Page last updated: 2024-10-24

candesartan and Body Weight

candesartan has been researched along with Body Weight in 47 studies

candesartan: a nonpeptide angiotensin II receptor antagonist
candesartan : A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

ExcerptRelevanceReference
"Both candesartan and a low dose of hydrochlorothiazide are effective and well-tolerated antihypertensive agents in isolated systolic hypertension with additive effects in combination."9.10Candesartan and hydrochlorothiazide in isolated systolic hypertension. ( Arnolda, LF; Molloy, D; Upton, J; Wing, LM, 2003)
"SHR/NDmcr-cp (SHRcp), a rat model of human metabolic syndrome, were divided into four groups, and were administered (i) vehicle, (ii) candesartan (an ARB) 0."7.78Amlodipine enhances amelioration of vascular insulin resistance, oxidative stress, and metabolic disorders by candesartan in metabolic syndrome rats. ( Dong, YF; Kataoka, K; Kim-Mitsuyama, S; Koibuchi, N; Nakamura, T; Ogawa, H; Sueta, D; Toyama, K; Yamamoto, E; Yasuda, O, 2012)
" Throughout the whole clinical course mentioned above, he was under treatment for schizophrenia with drugs including risperidone which possibly affects glucose metabolism."7.76The insulin sparing effect of telmisartan in a case of type 2 diabetes mellitus associated with schizophrenia under treatment of risperidone. ( Tsutsumi, E; Yamaguchi, K, 2010)
"These data demonstrate that the urinary excretion of angiotensinogen is markedly augmented in ANG II-dependent malignant hypertension."7.76Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension. ( Kobori, H; Milani, CJ; Mitchell, KD; Mullins, JJ, 2010)
"We have shown that acute treatment with candesartan in an experimental model of stroke resulted in vascular protection and improved outcomes at 24 hours poststroke, but the mechanisms are unknown."7.75Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after stroke. ( Abdelsaid, M; El-Remessy, AB; Elewa, HF; Ergul, A; Fagan, SC; Johnson, MH; Kozak, A; Machado, LS; Wiley, DC, 2009)
"To clarify the mechanism of the effects of angiotensin II receptor type 1 antagonist, candesartan, upon cardiac adiponectin in the combination of myocarditis with obesity, we examined obese KKAy mice with acute viral myocarditis treated by candesartan and investigated cardiac adiponectin regulation."7.74Candesartan improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin. ( Chen, R; Iwai, K; Kanda, T; Matsumoto, M; Morimoto, S; Nakahashi, T; Sumino, H; Takahashi, T; Yu, F, 2008)
"These results indicate that easily determined characteristics such as ethnicity, gender, body weight, as well as pretreatment levels of BP and PRA predict a substantial fraction of the BP response to candesartan and support the notion that characteristics associated with a poor response to diuretic therapy are associated with better responses to an angiotensin receptor blocker (ARB)."7.74Predictors of blood pressure response to the angiotensin receptor blocker candesartan in essential hypertension. ( Baranco-Pryor, E; Boerwinkle, E; Canzanello, VJ; Chapman, AB; Rahbari-Oskoui, F; Schwartz, GL; Turner, ST, 2008)
"We recently demonstrated that both lisinopril and candesartan, an angiotensin-converting enzyme inhibitor and angiotensin II type 1 receptor blocker, respectively, attenuate pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori (WBN/Kob) rats."7.73Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats. ( Ando, T; Itoh, M; Joh, T; Kuno, A; Masuda, K; Nakamura, S; Nomura, T; Ogawa, K; Ohara, H; Okamoto, T; Shirai, T; Tang, M; Yamada, T, 2005)
"This study was designed to examine the hypothesis that a calcium channel blocker nifedipine (CCB) could enhance the cardioprotective effect of an angiotensin-ll receptor blocker candesartan (ARB) in the treatment for heart failure."7.73Nifedipine enhances the cardioprotective effect of an angiotensin-II receptor blocker in an experimental animal model of heart failure. ( Hayashi, T; Horimoto, H; Inamoto, S; Kitaura, Y; Mieno, S; Mori, T; Okabe, M; Okuda, N, 2005)
"The aim of this study is to compare the effects of candesartan and olmesartan on insulin sensitivity-related parameters, before and after antihypertensive therapy."5.14Differential effects of candesartan and olmesartan on adipose tissue activity biomarkers in type II diabetic hypertensive patients. ( Cicero, AF; D'Angelo, A; Derosa, G; Ferrari, I; Fogari, E; Gravina, A; Maffioli, P; Mereu, R; Palumbo, I; Salvadeo, SA, 2010)
"Both candesartan and a low dose of hydrochlorothiazide are effective and well-tolerated antihypertensive agents in isolated systolic hypertension with additive effects in combination."5.10Candesartan and hydrochlorothiazide in isolated systolic hypertension. ( Arnolda, LF; Molloy, D; Upton, J; Wing, LM, 2003)
" CD-fed SHR were simultaneously treated with either telmisartan (TEL; 8 mg/kg(body weight)· d) or candesartan (CAND; 10 mg/kg(body weight)· d) for 3 months because TEL, but not CAND, has been demonstrated to be a strong activator of PPARγ."3.78Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPARγ target gene regulation. ( Heidbreder, M; Jöhren, O; Landolt, J; Müller-Fielitz, H; Raasch, W; Vogt, FM; Werth, S, 2012)
"SHR/NDmcr-cp (SHRcp), a rat model of human metabolic syndrome, were divided into four groups, and were administered (i) vehicle, (ii) candesartan (an ARB) 0."3.78Amlodipine enhances amelioration of vascular insulin resistance, oxidative stress, and metabolic disorders by candesartan in metabolic syndrome rats. ( Dong, YF; Kataoka, K; Kim-Mitsuyama, S; Koibuchi, N; Nakamura, T; Ogawa, H; Sueta, D; Toyama, K; Yamamoto, E; Yasuda, O, 2012)
" Throughout the whole clinical course mentioned above, he was under treatment for schizophrenia with drugs including risperidone which possibly affects glucose metabolism."3.76The insulin sparing effect of telmisartan in a case of type 2 diabetes mellitus associated with schizophrenia under treatment of risperidone. ( Tsutsumi, E; Yamaguchi, K, 2010)
"These data demonstrate that the urinary excretion of angiotensinogen is markedly augmented in ANG II-dependent malignant hypertension."3.76Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension. ( Kobori, H; Milani, CJ; Mitchell, KD; Mullins, JJ, 2010)
" After 16 weeks, they were randomized into 4 groups (n = 10 each) with comparable proteinuria: (1) control group sacrificed immediately for baseline data, and groups gavaged daily for 8 weeks with (2) placebo, (3) perindopril (1 mg/kg/day), or (4) candesartan (10 mg/kg/day)."3.75Functional and partial morphological regression of established renal injury in the obese zucker rat by blockade of the renin-angiotensin system. ( Amann, K; Boor, P; Heidland, A; Lill, M; Sebeková, K, 2009)
"We have shown that acute treatment with candesartan in an experimental model of stroke resulted in vascular protection and improved outcomes at 24 hours poststroke, but the mechanisms are unknown."3.75Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after stroke. ( Abdelsaid, M; El-Remessy, AB; Elewa, HF; Ergul, A; Fagan, SC; Johnson, MH; Kozak, A; Machado, LS; Wiley, DC, 2009)
"Both TAK-536 and candesartan suppressed the increase in plasma glucose level in the OGTT without significant change in insulin concentration and improved insulin sensitivity."3.74TAK-536, a new AT1 receptor blocker, improves glucose intolerance and adipocyte differentiation. ( Chen, R; Horiuchi, M; Imura, Y; Iwai, M, 2007)
"To clarify the mechanism of the effects of angiotensin II receptor type 1 antagonist, candesartan, upon cardiac adiponectin in the combination of myocarditis with obesity, we examined obese KKAy mice with acute viral myocarditis treated by candesartan and investigated cardiac adiponectin regulation."3.74Candesartan improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin. ( Chen, R; Iwai, K; Kanda, T; Matsumoto, M; Morimoto, S; Nakahashi, T; Sumino, H; Takahashi, T; Yu, F, 2008)
"These results indicate that easily determined characteristics such as ethnicity, gender, body weight, as well as pretreatment levels of BP and PRA predict a substantial fraction of the BP response to candesartan and support the notion that characteristics associated with a poor response to diuretic therapy are associated with better responses to an angiotensin receptor blocker (ARB)."3.74Predictors of blood pressure response to the angiotensin receptor blocker candesartan in essential hypertension. ( Baranco-Pryor, E; Boerwinkle, E; Canzanello, VJ; Chapman, AB; Rahbari-Oskoui, F; Schwartz, GL; Turner, ST, 2008)
"We recently demonstrated that both lisinopril and candesartan, an angiotensin-converting enzyme inhibitor and angiotensin II type 1 receptor blocker, respectively, attenuate pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori (WBN/Kob) rats."3.73Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats. ( Ando, T; Itoh, M; Joh, T; Kuno, A; Masuda, K; Nakamura, S; Nomura, T; Ogawa, K; Ohara, H; Okamoto, T; Shirai, T; Tang, M; Yamada, T, 2005)
"This study was designed to examine the hypothesis that a calcium channel blocker nifedipine (CCB) could enhance the cardioprotective effect of an angiotensin-ll receptor blocker candesartan (ARB) in the treatment for heart failure."3.73Nifedipine enhances the cardioprotective effect of an angiotensin-II receptor blocker in an experimental animal model of heart failure. ( Hayashi, T; Horimoto, H; Inamoto, S; Kitaura, Y; Mieno, S; Mori, T; Okabe, M; Okuda, N, 2005)
" Cardiomyopathic hearts showed significant increases in % fibrosis, % apoptosis, and myocyte diameter/body weight ratio; candesartan treatment reversed these changes."3.73Effects of angiotensin II receptor blocker (candesartan) in daunorubicin-induced cardiomyopathic rats. ( Aizawa, Y; Kamal, FA; Kodama, M; Kunisaki, M; Ma, M; Mito, S; Palaniyandi, S; Prakash, P; Soga, M; Tachikawa, H; Veeraveedu, P; Watanabe, K, 2006)
" Chronic administration of haloperidol significantly increased oxidative stress and neuro-inflammation in the striatum region of the rat's brain."1.42Beneficial effect of candesartan and lisinopril against haloperidol-induced tardive dyskinesia in rat. ( Bansal, PK; Bisht, R; Prakash, A; Thakur, KS, 2015)
"Type 1 diabetes was induced in rats by intraperitoneally injecting spontaneously hypertensive rats with streptozotocin."1.35Candesartan and insulin reduce renal sympathetic nerve activity in hypertensive type 1 diabetic rats. ( Hayashi, K; Iigaya, K; Itoh, H; Kamayachi, T; Kumagai, H; Onami, T; Osaka, M; Sakata, K; Saruta, T; Takimoto, C, 2008)
"Also, body weight was measured two times, at initial time (before STZ injection) and terminal (at the last day in the experiment)."1.33Role of AT1 receptors in permeability of the blood-brain barrier in diabetic hypertensive rats. ( Awad, AS, 2006)
"Candesartan treatment prevented the hypertension (87 +/- 3 mmHg) and led to increased plasma Ang II concentrations (441 +/- 27 fmol/ml), but prevented increases in kidney (120 +/- 15 fmol/g) and renal interstitial fluid (2."1.32Angiotensin II type 1 receptor-mediated augmentation of renal interstitial fluid angiotensin II in angiotensin II-induced hypertension. ( Navar, LG; Nishiyama, A; Seth, DM, 2003)
" Estrogen has been shown to downregulate angiotensin type 1 (AT1) receptor expression and to increase the bioavailability of endothelium-derived NO, which decreases AT1 receptor expression."1.32Postovariectomy hypertension is linked to increased renal AT1 receptor and salt sensitivity. ( Harrison-Bernard, LM; Raij, L; Schulman, IH, 2003)
"Treatment with candesartan, but not the combination of hydralazine and hydrochlorothiazide, significantly increased the expression of Cx37 and Cx40, although blood pressure decreased similarly."1.32Angiotensin II receptor blockade corrects altered expression of gap junctions in vascular endothelial cells from hypertensive rats. ( Abe, I; Fujii, K; Goto, K; Iida, M; Kansui, Y; Nakamura, K; Oniki, H; Shibata, Y, 2004)
"Focal cerebral ischemia, induced by middle cerebral artery occlusion/reperfusion (MCAO), was conducted at 4 wk after STZ injection."1.32Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury. ( Granger, DN; Ishikawa, M; Kusaka, G; Kusaka, I; Nanda, A; Tang, J; Zhang, JH; Zhou, C, 2004)
"Treatment with candesartan attenuated all of these changes and prevented significant albuminuria."1.32Candesartan reduced advanced glycation end-products accumulation and diminished nitro-oxidative stress in type 2 diabetic KK/Ta mice. ( Fan, Q; Gohda, T; Gu, L; Horikoshi, S; Kobayashi, M; Liao, J; Suzuki, Y; Tomino, Y; Wang, LN; Yamashita, M, 2004)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (4.26)18.2507
2000's36 (76.60)29.6817
2010's9 (19.15)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Thakur, KS1
Prakash, A1
Bisht, R1
Bansal, PK1
Susic, D2
Krousel-Wood, M1
Zhou, X2
Frohlich, ED2
Sebeková, K1
Lill, M1
Boor, P1
Heidland, A1
Amann, K1
Makita, S1
Abiko, A1
Naganuma, Y1
Moriai, Y1
Nakamura, M1
Takimoto, C1
Kumagai, H1
Osaka, M1
Sakata, K1
Onami, T1
Kamayachi, T1
Iigaya, K1
Hayashi, K1
Saruta, T1
Itoh, H1
Zhou, MS1
Schulman, IH2
Raij, L2
Kozak, A1
Ergul, A1
El-Remessy, AB1
Johnson, MH1
Machado, LS1
Elewa, HF1
Abdelsaid, M1
Wiley, DC1
Fagan, SC1
Yang, R1
Walther, T1
Gembardt, F1
Smolders, I1
Vanderheyden, P1
Albiston, AL1
Chai, SY1
Dupont, AG1
Pelisch, N1
Hosomi, N1
Ueno, M1
Masugata, H1
Murao, K1
Hitomi, H1
Nakano, D1
Kobori, H2
Nishiyama, A2
Kohno, M1
Yamaguchi, K1
Tsutsumi, E1
Derosa, G1
Maffioli, P1
Salvadeo, SA1
Ferrari, I1
Gravina, A1
Mereu, R1
Palumbo, I1
Fogari, E1
D'Angelo, A1
Cicero, AF1
Milani, CJ1
Mullins, JJ1
Mitchell, KD1
Ishimitsu, T1
Honda, T2
Ohno, E1
Furukata, S1
Sudo, Y1
Nakano, N1
Takahashi, T2
Ono, H1
Matsuoka, H2
Müller-Fielitz, H1
Landolt, J1
Heidbreder, M1
Werth, S1
Vogt, FM1
Jöhren, O1
Raasch, W1
Sueta, D1
Nakamura, T1
Dong, YF1
Kataoka, K1
Koibuchi, N1
Yamamoto, E1
Toyama, K1
Yasuda, O1
Ogawa, H1
Kim-Mitsuyama, S1
Padi, SS1
Chopra, K1
Chabrashvili, T1
Kitiyakara, C1
Blau, J1
Karber, A1
Aslam, S1
Welch, WJ1
Wilcox, CS1
Yamada, T2
Kuno, A2
Masuda, K2
Ogawa, K2
Sogawa, M1
Nakamura, S2
Ando, T2
Sano, H1
Nakazawa, T1
Ohara, H2
Nomura, T2
Joh, T2
Itoh, M2
Hayashi, T2
Sohmiya, K1
Ukimura, A1
Endoh, S1
Mori, T2
Shimomura, H1
Okabe, M2
Terasaki, F1
Kitaura, Y2
Seth, DM1
Navar, LG1
Yao, K1
Sato, H1
Ina, Y1
Suzuki, K1
Ohno, T1
Shirakura, S1
Wing, LM1
Arnolda, LF1
Upton, J1
Molloy, D1
Harrison-Bernard, LM1
Sata, N1
Tanaka, Y1
Suzuki, S1
Kamimura, R1
Mifune, H1
Nakamura, K2
Miyahara, K1
Arima, T1
Kansui, Y1
Fujii, K1
Goto, K1
Oniki, H1
Abe, I3
Shibata, Y1
Iida, M2
Tanabe, A1
Naruse, M1
Hara, Y1
Sato, A1
Tsuchiya, K1
Nishikawa, T1
Imaki, T1
Takano, K1
Kusaka, I1
Kusaka, G1
Zhou, C1
Ishikawa, M1
Nanda, A1
Granger, DN1
Zhang, JH1
Tang, J1
Fan, Q1
Liao, J1
Kobayashi, M1
Yamashita, M1
Gu, L1
Gohda, T1
Suzuki, Y1
Wang, LN1
Horikoshi, S1
Tomino, Y1
Tang, M1
Okamoto, T1
Shirai, T1
Okuda, N1
Inamoto, S1
Mieno, S1
Horimoto, H1
Takahashi, M1
Tanonaka, K1
Yoshida, H1
Koshimizu, M1
Oikawa, R1
Daicho, T1
Takeo, S1
Lu, Q1
Zhu, YZ1
Wong, PT1
Soga, M1
Kamal, FA1
Watanabe, K1
Ma, M1
Palaniyandi, S1
Prakash, P1
Veeraveedu, P1
Mito, S1
Kunisaki, M1
Tachikawa, H1
Kodama, M1
Aizawa, Y1
Awad, AS1
Ozacmak, VH1
Sayan, H1
Cetin, A1
Akyildiz-Igdem, A1
Iwai, M1
Chen, R2
Imura, Y1
Horiuchi, M1
Tsutsui, H1
Matsushima, S1
Kinugawa, S1
Ide, T1
Inoue, N1
Ohta, Y1
Yokota, T1
Hamaguchi, S1
Sunagawa, K1
Yu, F1
Sumino, H1
Morimoto, S1
Nakahashi, T1
Iwai, K1
Matsumoto, M1
Kanda, T1
Blumenfeld, JD1
Canzanello, VJ1
Baranco-Pryor, E1
Rahbari-Oskoui, F1
Schwartz, GL1
Boerwinkle, E1
Turner, ST1
Chapman, AB1
Bennai, F1
Morsing, P1
Paliege, A1
Ketteler, M1
Mayer, B1
Tapp, R1
Bachmann, S1
Matsumura, K3
Averill, DB1
Ferrario, CM1
Lin, Y2
Tsuchihashi, T2
Kagiyama, S1
Pollock, DM1
Derebail, VK1
Yamamoto, T1
Pollock, JS1
Kobayashi, N1
Nakano, S1
Mita, S1
Kobayashi, T1
Tsubokou, Y1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Molecular - Genetic Alterations in Adipose Tissue After Change in Therapy From ACE Inhibitors to AT1 Receptor Blockers in Patients With Essential Hypertension[NCT01444833]35 participants (Anticipated)Interventional2008-10-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for candesartan and Body Weight

ArticleYear
Effects of telmisartan on adiponectin levels and body weight in hypertensive patients with glucose intolerance.
    Metabolism: clinical and experimental, 2008, Volume: 57, Issue:10

    Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles

2008
Differential effects of candesartan and olmesartan on adipose tissue activity biomarkers in type II diabetic hypertensive patients.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8

    Topics: Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biomarkers; Biphenyl Compou

2010
Candesartan and hydrochlorothiazide in isolated systolic hypertension.
    Blood pressure, 2003, Volume: 12, Issue:4

    Topics: Aged; Aged, 80 and over; Australia; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood Pressu

2003

Other Studies

44 other studies available for candesartan and Body Weight

ArticleYear
Beneficial effect of candesartan and lisinopril against haloperidol-induced tardive dyskinesia in rat.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2015, Volume: 16, Issue:4

    Topics: Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Body Weight; Grooming; Haloperidol; Hand

2015
Partial adherence to antihypertensive therapy fails to achieve full cardiovascular benefits in hypertensive rats.
    The American journal of the medical sciences, 2008, Volume: 335, Issue:6

    Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Body Weight; Disease Models, A

2008
Functional and partial morphological regression of established renal injury in the obese zucker rat by blockade of the renin-angiotensin system.
    American journal of nephrology, 2009, Volume: 29, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimid

2009
Candesartan and insulin reduce renal sympathetic nerve activity in hypertensive type 1 diabetic rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:10

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Glucose;

2008
Role of angiotensin II and oxidative stress in vascular insulin resistance linked to hypertension.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:3

    Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzi

2009
Angiotensin blockade prevents salt-induced injury of the renal circulation in spontaneously hypertensive rats.
    American journal of nephrology, 2009, Volume: 29, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Benzimidazoles; Biphenyl Compounds; Body We

2009
Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after stroke.
    Stroke, 2009, Volume: 40, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Behavior, Animal; Benzimidazoles; Biphenyl Compoun

2009
Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated.
    Journal of hypertension, 2010, Volume: 28, Issue:3

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Base Sequence; Benzimidazoles; Bip

2010
Systemic candesartan reduces brain angiotensin II via downregulation of brain renin-angiotensin system.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:2

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds

2010
The insulin sparing effect of telmisartan in a case of type 2 diabetes mellitus associated with schizophrenia under treatment of risperidone.
    Internal medicine (Tokyo, Japan), 2010, Volume: 49, Issue:10

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Antipsychotic Agents; Benzimidazol

2010
Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension.
    The American journal of the medical sciences, 2010, Volume: 340, Issue:5

    Topics: Angiotensin II; Angiotensinogen; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compound

2010
Year-long antihypertensive therapy with candesartan completely prevents development of cardiovascular organ injuries in spontaneously hypertensive rats.
    International heart journal, 2010, Volume: 51, Issue:5

    Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; D

2010
Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPARγ target gene regulation.
    Endocrinology, 2012, Volume: 153, Issue:3

    Topics: Adipocytes; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Biphenyl Co

2012
Amlodipine enhances amelioration of vascular insulin resistance, oxidative stress, and metabolic disorders by candesartan in metabolic syndrome rats.
    American journal of hypertension, 2012, Volume: 25, Issue:6

    Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Bl

2012
Selective angiotensin II type 1 receptor blockade ameliorates cyclosporine nephrotoxicity.
    Pharmacological research, 2002, Volume: 45, Issue:5

    Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood

2002
Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 285, Issue:1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles;

2003
Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:1

    Topics: Actins; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl

2003
Angiotensin II receptor blockade prevents microangiopathy and preserves diastolic function in the diabetic rat heart.
    Heart (British Cardiac Society), 2003, Volume: 89, Issue:10

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood

2003
Angiotensin II type 1 receptor-mediated augmentation of renal interstitial fluid angiotensin II in angiotensin II-induced hypertension.
    Journal of hypertension, 2003, Volume: 21, Issue:10

    Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Ag

2003
Renoprotective effects of benidipine in combination with angiotensin II type 1 receptor blocker in hypertensive Dahl rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2003, Volume: 26, Issue:8

    Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazol

2003
Postovariectomy hypertension is linked to increased renal AT1 receptor and salt sensitivity.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure

2003
Effectiveness of angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker on atrial natriuretic peptide.
    Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:12

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensiv

2003
Angiotensin II receptor blockade corrects altered expression of gap junctions in vascular endothelial cells from hypertensive rats.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Antihypertensive

2004
Aldosterone antagonist facilitates the cardioprotective effects of angiotensin receptor blockers in hypertensive rats.
    Journal of hypertension, 2004, Volume: 22, Issue:5

    Topics: Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; B

2004
Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 286, Issue:6

    Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Glucose; Blood Pressure;

2004
Candesartan reduced advanced glycation end-products accumulation and diminished nitro-oxidative stress in type 2 diabetic KK/Ta mice.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:12

    Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Glucose; Body Weight; Di

2004
Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1

    Topics: Actins; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazol

2005
Nifedipine enhances the cardioprotective effect of an angiotensin-II receptor blocker in an experimental animal model of heart failure.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2005, Volume: 28, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Body Weight; C

2005
Effects of angiotensin I-converting enzyme inhibitor and angiotensin II type 1 receptor blocker on the right ventricular sarcoglycans and dystrophin after left coronary artery ligation.
    European journal of pharmacology, 2005, Oct-17, Volume: 522, Issue:1-3

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimid

2005
Neuroprotective effects of candesartan against cerebral ischemia in spontaneously hypertensive rats.
    Neuroreport, 2005, Nov-28, Volume: 16, Issue:17

    Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; B

2005
Effects of angiotensin II receptor blocker (candesartan) in daunorubicin-induced cardiomyopathic rats.
    International journal of cardiology, 2006, Jun-28, Volume: 110, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Apoptosis

2006
Role of AT1 receptors in permeability of the blood-brain barrier in diabetic hypertensive rats.
    Vascular pharmacology, 2006, Volume: 45, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds;

2006
AT1 receptor blocker candesartan-induced attenuation of brain injury of rats subjected to chronic cerebral hypoperfusion.
    Neurochemical research, 2007, Volume: 32, Issue:8

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds;

2007
TAK-536, a new AT1 receptor blocker, improves glucose intolerance and adipocyte differentiation.
    American journal of hypertension, 2007, Volume: 20, Issue:5

    Topics: Adipocytes; Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphen

2007
Angiotensin II type 1 receptor blocker attenuates myocardial remodeling and preserves diastolic function in diabetic heart.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2007, Volume: 30, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Benzimidazoles; Biphenyl Compounds; Blo

2007
Candesartan improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin.
    International journal of cardiology, 2008, Oct-13, Volume: 129, Issue:3

    Topics: Adiponectin; Animals; Benzimidazoles; Biphenyl Compounds; Body Weight; Cardiovirus Infections; Encep

2008
Plasma renin activity for predicting antihypertensive drug efficacy.
    American journal of hypertension, 2008, Volume: 21, Issue:1

    Topics: Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Biomarkers

2008
Predictors of blood pressure response to the angiotensin receptor blocker candesartan in essential hypertension.
    American journal of hypertension, 2008, Volume: 21, Issue:1

    Topics: Administration, Oral; Adult; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biomarkers; Bi

2008
Normalizing the expression of nitric oxide synthase by low-dose AT1 receptor antagonism parallels improved vascular morphology in hypertensive rats.
    Journal of the American Society of Nephrology : JASN, 1999, Volume: 10 Suppl 11

    Topics: Angiotensin Receptor Antagonists; Animals; Arterioles; Benzimidazoles; Biphenyl Compounds; Blood Pre

1999
Role of AT1 receptors in area postrema on baroreceptor reflex in spontaneously hypertensive rats.
    Brain research, 1999, Dec-11, Volume: 850, Issue:1-2

    Topics: Angiotensin Receptor Antagonists; Animals; Baroreflex; Benzimidazoles; Biphenyl Compounds; Blood Pre

1999
The influence of chronic antihypertensive treatment on the central pressor response in SHR.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2001, Volume: 24, Issue:2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl

2001
Combined effects of AT(1) and ET(A) receptor antagonists, candesartan, and A-127722 in DOCA-salt hypertensive rats.
    General pharmacology, 2000, Volume: 34, Issue:5

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrasentan; Benzimidazoles; Biphenyl Comp

2000
Chronic central infusion of orexin-A increases arterial pressure in rats.
    Brain research bulletin, 2002, Mar-15, Volume: 57, Issue:5

    Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; B

2002
Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:2

    Topics: Amides; Angiotensin II; Animals; Benzimidazoles; Biphenyl Compounds; Body Weight; Hemodynamics; Hype

2002