Page last updated: 2024-08-22

camptothecin and Leukemia

camptothecin has been researched along with Leukemia in 58 studies

Research

Studies (58)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	32 (55.17)	18.2507
2000's	22 (37.93)	29.6817
2010's	4 (6.90)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Asao, Y; Matsuda, H; Miyagawa, K; Nemoto, Y; Yoshida, K; Yoshikawa, M	1
Bailly, C; Baldeyrou, B; Beauchard, A; Besson, T; Chérouvrier, JR; Domon, L; Jaunet, A; Lansiaux, A; Murillo, L; Picot, L; Thiéry, V	1
Addo, SN; Das, SG; Doshi, JM; Hermanson, DL; Srinivasan, B; Tian, D; Xing, C	1
Dezhenkova, LG; Kalinina, AA; Kaluzhny, DN; Kubbutat, M; Luzikov, YN; Pommier, Y; Preobrazhenskaya, MN; Romanenko, VI; Schols, D; Shchekotikhin, AE; Shtil, AA; Tatarskiy, VV; Treshalin, MI; Treshalina, HM; Tsvetkov, VB; Volodina, YL	1
Huang, HL; Huang, RL; Huang, YL; Lin, TW	1
Chen, GQ; Duan, XF; Wen, DH; Zhao, M	1
Chen, GQ; Huang, Y; Wang, LS; Yu, Y; Yuan, TT; Zhou, CX; Zhuang, HY	1
Bligh, SW; Hartley, JA; Hartley, JM; Pan, X; Wang, Z; White, KN	1
Wiart, C	1
Chauvier, D; Kegelaer, G; Manfait, M; Morjani, H	1
Bergamaschi, A; Darzynkiewicz, Z; De Nicola, M; Ghibelli, L; Grabarek, J; Smolewski, P; Teodori, L	1
Bailly, C	1
Kwee, JK; Maia, RC; Marques-Santos, LF; Silva, KL; Vasconcelos, FC	1
Banai, Y; Gokulan, K; Khare, S; Linthicum, DS; Modiano, JF; Smith, R	1
Austin, RC; Baumeister, P; Kaufman, RJ; Lee, AS; Mao, C; Reddy, RK	1
Beauchemin, M; Bergeron, S; Bertrand, R	1
Chen, GQ; Chen, Z; Du, KM; Gao, SM; Song, MG; Wang, Q; Xu, M; Yu, Y; Zhou, YH; Zhu, YS	1
Hannemann, RE; Ramkrishna, D; Rundell, A; Sherer, E	1
Akutsu, M; Furukawa, Y; Izumi, T; Kano, Y; Kobayashi, H; Mano, H; Tsunoda, S	1
Barge, RM; de Vries, JF; Falkenburg, JH; Heemskerk, MH; Jedema, I; Nijmeijer, BA; van Dreunen, L; Wammes, LJ; Willemze, R	1
Meropol, NJ	1
Berg, SL; Blaney, SM; D'Argenio, DZ; Jacob, E; Scorsone, K	1
Adams, DJ; Giles, F; Jacobsen, TF; Myhren, F; Rizzieri, DA; Sandvold, ML	1
Donehower, RC; Grochow, LB; Kaufmann, SH; Rowinsky, EK; Slichenmyer, WJ	1
Dubrez, L; Genne, P; Goldwasser, F; Pommier, Y; Solary, E	1
DeJesus, A; Early, J; Giovanella, B; Kozielski, A; Mendoza, J; Pantazis, P; Vardeman, D	1
Fujimori, A; Harker, WG; Hoki, Y; Kohlhagen, G; Pommier, Y	1
DeJesus, A; Giovanella, BC; Kufe, D; Mendoza, JT; Pantazis, P; Rubin, E	1
Adjei, A; Burke, PJ; Cheng, YC; Donehower, RC; Gore, SD; Grochow, LB; Jones, RJ; Kaufmann, SH; Rowinsky, EK	1
Ariyoshi, Y; Ogawa, M	1
Ellis, AL; Nowak, B; Plunkett, W; Zwelling, LA	1
Darzynkiewicz, Z; Gong, J; Traganos, F	1
Beran, M; Cazenave, L; Ellis, A; Kantarjian, HM; Keating, MJ; Koller, C; O'Brien, S; Plunkett, W; Rios, MB; Zwelling, L	1
Ahmed, T; Bigman, K; Darzynkiewicz, Z; Gong, J; Gorczyca, W; Melamed, MR; Mittelman, A	1
Pantazis, P	1
Baguley, BC; Finlay, GJ	1
Baker, SD; Evans, WE; Furman, WL; Pratt, CB; Rivera, GK; Stewart, CF	1
Bertrand, R; Dubrez, L; Eymin, B; Pommier, Y; Solary, E	1
Darzynkiewicz, Z; Feldman, E; Halicka, HD; Seiter, K; Traganos, F	1
Buckwalter, CA; Burke, PJ; Donehower, RC; Gore, SD; Grochow, LB; Jones, RJ; Kaufmann, SH; Kottke, T; Letendre, L; Rowinsky, EK; Svingen, PA	1
Bryant, M; Eder, JP; Grossbard, M; Huberman, M; Hurwitz, S; Kinchla, N; Kufe, DW; Lynch, T; Rodriguez, D; Rubin, E; Schnipper, L; Shapiro, C; Shulman, L; Stone, R; Supko, J; Toppmeyer, D; Vosburg, E; Xu, G	1
Charron, M; Kaufmann, SH; Peereboom, D	1
Mashima, T; Tsuruo, T	1
Allouche, M; Dubrez, L; Eymin, B; Solary, E	1
Armstrong, DK; Cheng, YC; Gore, SD; Kaufmann, SH; Rowinsky, EK; Svingen, PA	1
Gupta, E; Ibrahim, N; Li, XG; Mendoza, J; Pantazis, P; Patel, M; Rubin, EH; Saleem, A	1
Eckhardt, SG	1
Rosen, LS	1
Chanock, SJ; Hiraoka, W; Nieves-Neira, W; Pommier, Y; Vazquez, N	1
Chatterjee, D; Han, Z; Pantazis, P; Wyche, J	1
Bascans, E; Belaud-Rotureau, MA; Belloc, F; Braz-Pereira, E; Durrieu, F; Lacombe, F; Lavignolle, V	1
Bradbury, DA; Crouch, SP; Simmons, TD; Slater, KJ	1
Adams, DJ; Bass, AJ; Davis, P; DeCastro, CM; Foster, T; Gockerman, JP; Hammett, E; Moore, JO; Payne, N; Rizzieri, DA; Rosner, GL	1
Donehower, RC; Grochow, LB; Hendricks, CB; Kaufmann, SH; Rowinsky, EK	1
D'Incalci, M; Erba, E; Gervasoni, M; Lampasona, V; McSheehy, PM	1
Cotter, TG; Glynn, JM; Green, DR; Lennon, SV	1
Arima, T; Ariyoshi, H; Ichimaru, M; Kuramoto, A; Masaoka, T; Oguro, M; Ohno, R; Okada, K; Sakai, Y; Yoshida, Y	1
Chou, S; Kaneko, M; Nakamura, Y; Nakaya, K	1

Reviews

6 review(s) available for camptothecin and Leukemia

Article	Year
Homocamptothecins: potent topoisomerase I inhibitors and promising anticancer drugs. Critical reviews in oncology/hematology, 2003, Volume: 45, Issue:1 Topics: Animals; Antineoplastic Agents; Camptothecin; DNA Topoisomerases, Type I; Drug Design; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Leukemia; Topoisomerase I Inhibitors	2003
[Clinical trials of new antitumor drugs in hematopoietic malignancies]. Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21 Suppl 3 Topics: Acute Disease; Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials as Topic; Doxorubicin; Ethics, Medical; Humans; Idarubicin; Irinotecan; Leukemia; Lymphoma	1994
The water-insoluble camptothecin analogues: promising drugs for the effective treatment of haematological malignancies. Leukemia research, 1995, Volume: 19, Issue:11 Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biotransformation; Camptothecin; Cell Differentiation; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Humans; Leukemia; Leukemia, Experimental; Lymphoma; Mice; Phosphorylation; Solubility; Topoisomerase I Inhibitors; Tumor Cells, Cultured	1995
Factors affecting topotecan sensitivity in human leukemia samples. Annals of the New York Academy of Sciences, 1996, Dec-13, Volume: 803 Topics: Antineoplastic Agents; Camptothecin; Cell Differentiation; Clinical Trials, Phase I as Topic; Drug Resistance; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Forecasting; Humans; Leukemia; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured	1996
Topoisomerases in human leukemia. Advances in pharmacology (San Diego, Calif.), 1994, Volume: 29B Topics: Antineoplastic Agents; Camptothecin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Hematopoietic System; Humans; Leukemia; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors	1994
Irinotecan in lymphoma, leukemia, and breast, pancreatic, ovarian, and small-cell lung cancers. Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:8 Suppl 6 Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Female; Humans; Irinotecan; Leukemia; Lung Neoplasms; Lymphoma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms	1998

Trials

6 trial(s) available for camptothecin and Leukemia

Article	Year
Camptothecin analogues: studies from the Johns Hopkins Oncology Center. Cancer chemotherapy and pharmacology, 1994, Volume: 34 Suppl Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Drug Administration Schedule; Granulocyte Colony-Stimulating Factor; Humans; Infusions, Intravenous; Irinotecan; Kidney; Leukemia; Liver; Metabolic Clearance Rate; Neoplasms; Platelet Count; Topoisomerase I Inhibitors; Topotecan	1994
Phase I and pharmacodynamic study of the topoisomerase I-inhibitor topotecan in patients with refractory acute leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:10 Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Camptothecin; Daunorubicin; Drug Administration Schedule; Drug Resistance, Multiple; Female; Follow-Up Studies; Humans; Immunohistochemistry; Leukemia; Male; Middle Aged; Mouth Mucosa; Quinidine; Remission Induction; Stomatitis; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured; Tumor Stem Cell Assay	1994
Phase I study of Topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia. Blood, 1993, Mar-01, Volume: 81, Issue:5 Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; Camptothecin; DNA; DNA Topoisomerases, Type I; Drug Administration Schedule; Female; Humans; Irinotecan; Leukemia; Male; Middle Aged; Topoisomerase I Inhibitors; Topotecan	1993
Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:5 Topics: Acute Disease; Adolescent; Adult; Antineoplastic Agents; Camptothecin; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infant; Infusions, Intravenous; Leukemia; Male; Metabolic Clearance Rate; Recurrence; Topotecan	1996
Trials of 9-amino-20(S)-camptothecin in Boston. Annals of the New York Academy of Sciences, 1996, Dec-13, Volume: 803 Topics: Adult; Antineoplastic Agents; Boston; Breast Neoplasms; Camptothecin; DNA Topoisomerases, Type I; Female; Humans; Leukemia; Male; Middle Aged; Neoplasms	1996
Phase I evaluation of prolonged-infusion gemcitabine with irinotecan for relapsed or refractory leukemia or lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Jul-01, Volume: 20, Issue:13 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Camptothecin; Deoxycytidine; Drug Administration Schedule; Esophagitis; Evaluation Studies as Topic; Female; Gemcitabine; Humans; Infusions, Intravenous; Irinotecan; Leukemia; Lymphoma; Male; Middle Aged; Nausea; Neutropenia; Recurrence; Stomatitis; Treatment Outcome; Vomiting	2002

Other Studies

46 other study(ies) available for camptothecin and Leukemia

Article	Year
Nuphar alkaloids with immediately apoptosis-inducing activity from Nuphar pumilum and their structural requirements for the activity. Bioorganic & medicinal chemistry letters, 2006, Mar-15, Volume: 16, Issue:6 Topics: Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Cells, Cultured; Fibroblasts; Humans; In Situ Nick-End Labeling; Leukemia; Melanoma, Experimental; Mice; Nuphar; Rhizome; Sesquiterpenes; Structure-Activity Relationship	2006
Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives. European journal of medicinal chemistry, 2009, Volume: 44, Issue:10 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA; DNA Topoisomerases, Type I; Female; Humans; Indoles; Leukemia; Quinolines; Thiazoles; Topoisomerase I Inhibitors; Triazoles	2009
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues. Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19 Topics: Apoptosis; Benzopyrans; Camptothecin; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Leukemia; Mitoxantrone; Structure-Activity Relationship	2009
Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties. European journal of medicinal chemistry, 2016, Apr-13, Volume: 112 Topics: Animals; Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Furans; Humans; Leukemia; Mice; Neoplasms; Protein Kinase Inhibitors; Structure-Activity Relationship; Topoisomerase Inhibitors	2016
Induction of apoptosis and differentiation by atractylenolide-1 isolated from Atractylodes macrocephala in human leukemia cells. Bioorganic & medicinal chemistry letters, 2016, Apr-15, Volume: 26, Issue:8 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Atractylodes; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia; Molecular Structure; Sesquiterpenes; Structure-Activity Relationship	2016
PU.1, a novel caspase-3 substrate, partially contributes to chemotherapeutic agents-induced apoptosis in leukemic cells. Biochemical and biophysical research communications, 2009, May-08, Volume: 382, Issue:3 Topics: Antineoplastic Agents; Apoptosis; Aspartic Acid; Camptothecin; Caspase 3; Caspase Inhibitors; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Etoposide; Humans; Leukemia; Mutagenesis, Site-Directed; Oligopeptides; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Trans-Activators	2009
Nuclear translocation of dihydrofolate reductase is not a pre-requisite for DNA damage induced apoptosis. Apoptosis : an international journal on programmed cell death, 2009, Volume: 14, Issue:5 Topics: Amino Acid Sequence; Apoptosis; Camptothecin; Caspase 3; Cell Line, Tumor; Cell Nucleus; DNA Damage; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Enzyme Activation; Etoposide; Humans; Leukemia; Methotrexate; Microtubules; Molecular Sequence Data; Neoplasm Proteins; Protein Transport; Tetrahydrofolate Dehydrogenase	2009
Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2012, May-15, Volume: 19, Issue:7 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA Topoisomerases; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Evodia; Fruit; Humans; Inhibitory Concentration 50; Leukemia; Phytotherapy; Quinazolines; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topoisomerase Inhibitors	2012
A note on Evodia rutaecarpa. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2012, Nov-15, Volume: 19, Issue:14 Topics: Camptothecin; DNA Topoisomerases; Drug Resistance, Neoplasm; Humans; Leukemia; Phytotherapy; Quinazolines; Topoisomerase Inhibitors	2012
Reversal of multidrug resistance-associated protein-mediated daunorubicin resistance by camptothecin. Journal of pharmaceutical sciences, 2002, Volume: 91, Issue:8 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Line; Cell Nucleus; Chemokines, CC; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Microscopy, Confocal; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured	2002
Exposure of cells to static magnetic field accelerates loss of integrity of plasma membrane during apoptosis. Cytometry, 2002, Nov-01, Volume: 49, Issue:3 Topics: Apoptosis; Camptothecin; Cell Count; Cell Membrane; Cell Survival; Flow Cytometry; HL-60 Cells; Humans; Image Cytometry; Leukemia; Magnetics; Necrosis	2002
CPT-11-induced cell death in leukemic cells is not affected by the MDR phenotype. Leukemia research, 2003, Volume: 27, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Cells; Bone Marrow Cells; Camptothecin; Cell Death; Drug Resistance, Multiple; Female; Humans; Interphase; Irinotecan; Leukemia; Leukocytes, Mononuclear; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Phenotype; Rhodamine 123; Topoisomerase I Inhibitors; Tumor Cells, Cultured	2003
Early changes in metabolism of leukemic cell lines upon induction of apoptosis by cytotoxic drugs. European journal of pharmacology, 2003, Mar-28, Volume: 465, Issue:1-2 Topics: Amiloride; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; K562 Cells; Leukemia; Paclitaxel; Sodium Azide; U937 Cells	2003
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. The Journal of biological chemistry, 2003, Jun-06, Volume: 278, Issue:23 Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Binding Sites; Camptothecin; Carrier Proteins; Caspase 7; Caspases; Cell Membrane; Cricetinae; Doxorubicin; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Precursors; Etoposide; G1 Phase; Gene Expression; Heat-Shock Proteins; Humans; Leukemia; Molecular Chaperones; Protein Structure, Tertiary; Subcellular Fractions; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transfection; Tumor Cells, Cultured; Urinary Bladder Neoplasms	2003
Camptothecin- and etoposide-induced apoptosis in human leukemia cells is independent of cell death receptor-3 and -4 aggregation but accelerates tumor necrosis factor-related apoptosis-inducing ligand-mediated cell death. Molecular cancer therapeutics, 2004, Volume: 3, Issue:12 Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; CASP8 and FADD-Like Apoptosis Regulating Protein; Etoposide; Fas-Associated Death Domain Protein; Gene Deletion; Genes, Dominant; HL-60 Cells; Humans; Intracellular Signaling Peptides and Proteins; Leukemia; Ligands; Membrane Glycoproteins; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Member 25; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor Ligand Superfamily Member 15; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; Tumor Necrosis Factor-alpha; TWEAK Receptor; U937 Cells	2004
Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cdelta-dependent mechanisms. Blood, 2005, May-01, Volume: 105, Issue:9 Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 3; Caspases; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Intracellular Membranes; Leukemia; Membrane Potentials; Mitochondria; Protein Kinase C; Protein Kinase C-delta	2005
Analysis of resonance chemotherapy in leukemia treatment via multi-staged population balance models. Journal of theoretical biology, 2006, Jun-21, Volume: 240, Issue:4 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Cycle; Cell Death; Cell Division; Coculture Techniques; Drug Administration Schedule; Half-Life; HL-60 Cells; Humans; Jurkat Cells; Leukemia; Models, Biological	2006
Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines. Investigational new drugs, 2007, Volume: 25, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Benzamides; Camptothecin; Carboplatin; Cell Line, Tumor; Cell Survival; Cyclophosphamide; Cytarabine; Depsipeptides; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Etoposide; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Imatinib Mesylate; Irinotecan; K562 Cells; Leukemia; Lymphoma; Mercaptopurine; Piperazines; Pyrimidines; Time Factors	2007
Involvement of caspase-8 in chemotherapy-induced apoptosis of patient derived leukemia cell lines independent of the death receptor pathway and downstream from mitochondria. Apoptosis : an international journal on programmed cell death, 2007, Volume: 12, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 8; Caspase 9; Cell Line, Tumor; Daunorubicin; Enzyme Activation; Humans; Leukemia; Mitochondria; Receptors, Death Domain	2007
A renewed call for equipoise. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Aug-10, Volume: 25, Issue:23 Topics: Adenocarcinoma; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Ethics, Medical; Fluorouracil; Humans; Irinotecan; Leucovorin; Leukemia; Randomized Controlled Trials as Topic; Recurrence; Treatment Outcome; Uncertainty	2007
Synergy of karenitecin and mafosfamide in pediatric leukemia, medulloblastoma, and neuroblastoma cell lines. Pediatric blood & cancer, 2008, Volume: 50, Issue:4 Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Child; Cyclophosphamide; Drug Synergism; Humans; Leukemia; Medulloblastoma; Neuroblastoma	2008
Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells. Leukemia & lymphoma, 2008, Volume: 49, Issue:4 Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Cytarabine; Deoxycytidine; Drug Interactions; Drug Screening Assays, Antitumor; Gemcitabine; Humans; Hydrazines; Idarubicin; Irinotecan; Leukemia; Lymphoma; Sulfonamides; Topotecan	2008
The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors. Leukemia, 1995, Volume: 9, Issue:6 Topics: Apoptosis; Base Sequence; Camptothecin; Cell Cycle; Cell Line; Cell Survival; DNA Damage; DNA Primers; DNA, Neoplasm; Dose-Response Relationship, Drug; Etoposide; Humans; Leukemia; Microscopy, Electron; Molecular Sequence Data; Polymerase Chain Reaction; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured	1995
Sensitivity of camptothecin-resistant human leukemia cells and tumors to anticancer drugs with diverse mechanisms of action. Leukemia research, 1995, Volume: 19, Issue:1 Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Cycle; Cell Division; DNA, Neoplasm; Drug Resistance; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Leukemia; Male; Mice; Mice, Nude; Topoisomerase II Inhibitors	1995
Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin. Cancer research, 1995, Mar-15, Volume: 55, Issue:6 Topics: Amino Acid Sequence; Animals; Base Sequence; Camptothecin; Cricetinae; Cricetulus; DNA Topoisomerases, Type I; Drug Resistance; Humans; Leukemia; Molecular Sequence Data; Point Mutation; Recombinant Proteins; Tumor Cells, Cultured	1995
Partial characterization of human leukemia U-937 cell sublines resistant to 9-nitrocamptothecin. European journal of haematology, 1994, Volume: 53, Issue:3 Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Adhesion; Cell Differentiation; Cell Division; DNA Topoisomerases, Type I; DNA, Neoplasm; Drug Resistance; Flow Cytometry; Humans; Leukemia; Male; Mice; Mice, Nude; Monocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured	1994
Quantification of topoisomerase-DNA complexes in leukemia cells from patients undergoing therapy with a topoisomerase-directed agent. Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:3 Topics: Amsacrine; Antineoplastic Agents; Camptothecin; DNA Probes; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Resistance; Etoposide; Humans; Immunoblotting; Leukemia; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan; Tumor Cells, Cultured	1994
A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Analytical biochemistry, 1994, May-01, Volume: 218, Issue:2 Topics: Apoptosis; Bone Marrow; Camptothecin; DNA, Neoplasm; Electrophoresis; Ethanol; Flow Cytometry; Humans; Leukemia; Leukemia, Promyelocytic, Acute; Time Factors; Tumor Cells, Cultured	1994
Induction of DNA strand breaks associated with apoptosis during treatment of leukemias. Leukemia, 1993, Volume: 7, Issue:5 Topics: Adult; Aged; Alkenes; Antineoplastic Agents; Apoptosis; Camptothecin; DNA Damage; DNA Nucleotidylexotransferase; DNA, Neoplasm; Gamma Rays; Humans; In Vitro Techniques; Leukemia; Male; Middle Aged; Polyenes; Pyrones; Tumor Cells, Cultured	1993
Pharmacokinetic/cytokinetic principles in the chemotherapy of solid tumours. Clinical and experimental pharmacology & physiology, 1995, Volume: 22, Issue:11 Topics: Acridines; Antineoplastic Agents; Camptothecin; Cell Cycle; Drug Design; Drug Screening Assays, Antitumor; Humans; Leukemia; Paclitaxel; Tumor Cells, Cultured	1995
[Apoptosis of human leukemic cells induced by topoisomerase I and II inhibitors]. Bulletin du cancer, 1996, Volume: 83, Issue:3 Topics: Alkaloids; Apoptosis; Camptothecin; Cell Cycle; Cell Differentiation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Humans; Leukemia; Protein Kinase C; Signal Transduction; Staurosporine; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured	1996
Induction of apoptosis by camptothecin and topotecan. Annals of the New York Academy of Sciences, 1996, Dec-13, Volume: 803 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Bone Marrow; Camptothecin; Cell Cycle; Cytarabine; DNA Damage; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia; Topotecan	1996
[Involvement of ICE/CED 3 family proteases in antitumor agent-induced apoptosis]. Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 1; Cycloheximide; Cysteine Endopeptidases; Cytarabine; Doxorubicin; Humans; Leukemia; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	1997
Increased gadd153 messenger RNA level is associated with apoptosis in human leukemic cells treated with etoposide. Cancer research, 1997, Feb-15, Volume: 57, Issue:4 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; CCAAT-Enhancer-Binding Proteins; Daunorubicin; DNA Fragmentation; DNA-Binding Proteins; Etoposide; HL-60 Cells; Humans; Leukemia; Nuclear Proteins; RNA, Messenger; Serine Proteinase Inhibitors; Transcription Factor CHOP; Transcription Factors; Tumor Cells, Cultured	1997
Altered formation of topotecan-stabilized topoisomerase I-DNA adducts in human leukemia cells. Blood, 1997, Mar-15, Volume: 89, Issue:6 Topics: Antineoplastic Agents; Camptothecin; DNA Adducts; DNA Topoisomerases, Type I; DNA, Neoplasm; Drug Resistance, Neoplasm; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Humans; Leukemia; Prospective Studies; Topotecan	1997
Mechanisms of resistance in a human cell line exposed to sequential topoisomerase poisoning. Cancer research, 1997, Nov-15, Volume: 57, Issue:22 Topics: Antineoplastic Agents; Camptothecin; Cell Nucleus; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Etoposide; Humans; Leukemia; Phenotype; Point Mutation; RNA, Messenger; Tumor Cells, Cultured	1997
Irinotecan: a review of the initial phase I trials. Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:8 Suppl 6 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; France; Hodgkin Disease; Humans; Irinotecan; Japan; Leukemia; Lymphoma, Non-Hodgkin; United States	1998
Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells. The Journal of clinical investigation, 1998, Dec-01, Volume: 102, Issue:11 Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Camptothecin; Catalase; Cell Differentiation; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Etoposide; Flow Cytometry; Granulomatous Disease, Chronic; Humans; Hydrogen Peroxide; Leukemia; Membrane Glycoproteins; Monocytes; NADPH Oxidase 2; NADPH Oxidases; Neoplasm Proteins; Neutrophils; NF-kappa B; Pyrrolidines; Reactive Oxygen Species; Staurosporine; Thiocarbamates; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Ultraviolet Rays	1998
Modulation of 9-nitrocamptothecin-induced apoptosis by hyperthermia in human leukemia HL-60 cells. Anti-cancer drugs, 1999, Volume: 10, Issue:3 Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Flow Cytometry; HL-60 Cells; Humans; Hyperthermia, Induced; Leukemia	1999
Flow cytometry detection of caspase 3 activation in preapoptotic leukemic cells. Cytometry, 2000, Jun-01, Volume: 40, Issue:2 Topics: Adult; Annexin A5; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Apoptosis; Biomarkers; Blotting, Western; Bone Marrow Cells; Camptothecin; Caspase 3; Caspase 7; Caspases; Daunorubicin; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Idarubicin; Leukemia; Peptide Hydrolases; Protein Binding; U937 Cells	2000
Measurement of the ADP:ATP ratio in human leukaemic cell lines can be used as an indicator of cell viability, necrosis and apoptosis. Journal of immunological methods, 2000, Jun-23, Volume: 240, Issue:1-2 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Apoptosis; Camptothecin; Cell Death; Cell Survival; Dexamethasone; Energy Metabolism; HL-60 Cells; Humans; In Situ Nick-End Labeling; Jurkat Cells; Leukemia; Microscopy, Fluorescence; Necrosis; U937 Cells	2000
Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue. Cancer research, 1992, Apr-15, Volume: 52, Issue:8 Topics: Acute Disease; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Camptothecin; CHO Cells; Cricetinae; DNA Topoisomerases, Type I; DNA, Neoplasm; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Flow Cytometry; Leukemia; Membrane Glycoproteins; Quinidine; Topotecan; Tumor Cells, Cultured	1992
Studies of the differentiation properties of camptothecin in the human leukaemic cells K562. European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:11 Topics: Camptothecin; Cell Differentiation; Dose-Response Relationship, Drug; Down-Regulation; Globins; Humans; Leukemia; Lymphocytes, Null; Methotrexate; Mitosis; RNA, Messenger; Topoisomerase I Inhibitors; Tumor Cells, Cultured	1991
Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis. Cancer research, 1992, Feb-15, Volume: 52, Issue:4 Topics: Actin Cytoskeleton; Aphidicolin; Camptothecin; Cell Death; Cell Line; Cell Survival; Cytochalasin B; Humans; Ionomycin; Kinetics; Leukemia; Tetradecanoylphorbol Acetate; Ultraviolet Rays	1992
An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:11 Topics: Adolescent; Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Drug Evaluation; Female; Humans; Irinotecan; Leukemia; Lymphoma; Male; Middle Aged	1990
Induction of differentiation of human and mouse myeloid leukemia cells by camptothecin. Biochemical and biophysical research communications, 1990, Jan-15, Volume: 166, Issue:1 Topics: Animals; Biomarkers; Camptothecin; Cell Differentiation; Cell Line; Humans; Kinetics; Leukemia; Leukemia, Experimental; Mice; Phagocytosis; Receptors, Fc; Time Factors; Tumor Cells, Cultured	1990