Page last updated: 2024-10-24

candesartan and Cardiomegaly

candesartan has been researched along with Cardiomegaly in 30 studies

candesartan: a nonpeptide angiotensin II receptor antagonist
candesartan : A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
" Many lines of evidence have suggested that angiotensin II (Ang II) plays a vital role in cardiac hypertrophy, and it has been reported that secretion of Ang II from cultured cardiac myocytes was induced by mechanical stretch."7.69Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy. ( Hiroi, Y; Komuro, I; Kudoh, S; Mizuno, T; Shiojima, I; Takano, H; Tobe, K; Ueki, K; Yamazaki, T; Zou, Y, 1995)
"The angiotensin II (AngII) type 1 (AT1) receptor is a seven transmembrane-spanning G-protein-coupled receptor, and the activation of AT1 receptor plays an important role in the development of load-induced cardiac hypertrophy."4.84A novel mechanism of mechanical stress-induced angiotensin II type 1-receptor activation without the involvement of angiotensin II. ( Akazawa, H; Komuro, I; Qin, Y; Yasuda, N; Zou, Y, 2008)
" After surgery, the AAB-induced hypertension (AABIH) rats were treated with losartan 40 mg/kg/day, candesartan 10 mg/kg/day, irbesartan 10 mg/kg/day per os for 16 weeks."3.79Modulation of haemodynamics, endogeneous antioxidant enzymes, and pathophysiological changes by selective inhibition of angiotensin II type 1 receptors in pressureoverload rats. ( Inamdar, MN; Kulkarni, C; Kulkarni, KS; Moinuddin, G, 2013)
" Here we compared the effects of five commonly used ARBs (Candesartan, Olmesartan, Losartan, Telmisartan and Valsartan) on pressure overload-induced cardiac hypertrophy in mice model."3.76Comparison of angiotensin II type 1-receptor blockers to regress pressure overload-induced cardiac hypertrophy in mice. ( Ge, J; Gong, H; Komuro, I; Li, L; Lin, L; Wu, J; Zhou, N; Zou, Y, 2010)
" Stroke-prone spontaneously hypertensive rats (SHRSP) were orally given pioglitazone, candesartan, or combined pioglitazone and candesartan for 4 weeks to compare their effects on cardiovascular injury."3.74Beneficial effects of pioglitazone on hypertensive cardiovascular injury are enhanced by combination with candesartan. ( Dong, YF; Kataoka, K; Kim-Mitsuyama, S; Matsuba, S; Nakamura, T; Ogawa, H; Tokutomi, Y; Yamamoto, E; Yamashita, T, 2008)
"The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac hypertrophy."3.72Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. ( Akazawa, H; Fujita, T; Fukamizu, A; Iiri, T; Iwanaga, K; Kihara, M; Komuro, I; Kudoh, S; Makita, N; Minamino, T; Nagai, T; Qin, Y; Sano, M; Takano, H; Tamura, K; Toko, H; Umemura, S; Zhu, W; Zou, Y, 2004)
"The possible role of calcineurin in the attenuation of cardiac hypertrophy and fibrosis by blockade of the angiotensin II type 1 (AT1) receptor was investigated in Dahl salt-sensitive (DS) rats."3.71AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats. ( Ichihara, S; Iwase, M; Izawa, H; Nagasaka, T; Nagata, K; Nakashima, N; Obata, K; Odashima, M; Somura, F; Yamada, Y; Yokota, M, 2002)
" Chronic treatment with enalapril or candesartan inhibited the development of hypertension and cardiac hypertrophy equally in SHR."3.71Comparative effects of candesartan and enalapril on augmented vasoconstrictive responses to endothelin-1 in coronary vessels of spontaneously hypertensive rats. ( Harada, S; Hatta, T; Kawa, T; Kido, H; Miki, S; Moriguchi, J; Morimoto, S; Nakagawa, M; Oguni, A; Sasaki, S; Takeda, K, 2002)
" Many lines of evidence have suggested that angiotensin II (Ang II) plays a vital role in cardiac hypertrophy, and it has been reported that secretion of Ang II from cultured cardiac myocytes was induced by mechanical stretch."3.69Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy. ( Hiroi, Y; Komuro, I; Kudoh, S; Mizuno, T; Shiojima, I; Takano, H; Tobe, K; Ueki, K; Yamazaki, T; Zou, Y, 1995)
"Candesartan-pretreated SHHF (5 mg/kg/day candesartan; weeks 4-8) received during adulthood (20-28 weeks of age) either candesartan at a dose of 1."1.36Prehypertensive preconditioning improves adult antihypertensive and cardioprotective treatment. ( Baumann, M; Heemann, U; Lutz, J; Roos, M; Sollinger, D, 2010)
"Chronic isoproterenol (ISO)-induced cardiac hypertrophy was inhibited in wild-type mice and AT1aR(-/-) mice treated with the ARB Candesartan (CV11974)."1.36Effects of angiotensin type I receptor blockade on the cardiac Raf/MEK/ERK cascade activated via adrenergic receptors. ( Kimura, S; Matsuyoshi, H; Murao, K; Obata, K; Takaki, M; Yu, X; Zhang, GX, 2010)
"Pressure overload induced cardiac hypertrophy in angiotensinogen null mice as well as in wild-type mice, which was significantly inhibited by candesartan."1.33A novel mechanism of mechanical stress-induced hypertrophy. ( Akazawa, H; Komuro, I; Zou, Y, 2006)
"Candesartan treatment decreased cardiac PAI-1 expression only in the dark in WKY rats but throughout the day in SHR."1.32Circadian gene expression of clock genes and plasminogen activator inhibitor-1 in heart and aorta of spontaneously hypertensive and Wistar-Kyoto rats. ( Fujioka, Y; Iwasaki, T; Kawasaki, D; Masai, M; Morimoto, S; Naito, Y; Ohyanagi, M; Okumura, T; Sakoda, T; Tsujino, T, 2003)
"Also, low-dose perindopril prevented cardiac hypertrophy and fibrosis."1.32Cardioprotective action of perindopril versus candesartan in renovascular hypertensive rats. ( Horikoshi, K; Izumi, T; Mochizuki, S; Nagai, M; Seki, S; Taniguchi, I; Taniguchi, M, 2004)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (20.00)18.2507
2000's17 (56.67)29.6817
2010's7 (23.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ohkura, SI1
Usui, S1
Takashima, SI1
Takuwa, N1
Yoshioka, K1
Okamoto, Y1
Inagaki, Y1
Sugimoto, N1
Kitano, T1
Takamura, M1
Wada, T1
Kaneko, S1
Takuwa, Y1
Moinuddin, G1
Inamdar, MN1
Kulkarni, KS1
Kulkarni, C1
Suzuki, H1
Katanasaka, Y1
Sunagawa, Y1
Miyazaki, Y1
Funamoto, M1
Wada, H1
Hasegawa, K1
Morimoto, T1
Nakamura, K1
Koibuchi, N1
Nishimatsu, H1
Higashikuni, Y1
Hirata, Y2
Kugiyama, K1
Nagai, R2
Sata, M1
Takahara, A1
Nakamura, Y1
Wagatsuma, H1
Aritomi, S1
Nakayama, A1
Satoh, Y1
Akie, Y1
Sugiyama, A1
Baumann, M1
Sollinger, D1
Roos, M1
Lutz, J1
Heemann, U1
Ocaranza, MP1
Lavandero, S1
Jalil, JE1
Moya, J1
Pinto, M1
Novoa, U1
Apablaza, F1
Gonzalez, L1
Hernandez, C1
Varas, M1
Lopez, R1
Godoy, I1
Verdejo, H1
Chiong, M1
Zhang, GX1
Kimura, S1
Murao, K1
Yu, X1
Obata, K2
Matsuyoshi, H1
Takaki, M1
Li, L1
Zhou, N1
Gong, H1
Wu, J1
Lin, L1
Komuro, I8
Ge, J1
Zou, Y7
Shimizu, T1
Hirayama, H1
Hiramitsu, S1
Shimizu, K1
Yoshida, O1
Miao, CY1
Xie, HH1
Wang, JJ1
Su, DF1
Nagata, K1
Somura, F1
Odashima, M1
Izawa, H1
Ichihara, S1
Nagasaka, T1
Iwase, M1
Yamada, Y1
Nakashima, N1
Yokota, M1
Yayama, K1
Matsuoka, S1
Nagaoka, M1
Shimazu, E1
Takano, M1
Okamoto, H1
Naito, Y1
Tsujino, T1
Kawasaki, D1
Okumura, T1
Morimoto, S2
Masai, M1
Sakoda, T1
Fujioka, Y1
Ohyanagi, M1
Iwasaki, T1
Tanabe, A1
Naruse, M1
Hara, Y1
Sato, A1
Tsuchiya, K1
Nishikawa, T1
Imaki, T1
Takano, K1
Akazawa, H3
Qin, Y2
Sano, M2
Takano, H3
Minamino, T2
Makita, N1
Iwanaga, K1
Zhu, W1
Kudoh, S4
Toko, H1
Tamura, K1
Kihara, M1
Nagai, T1
Fukamizu, A1
Umemura, S1
Iiri, T1
Fujita, T1
Nagai, M1
Horikoshi, K1
Izumi, T1
Seki, S1
Taniguchi, M1
Taniguchi, I1
Mochizuki, S1
Iwashima, Y1
Okada, M1
Haneda, M1
Yoshida, T1
Okazaki, H1
Tsukamoto, O1
Kim, J1
Okada, K1
Myoishi, M1
Wakeno, M1
Takashima, S1
Mochizuki, N1
Kitakaze, M1
Takeda, Y1
Zhu, A1
Yoneda, T1
Usukura, M1
Takata, H1
Yamagishi, M1
Yasuda, N1
Nakamura, T1
Yamamoto, E1
Kataoka, K1
Yamashita, T1
Tokutomi, Y1
Dong, YF1
Matsuba, S1
Ogawa, H1
Kim-Mitsuyama, S1
Yamazaki, T3
Shiojima, I2
Mizuno, T2
Hiroi, Y2
Ueki, K1
Tobe, K1
Kanno, K1
Eguchi, S1
Kano, H1
Maemura, K1
Kurihara, H1
Aikawa, R2
Yazaki, Y2
Kodama, H1
Fukuda, K1
Pan, J1
Makino, S1
Takahashi, T1
Hori, S1
Ogawa, S1
Harada, M1
Saito, Y1
Nakagawa, O1
Miyamoto, Y1
Ishikawa, M1
Kuwahara, K1
Ogawa, E1
Nakayama, M1
Kamitani, S1
Hamanaka, I1
Kajiyama, N1
Masuda, I1
Itoh, H1
Tanaka, I1
Nakao, K1
Uozumi, H1
Miki, S1
Takeda, K1
Hatta, T1
Harada, S1
Kido, H1
Oguni, A1
Moriguchi, J1
Kawa, T1
Sasaki, S1
Nakagawa, M1

Reviews

1 review available for candesartan and Cardiomegaly

ArticleYear
A novel mechanism of mechanical stress-induced angiotensin II type 1-receptor activation without the involvement of angiotensin II.
    Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 377, Issue:4-6

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds

2008

Trials

1 trial available for candesartan and Cardiomegaly

ArticleYear
Regression of cardiac hypertrophy in type 2 diabetes with hypertension by candesartan.
    Diabetes research and clinical practice, 2006, Volume: 74, Issue:1

    Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure

2006

Other Studies

28 other studies available for candesartan and Cardiomegaly

ArticleYear
Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6.
    PloS one, 2017, Volume: 12, Issue:8

    Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compound

2017
Modulation of haemodynamics, endogeneous antioxidant enzymes, and pathophysiological changes by selective inhibition of angiotensin II type 1 receptors in pressureoverload rats.
    Cardiovascular journal of Africa, 2013, Volume: 24, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds;

2013
Tyrosine phosphorylation of RACK1 triggers cardiomyocyte hypertrophy by regulating the interaction between p300 and GATA4.
    Biochimica et biophysica acta, 2016, Volume: 1862, Issue:9

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Cardiomegaly;

2016
Candesartan ameliorates cardiac dysfunction observed in angiotensin-converting enzyme 2-deficient mice.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:10

    Topics: Age Factors; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme

2008
Long-term blockade of L/N-type Ca(2+) channels by cilnidipine ameliorates repolarization abnormality of the canine hypertrophied heart.
    British journal of pharmacology, 2009, Volume: 158, Issue:5

    Topics: Action Potentials; Amlodipine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Atr

2009
Prehypertensive preconditioning improves adult antihypertensive and cardioprotective treatment.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:3

    Topics: Age Factors; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; Benzi

2010
Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro.
    Journal of hypertension, 2010, Volume: 28, Issue:5

    Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzym

2010
Effects of angiotensin type I receptor blockade on the cardiac Raf/MEK/ERK cascade activated via adrenergic receptors.
    Journal of pharmacological sciences, 2010, Volume: 113, Issue:3

    Topics: Adrenergic beta-Agonists; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents;

2010
Comparison of angiotensin II type 1-receptor blockers to regress pressure overload-induced cardiac hypertrophy in mice.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:12

    Topics: Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Atrial Natr

2010
[Drug therapies following heart failure and myocardial infarction(discussion)].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60, Issue:6

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles;

2002
Candesartan inhibits sinoaortic denervation-induced cardiovascular hypertrophy in rats.
    Acta pharmacologica Sinica, 2002, Volume: 23, Issue:8

    Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Benzimidazoles; Biphenyl

2002
AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood

2002
Down-regulation of bradykinin B2-receptor mRNA in the heart in pressure-overload cardiac hypertrophy in the rat.
    Biochemical pharmacology, 2003, Mar-15, Volume: 65, Issue:6

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Benzimidazoles; Biphenyl Compounds; Cardiom

2003
Circadian gene expression of clock genes and plasminogen activator inhibitor-1 in heart and aorta of spontaneously hypertensive and Wistar-Kyoto rats.
    Journal of hypertension, 2003, Volume: 21, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; ARNTL Transcriptio

2003
Aldosterone antagonist facilitates the cardioprotective effects of angiotensin receptor blockers in hypertensive rats.
    Journal of hypertension, 2004, Volume: 22, Issue:5

    Topics: Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; B

2004
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.
    Nature cell biology, 2004, Volume: 6, Issue:6

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds

2004
Cardioprotective action of perindopril versus candesartan in renovascular hypertensive rats.
    Cardiovascular drugs and therapy, 2004, Volume: 18, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimid

2004
Angiotensin II type 1 receptor blocker prevents atrial structural remodeling in rats with hypertension induced by chronic nitric oxide inhibition.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2006, Volume: 29, Issue:4

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl

2006
A novel mechanism of mechanical stress-induced hypertrophy.
    Novartis Foundation symposium, 2006, Volume: 274

    Topics: Animals; Benzimidazoles; Biphenyl Compounds; Cardiomegaly; Chlorocebus aethiops; COS Cells; Enzyme A

2006
Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats.
    American journal of hypertension, 2007, Volume: 20, Issue:10

    Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensinog

2007
Beneficial effects of pioglitazone on hypertensive cardiovascular injury are enhanced by combination with candesartan.
    Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressur

2008
Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy.
    Circulation research, 1995, Volume: 77, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Cardi

1995
Effect of an AT1 receptor antagonist (CV-11974) on angiotensin II-induced cardiomyocyte hypertrophy in vitro.
    Blood pressure. Supplement, 1994, Volume: 5

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blott

1994
Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy.
    The Journal of biological chemistry, 1996, Feb-09, Volume: 271, Issue:6

    Topics: Animals; Animals, Newborn; Antibodies; Benzimidazoles; Biphenyl Compounds; Calcium-Calmodulin-Depend

1996
Biphasic activation of the JAK/STAT pathway by angiotensin II in rat cardiomyocytes.
    Circulation research, 1998, Feb-09, Volume: 82, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Cardi

1998
Role of cardiac nonmyocytes in cyclic mechanical stretch-induced myocyte hypertrophy.
    Heart and vessels, 1997, Volume: Suppl 12

    Topics: Angiotensin Receptor Antagonists; Animals; Atrial Natriuretic Factor; Benzimidazoles; Biphenyl Compo

1997
Role of ion channels and exchangers in mechanical stretch-induced cardiomyocyte hypertrophy.
    Circulation research, 1998, Mar-09, Volume: 82, Issue:4

    Topics: Angiotensin II; Animals; Benzimidazoles; Biphenyl Compounds; Calcium-Calmodulin-Dependent Protein Ki

1998
Comparative effects of candesartan and enalapril on augmented vasoconstrictive responses to endothelin-1 in coronary vessels of spontaneously hypertensive rats.
    American journal of hypertension, 2002, Volume: 15, Issue:3

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressur

2002
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