Page last updated: 2024-08-22

camptothecin and Melanoma

camptothecin has been researched along with Melanoma in 60 studies

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-19903 (5.00)18.7374
1990's15 (25.00)18.2507
2000's24 (40.00)29.6817
2010's15 (25.00)24.3611
2020's3 (5.00)2.80

Authors

AuthorsStudies
Adamovics, JA; Hutchinson, CR1
Acoca, S; Beauparlant, P; Bélec, L; Billot, X; Cluse, L; Goulet, D; Johnstone, RW; Marcellus, RC; Murthy Madiraju, SR; Nguyen, M; Purisima, E; Roulston, A; Serfass, L; Shore, GC; Viallet, J; Watson, M; Wiegmans, A1
Ben-David, G; Firer, MA; Gancz, A; Gellerman, G; Gilad, Y; Luboshits, G; Minnes, R; Senderowitz, H; Tuchinsky, H1
Kumar, RS; Nayaka, S; Rudrappa, M1
Cao, S; Chen, X; Li, J; Li, Y; Lian, C; Peng, C; Su, J; Tao, J; Wu, L; Zeng, W; Zhao, S; Zhou, J1
Li, S; Yu, Y; Zhang, F; Zhang, Q1
Kim, HS; Lee, JJ; Park, IH; Rhee, WJ; Shin, JS1
Aliberti, C; Bazzi, M; Campana, LG; Chiarion-Sileni, V; Midena, E; Parrozzani, R; Pigozzo, J; Pilati, P; Valpione, S1
Berntzen, DT; Carling, U; Dorenberg, EJ; Dueland, S; Edwin, B; Eide, NA; Haugvik, SP; Røsok, B1
Arifa, RDN; Barcelos, LS; Garcia, ZM; Krambrock, K; Ladeira, LO; Lima, RL; Madeira, MFM; Paula, TP; Pinheiro, MVB; Pinho, V; Souza, DG; Teixeira, MM; Ÿvila, TV1
Chen, X; Kent, MS; Rodriguez, CO; Zhang, J1
Bastien, S; Bicaku, E; Daud, AI; Dawson, J; DeConti, RC; Hausheer, FA; Lush, R; Marchion, D; Munster, PN; Neuger, A; Sullivan, DM1
He, QJ; Lu, W; Luo, PH; Tu, CX; Wu, HH; Yang, B; Yang, XC; Zhou, XL; Zhu, DF; Zhu, H1
Amschler, K; Erpenbeck, L; Pletz, N; Schön, M; Schön, MP; Wallbrecht, K1
Aboody, KS; Chen, MY; Gutova, M; Kim, SU; Najbauer, J; Potter, PM1
Cervinka, M; Rudolf, E; Rudolf, K2
Berrevoet, F; Bocchetti, T; de Hemptinne, B; Ricciardi, S; Rogiers, X; Sainz-Barriga, M; Troisi, RI; Van Huysse, J; Vandenbossche, B; Vinci, A1
Cichorek, M1
Balivada, S; Basel, MT; Bossmann, SH; Myers, C; Pyle, M; Rachakatla, RS; Seo, GM; Shrestha, TB; Tamura, M; Troyer, DL; Wang, H1
Daud, AI; Munster, PN1
Agostini, G; Aldrighetti, L; Cappio, S; De Cobelli, F; Del Maschio, A; Losio, C; Orsi, M; Pilla, L; Ratti, F; Venturini, M1
Aydiner, A; Camlica, H; Kurul, S; Tas, F; Topuz, E1
Hao, C; Herlyn, M; Petruk, KC; Song, DK; Song, JH1
Anichini, A; Bersani, I; Molla, A; Piris, A; Scarito, A; Vegetti, C; Zanon, M1
Bergottini, R; De Cesare, M; Pratesi, G; Veneroni, S; Zunino, F1
Berghorn, E; Centeno, B; Daud, A; Deconti, RC; Derderian, J; Hausheer, F; Liu, Z; Munster, P; Sullivan, D; Sullivan, P; Urbas, P; Valkov, N1
Balsari, A; Carenini, N; De Cesare, M; Del Bufalo, D; Perego, P; Pratesi, G; Righetti, SC; Rivoltini, L; Zunino, F; Zupi, G1
Duncan, J; McLeod, HL; Scheffer, GL; Scheper, RJ; Shannon, WD; Zhang, W1
Alvarez-Silva, M; da Costa, R; de Faria, TJ; Dora, CL; Fernandes, D; Lemos-Senna, E; Stimamiglio, M; Trentin, AG1
Bryl, E; Cichorek, M; Kozłowska, K1
Eiseman, JL; Engbers, C; Joseph, E; Parise, RA; Strychor, S; Tonda, ME; Walsh, DR; Yu, NY; Zamboni, BA; Zamboni, WC1
Gao, K; Lam, W; Li, G; Li, J; Lockwood, WW1
Giovanella, BC; Kozielski, AJ; Mendoza, J; Potmesil, M; Stehlin, JS; Vardeman, D1
Kraut, E; Muller, MT; Staubus, A; Subramanian, D; Young, DC1
Bussey, AM; Ng, CE; Raaphorst, GP1
Giovanella, B; Kozielski, A; Pantazis, P; Petry, E; Rodriguez, R; Wall, M; Wani, M1
DeJesus, AR; Early, JA; Giovanella, BC; Mendoza, JT; Pantazis, P1
Caserini, C; Orlandi, L; Silvestrini, R; Supino, R; Vaglini, M; Zaffaroni, N; Zunino, F1
Boothman, DA; Kinsella, TJ; Lamond, JP; Wang, M2
Balcerzak, SP; Gochnour, D; Kraut, EH; Staubus, A; Walker, MJ1
Aoyagi, K; Aoyagi, Y; Asao, T; Okazaki, S; Sano, M; Utsugi, T; Wierzba, K; Yamada, Y1
Ho, V; Li, G; Tang, L; Tron, V; Zhou, X1
Bush, JA; Ho, VC; Li, G1
Chatterjee, D; Han, Z; Pantazis, P; Wyche, J1
Boven, E; Hausheer, FH; Pinedo, HM; Schlüper, HM; Van Hattum, AH1
Amodei, S; Benassi, B; Biroccio, A; Del Bufalo, D; Gabellini, C; Zupi, G1
Bastow, KF; Cheng, HH; Ito, J; Lee, KH; Luo, TY; Nakanishi, Y; Tachibana, Y; Wang, HK; Xu, Z1
McNamee, JP; Ng, CE; Owen, DG; Raaphorst, GP1
Ng, CE; Quto b, SS1
Bedikian, AY; Ellerhorst, JA; Eton, O; Papadopoulos, NE; Plager, C; Smith, TM1
Densmore, CL; Gautam, A; Gilbert, B; Knight, V; Koshkina, N; Melton, S; Roberts, L; Waldrep, JC1
Cheung, KJ; Li, G1
Brozek, J; Cichorek, M; Kozłowska, K; Witkowski, JM; Zarzeczna, M1
Adamson, RH; Mead, JA; Sieber, SM1
Boothman, DA; Burrows, HL; Owens, JK; Schea, RA; Strickfaden, S; Wang, M1
Giovanella, BC; Hinz, HR; Kozielski, AJ; Mendoza, JT; Pantazis, P; Stehlin, JS; Williams, LJ1
Slichenmyer, WJ; Von Hoff, DD1
Paparopoli, G; Sciarrino, E1

Reviews

4 review(s) available for camptothecin and Melanoma

ArticleYear
Preclinical and clinical activity of the topoisomerase I inhibitor, karenitecin, in melanoma.
    Expert opinion on investigational drugs, 2011, Volume: 20, Issue:11

    Topics: Animals; Camptothecin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Evaluation, Preclinical; Humans; Melanoma; Randomized Controlled Trials as Topic; Topoisomerase I Inhibitors

2011
Radiation lethality enhancement with 9-aminocamptothecin: comparison to other topoisomerase I inhibitors.
    International journal of radiation oncology, biology, physics, 1996, Sep-01, Volume: 36, Issue:2

    Topics: Antineoplastic Agents; Camptothecin; Cell Survival; DNA Topoisomerases, Type I; Dose-Response Relationship, Radiation; Humans; Melanoma; Radiation Tolerance; Time Factors; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1996
Pharmacology of antitumor agents from higher plants.
    Cancer treatment reports, 1976, Volume: 60, Issue:8

    Topics: Animals; Antineoplastic Agents, Phytogenic; Aporphines; Camptothecin; Carcinoma, Squamous Cell; Chemical Phenomena; Chemistry; Etoposide; Humans; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Maytansine; Melanoma; Naphthoquinones; Nasopharyngeal Neoplasms; Neoplasms; Neoplasms, Experimental; Phenanthrenes; Structure-Activity Relationship; Teniposide; Vinblastine; Vincristine

1976
New natural products in cancer chemotherapy.
    Journal of clinical pharmacology, 1990, Volume: 30, Issue:9

    Topics: Adenocarcinoma; Alkaloids; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Squamous Cell; Chemical Phenomena; Chemistry; Drugs, Investigational; Harringtonines; Homoharringtonine; Humans; Infusions, Intravenous; Irinotecan; Melanoma; Paclitaxel; Phytotherapy; Plant Extracts; Plants, Medicinal; Topotecan

1990

Trials

7 trial(s) available for camptothecin and Melanoma

ArticleYear
Potentiation of a topoisomerase I inhibitor, karenitecin, by the histone deacetylase inhibitor valproic acid in melanoma: translational and phase I/II clinical trial.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Apr-01, Volume: 15, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Drug Synergism; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Histones; Humans; Male; Melanoma; Mice; Mice, Nude; Middle Aged; Skin Neoplasms; Topoisomerase I Inhibitors; Valproic Acid

2009
Transarterial chemoembolization with drug-eluting beads preloaded with irinotecan as a first-line approach in uveal melanoma liver metastases: tumor response and predictive value of diffusion-weighted MR imaging in five patients.
    Journal of vascular and interventional radiology : JVIR, 2012, Volume: 23, Issue:7

    Topics: Aged; Antineoplastic Agents; Camptothecin; Chemoembolization, Therapeutic; Chemotherapy, Adjuvant; Delayed-Action Preparations; Diffusion Magnetic Resonance Imaging; Female; Humans; Irinotecan; Liver Neoplasms; Magnetic Resonance Angiography; Male; Melanoma; Microspheres; Middle Aged; Prognosis; Treatment Outcome; Uveal Neoplasms

2012
Combination chemotherapy with docetaxel and irinotecan in metastatic malignant melanoma.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2003, Volume: 15, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Docetaxel; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Irinotecan; Male; Melanoma; Middle Aged; Paclitaxel; Skin Neoplasms; Survival Analysis; Taxoids; Treatment Outcome

2003
Phase II trial of karenitecin in patients with malignant melanoma: clinical and translational study.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Apr-15, Volume: 11, Issue:8

    Topics: Adult; Aged; Anemia; Camptothecin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Fatigue; Female; HL-60 Cells; Humans; Male; Melanoma; Middle Aged; Nausea; Neutropenia; Survival Analysis; Thrombocytopenia; Treatment Outcome; Vomiting

2005
Analysis of topoisomerase I/DNA complexes in patients administered topotecan.
    Cancer research, 1995, May-15, Volume: 55, Issue:10

    Topics: Antineoplastic Agents; Camptothecin; DNA Damage; DNA Topoisomerases, Type I; DNA, Neoplasm; HeLa Cells; Humans; Lymphoma, Non-Hodgkin; Melanoma; Topotecan

1995
Phase II trial of topotecan in malignant melanoma.
    Cancer investigation, 1997, Volume: 15, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Camptothecin; Enzyme Inhibitors; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Recurrence, Local; Topotecan

1997
Phase II trial of 9-nitrocamptothecin (RFS 2000) for patients with metastatic cutaneous or uveal melanoma.
    Anti-cancer drugs, 2002, Volume: 13, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Camptothecin; Diarrhea; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Neutropenia; Skin Neoplasms; Treatment Outcome; Uveal Neoplasms

2002

Other Studies

49 other study(ies) available for camptothecin and Melanoma

ArticleYear
Prodrug analogues of the antitumor alkaloid camptothecin.
    Journal of medicinal chemistry, 1979, Volume: 22, Issue:3

    Topics: Animals; Antineoplastic Agents; Camptothecin; Leukemia L1210; Leukemia, Experimental; Lung Neoplasms; Melanoma; Mice; Neoplasms, Experimental

1979
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-04, Volume: 104, Issue:49

    Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Boronic Acids; Bortezomib; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Drug Resistance, Neoplasm; Humans; Indoles; Melanoma; Mice; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyrroles

2007
Discovery of potent molecular chimera (CM358) to treat human metastatic melanoma.
    European journal of medicinal chemistry, 2017, Sep-29, Volume: 138

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 3-Ring; Humans; Melanoma; Mice; Mice, Nude; Models, Molecular; Molecular Structure; Neoplasms, Experimental; Pyrimidinones; Structure-Activity Relationship; Topoisomerase II Inhibitors

2017
In Silico Molecular Docking Approach of Melanin Against Melanoma Causing MITF Proteins and Anticancer, Oxidation-Reduction, Photoprotection, and Drug-Binding Affinity Properties of Extracted Melanin from Streptomyces sp. strain MR28.
    Applied biochemistry and biotechnology, 2023, Volume: 195, Issue:7

    Topics: Camptothecin; Cell Line, Tumor; Doxorubicin; Humans; Melanins; Melanoma; Microphthalmia-Associated Transcription Factor; Molecular Docking Simulation; Oxidation-Reduction; Streptomyces

2023
RJT-101, a novel camptothecin derivative, is highly effective in the treatment of melanoma through DNA damage by targeting topoisomerase 1.
    Biochemical pharmacology, 2020, Volume: 171

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Female; Humans; Melanoma; Mice, Inbred C57BL; Mice, Nude; Molecular Structure; Skin Neoplasms; Topoisomerase I Inhibitors; Tumor Burden; Xenograft Model Antitumor Assays

2020
A dermatan sulfate-functionalized biomimetic nanocarrier for melanoma targeted chemotherapy.
    Carbohydrate polymers, 2020, May-01, Volume: 235

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biomimetic Materials; Camptothecin; Cell Proliferation; Dermatan Sulfate; Drug Carriers; Drug Liberation; Drug Screening Assays, Antitumor; Melanoma; Mice; Molecular Structure; Nanoparticles; Particle Size; Skin Neoplasms; Surface Properties; Tumor Cells, Cultured

2020
HMGB1 modulates the balance between senescence and apoptosis in response to genotoxic stress.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:10

    Topics: Animals; Apoptosis; Camptothecin; Cell Line, Tumor; Cells, Cultured; Cellular Senescence; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Doxorubicin; Fibroblasts; HMGB1 Protein; Humans; Melanoma; Mice

2019
A retrospective analysis of 141 patients with liver metastases from uveal melanoma: a two-cohort study comparing transarterial chemoembolization with CPT-11 charged microbeads and historical treatments.
    Melanoma research, 2015, Volume: 25, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Camptothecin; Chemoembolization, Therapeutic; Databases, Factual; Feasibility Studies; Female; Humans; Irinotecan; Kaplan-Meier Estimate; Liver Neoplasms; Male; Melanoma; Middle Aged; Proportional Hazards Models; Retrospective Studies; Risk Factors; Treatment Outcome; Uveal Neoplasms; Young Adult

2015
Transarterial Chemoembolization of Liver Metastases from Uveal Melanoma Using Irinotecan-Loaded Beads: Treatment Response and Complications.
    Cardiovascular and interventional radiology, 2015, Volume: 38, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Camptothecin; Chemoembolization, Therapeutic; Contrast Media; Drug Delivery Systems; Female; Humans; Irinotecan; Liver; Liver Neoplasms; Male; Melanoma; Middle Aged; Radiographic Image Enhancement; Retrospective Studies; Therapeutics; Tomography, X-Ray Computed; Uveal Neoplasms; Young Adult

2015
The reduction of oxidative stress by nanocomposite Fullerol decreases mucositis severity and reverts leukopenia induced by Irinotecan.
    Pharmacological research, 2016, Volume: 107

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Fullerenes; Glutathione; Ileum; Interleukin-1beta; Intestinal Mucosa; Irinotecan; Leukopenia; Male; Melanoma; Mice, Inbred C57BL; Mice, Transgenic; Mucositis; Nanocomposites; Oxidative Stress; Peroxidase; Thiobarbituric Acid Reactive Substances; Tumor Burden

2016
Establishment of a dog model for the p53 family pathway and identification of a novel isoform of p21 cyclin-dependent kinase inhibitor.
    Molecular cancer research : MCR, 2009, Volume: 7, Issue:1

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Bone Neoplasms; Camptothecin; Cell Line; Cell Line, Tumor; Conserved Sequence; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Dogs; Doxorubicin; Humans; Kidney; Melanoma; Mice; Models, Animal; Molecular Sequence Data; Osteosarcoma; Sequence Alignment; Sequence Homology, Amino Acid; Tumor Suppressor Protein p53

2009
Antimetastatic activity of MONCPT in preclinical melanoma mice model.
    Investigational new drugs, 2010, Volume: 28, Issue:6

    Topics: Animals; Camptothecin; Cell Adhesion; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Separation; Disease Models, Animal; Drug Screening Assays, Antitumor; Extracellular Signal-Regulated MAP Kinases; Female; Green Fluorescent Proteins; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Transduction, Genetic; Vascular Endothelial Growth Factor A

2010
NF-kappaB inhibition through proteasome inhibition or IKKbeta blockade increases the susceptibility of melanoma cells to cytostatic treatment through distinct pathways.
    The Journal of investigative dermatology, 2010, Volume: 130, Issue:4

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Boronic Acids; Bortezomib; Camptothecin; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Kinase; Lung Neoplasms; Melanoma; Mice; NF-kappa B; Oxazines; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase Inhibitors; Pyrazines; Pyridines; Skin Neoplasms

2010
Therapeutic targeting of melanoma cells using neural stem cells expressing carboxylesterase, a CPT-11 activating enzyme.
    Current stem cell research & therapy, 2010, Volume: 5, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylesterase; Cell Line, Tumor; Cell Movement; Cytokines; Enzyme Inhibitors; Humans; Irinotecan; Melanoma; Neurons; Rabbits; Stem Cells

2010
Dual inhibition of topoisomerases enhances apoptosis in melanoma cells.
    Neoplasma, 2010, Volume: 57, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Caspases; Cell Proliferation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Etoposide; Humans; Immunoblotting; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Melanoma; Membrane Potential, Mitochondrial; Mutation; Oxidative Stress; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2010
Evolution of laparoscopic left lateral sectionectomy without the Pringle maneuver: through resection of benign and malignant tumors to living liver donation.
    Surgical endoscopy, 2011, Volume: 25, Issue:1

    Topics: Adenocarcinoma; Adenoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Loss, Surgical; Camptothecin; Carcinoma, Hepatocellular; Combined Modality Therapy; Disease-Free Survival; Female; Fluorouracil; Follow-Up Studies; Gastrointestinal Stromal Tumors; Hepatectomy; Humans; Laparoscopy; Length of Stay; Leucovorin; Liver Neoplasms; Liver Transplantation; Living Donors; Male; Melanoma; Middle Aged; Organoplatinum Compounds; Postoperative Complications; Retrospective Studies; Tissue and Organ Harvesting

2011
Camptothecin-induced death of amelanotic and melanotic melanoma cells in different phases of cell cycle.
    Neoplasma, 2011, Volume: 58, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Cycle; Cricetinae; Male; Melanoma; Melanoma, Amelanotic; Mesocricetus; Skin Neoplasms

2011
A self-contained enzyme activating prodrug cytotherapy for preclinical melanoma.
    Molecular biology reports, 2012, Volume: 39, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylesterase; Cell Transplantation; DNA Primers; Drug Carriers; Drug Evaluation, Preclinical; Female; Genes, Transgenic, Suicide; Irinotecan; Lung Neoplasms; Magnetics; Melanoma; Mice; Mice, Inbred C57BL; Monocyte-Macrophage Precursor Cells; Nanoparticles; Prodrugs

2012
Camptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cells.
    Apoptosis : an international journal on programmed cell death, 2011, Volume: 16, Issue:11

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase 2; Cell Line, Tumor; Cysteine Endopeptidases; DNA Damage; DNA-Binding Proteins; Humans; Melanoma; MicroRNAs; Mitochondria; Nuclear Proteins; Proto-Oncogene Proteins c-bcl-2; Real-Time Polymerase Chain Reaction; Signal Transduction; Topoisomerase I Inhibitors; Tumor Protein p73; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2011
Cisplatin down-regulation of cellular Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory proteins to restore tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human melanoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Sep-15, Volume: 9, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Caspases; Cell Line, Tumor; Cisplatin; Etoposide; Flow Cytometry; Humans; Melanoma; Membrane Glycoproteins; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha

2003
Apoptosis protease activator protein-1 expression is dispensable for response of human melanoma cells to distinct proapoptotic agents.
    Cancer research, 2004, Oct-15, Volume: 64, Issue:20

    Topics: Amidines; Antineoplastic Agents; Apoptosis; Apoptotic Protease-Activating Factor 1; Benzylamines; Camptothecin; Caspase 9; Caspase Inhibitors; Caspases; Celecoxib; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Humans; Immunohistochemistry; Melanoma; Protein Biosynthesis; Proteins; Pyrazoles; RNA, Messenger; Sulfonamides

2004
Efficacy of the novel camptothecin gimatecan against orthotopic and metastatic human tumor xenograft models.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Nov-01, Volume: 10, Issue:21

    Topics: Animals; Brain; Camptothecin; Female; Humans; Melanoma; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nervous System Neoplasms; Ovarian Neoplasms; Time Factors; Xenograft Model Antitumor Assays

2004
Enhanced antitumour efficacy of gimatecan in combination with Bcl-2 antisense oligonucleotide in human melanoma xenografts.
    European journal of cancer (Oxford, England : 1990), 2005, Volume: 41, Issue:8

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Division; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Female; Humans; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Proto-Oncogene Proteins c-bcl-2; Thionucleotides; Transplantation, Heterologous

2005
Expression of drug pathway proteins is independent of tumour type.
    The Journal of pathology, 2006, Volume: 209, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Breast Neoplasms; Camptothecin; Colonic Neoplasms; Cytochrome P-450 Enzyme System; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Irinotecan; Lung Neoplasms; Lymphoma; Male; Melanoma; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Tissue Array Analysis

2006
Evaluation of antimetastatic activity and systemic toxicity of camptothecin-loaded microspheres in mice injected with B16-F10 melanoma cells.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2006, Volume: 9, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Capsules; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Melanoma; Mice; Microspheres; Neoplasm Metastasis; Neoplasm Transplantation; Particle Size

2006
Mitochondrial transmembrane potential in spontaneous and camptothecin-induced apoptosis of melanotic and amelanotic melanoma cells.
    Neoplasma, 2007, Volume: 54, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Cricetinae; Cytochromes c; Cytosol; Flow Cytometry; Male; Melanoma; Membrane Potential, Mitochondrial; Mesocricetus; Poly(ADP-ribose) Polymerases; Time Factors; Tumor Cells, Cultured

2007
Plasma, tumor, and tissue disposition of STEALTH liposomal CKD-602 (S-CKD602) and nonliposomal CKD-602 in mice bearing A375 human melanoma xenografts.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Dec-01, Volume: 13, Issue:23

    Topics: Animals; Camptothecin; Cell Line, Tumor; Drug Screening Assays, Antitumor; Extracellular Fluid; Female; Humans; Liposomes; Melanoma; Mice; Mice, SCID; Microdialysis; Polyethylene Glycols; Tissue Distribution; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2007
Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells.
    International journal of oncology, 2008, Volume: 32, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Camptothecin; Chromosomes, Human, Pair 14; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Melanoma; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2008
Growth inhibition of human cancer metastases by camptothecins in newly developed xenograft models.
    Cancer research, 1995, Dec-01, Volume: 55, Issue:23

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Burkitt Lymphoma; Camptothecin; Carcinoma, Squamous Cell; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Male; Melanoma; Mice; Mice, Inbred Strains; Mice, Nude; Reproducibility of Results; Tumor Cells, Cultured

1995
Inhibition of potentially lethal and sublethal damage repair by camptothecin and etoposide in human melanoma cell lines.
    International journal of radiation biology, 1994, Volume: 66, Issue:1

    Topics: Camptothecin; Cell Death; DNA; DNA Repair; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Etoposide; Humans; Melanoma; Radiation Tolerance; Radiation-Sensitizing Agents; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1994
Therapeutic efficacy of camptothecin derivatives against human malignant melanoma xenografts.
    Melanoma research, 1994, Volume: 4, Issue:1

    Topics: Animals; Antineoplastic Agents; Camptothecin; Drug Administration Routes; Drug Screening Assays, Antitumor; Humans; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous

1994
Cytotoxic efficacy of 9-nitrocamptothecin in the treatment of human malignant melanoma cells in vitro.
    Cancer research, 1994, Feb-01, Volume: 54, Issue:3

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Cycle; Cell Division; Drug Administration Schedule; Humans; Kinetics; Melanocytes; Melanoma; Mice; Mice, Nude; Tumor Cells, Cultured

1994
Modulation of melphalan cytotoxic activity in human melanoma cell lines.
    Anti-cancer drugs, 1996, Volume: 7, Issue:5

    Topics: Antineoplastic Agents, Alkylating; Blotting, Northern; Camptothecin; Drug Interactions; Enzyme Inhibitors; Ethacrynic Acid; Humans; Melanoma; Melphalan; Temperature; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured

1996
Concentration and timing dependence of lethality enhancement between topotecan, a topoisomerase I inhibitor, and ionizing radiation.
    International journal of radiation oncology, biology, physics, 1996, Sep-01, Volume: 36, Issue:2

    Topics: Antineoplastic Agents; Camptothecin; Cell Survival; Combined Modality Therapy; Fibroblasts; Humans; Melanoma; Neoplasms; Radiation Dosage; Radiation Tolerance; Time Factors; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured

1996
Antitumor activity of a novel quinoline derivative, TAS-103, with inhibitory effects on topoisomerases I and II.
    Japanese journal of cancer research : Gann, 1997, Volume: 88, Issue:10

    Topics: Adenocarcinoma; Aminoquinolines; Animals; Antineoplastic Agents; Camptothecin; Cisplatin; Colonic Neoplasms; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Etoposide; Humans; Indenes; Indoles; Irinotecan; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Pyridines; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1997
Chemotherapy-induced apoptosis in melanoma cells is p53 dependent.
    Melanoma research, 1998, Volume: 8, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Cell Division; Cell Survival; Cisplatin; DNA Fragmentation; DNA, Neoplasm; Electrophoresis, Agar Gel; Genes, p53; Humans; Melanocytes; Melanoma; Mutation; Skin Neoplasms; Tumor Cells, Cultured; Vincristine

1998
p53-dependent apoptosis in melanoma cells after treatment with camptothecin.
    The Journal of investigative dermatology, 2000, Volume: 114, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Camptothecin; Cricetinae; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Gene Expression; Genes, p53; Humans; Melanoma; Membrane Proteins; Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured

2000
Differentiation of human malignant melanoma cells that escape apoptosis after treatment with 9-nitrocamptothecin in vitro.
    Neoplasia (New York, N.Y.), 1999, Volume: 1, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Flow Cytometry; G2 Phase; Humans; Melanins; Melanoma; Mice; Mice, Nude; Tumor Cells, Cultured

1999
New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer.
    International journal of cancer, 2000, Oct-15, Volume: 88, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Colonic Neoplasms; Doxorubicin; Drug Resistance, Multiple; Enzyme Inhibitors; Female; Humans; Irinotecan; Lung Neoplasms; Melanoma; Mice; Mice, Nude; Neoplasms; Ovarian Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2000
c-Myc down-regulation increases susceptibility to cisplatin through reactive oxygen species-mediated apoptosis in M14 human melanoma cells.
    Molecular pharmacology, 2001, Volume: 60, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Camptothecin; Caspase 1; Caspase 3; Caspases; Cisplatin; Down-Regulation; Doxorubicin; Enzyme Activation; Humans; Melanoma; Peptide Hydrolases; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Reactive Oxygen Species; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2001
Cytotoxic pheophorbide-related compounds from Clerodendrum calamitosum and C. cyrtophyllum.
    Journal of natural products, 2001, Volume: 64, Issue:7

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Survival; Chlorophyll; Dose-Response Relationship, Drug; Drug Resistance; Etoposide; Female; Humans; Ileal Neoplasms; KB Cells; Kidney Neoplasms; Lung Neoplasms; Magnetic Resonance Spectroscopy; Melanoma; Molecular Structure; Ovarian Neoplasms; Plant Leaves; Plant Stems; Plants, Medicinal; Stereoisomerism; Structure-Activity Relationship; Taiwan; Tumor Cells, Cultured; Vincristine

2001
Potentiation of cell killing by low-dose-rate radiation by camptothecin is related to an increase in the level of DNA double-strand breaks.
    Radiation research, 2002, Volume: 157, Issue:2

    Topics: Camptothecin; Cell Survival; Comet Assay; DNA; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Radiation; Gamma Rays; Humans; Melanoma; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Cells, Cultured; Tumor Stem Cell Assay

2002
Comparison of apoptotic, necrotic and clonogenic cell death and inhibition of cell growth following camptothecin and X-radiation treatment in a human melanoma and a human fibroblast cell line.
    Cancer chemotherapy and pharmacology, 2002, Volume: 49, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Death; Combined Modality Therapy; Fibroblasts; Humans; Melanoma; Necrosis; Stem Cells; Tumor Cells, Cultured; X-Rays

2002
Growth inhibition of established B16-F10 lung metastases by sequential aerosol delivery of p53 gene and 9-nitrocamptothecin.
    Gene therapy, 2002, Volume: 9, Issue:5

    Topics: Aerosols; Animals; Antineoplastic Agents; Camptothecin; Combined Modality Therapy; Genes, p53; Genetic Therapy; Liposomes; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Survival Rate

2002
The tumour suppressor p33ING1 does not enhance camptothecin-induced cell death in melanoma cells.
    International journal of oncology, 2002, Volume: 20, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Cycle Proteins; Cell Death; DNA-Binding Proteins; Genes, Tumor Suppressor; Humans; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Melanoma; Nuclear Proteins; Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2002
Heterogeneous susceptibility to spontaneous and induced apoptosis characterizes two related transplantable melanomas with different biological properties.
    Pigment cell research, 2002, Volume: 15, Issue:3

    Topics: Animals; Annexin A5; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase 3; Caspases; Cells, Cultured; Cricetinae; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; Humans; Jurkat Cells; Male; Melanoma; Mesocricetus; Tumor Cells, Cultured

2002
Posttreatment exposure to camptothecin enhances the lethal effects of x-rays on radioresistant human malignant melanoma cells.
    International journal of radiation oncology, biology, physics, 1992, Volume: 24, Issue:5

    Topics: Camptothecin; Cell Survival; DNA; Humans; Melanoma; Radiation-Sensitizing Agents; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; X-Rays

1992
Complete inhibition of growth followed by death of human malignant melanoma cells in vitro and regression of human melanoma xenografts in immunodeficient mice induced by camptothecins.
    Cancer research, 1992, Jul-15, Volume: 52, Issue:14

    Topics: Animals; Body Weight; Camptothecin; Cell Death; Cell Division; Drug Screening Assays, Antitumor; Graft Survival; Male; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Remission Induction; Tumor Cells, Cultured

1992
[Recent diagnostic and therapeutic acquisitions in malignant melanoma].
    Il Cancro, 1974, Volume: 27, Issue:1

    Topics: Antineoplastic Agents; Camptothecin; Chloroquine; Colchicine; Humans; Hydroxyurea; Imidazoles; Immunotherapy; Iodine Radioisotopes; Melanoma; Nitrosourea Compounds; Radionuclide Imaging; Triazenes

1974