camptothecin has been researched along with Sensitivity and Specificity in 110 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (16.36) | 18.2507 |
| 2000's | 64 (58.18) | 29.6817 |
| 2010's | 28 (25.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Cho, DH; Kim, CW; Kim, JC; Kim, MB; Kim, TW; Roh, SA; Yoon, YS | 1 |
| Chen, A; Chen, M; Huang, Y; Xu, L; Zhang, G; Zhang, H | 1 |
| Cao, Y; Chen, Y; Jiang, J; Kang, A; Qin, Y; Shi, Y; Tang, Y; Wang, H; Wang, J; Wei, W; Zhou, G | 1 |
| Fan, B; Jing, L; Li, S; Shao, C; Wang, Y; Yan, X; Zheng, J | 1 |
| Cao, Y; Cheng, Q; Lu, H; Zhang, H | 1 |
| Hendel, HW; Jensen, BV; Nielsen, D; Skougaard, K | 1 |
| Ahn, G; Cho, JY; Jang, IJ; Kim, HK; Kim, HY; Park, DM; Park, JW; Rhee, SJ | 1 |
| Chen, X; Yu, Y; Zhan, Y; Zhang, Y; Zhong, D | 1 |
| Fan, B; Li, S; Liu, Y; Shao, C; Wang, Y; Zheng, J | 1 |
| Ghazaly, E; Joel, S; Kitromilidou, C; Perry, J; Powles, T | 1 |
| Cho, H; Kim, JH; Kim, S; Kim, SW; Kim, YT; Lee, M; Nam, EJ | 1 |
| Hummon, AB; Liu, X | 1 |
| Chen, Q; Li, P; Wang, S; Xie, X; Yu, F | 1 |
| Agostini, M; Calandra, E; Crotti, S; Giodini, L; Marangon, E; Nitti, D; Posocco, B; Toffoli, G; Traldi, P | 1 |
| Awasthi, A; Bansal, T; Jaggi, M; Khar, RK; Talegaonkar, S | 1 |
| D'Esposito, F; Murray, M; Ramzan, I; Tattam, BN | 1 |
| Bueno, S; Capranico, G; Chillemi, G; Fogli, MV; Lotito, L; Russo, A | 1 |
| Flowers, C; Kauh, J; Moore, SG; Shenoy, PJ; Tumeh, JW | 1 |
| Macchia, M; Maldini, M; Montoro, P; Piacente, S; Pizza, C | 1 |
| Edwards, CC; Hicks, LD; Hyatt, JL; Potter, PM; Stoddard, S; Tsurkan, L; Wadkins, RM | 1 |
| Cheng, YC; Dutschman, GE; Li, X; Ye, M; Zhang, W | 1 |
| Aladag, N; Aydinlik, S; Ozkan-Ariksoysal, D; Ozsoz, M; Topkaya, SN | 1 |
| Doi, T; Fuse, N; Ikematsu, H; Kaneko, K; Koike, K; Kojima, T; Minashi, K; Mochizuki, S; Ohtsu, A; Tahara, M; Yano, T; Yoshino, T | 1 |
| Gizewski, ER; Lanzman, RS; Mathys, C; Mödder, U; Rapp, M; Ringelstein, A; Sabel, M; Saleh, A; Schroeteler, J; Turowski, B | 1 |
| Horn, J; Leggas, M; Tsakalozou, E | 1 |
| Aucélio, RQ; da Cunha, AL; Marques, FF | 1 |
| Iinuma, H; Ikeuchi, H; Ishihara, S; Kobunai, T; Matsuda, K; Nozawa, K; Watanabe, T; Yamamoto, Y | 1 |
| Du, F; Hu, Z; Huang, Y; Li, C; Niu, W; Sun, Y; Xu, F | 1 |
| Kamei, T; Kawanishi, T; Nishimiya, K; Uchimura, T | 1 |
| Bedekar, DP; Donohoe, DL; Kurpad, SN; Pechman, KR; Schmainda, KM | 1 |
| Choi, BI; Eo, JS; Goo, JM; Han, JK; Han, SW; Im, SA; Kim, DH; Kim, SH; Lee, ES; Paeng, JC; Willmann, JK | 1 |
| Hu, Z; Shao, C; Wang, D; Wang, Y; Yan, X; Yu, T; Zhang, R; Zheng, J | 1 |
| Berglund, Å; Byström, P; Glimelius, B; Johansson, B; Larsson, A; Nygren, P; Wernroth, L | 1 |
| Arakawa, R; Iwaki, Y; Kawasaki, H | 1 |
| Beijnen, JH; Jansen, S; Rizzo, J; Rosing, H; Schellens, JH; Schoemaker, NE; Schöffski, P | 1 |
| Bachelot, A; Baudin, E; Docao, C; Gicquel, C; Penfornis, A; Schlumberger, M; Vassal, G | 1 |
| Danesi, R; Di Paolo, A | 1 |
| Villalona-Calero, MA; Xu, Y | 1 |
| Bae, KS; Cho, JY; Jang, IJ; Seo, HB; Shin, SG; Yi, SY; Yu, KS | 1 |
| Crews, KR; Dodds, H; Fricke, K; Hanna, SK; Owens, TS | 1 |
| Ahmad, A; Ahmad, I; Dahhani, F; Guo, W; Khan, S; Wang, YF | 1 |
| Nyormoi, O; Satoh, TH; Surmacz, TA; Whitacre, CM | 1 |
| Katneni, K; Mamidi, RN; Srinivas, NR; Upreti, VV | 1 |
| Burke, TG; Latus, LJ; Zhang, J | 1 |
| de Bruijn, P; de Jong, FA; Loos, WJ; Mathijssen, RH; Sparreboom, A; Verweij, J | 1 |
| Fan, JJ; Jia, ZP; Jiang, NX; Ma, J; Wang, J; Wang, R; Xie, H; Zhang, Q | 1 |
| Enomoto, K; Maruyama, K; Matsui, A; Okuda, M; Tsujitsuka, K | 1 |
| Astre, C; Bressolle, F; Culine, S; Malosse, F; Pinguet, F; Poujol, S; Ychou, M | 1 |
| Ahmad, A; Ahmad, I; Khan, S | 1 |
| Atsumi, R; de Bruijn, P; Soepenberg, O; Sparreboom, A; Verweij, J | 1 |
| Konno, T; Nakaoka, M; Oguma, T | 1 |
| Malik, M; Nitiss, JL | 1 |
| Cloughesy, T; Filka, E; Fruehauf, JP; Mehta, R; Parker, RJ | 1 |
| Kishida, T; Komiyama, M; Mori, T; Noguchi, M; Noguchi, Y; Ohnishi, M; Sawaguchi, K; Yabushita, H | 1 |
| Ajani, JA; Bresalier, R; Correa, AM; Erasmus, JJ; Komaki, R; Macapinlac, H; Maish, M; Munden, RF; Putnam, JB; Rice, D; Roth, JA; Smythe, WR; Swisher, SG; Vaporciyan, AA; Walsh, GL; Wu, TT | 1 |
| Atsumi, R; Iwasaki, D; Morikawa, H; Oguma, T | 1 |
| Lansdell, TA; Peddibhotla, S; Sharma, V; Tepe, JJ | 1 |
| Alexander, J; Becker, RC; Bovill, E; Dyke, CK; Harrington, RA; Kunitada, S; Li, YF; Robertson, TL; Spencer, FA | 1 |
| Cecchin, E; Toffoli, G | 1 |
| Dadashzadeh, S; Derakhshandeh, K | 1 |
| Atsumi, R; Cicci, D; Gaudette, F; Gauthier-Dubois, G; Guilbaud, R; Oguma, T | 1 |
| Li, GZ; Li, KS; Li, ZH; Yang, WM; Yu, WH; Zhou, XM | 1 |
| Dan, S; Fukui, Y; Nakamura, T; Nakatsu, N; Yamazaki, K; Yamori, T; Yoshida, Y | 1 |
| Arnold, CN; Blum, HE | 1 |
| Fan, Y; Feng, YQ; Wen, Y; Zhang, M | 1 |
| Ahmad, A; Ahmad, I; Ayoub, J; Bardin, S; Duggan, JX; Guo, W; Johnson, JL; Khan, S | 1 |
| Chen, T; Chu, ZH; Liu, JP; Ou, QJ; Wang, J; Zhao, HY | 1 |
| Adjei, AA; Alberts, SR; Atherton, PJ; Denis, L; Duncan, BA; Erlichman, C; McGovren, P; Miller, LL; Pitot, HC; Reid, JM; Rubin, J; Schaaf, LJ; Sharma, A; Sloan, JA; Yin, D | 1 |
| Buxhofer-Ausch, V; Hinterberger, W; Hinterberger-Fischer, M | 1 |
| Chen, HL; Gao, JQ; Liang, WQ; Qiao, HL; Zhao, YX | 1 |
| Chen, GQ; Fliegauf, M; Lu, Y; Lübbert, M; Song, MG; Xu, YB; Yuan, TT | 1 |
| Anderson, BD; Horn, J; Jordan, SL; Leggas, M; Roberts, MJ; Song, L | 1 |
| Norum, J | 1 |
| Falk, S; Glynne-Jones, R; Maughan, TS; Meadows, HM; Sebag-Montefiore, D | 1 |
| Cardellina, JH; Klausmeyer, P; McCloud, TG; Melillo, G; Scudiero, DA; Shoemaker, RH | 1 |
| Badaloni, E; Cabri, W; Ciogli, A; Deias, R; Gasparrini, F; Giorgi, F; Vigevani, A; Villani, C | 1 |
| Biesmans, B; De Hertogh, G; De Roock, W; De Schutter, J; Humblet, Y; Janssens, M; Peeters, M; Personeni, N; Piessevaux, H; Tejpar, S; Van Cutsem, E; Van Laethem, JL | 1 |
| Cao, Z; Giovanella, B; Liu, X; Vardeman, D; Wang, Y | 1 |
| St Claire, RL; Stafford, CG | 1 |
| Kim, K | 1 |
| Canellakis, ZN; Costin, D; Degar, B; Drygas, JC; Mani, M; Morse, L; Newcomb, EW; Potmesil, M; Rosenberg, CR; Silber, R | 1 |
| Evans, A; Johnson, RT; Ryan, AJ; Squires, S; Strutt, HL | 1 |
| Hsiung, Y; Liu, YX; Nitiss, JL | 1 |
| Darzynkiewicz, Z; Li, X | 1 |
| Dalgleish, AG; Gibson, FM; Gordon-Smith, EC; Marsh, JC; Philpott, NJ; Scopes, J; Turner, AJ; Westby, M | 1 |
| Loos, WJ; Schellens, JH; Stoter, G; Verweij, J | 1 |
| Bissery, MC; Chabot, GG; Lavelle, F; Vrignaud, P | 1 |
| Li, YF; Zhang, R | 1 |
| Loos, WJ; Nooter, K; Schellens, JH; Sparreboom, A; Stoter, G; Verweij, J | 1 |
| Hall, DJ; Min, I; Strachan, GD; Stubbs, MC | 1 |
| Durka, S; Hueber, A; Weller, M | 1 |
| Al-Rubeai, M; Ishaque, A | 1 |
| de Bruijn, P; de Jonge, MJ; Loos, WJ; Nooter, K; Sparreboom, A; Stoter, G; Verweij, J | 1 |
| Ardizzoni, A; de Cupis, A; Favoni, RE; Grossi, F; Loprevite, M; Merlo, F; Pirani, P | 1 |
| Dupuy, JL; Gaulier, JM; Lacassie, E; Lachâtre, F; Lachâtre, G; Marquet, P; Ragot, S; Rousseau, A | 1 |
| Handa, T; Kai, S; Kazami, A; Koizumi, K; Maruyama, M; Takemoto, N; Yamao, T | 1 |
| Bellanger, A; Durand-Zaleski, I; Juhel, H; Levy-Piedbois, C; Piedbois, P; Schmitt, C | 1 |
| Brouwer, E; de Bruijn, P; Gill, S; Hamilton, M; Kehrer, D; Loos, WJ; Nooter, K; Sparreboom, A; Stoter, G; Verweij, J | 1 |
| Honma, KI; Honma, S; Katsuno, Y; Nakamura, H; Ohmiya, Y; Ohta, H; Tanahashi, Y | 1 |
| Iqbal, S; Lenz, HJ | 1 |
| Inukai, K; Konno, T; Nakaoka, M; Oguma, T; Yamada, M | 1 |
| Inaba, A; Konno, T; Nakaoka, M; Oguma, T | 1 |
| Hausheer, F; Madden, TL; Newman, RA; Smith, JA | 1 |
| Ando, M; Hanioka, N; Jinno, H; Nishimura, T; Ozawa, S; Sawada, J | 1 |
| Boyd, G; Cummings, J; Jodrell, DI; Smyth, JF | 1 |
| Beijnen, JH; Fraier, D; Frigerio, E; Jansen, S; Rosing, H; Schellens, JH; Schoemaker, NE | 1 |
| Castell, JV; Gómez-Lechón, MJ; Jover, R; O'Connor, E | 1 |
| Kaniwa, N; Ozawa, S; Sai, K; Sawada, J | 1 |
| Jia, ZP; Liu, CL; Ma, J; Wang, R; Xu, LT; Zhu, PL | 1 |
6 review(s) available for camptothecin and Sensitivity and Specificity
| Article | Year |
|---|---|
Irinotecan: mechanisms of tumor resistance and novel strategies for modulating its activity.
Topics: Animals; Apoptosis; Camptothecin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Humans; Irinotecan; Male; Maximum Tolerated Dose; Neoplasms; NF-kappa B; Risk Assessment; Sensitivity and Specificity; Topoisomerase I Inhibitors | 2002 |
Pharmacology of intraperitoneal CPT-11.
Topics: Antineoplastic Agents, Phytogenic; Biological Availability; Camptothecin; Chemotherapy, Adjuvant; Clinical Trials as Topic; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Infusions, Parenteral; Irinotecan; Male; Maximum Tolerated Dose; Risk Assessment; Sensitivity and Specificity | 2003 |
Utility of PET, CT, and EUS to identify pathologic responders in esophageal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carboplatin; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Docetaxel; Endosonography; Esophageal Neoplasms; Esophagectomy; Female; Fluorodeoxyglucose F18; Fluorouracil; Humans; Irinotecan; Life Tables; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Paclitaxel; Positron-Emission Tomography; Preoperative Care; Prognosis; Proportional Hazards Models; Radiopharmaceuticals; Radiotherapy, Adjuvant; Retrospective Studies; Sensitivity and Specificity; Survival Analysis; Taxoids; Tomography, X-Ray Computed; Treatment Outcome | 2004 |
Uridine diphosphoglucuronosyl transferase and methylenetetrahydrofolate reductase polymorphisms as genomic predictors of toxicity and response to irinotecan-, antifolate- and fluoropyrimidine-based chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Female; Fluorouracil; Glucuronosyltransferase; Humans; Irinotecan; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Pharmacogenetics; Polymorphism, Genetic; Sensitivity and Specificity; Toxicogenetics | 2004 |
[Colon cancer: molecular markers].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Camptothecin; Clinical Trials as Topic; Colorectal Neoplasms; DNA Repair; DNA, Neoplasm; Feces; Fluorouracil; Genes, ras; Genes, Tumor Suppressor; Genetic Markers; Humans; Irinotecan; Microsatellite Repeats; Mutation; Oncogenes; Polymerase Chain Reaction; Prognosis; Prospective Studies; Sensitivity and Specificity; Treatment Outcome; Tumor Cells, Cultured | 2005 |
Determinants of prognosis and response to therapy in colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Gene Expression Regulation, Neoplastic; Glucuronosyltransferase; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Oxidoreductases; Polymorphism, Genetic; Predictive Value of Tests; Prognosis; Sensitivity and Specificity; Survival Analysis; Thymidine Phosphorylase; Thymidylate Synthase | 2001 |
13 trial(s) available for camptothecin and Sensitivity and Specificity
| Article | Year |
|---|---|
Comparison of EORTC criteria and PERCIST for PET/CT response evaluation of patients with metastatic colorectal cancer treated with irinotecan and cetuximab.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Cetuximab; Colorectal Neoplasms; Denmark; Digestive System Neoplasms; Female; Fluorodeoxyglucose F18; Humans; Image Interpretation, Computer-Assisted; Irinotecan; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Multimodal Imaging; Outcome Assessment, Health Care; Positron-Emission Tomography; Prevalence; Radiopharmaceuticals; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity; Survival Analysis; Survival Rate; Tomography, X-Ray Computed; Treatment Outcome | 2013 |
Development and validation of a sensitive LC-MS/MS method for simultaneous quantification of sinotecan and its active metabolite in human blood.
Topics: Camptothecin; Chromatography, Liquid; Drug Stability; Female; Humans; Male; Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2014 |
Cross-validation of a mass spectrometric-based method for the therapeutic drug monitoring of irinotecan: implementation of matrix-assisted laser desorption/ionization mass spectrometry in pharmacokinetic measurements.
Topics: Algorithms; Antineoplastic Agents; Camptothecin; Colorectal Neoplasms; Drug Monitoring; Humans; Irinotecan; Metabolic Clearance Rate; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2016 |
Intermodality comparison between 3D perfusion CT and 18F-FDG PET/CT imaging for predicting early tumor response in patients with liver metastasis after chemotherapy: preliminary results of a prospective study.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Early Detection of Cancer; Female; Fluorodeoxyglucose F18; Fluorouracil; Humans; Imaging, Three-Dimensional; Leucovorin; Liver Neoplasms; Male; Middle Aged; Multimodal Imaging; Organoplatinum Compounds; Perfusion Imaging; Pilot Projects; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tomography, X-Ray Computed | 2012 |
Evaluation of predictive markers for patients with advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Biomarkers, Tumor; C-Reactive Protein; CA-19-9 Antigen; Camptothecin; Carcinoembryonic Antigen; Colorectal Neoplasms; Disease-Free Survival; Drug Administration Schedule; Evaluation Studies as Topic; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Linear Models; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Prealbumin; Predictive Value of Tests; Prognosis; Receptors, Albumin; Sensitivity and Specificity; Serum Amyloid A Protein; Sweden; Tissue Inhibitor of Metalloproteinase-1; Tissue Polypeptide Antigen | 2012 |
Use of a topoisomerase I inhibitor (irinotecan, CPT-11) in metastatic adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Biopsy, Needle; Camptothecin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; France; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Neoplasm Staging; Prospective Studies; Sensitivity and Specificity; Survival Rate; Treatment Outcome | 2002 |
Irinotecan in 5-fluorouracil-refractory colorectal cancer.
Topics: Adult; Aged; Camptothecin; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Palliative Care; Sensitivity and Specificity; Survival Analysis; Treatment Outcome | 2002 |
Sensitive HPLC-fluorescence method for irinotecan and four major metabolites in human plasma and saliva: application to pharmacokinetic studies.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Drug Stability; Glucuronates; Humans; Irinotecan; Neoplasm Metastasis; Reproducibility of Results; Saliva; Sensitivity and Specificity; Spectrometry, Fluorescence | 2003 |
A prospective blinded study of the predictive value of an extreme drug resistance assay in patients receiving CPT-11 for recurrent glioma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Disease Progression; Drug Resistance, Neoplasm; Female; Glioma; Humans; Irinotecan; Male; Middle Aged; Neoplasm Recurrence, Local; Predictive Value of Tests; Prospective Studies; Sensitivity and Specificity; Survival Rate; Topoisomerase I Inhibitors; Treatment Outcome | 2004 |
A phase I and pharmacokinetic study of a powder-filled capsule formulation of oral irinotecan (CPT-11) given daily for 5 days every 3 weeks in patients with advanced solid tumors.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Chromatography, High Pressure Liquid; Female; Humans; Irinotecan; Male; Middle Aged; Neoplasms; Powders; Sensitivity and Specificity | 2006 |
A phase I/II study of irinotecan when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group Study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cohort Studies; Combined Modality Therapy; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Humans; Irinotecan; Leucovorin; Magnetic Resonance Imaging; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Pelvic Neoplasms; Rectal Neoplasms; Sensitivity and Specificity; Survival Rate; Treatment Outcome | 2007 |
Chemosensitivity of lymphocytes from patients with B-cell chronic lymphocytic leukemia to chlorambucil, fludarabine, and camptothecin analogs.
Topics: Antineoplastic Agents; B-Lymphocytes; Camptothecin; Cell Survival; Cells, Cultured; Chlorambucil; Genes, p53; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Mutation; Neoplasm Staging; Sensitivity and Specificity; Tumor Cells, Cultured; Vidarabine | 1994 |
Cost-effectiveness of second-line treatment with irinotecan or infusional 5-fluorouracil in metastatic colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Cost-Benefit Analysis; Costs and Cost Analysis; Drug Administration Schedule; Female; Fluorouracil; France; Health Care Costs; Hospital Costs; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Salvage Therapy; Sensitivity and Specificity; Survival Analysis | 2000 |
91 other study(ies) available for camptothecin and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Development and Applicability of Integrative Tumor Response Assays for Metastatic Colorectal Cancer.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Molecular Targeted Therapy; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Prospective Studies; Reproducibility of Results; Sensitivity and Specificity | 2017 |
Simultaneous separation and analysis of camptothecin alkaloids in real samples by large-volume sample stacking in capillary electrophoresis.
Topics: beta-Cyclodextrins; Camptotheca; Camptothecin; Electrophoresis, Capillary; Fruit; Hydrogen-Ion Concentration; Linear Models; Plant Bark; Plant Extracts; Reproducibility of Results; Sensitivity and Specificity; Temperature | 2018 |
Carboxylesterase and UDP-glucuronosyltransferases mediated metabolism of irinotecan: In vitro and in vivo insights from quantitative ultra-performance liquid chromatography-mass spectrometry analysis.
Topics: Animals; Camptothecin; Carboxylesterase; Chromatography, High Pressure Liquid; Glucuronosyltransferase; Humans; Irinotecan; Linear Models; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2018 |
Synthesis, antitumor activity and pharmacokinetic study of 10-propionyloxy camptothecin in rats.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; Linear Models; Male; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Xenograft Model Antitumor Assays | 2018 |
[Determination of 7-ethyl-10-hydroxycamptothecin in microdialysates from rat brain with LC-MS/MS].
Topics: Animals; Brain Chemistry; Camptothecin; Chromatography, Liquid; Irinotecan; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Tandem Mass Spectrometry | 2013 |
A rapid, simple and reliable HPLC-triple quadrupole tandem mass spectrometer method for a simultaneous quantification of irinotecan and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma.
Topics: Animals; Camptothecin; Chromatography, High Pressure Liquid; Female; Irinotecan; Linear Models; Male; Mice; Mice, Inbred ICR; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2014 |
A simple HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat liver tissue.
Topics: Animals; Calibration; Camptothecin; Chromatography, High Pressure Liquid; Fluorescence; Limit of Detection; Liver; Male; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Tissue Distribution | 2015 |
Development and validation of an ultra-high performance LC-MS/MS assay for intracellular SN-38 in human solid tumour cell lines: comparison with a validated HPLC-fluorescence method.
Topics: Acetonitriles; Camptothecin; Cell Line, Tumor; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Stability; HCT116 Cells; HT29 Cells; Humans; Intracellular Space; Irinotecan; Least-Squares Analysis; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Tandem Mass Spectrometry | 2014 |
ATP-based chemotherapy response assay in primary or recurrent ovarian and peritoneal cancer.
Topics: Adenocarcinoma, Clear Cell; Adenosine Triphosphate; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carboplatin; Carcinoma, Ovarian Epithelial; Cisplatin; Docetaxel; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Ifosfamide; Irinotecan; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Paclitaxel; Peritoneal Neoplasms; Predictive Value of Tests; Sensitivity and Specificity; Taxoids | 2014 |
Quantitative determination of irinotecan and the metabolite SN-38 by nanoflow liquid chromatography-tandem mass spectrometry in different regions of multicellular tumor spheroids.
Topics: Camptothecin; Chromatography, Liquid; Drug Stability; HCT116 Cells; Humans; Irinotecan; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Spheroids, Cellular; Tandem Mass Spectrometry; Tumor Cells, Cultured | 2015 |
Simultaneous determination of camptothecin and 10-hydroxycamptothecine in the Camptotheca acuminate, its medicinal preparation and in rat plasma by liquid chromatography with fluorescence detection.
Topics: Administration, Oral; Animals; Camptotheca; Camptothecin; Chromatography, Liquid; Drugs, Chinese Herbal; Fluorescence; Limit of Detection; Plants, Medicinal; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity | 2015 |
Development and validation of reversed phase liquid chromatographic method utilizing ultraviolet detection for quantification of irinotecan (CPT-11) and its active metabolite, SN-38, in rat plasma and bile samples: application to pharmacokinetic studies.
Topics: Animals; Bile; Camptothecin; Chromatography, High Pressure Liquid; Female; Irinotecan; Linear Models; Rats; Reference Standards; Sensitivity and Specificity; Time Factors; Ultraviolet Rays | 2008 |
A liquid chromatography/electrospray ionization mass spectrometry (LC-MS/MS) assay for the determination of irinotecan (CPT-11) and its two major metabolites in human liver microsomal incubations and human plasma samples.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Chromatography, Liquid; Drug Stability; Humans; Irinotecan; Microsomes, Liver; Reference Standards; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2008 |
A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors.
Topics: Antineoplastic Agents; Base Sequence; Camptothecin; Cell Cycle; Cell Proliferation; DNA Replication; DNA Topoisomerases, Type I; DNA-Binding Proteins; Down-Regulation; Gene Regulatory Networks; Genes, Fungal; Mutation; Promoter Regions, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sensitivity and Specificity; Time Factors; Transcription Factors; Transcription, Genetic; Up-Regulation | 2009 |
A Markov model assessing the effectiveness and cost-effectiveness of FOLFOX compared with FOLFIRI for the initial treatment of metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cohort Studies; Colorectal Neoplasms; Cost-Benefit Analysis; Disease-Free Survival; Fluorouracil; Humans; Leucovorin; Markov Chains; Models, Econometric; Neoplasm Staging; Organoplatinum Compounds; Quality of Life; Quality-Adjusted Life Years; Sensitivity and Specificity; Treatment Outcome | 2009 |
Metabolite fingerprinting of Camptotheca acuminata and the HPLC-ESI-MS/MS analysis of camptothecin and related alkaloids.
Topics: Alkaloids; Calibration; Camptotheca; Camptothecin; Chromatography, High Pressure Liquid; Molecular Structure; Molecular Weight; Plant Extracts; Plant Leaves; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.
Topics: Camptothecin; Carboxylic Ester Hydrolases; Drug Design; Enzyme Inhibitors; Humans; Intestines; Irinotecan; Molecular Structure; Quantitative Structure-Activity Relationship; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Substrate Specificity | 2009 |
Quantitation of Irinotecan and its two major metabolites using a liquid chromatography-electrospray ionization tandem mass spectrometric.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Chromatography, Liquid; Glucuronates; Glucuronidase; Humans; Irinotecan; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2009 |
Different DNA immobilization strategies for the interaction of anticancer drug irinotecan with DNA based on electrochemical DNA biosensors.
Topics: Adsorption; Animals; Antineoplastic Agents; Biosensing Techniques; Camptothecin; DNA; Electrochemistry; Electrodes; Fishes; Graphite; High-Throughput Screening Assays; Irinotecan; Male; Oligonucleotides; Oxidation-Reduction; Sensitivity and Specificity; Spermatozoa; Surface Properties | 2010 |
Therapeutic significance of a D-dimer cut-off level of >3 µg/ml in colorectal cancer patients treated with standard chemotherapy plus bevacizumab.
Topics: Adenocarcinoma; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Disease Progression; Female; Fibrin Fibrinogen Degradation Products; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Retrospective Studies; Sensitivity and Specificity; Sepsis; Venous Thromboembolism | 2010 |
[Evaluation of ADC mapping as an early predictor for tumor response to chemotherapy in recurrent glioma treated with bevacizumab/irinotecan: proof of principle].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain; Brain Neoplasms; Camptothecin; Contrast Media; Diffusion Magnetic Resonance Imaging; Female; Follow-Up Studies; Gadolinium; Glioblastoma; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Irinotecan; Male; Neoplasm Recurrence, Local; Sensitivity and Specificity; Vascular Endothelial Growth Factor A | 2010 |
An HPLC assay for the lipophilic camptothecin analog AR-67 carboxylate and lactone in human whole blood.
Topics: Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Drug Stability; Humans; Lactones; Linear Models; Organosilicon Compounds; Reproducibility of Results; Sensitivity and Specificity | 2010 |
Laser induced fluorescence and photochemical derivatization for trace determination of camptothecin.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Fluorescence; Irinotecan; Lasers; Pharmaceutical Preparations; Photochemistry; Sensitivity and Specificity; Spectrometry, Fluorescence; Topotecan | 2010 |
Gene expression of vascular endothelial growth factor A, thymidylate synthase, and tissue inhibitor of metalloproteinase 3 in prediction of response to bevacizumab treatment in colorectal cancer patients.
Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers, Tumor; Camptothecin; Colorectal Neoplasms; Female; Fluorouracil; Gene Expression; Humans; Leucovorin; Male; Microarray Analysis; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Predictive Value of Tests; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Thymidylate Synthase; Tissue Inhibitor of Metalloproteinase-3; Treatment Outcome; Vascular Endothelial Growth Factor A | 2011 |
Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases.
Topics: Animals; Antineoplastic Agents; Camptothecin; Carboxylic Ester Hydrolases; Chromatography, High Pressure Liquid; Dogs; Enzyme Inhibitors; Male; Mice; Mice, Nude; Prodrugs; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2011 |
Method development and validation of the simultaneous determination of a novel topoisomerase 1 inhibitor, the prodrug, and the active metabolite in human plasma using column-switching LC-MS/MS, and its application in a clinical trial.
Topics: Camptothecin; Chromatography, Liquid; Dipeptides; Drug Stability; Heterocyclic Compounds, 4 or More Rings; Humans; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Topoisomerase I Inhibitors | 2011 |
Evaluation of combined bevacizumab plus irinotecan therapy in brain tumors using magnetic resonance imaging measures of relative cerebral blood volume.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Blood Volume; Blood Volume Determination; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Cerebrovascular Circulation; Irinotecan; Magnetic Resonance Imaging; Male; Rats; Rats, Nude; Reproducibility of Results; Sensitivity and Specificity; Treatment Outcome | 2012 |
Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Humans; Linear Models; Male; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2012 |
Human serum albumin-modified Fe3O4 magnetic nanoparticles for affinity-SALDI-MS of small-molecule drugs in biological liquids.
Topics: Camptothecin; Ferrosoferric Oxide; Humans; Ibuprofen; Magnetite Nanoparticles; Molecular Weight; Phenytoin; Sensitivity and Specificity; Serum Albumin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Warfarin | 2012 |
Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection.
Topics: Camptothecin; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 2002 |
Simple and sensitive determination of the new antitumor drug CKD-602 in human plasma by liquid chromatography.
Topics: Antineoplastic Agents; Camptothecin; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity | 2003 |
High-performance liquid chromatographic assay with fluorescence detection for the simultaneous measurement of carboxylate and lactone forms of irinotecan and three metabolites in human plasma.
Topics: Antineoplastic Agents, Phytogenic; Calibration; Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Humans; Irinotecan; Lactones; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2003 |
Determination by liquid chromatography with fluorescence detection of total 7-ethyl-10-hydroxy-camptothecin (SN-38) in beagle dog plasma after intravenous administration of liposome-based SN-38 (LE-SN38).
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chromatography, High Pressure Liquid; Dogs; Enzyme Inhibitors; Irinotecan; Liposomes; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2003 |
Inhibition of focal adhesion kinase by antisense oligonucleotides enhances the sensitivity of breast cancer cells to camptothecins.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Camptothecin; Caspase 3; Caspase 9; Caspases; Cell Adhesion; Enzyme Activation; Enzyme Precursors; Female; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Humans; Oligonucleotides, Antisense; Poly(ADP-ribose) Polymerases; Protein-Tyrosine Kinases; Sensitivity and Specificity; Topotecan; Tumor Cells, Cultured; Tumor Protein, Translationally-Controlled 1 | 2003 |
Quantitative determination of DRF-1042 in human plasma by HPLC: validation and application in clinical pharmacokinetics.
Topics: Antineoplastic Agents; Calibration; Camptothecin; Chromatography, High Pressure Liquid; Humans; Neoplasms; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Determination of 9-nitrocamptothecin by precolumn derivatization and its metabolite 9-aminocamptothecin in a biological fluid using reversed-phase high-performance liquid chromatography with fluorescence detection.
Topics: Animals; Calibration; Camptothecin; Chromatography, High Pressure Liquid; Dogs; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2003 |
Determination of irinotecan (CPT-11) and SN-38 in human whole blood and red blood cells by liquid chromatography with fluorescence detection.
Topics: Antineoplastic Agents; Camptothecin; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Erythrocytes; Humans; Irinotecan; Reproducibility of Results; Sensitivity and Specificity; Topoisomerase I Inhibitors | 2003 |
Liquid chromatography determination of 10-hydroxycamptothecin in human serum by a column-switching system containing a pre-column with restricted access media and its application to a clinical pharmacokinetic study.
Topics: Antineoplastic Agents, Phytogenic; Calibration; Camptothecin; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reference Values; Sensitivity and Specificity; Spectrometry, Fluorescence | 2003 |
A sensitive and rapid liquid chromatography tandem mass spectrometry method for quantitative determination of 7-ethyl-10-hydroxycamptothecin (SN-38) in human plasma containing liposome-based SN-38 (LE-SN38).
Topics: Camptothecin; Chromatography, High Pressure Liquid; Humans; Irinotecan; Liposomes; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2003 |
Liquid chromatographic assays for DE-310, a novel camptothecin analog, and two major enzymatic products in human matrices.
Topics: Calibration; Camptothecin; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Reference Standards; Reproducibility of Results; Saliva; Sensitivity and Specificity | 2004 |
Validation study of assay method for DE-310, a novel polymer-bound camptothecin derivative, and the free drug in mouse plasma by liquid chromatography with fluorimetric detection.
Topics: Animals; Camptothecin; Chemical Precipitation; Chromatography, High Pressure Liquid; Fluorometry; Mice; Reproducibility of Results; Sensitivity and Specificity; Thermolysin | 2004 |
DNA repair functions that control sensitivity to topoisomerase-targeting drugs.
Topics: Camptothecin; Cell Cycle; DNA Damage; DNA Repair; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Etoposide; Genotype; Mutation; Plasmids; Recombination, Genetic; Schizosaccharomyces; Sensitivity and Specificity; Temperature; Time Factors; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; X-Rays | 2004 |
Usefulness of collagen gel droplet embedded culture drug sensitivity testing in ovarian cancer.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Culture Techniques; Cell Line, Tumor; Chemotherapy, Adjuvant; Cisplatin; Clinical Laboratory Techniques; Collagen; Disease Progression; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Female; Gels; Humans; Irinotecan; Middle Aged; Ovarian Neoplasms; Paclitaxel; Pharmaceutical Preparations; Recurrence; Remission Induction; Sensitivity and Specificity; Time Factors; Treatment Outcome | 2004 |
Validation study of a method for assaying DE-310, a macromolecular carrier conjugate containing an anti-tumor camptothecin derivative, and the free drug in tumor tissue by high performance liquid chromatography/atmospheric pressure chemical ionization tan
Topics: Animals; Atmospheric Pressure; Camptothecin; Chromatography, High Pressure Liquid; Drug Carriers; Drug Stability; Fibrosarcoma; Freezing; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Sensitization of tumor cells toward chemotherapy: enhancing the efficacy of camptothecin with imidazolines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Cell Death; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; I-kappa B Proteins; Imidazolines; Leukemia, T-Cell; Luciferases; Models, Biological; Molecular Conformation; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Sensitivity and Specificity | 2004 |
Combined coagulation phase-directed factor Xa inhibition with heparin compounds and DX-9065a - a direct and selective antagonist.
Topics: Anticoagulants; Blood Coagulation Tests; Calcium Chloride; Camptothecin; Drug Synergism; Enoxaparin; Factor Xa; Factor Xa Inhibitors; Heparin; Heparin, Low-Molecular-Weight; Humans; Sensitivity and Specificity | 2004 |
Liquid chromatographic quantitation of the lactone and the total of lactone and carboxylate forms of 9-nitrocamptothecin in human plasma.
Topics: Antineoplastic Agents; Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Drug Stability; Humans; Lactones; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Validation study of a method for assaying DE-310, a macromolecular carrier conjugate containing an anti-tumor camptothecin derivative, and the free drug in human plasma by HPLC and LC/MS/MS.
Topics: Antineoplastic Agents; Camptothecin; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug Stability; Humans; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity; Thermolysin | 2005 |
[Comparison between two methods for staining DNA of apoptotic spermatozoa].
Topics: Apoptosis; Benzimidazoles; Camptothecin; Cell Survival; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; Genistein; Humans; Male; Propidium; Sensitivity and Specificity; Spermatozoa; Staining and Labeling | 2005 |
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cluster Analysis; Computational Biology; Databases as Topic; DNA, Complementary; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Mitomycin; Oligonucleotide Array Sequence Analysis; Paclitaxel; Phylogeny; Sensitivity and Specificity; Tissue Distribution; Transfection; Vinblastine; Vinorelbine | 2005 |
Determination of camptothecin and 10-hydroxycamptothecin in human plasma using polymer monolithic in-tube solid phase microextraction combined with high-performance liquid chromatography.
Topics: Camptothecin; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 2005 |
Liquid chromatographic-tandem mass spectrometric assay for the simultaneous quantification of Camptosar and its metabolite SN-38 in mouse plasma and tissues.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chromatography, High Pressure Liquid; Irinotecan; Mass Spectrometry; Mice; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution | 2005 |
[Application of adenosine triphosphate tumor chemosensitive assay system to individual chemotherapy for hepatocellular carcinoma].
Topics: Adenosine Triphosphate; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Deoxycytidine; Disease-Free Survival; Drug Screening Assays, Antitumor; Female; Gemcitabine; Humans; Irinotecan; Liver Neoplasms; Male; Middle Aged; Paclitaxel; Postoperative Period; Remission Induction; Sensitivity and Specificity; Survival Rate | 2005 |
Bcr-abl positive blast crisis of chronic myeloid leukemia emerging in a case of metastatic colorectal cancer 3 months after completion of an 8-month course of cetuximab and irinotecan.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Blast Crisis; Camptothecin; Cetuximab; Chemotherapy, Adjuvant; Colorectal Neoplasms; Diagnosis, Differential; Disease Progression; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Irinotecan; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocyte Count; Male; Middle Aged; Neoplasm Staging; Neoplasms, Second Primary; Piperazines; Pyrimidines; Remission Induction; Sensitivity and Specificity; Tomography, X-Ray Computed; Treatment Outcome | 2006 |
Development and validation of a sensitive reversed-phase HPLC method to determine intracellular accumulation of hydroxycamptothecin.
Topics: Calibration; Camptothecin; Cell Line; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2006 |
Inducible expression of AML1-ETO fusion protein endows leukemic cells with susceptibility to extrinsic and intrinsic apoptosis.
Topics: Antibodies, Monoclonal; Apoptosis; Blotting, Western; Camptothecin; Cell Line, Tumor; Core Binding Factor Alpha 2 Subunit; Cycloheximide; Ecdysterone; fas Receptor; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Oncogene Proteins, Fusion; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RUNX1 Translocation Partner 1 Protein; Sensitivity and Specificity; Time Factors; Ultraviolet Rays | 2006 |
Validation of an HPLC method for analysis of DB-67 and its water soluble prodrug in mouse plasma.
Topics: Animals; Camptothecin; Chromatography, High Pressure Liquid; Male; Mice; Mice, Inbred C57BL; Organosilicon Compounds; Prodrugs; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2006 |
Cetuximab in the treatment of metastatic colorectal cancer: a model-based cost-effectiveness analysis.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Clinical Trials as Topic; Colorectal Neoplasms; Cost-Benefit Analysis; Humans; Irinotecan; Middle Aged; Models, Theoretical; Neoplasm Metastasis; Sensitivity and Specificity | 2006 |
Identification of a new natural camptothecin analogue in targeted screening for HIF-1alpha inhibitors.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Drug Screening Assays, Antitumor; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Phytotherapy; Plant Extracts; Plant Structures; Rubiaceae; Sensitivity and Specificity | 2007 |
Combination of HPLC "inverted chirality columns approach" and MS/MS detection for extreme enantiomeric excess determination even in absence of reference samples. Application to camptothecin derivatives.
Topics: Camptothecin; Chromatography, High Pressure Liquid; Circular Dichroism; Mass Spectrometry; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism | 2007 |
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colorectal Neoplasms; Disease-Free Survival; Female; Humans; Irinotecan; Logistic Models; Male; Middle Aged; Mutation; Proportional Hazards Models; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Retrospective Studies; Sensitivity and Specificity; Survival Rate; Tomography, X-Ray Computed | 2008 |
Development and validation of a reverse-phase HPLC with fluorescence detector method for simultaneous determination of CZ48 and its active metabolite camptothecin in mouse plasma.
Topics: Animals; Antineoplastic Agents; Calibration; Camptothecin; Chromatography, High Pressure Liquid; Mice; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2008 |
High-performance liquid chromatographic analysis of the lactone and carboxylate forms of a topoisomerase I inhibitor (the antitumor drug GI147211) in plasma.
Topics: Animals; Antineoplastic Agents; Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Dogs; Drug Stability; Hydrogen-Ion Concentration; Lactones; Sensitivity and Specificity; Topoisomerase I Inhibitors | 1995 |
SEQPWR and SEQOPR: computer programs for design of maximum information trials based on group sequential logrank tests.
Topics: Algorithms; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Small Cell; Cisplatin; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Data Interpretation, Statistical; Etoposide; Feasibility Studies; Follow-Up Studies; Humans; Linear Models; Lung Neoplasms; Programming Languages; Research Design; Sensitivity and Specificity; Software; Survival Rate; Topotecan | 1995 |
Different fates of camptothecin-induced replication fork-associated double-strand DNA breaks in mammalian cells.
Topics: Animals; Caffeine; Camptothecin; Cell Line; CHO Cells; Chromosome Aberrations; Cricetinae; DNA; DNA Damage; DNA Replication; DNA, Neoplasm; Humans; Mitosis; Sensitivity and Specificity; Skin; Skin Physiological Phenomena; Urinary Bladder Neoplasms | 1994 |
A temperature sensitive topoisomerase II allele confers temperature dependent drug resistance on amsacrine and etoposide: a genetic system for determining the targets of topoisomerase II inhibitors.
Topics: Alleles; Amsacrine; Camptothecin; Cell Division; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; Drug Resistance; Etoposide; Models, Biological; Saccharomyces cerevisiae; Sensitivity and Specificity; Temperature; Topoisomerase II Inhibitors | 1993 |
Labelling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation.
Topics: Apoptosis; Biomarkers; Boron Compounds; Camptothecin; Cell Cycle; Cell Division; Deoxyuracil Nucleotides; DNA Damage; Fluorescein-5-isothiocyanate; Fluorescent Dyes; HL-60 Cells; Humans; Sensitivity and Specificity; Topoisomerase I Inhibitors | 1995 |
The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques.
Topics: Apoptosis; Camptothecin; Carcinoma; Cell Count; Cell Separation; Dactinomycin; DNA Damage; DNA, Neoplasm; Flow Cytometry; Fluorescent Dyes; Humans; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Erythroblastic, Acute; Pancreatic Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Tumor Cells, Cultured | 1996 |
Sensitive high-performance liquid chromatographic fluorescence assay for the quantitation of topotecan (SKF 104864-A) and its lactone ring-opened product (hydroxy acid) in human plasma and urine.
Topics: Camptothecin; Chromatography, High Pressure Liquid; Drug Stability; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Hydrolysis; Hydroxy Acids; Kinetics; Regression Analysis; Sensitivity and Specificity; Topoisomerase I Inhibitors; Topotecan | 1996 |
Experimental antitumor activity and pharmacokinetics of the camptothecin analog irinotecan (CPT-11) in mice.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Docetaxel; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Irinotecan; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Paclitaxel; Sensitivity and Specificity; Taxoids; Vincristine | 1996 |
Reversed-phase high-performance liquid chromatography method for the simultaneous quantitation of the lactone and carboxylate forms of the novel natural product anticancer agent 10-hydroxycamptothecin in biological fluids and tissues.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Lactones; Rats; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 1996 |
Determination of the lactone and lactone plus carboxylate forms of 9-aminocamptothecin in human plasma by sensitive high-performance liquid chromatography with fluorescence detection.
Topics: Antineoplastic Agents; Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Lactones; Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 1997 |
Cyclin A levels, the duration of S phase and sensitivity to a chemotherapeutic agent are altered in fibroblasts cultured on a fibronectin matrix.
Topics: 3T3 Cells; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carrier Proteins; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cells, Cultured; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Extracellular Matrix; Fibronectins; Mice; Mutation; Protein Serine-Threonine Kinases; Retinoblastoma-Binding Protein 1; S Phase; Sensitivity and Specificity; Transcription Factor DP1; Transcription Factors | 1998 |
CD95-mediated apoptosis: no variation in cellular sensitivity during cell cycle progression.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Aphidicolin; Apoptosis; Camptothecin; Cell Cycle; Cell Death; Cisplatin; Culture Media, Serum-Free; Doxorubicin; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Gene Expression; HeLa Cells; Humans; Hydroxyurea; Jurkat Cells; Membrane Glycoproteins; Nimustine; Nocodazole; Paclitaxel; Sensitivity and Specificity; Teniposide; Tumor Cells, Cultured; Vincristine | 1998 |
Use of intracellular pH and annexin-V flow cytometric assays to monitor apoptosis and its suppression by bcl-2 over-expression in hybridoma cell culture.
Topics: Annexin A5; Apoptosis; Benzopyrans; Camptothecin; Cell Cycle; Cells, Cultured; Enzyme Inhibitors; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; G1 Phase; Gene Expression; Genes, bcl-2; Humans; Hybridomas; Hydrogen-Ion Concentration; Intracellular Fluid; Microscopy, Fluorescence; Naphthols; Proto-Oncogene Proteins c-bcl-2; Rhodamines; Sensitivity and Specificity; Staurosporine | 1998 |
Femtomole quantitation of 7-ethyl-10-hydroxycamptothecine (SN-38) in plasma samples by reversed-phase high-performance liquid chromatography.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Chromatography, High Pressure Liquid; Humans; Irinotecan; Sensitivity and Specificity | 1999 |
Pre-clinical evaluation of new antineoplastic agents in NSCLC cell lines: evidence of histological subtype-dependent cytotoxicity.
Topics: Adenocarcinoma; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cisplatin; Deoxycytidine; Docetaxel; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gemcitabine; Humans; Inhibitory Concentration 50; Irinotecan; Lung Neoplasms; Paclitaxel; Sensitivity and Specificity; Taxoids; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured | 1999 |
Sensitive determination of irinotecan (CPT-11) and its active metabolite SN-38 in human serum using liquid chromatography-electrospray mass spectrometry.
Topics: Acetonitriles; Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Chemical Precipitation; Chromatography, High Pressure Liquid; Humans; Irinotecan; Male; Mass Spectrometry; Neoplasms; Reproducibility of Results; Sensitivity and Specificity | 1999 |
Tumor markers CEA, CA19-9 and CA125 in monitoring of response to systemic chemotherapy in patients with advanced gastric cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; CA-125 Antigen; CA-19-9 Antigen; Camptothecin; Carcinoembryonic Antigen; Cisplatin; Female; Fluorouracil; Humans; Irinotecan; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prognosis; Sensitivity and Specificity; Stomach Neoplasms; Survival Rate | 1999 |
Liposomal lurtotecan (NX211): determination of total drug levels in human plasma and urine by reversed-phase high-performance liquid chromatography.
Topics: Acetonitriles; Antineoplastic Agents; Camptothecin; Chromatography, High Pressure Liquid; Humans; Perchlorates; Sensitivity and Specificity | 2000 |
Continuous measurement of targeted promoter activity by a secreted bioluminescence reporter, Vargula hilgendorfii luciferase.
Topics: Animals; Antineoplastic Agents, Hormonal; Blotting, Northern; Camptothecin; Cells, Cultured; Cyprinidae; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genes, Reporter; Immunoenzyme Techniques; Luciferases; Luminescent Measurements; Models, Genetic; Perfusion; Plasmids; Promoter Regions, Genetic; Rats; RNA; RNA, Messenger; Sensitivity and Specificity; Thyroid Hormones; Time Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2001 |
High-Performance liquid chromatographic analysis of lactone and hydroxy acid of new antitumor drug, DX-8951 (exatecan), in mouse plasma.
Topics: Animals; Antineoplastic Agents; Calibration; Camptothecin; Chromatography, High Pressure Liquid; Hydroxy Acids; Lactones; Male; Mice; Mice, Inbred BALB C; Reproducibility of Results; Sensitivity and Specificity | 2001 |
Validation study of assay method for DX-8951 and its metabolite in human plasma and urine by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry.
Topics: Antineoplastic Agents; Atmospheric Pressure; Calibration; Camptothecin; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Sensitivity and Specificity | 2001 |
Development of a high-performance liquid chromatographic method to determine the concentration of karenitecin, a novel highly lipophilic camptothecin derivative, in human plasma and urine.
Topics: Antineoplastic Agents; Camptothecin; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2001 |
High-performance liquid chromatographic assay for glucuronidation activity of 7-ethyl-10-hydroxycamptothecin (SN-38), the active metabolite of irinotecan (CPT-11), in human liver microsomes.
Topics: Camptothecin; Chromatography, High Pressure Liquid; Glucuronides; Humans; Irinotecan; Microsomes, Liver; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2001 |
High-performance liquid chromatographic technique for the simultaneous determination of lactone and hydroxy acid forms of camptothecin and SN-38 in tissue culture media and cancer cells.
Topics: Camptothecin; Cell Extracts; Chromatography, High Pressure Liquid; Colonic Neoplasms; Culture Media; Drug Stability; HT29 Cells; Humans; Irinotecan; Lactones; Reproducibility of Results; Sensitivity and Specificity; Sonication; Time Factors | 2001 |
High-performance liquid chromatographic analysis for the determination of a novel polymer-bound camptothecin derivative (MAG-camptothecin) and free camptothecin in human plasma.
Topics: Antineoplastic Agents, Phytogenic; Calibration; Camptothecin; Chromatography, High Pressure Liquid; Humans; Polymers; Reproducibility of Results; Sensitivity and Specificity | 2001 |
Sensitive markers used to identify compounds that trigger apoptosis in cultured hepatocytes.
Topics: Animals; Apoptosis; bcl-X Protein; Biomarkers; Camptothecin; Caspase 3; Caspases; Cells, Cultured; Curcumin; Cytochrome c Group; DNA; DNA Fragmentation; Down-Regulation; Etoposide; Flow Cytometry; Galactosamine; Hepatocytes; Male; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; tert-Butylhydroperoxide; Xenobiotics | 2002 |
An analytical method for irinotecan (CPT-11) and its metabolites using a high-performance liquid chromatography: parallel detection with fluorescence and mass spectrometry.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Chromatography, High Pressure Liquid; Humans; Irinotecan; Mass Spectrometry; Microsomes, Liver; Reference Standards; Sensitivity and Specificity; Spectrometry, Fluorescence | 2002 |
Simultaneous determination of the carboxylate and lactone forms of 10-hydroxycamptothecin in human serum by restricted-access media high-performance liquid chromatography.
Topics: Antineoplastic Agents; Calibration; Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Humans; Lactones; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2002 |