart failure.
Topics: Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; Atrial Fibrillation; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Fibrosis; Heart Failure; Hypoglycemic Agents; Male; Pioglitazone; Rabbits; Tetrazoles; Thiazolidinediones | 2008 |
Heart failure-related atrial fibrillation: a new model for a new prevention strategy?
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Atrial Fibrillation; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Fibrosis; Heart Failure; Hypoglycemic Agents; Male; Pioglitazone; Rabbits; Tetrazoles; Thiazolidinediones | 2008 |
Comparison between single and combined treatment with candesartan and pioglitazone following transient focal ischemia in rat brain.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Astrocytes; Benzimidazoles; Biphenyl Compounds; Brain; Cells, Cultured; Cerebrovascular Circulation; Disease Models, Animal; Drug Therapy, Combination; Gene Expression; Hypoglycemic Agents; Ischemic Attack, Transient; Magnetic Resonance Imaging; Male; Neurologic Examination; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; Tetrazoles; Thiazolidinediones | 2008 |
Effects of telmisartan, a unique angiotensin receptor blocker with selective peroxisome proliferator-activated receptor-gamma-modulating activity, on nitric oxide bioavailability and atherosclerotic change.
Topics: Angiotensin II Type 1 Receptor Blockers; Anilides; Animals; Aorta, Abdominal; Aorta, Thoracic; Atherosclerosis; Benzimidazoles; Benzoates; Biphenyl Compounds; Disease Models, Animal; Hyperlipidemias; Male; Nitric Oxide; PPAR gamma; Rabbits; Telmisartan; Tetrazoles; Up-Regulation | 2008 |
Angiotensin II type 1 receptors may not influence response of spinal autonomic neurons to axonal damage.
Topics: Acetylcholine; Acetylcholinesterase; Adrenergic Fibers; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; Cholinesterase Inhibitors; Disease Models, Animal; Male; Nerve Degeneration; Neurons, Efferent; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Spinal Cord; Sympathetic Nervous System; Tetrazoles; Wallerian Degeneration | 2008 |
Pharmacological profile of a novel nonpeptide angiotensin II subtype 1 receptor antagonist, TCV-116.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cough; Disease Models, Animal; Guinea Pigs; Hypertension; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prodrugs; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Rats, Wistar; Renin; Tetrazoles | 1994 |
Role of the angiotensin II type 1 receptor in preconditioning against infarction.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Rabbits; Radioimmunoassay; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles | 1997 |
Coinhibition of immune and renin-angiotensin systems reduces the pace of glomerulosclerosis in the rat remnant kidney.
Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cholesterol; Disease Models, Animal; Enalapril; Glomerulosclerosis, Focal Segmental; Immune System; Immunosuppressive Agents; Interleukin-2; Kidney; Male; Nephrectomy; Proteinuria; Rats; Rats, Wistar; Renin-Angiotensin System; Tacrolimus; Tetrazoles; Triglycerides | 1999 |
Blocking angiotensin II ameliorates proteinuria and glomerular lesions in progressive mesangioproliferative glomerulonephritis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Bradykinin; Bradykinin Receptor Antagonists; Cilazapril; Collagen; Disease Models, Animal; Glomerulonephritis, Membranoproliferative; Hydralazine; Kidney Failure, Chronic; Male; Proteinuria; Rats; Rats, Wistar; Renal Circulation; Renin-Angiotensin System; Tetrazoles; Transforming Growth Factor beta | 1999 |
[Effects of angiotensin II receptor antagonist on insulin sensitivity and sympathetic activity in spontaneously hypertensive rats].
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Hypertension; Insulin; Insulin Resistance; Male; Rats; Rats, Inbred SHR; Sympathetic Nervous System; Tetrazoles | 1999 |
Combined effects of AT(1) and ET(A) receptor antagonists, candesartan, and A-127722 in DOCA-salt hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrasentan; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; Desoxycorticosterone; Disease Models, Animal; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Kidney; Male; Natriuresis; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 2000 |
Non-AT(1)-receptor-mediated protective effect of angiotensin against acute ischaemic stroke in the gerbil.
Topics: Acute Disease; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Brain Ischemia; Disease Models, Animal; Enalapril; Gerbillinae; Lisinopril; Losartan; Male; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Reproducibility of Results; Stroke; Tetrazoles | 2001 |
Angiotensin II angiogenic effect in vivo involves vascular endothelial growth factor- and inflammation-related pathways.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies, Monoclonal; Benzimidazoles; Biphenyl Compounds; Collagen; Cyclooxygenase 2; Disease Models, Animal; Drug Combinations; Drug Therapy, Combination; Endothelial Growth Factors; Female; Imidazoles; Isoenzymes; Laminin; Lymphokines; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Prostaglandin-Endoperoxide Synthases; Proteoglycans; Pyridines; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Sulfonamides; Tetrazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |