Page last updated: 2024-08-22

camptothecin and Leukemia

camptothecin has been researched along with Leukemia in 58 studies

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's32 (55.17)18.2507
2000's22 (37.93)29.6817
2010's4 (6.90)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asao, Y; Matsuda, H; Miyagawa, K; Nemoto, Y; Yoshida, K; Yoshikawa, M1
Bailly, C; Baldeyrou, B; Beauchard, A; Besson, T; Chérouvrier, JR; Domon, L; Jaunet, A; Lansiaux, A; Murillo, L; Picot, L; Thiéry, V1
Addo, SN; Das, SG; Doshi, JM; Hermanson, DL; Srinivasan, B; Tian, D; Xing, C1
Dezhenkova, LG; Kalinina, AA; Kaluzhny, DN; Kubbutat, M; Luzikov, YN; Pommier, Y; Preobrazhenskaya, MN; Romanenko, VI; Schols, D; Shchekotikhin, AE; Shtil, AA; Tatarskiy, VV; Treshalin, MI; Treshalina, HM; Tsvetkov, VB; Volodina, YL1
Huang, HL; Huang, RL; Huang, YL; Lin, TW1
Chen, GQ; Duan, XF; Wen, DH; Zhao, M1
Chen, GQ; Huang, Y; Wang, LS; Yu, Y; Yuan, TT; Zhou, CX; Zhuang, HY1
Bligh, SW; Hartley, JA; Hartley, JM; Pan, X; Wang, Z; White, KN1
Wiart, C1
Chauvier, D; Kegelaer, G; Manfait, M; Morjani, H1
Bergamaschi, A; Darzynkiewicz, Z; De Nicola, M; Ghibelli, L; Grabarek, J; Smolewski, P; Teodori, L1
Bailly, C1
Kwee, JK; Maia, RC; Marques-Santos, LF; Silva, KL; Vasconcelos, FC1
Banai, Y; Gokulan, K; Khare, S; Linthicum, DS; Modiano, JF; Smith, R1
Austin, RC; Baumeister, P; Kaufman, RJ; Lee, AS; Mao, C; Reddy, RK1
Beauchemin, M; Bergeron, S; Bertrand, R1
Chen, GQ; Chen, Z; Du, KM; Gao, SM; Song, MG; Wang, Q; Xu, M; Yu, Y; Zhou, YH; Zhu, YS1
Hannemann, RE; Ramkrishna, D; Rundell, A; Sherer, E1
Akutsu, M; Furukawa, Y; Izumi, T; Kano, Y; Kobayashi, H; Mano, H; Tsunoda, S1
Barge, RM; de Vries, JF; Falkenburg, JH; Heemskerk, MH; Jedema, I; Nijmeijer, BA; van Dreunen, L; Wammes, LJ; Willemze, R1
Meropol, NJ1
Berg, SL; Blaney, SM; D'Argenio, DZ; Jacob, E; Scorsone, K1
Adams, DJ; Giles, F; Jacobsen, TF; Myhren, F; Rizzieri, DA; Sandvold, ML1
Donehower, RC; Grochow, LB; Kaufmann, SH; Rowinsky, EK; Slichenmyer, WJ1
Dubrez, L; Genne, P; Goldwasser, F; Pommier, Y; Solary, E1
DeJesus, A; Early, J; Giovanella, B; Kozielski, A; Mendoza, J; Pantazis, P; Vardeman, D1
Fujimori, A; Harker, WG; Hoki, Y; Kohlhagen, G; Pommier, Y1
DeJesus, A; Giovanella, BC; Kufe, D; Mendoza, JT; Pantazis, P; Rubin, E1
Adjei, A; Burke, PJ; Cheng, YC; Donehower, RC; Gore, SD; Grochow, LB; Jones, RJ; Kaufmann, SH; Rowinsky, EK1
Ariyoshi, Y; Ogawa, M1
Ellis, AL; Nowak, B; Plunkett, W; Zwelling, LA1
Darzynkiewicz, Z; Gong, J; Traganos, F1
Beran, M; Cazenave, L; Ellis, A; Kantarjian, HM; Keating, MJ; Koller, C; O'Brien, S; Plunkett, W; Rios, MB; Zwelling, L1
Ahmed, T; Bigman, K; Darzynkiewicz, Z; Gong, J; Gorczyca, W; Melamed, MR; Mittelman, A1
Pantazis, P1
Baguley, BC; Finlay, GJ1
Baker, SD; Evans, WE; Furman, WL; Pratt, CB; Rivera, GK; Stewart, CF1
Bertrand, R; Dubrez, L; Eymin, B; Pommier, Y; Solary, E1
Darzynkiewicz, Z; Feldman, E; Halicka, HD; Seiter, K; Traganos, F1
Buckwalter, CA; Burke, PJ; Donehower, RC; Gore, SD; Grochow, LB; Jones, RJ; Kaufmann, SH; Kottke, T; Letendre, L; Rowinsky, EK; Svingen, PA1
Bryant, M; Eder, JP; Grossbard, M; Huberman, M; Hurwitz, S; Kinchla, N; Kufe, DW; Lynch, T; Rodriguez, D; Rubin, E; Schnipper, L; Shapiro, C; Shulman, L; Stone, R; Supko, J; Toppmeyer, D; Vosburg, E; Xu, G1
Charron, M; Kaufmann, SH; Peereboom, D1
Mashima, T; Tsuruo, T1
Allouche, M; Dubrez, L; Eymin, B; Solary, E1
Armstrong, DK; Cheng, YC; Gore, SD; Kaufmann, SH; Rowinsky, EK; Svingen, PA1
Gupta, E; Ibrahim, N; Li, XG; Mendoza, J; Pantazis, P; Patel, M; Rubin, EH; Saleem, A1
Eckhardt, SG1
Rosen, LS1
Chanock, SJ; Hiraoka, W; Nieves-Neira, W; Pommier, Y; Vazquez, N1
Chatterjee, D; Han, Z; Pantazis, P; Wyche, J1
Bascans, E; Belaud-Rotureau, MA; Belloc, F; Braz-Pereira, E; Durrieu, F; Lacombe, F; Lavignolle, V1
Bradbury, DA; Crouch, SP; Simmons, TD; Slater, KJ1
Adams, DJ; Bass, AJ; Davis, P; DeCastro, CM; Foster, T; Gockerman, JP; Hammett, E; Moore, JO; Payne, N; Rizzieri, DA; Rosner, GL1
Donehower, RC; Grochow, LB; Hendricks, CB; Kaufmann, SH; Rowinsky, EK1
D'Incalci, M; Erba, E; Gervasoni, M; Lampasona, V; McSheehy, PM1
Cotter, TG; Glynn, JM; Green, DR; Lennon, SV1
Arima, T; Ariyoshi, H; Ichimaru, M; Kuramoto, A; Masaoka, T; Oguro, M; Ohno, R; Okada, K; Sakai, Y; Yoshida, Y1
Chou, S; Kaneko, M; Nakamura, Y; Nakaya, K1

Reviews

6 review(s) available for camptothecin and Leukemia

ArticleYear
Homocamptothecins: potent topoisomerase I inhibitors and promising anticancer drugs.
    Critical reviews in oncology/hematology, 2003, Volume: 45, Issue:1

    Topics: Animals; Antineoplastic Agents; Camptothecin; DNA Topoisomerases, Type I; Drug Design; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Leukemia; Topoisomerase I Inhibitors

2003
[Clinical trials of new antitumor drugs in hematopoietic malignancies].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21 Suppl 3

    Topics: Acute Disease; Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials as Topic; Doxorubicin; Ethics, Medical; Humans; Idarubicin; Irinotecan; Leukemia; Lymphoma

1994
The water-insoluble camptothecin analogues: promising drugs for the effective treatment of haematological malignancies.
    Leukemia research, 1995, Volume: 19, Issue:11

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biotransformation; Camptothecin; Cell Differentiation; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Humans; Leukemia; Leukemia, Experimental; Lymphoma; Mice; Phosphorylation; Solubility; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1995
Factors affecting topotecan sensitivity in human leukemia samples.
    Annals of the New York Academy of Sciences, 1996, Dec-13, Volume: 803

    Topics: Antineoplastic Agents; Camptothecin; Cell Differentiation; Clinical Trials, Phase I as Topic; Drug Resistance; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Forecasting; Humans; Leukemia; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured

1996
Topoisomerases in human leukemia.
    Advances in pharmacology (San Diego, Calif.), 1994, Volume: 29B

    Topics: Antineoplastic Agents; Camptothecin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Hematopoietic System; Humans; Leukemia; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1994
Irinotecan in lymphoma, leukemia, and breast, pancreatic, ovarian, and small-cell lung cancers.
    Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:8 Suppl 6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Female; Humans; Irinotecan; Leukemia; Lung Neoplasms; Lymphoma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms

1998

Trials

6 trial(s) available for camptothecin and Leukemia

ArticleYear
Camptothecin analogues: studies from the Johns Hopkins Oncology Center.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34 Suppl

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Drug Administration Schedule; Granulocyte Colony-Stimulating Factor; Humans; Infusions, Intravenous; Irinotecan; Kidney; Leukemia; Liver; Metabolic Clearance Rate; Neoplasms; Platelet Count; Topoisomerase I Inhibitors; Topotecan

1994
Phase I and pharmacodynamic study of the topoisomerase I-inhibitor topotecan in patients with refractory acute leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:10

    Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Camptothecin; Daunorubicin; Drug Administration Schedule; Drug Resistance, Multiple; Female; Follow-Up Studies; Humans; Immunohistochemistry; Leukemia; Male; Middle Aged; Mouth Mucosa; Quinidine; Remission Induction; Stomatitis; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured; Tumor Stem Cell Assay

1994
Phase I study of Topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia.
    Blood, 1993, Mar-01, Volume: 81, Issue:5

    Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; Camptothecin; DNA; DNA Topoisomerases, Type I; Drug Administration Schedule; Female; Humans; Irinotecan; Leukemia; Male; Middle Aged; Topoisomerase I Inhibitors; Topotecan

1993
Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Antineoplastic Agents; Camptothecin; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infant; Infusions, Intravenous; Leukemia; Male; Metabolic Clearance Rate; Recurrence; Topotecan

1996
Trials of 9-amino-20(S)-camptothecin in Boston.
    Annals of the New York Academy of Sciences, 1996, Dec-13, Volume: 803

    Topics: Adult; Antineoplastic Agents; Boston; Breast Neoplasms; Camptothecin; DNA Topoisomerases, Type I; Female; Humans; Leukemia; Male; Middle Aged; Neoplasms

1996
Phase I evaluation of prolonged-infusion gemcitabine with irinotecan for relapsed or refractory leukemia or lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Jul-01, Volume: 20, Issue:13

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Camptothecin; Deoxycytidine; Drug Administration Schedule; Esophagitis; Evaluation Studies as Topic; Female; Gemcitabine; Humans; Infusions, Intravenous; Irinotecan; Leukemia; Lymphoma; Male; Middle Aged; Nausea; Neutropenia; Recurrence; Stomatitis; Treatment Outcome; Vomiting

2002

Other Studies

46 other study(ies) available for camptothecin and Leukemia

ArticleYear
Nuphar alkaloids with immediately apoptosis-inducing activity from Nuphar pumilum and their structural requirements for the activity.
    Bioorganic & medicinal chemistry letters, 2006, Mar-15, Volume: 16, Issue:6

    Topics: Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Cells, Cultured; Fibroblasts; Humans; In Situ Nick-End Labeling; Leukemia; Melanoma, Experimental; Mice; Nuphar; Rhizome; Sesquiterpenes; Structure-Activity Relationship

2006
Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:10

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA; DNA Topoisomerases, Type I; Female; Humans; Indoles; Leukemia; Quinolines; Thiazoles; Topoisomerase I Inhibitors; Triazoles

2009
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues.
    Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19

    Topics: Apoptosis; Benzopyrans; Camptothecin; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Leukemia; Mitoxantrone; Structure-Activity Relationship

2009
Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties.
    European journal of medicinal chemistry, 2016, Apr-13, Volume: 112

    Topics: Animals; Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Furans; Humans; Leukemia; Mice; Neoplasms; Protein Kinase Inhibitors; Structure-Activity Relationship; Topoisomerase Inhibitors

2016
Induction of apoptosis and differentiation by atractylenolide-1 isolated from Atractylodes macrocephala in human leukemia cells.
    Bioorganic & medicinal chemistry letters, 2016, Apr-15, Volume: 26, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Atractylodes; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia; Molecular Structure; Sesquiterpenes; Structure-Activity Relationship

2016
PU.1, a novel caspase-3 substrate, partially contributes to chemotherapeutic agents-induced apoptosis in leukemic cells.
    Biochemical and biophysical research communications, 2009, May-08, Volume: 382, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Aspartic Acid; Camptothecin; Caspase 3; Caspase Inhibitors; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Etoposide; Humans; Leukemia; Mutagenesis, Site-Directed; Oligopeptides; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Trans-Activators

2009
Nuclear translocation of dihydrofolate reductase is not a pre-requisite for DNA damage induced apoptosis.
    Apoptosis : an international journal on programmed cell death, 2009, Volume: 14, Issue:5

    Topics: Amino Acid Sequence; Apoptosis; Camptothecin; Caspase 3; Cell Line, Tumor; Cell Nucleus; DNA Damage; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Enzyme Activation; Etoposide; Humans; Leukemia; Methotrexate; Microtubules; Molecular Sequence Data; Neoplasm Proteins; Protein Transport; Tetrahydrofolate Dehydrogenase

2009
Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2012, May-15, Volume: 19, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA Topoisomerases; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Evodia; Fruit; Humans; Inhibitory Concentration 50; Leukemia; Phytotherapy; Quinazolines; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topoisomerase Inhibitors

2012
A note on Evodia rutaecarpa.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2012, Nov-15, Volume: 19, Issue:14

    Topics: Camptothecin; DNA Topoisomerases; Drug Resistance, Neoplasm; Humans; Leukemia; Phytotherapy; Quinazolines; Topoisomerase Inhibitors

2012
Reversal of multidrug resistance-associated protein-mediated daunorubicin resistance by camptothecin.
    Journal of pharmaceutical sciences, 2002, Volume: 91, Issue:8

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Line; Cell Nucleus; Chemokines, CC; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Microscopy, Confocal; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured

2002
Exposure of cells to static magnetic field accelerates loss of integrity of plasma membrane during apoptosis.
    Cytometry, 2002, Nov-01, Volume: 49, Issue:3

    Topics: Apoptosis; Camptothecin; Cell Count; Cell Membrane; Cell Survival; Flow Cytometry; HL-60 Cells; Humans; Image Cytometry; Leukemia; Magnetics; Necrosis

2002
CPT-11-induced cell death in leukemic cells is not affected by the MDR phenotype.
    Leukemia research, 2003, Volume: 27, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Cells; Bone Marrow Cells; Camptothecin; Cell Death; Drug Resistance, Multiple; Female; Humans; Interphase; Irinotecan; Leukemia; Leukocytes, Mononuclear; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Phenotype; Rhodamine 123; Topoisomerase I Inhibitors; Tumor Cells, Cultured

2003
Early changes in metabolism of leukemic cell lines upon induction of apoptosis by cytotoxic drugs.
    European journal of pharmacology, 2003, Mar-28, Volume: 465, Issue:1-2

    Topics: Amiloride; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; K562 Cells; Leukemia; Paclitaxel; Sodium Azide; U937 Cells

2003
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation.
    The Journal of biological chemistry, 2003, Jun-06, Volume: 278, Issue:23

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Binding Sites; Camptothecin; Carrier Proteins; Caspase 7; Caspases; Cell Membrane; Cricetinae; Doxorubicin; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Precursors; Etoposide; G1 Phase; Gene Expression; Heat-Shock Proteins; Humans; Leukemia; Molecular Chaperones; Protein Structure, Tertiary; Subcellular Fractions; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transfection; Tumor Cells, Cultured; Urinary Bladder Neoplasms

2003
Camptothecin- and etoposide-induced apoptosis in human leukemia cells is independent of cell death receptor-3 and -4 aggregation but accelerates tumor necrosis factor-related apoptosis-inducing ligand-mediated cell death.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:12

    Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; CASP8 and FADD-Like Apoptosis Regulating Protein; Etoposide; Fas-Associated Death Domain Protein; Gene Deletion; Genes, Dominant; HL-60 Cells; Humans; Intracellular Signaling Peptides and Proteins; Leukemia; Ligands; Membrane Glycoproteins; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Member 25; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor Ligand Superfamily Member 15; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; Tumor Necrosis Factor-alpha; TWEAK Receptor; U937 Cells

2004
Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cdelta-dependent mechanisms.
    Blood, 2005, May-01, Volume: 105, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 3; Caspases; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Intracellular Membranes; Leukemia; Membrane Potentials; Mitochondria; Protein Kinase C; Protein Kinase C-delta

2005
Analysis of resonance chemotherapy in leukemia treatment via multi-staged population balance models.
    Journal of theoretical biology, 2006, Jun-21, Volume: 240, Issue:4

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Cycle; Cell Death; Cell Division; Coculture Techniques; Drug Administration Schedule; Half-Life; HL-60 Cells; Humans; Jurkat Cells; Leukemia; Models, Biological

2006
Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines.
    Investigational new drugs, 2007, Volume: 25, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Benzamides; Camptothecin; Carboplatin; Cell Line, Tumor; Cell Survival; Cyclophosphamide; Cytarabine; Depsipeptides; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Etoposide; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Imatinib Mesylate; Irinotecan; K562 Cells; Leukemia; Lymphoma; Mercaptopurine; Piperazines; Pyrimidines; Time Factors

2007
Involvement of caspase-8 in chemotherapy-induced apoptosis of patient derived leukemia cell lines independent of the death receptor pathway and downstream from mitochondria.
    Apoptosis : an international journal on programmed cell death, 2007, Volume: 12, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 8; Caspase 9; Cell Line, Tumor; Daunorubicin; Enzyme Activation; Humans; Leukemia; Mitochondria; Receptors, Death Domain

2007
A renewed call for equipoise.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Aug-10, Volume: 25, Issue:23

    Topics: Adenocarcinoma; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Ethics, Medical; Fluorouracil; Humans; Irinotecan; Leucovorin; Leukemia; Randomized Controlled Trials as Topic; Recurrence; Treatment Outcome; Uncertainty

2007
Synergy of karenitecin and mafosfamide in pediatric leukemia, medulloblastoma, and neuroblastoma cell lines.
    Pediatric blood & cancer, 2008, Volume: 50, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Child; Cyclophosphamide; Drug Synergism; Humans; Leukemia; Medulloblastoma; Neuroblastoma

2008
Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells.
    Leukemia & lymphoma, 2008, Volume: 49, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Cytarabine; Deoxycytidine; Drug Interactions; Drug Screening Assays, Antitumor; Gemcitabine; Humans; Hydrazines; Idarubicin; Irinotecan; Leukemia; Lymphoma; Sulfonamides; Topotecan

2008
The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors.
    Leukemia, 1995, Volume: 9, Issue:6

    Topics: Apoptosis; Base Sequence; Camptothecin; Cell Cycle; Cell Line; Cell Survival; DNA Damage; DNA Primers; DNA, Neoplasm; Dose-Response Relationship, Drug; Etoposide; Humans; Leukemia; Microscopy, Electron; Molecular Sequence Data; Polymerase Chain Reaction; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1995
Sensitivity of camptothecin-resistant human leukemia cells and tumors to anticancer drugs with diverse mechanisms of action.
    Leukemia research, 1995, Volume: 19, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Cycle; Cell Division; DNA, Neoplasm; Drug Resistance; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Leukemia; Male; Mice; Mice, Nude; Topoisomerase II Inhibitors

1995
Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin.
    Cancer research, 1995, Mar-15, Volume: 55, Issue:6

    Topics: Amino Acid Sequence; Animals; Base Sequence; Camptothecin; Cricetinae; Cricetulus; DNA Topoisomerases, Type I; Drug Resistance; Humans; Leukemia; Molecular Sequence Data; Point Mutation; Recombinant Proteins; Tumor Cells, Cultured

1995
Partial characterization of human leukemia U-937 cell sublines resistant to 9-nitrocamptothecin.
    European journal of haematology, 1994, Volume: 53, Issue:3

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Adhesion; Cell Differentiation; Cell Division; DNA Topoisomerases, Type I; DNA, Neoplasm; Drug Resistance; Flow Cytometry; Humans; Leukemia; Male; Mice; Mice, Nude; Monocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1994
Quantification of topoisomerase-DNA complexes in leukemia cells from patients undergoing therapy with a topoisomerase-directed agent.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:3

    Topics: Amsacrine; Antineoplastic Agents; Camptothecin; DNA Probes; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Resistance; Etoposide; Humans; Immunoblotting; Leukemia; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan; Tumor Cells, Cultured

1994
A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry.
    Analytical biochemistry, 1994, May-01, Volume: 218, Issue:2

    Topics: Apoptosis; Bone Marrow; Camptothecin; DNA, Neoplasm; Electrophoresis; Ethanol; Flow Cytometry; Humans; Leukemia; Leukemia, Promyelocytic, Acute; Time Factors; Tumor Cells, Cultured

1994
Induction of DNA strand breaks associated with apoptosis during treatment of leukemias.
    Leukemia, 1993, Volume: 7, Issue:5

    Topics: Adult; Aged; Alkenes; Antineoplastic Agents; Apoptosis; Camptothecin; DNA Damage; DNA Nucleotidylexotransferase; DNA, Neoplasm; Gamma Rays; Humans; In Vitro Techniques; Leukemia; Male; Middle Aged; Polyenes; Pyrones; Tumor Cells, Cultured

1993
Pharmacokinetic/cytokinetic principles in the chemotherapy of solid tumours.
    Clinical and experimental pharmacology & physiology, 1995, Volume: 22, Issue:11

    Topics: Acridines; Antineoplastic Agents; Camptothecin; Cell Cycle; Drug Design; Drug Screening Assays, Antitumor; Humans; Leukemia; Paclitaxel; Tumor Cells, Cultured

1995
[Apoptosis of human leukemic cells induced by topoisomerase I and II inhibitors].
    Bulletin du cancer, 1996, Volume: 83, Issue:3

    Topics: Alkaloids; Apoptosis; Camptothecin; Cell Cycle; Cell Differentiation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Humans; Leukemia; Protein Kinase C; Signal Transduction; Staurosporine; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1996
Induction of apoptosis by camptothecin and topotecan.
    Annals of the New York Academy of Sciences, 1996, Dec-13, Volume: 803

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Bone Marrow; Camptothecin; Cell Cycle; Cytarabine; DNA Damage; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia; Topotecan

1996
[Involvement of ICE/CED 3 family proteases in antitumor agent-induced apoptosis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 1; Cycloheximide; Cysteine Endopeptidases; Cytarabine; Doxorubicin; Humans; Leukemia; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1997
Increased gadd153 messenger RNA level is associated with apoptosis in human leukemic cells treated with etoposide.
    Cancer research, 1997, Feb-15, Volume: 57, Issue:4

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; CCAAT-Enhancer-Binding Proteins; Daunorubicin; DNA Fragmentation; DNA-Binding Proteins; Etoposide; HL-60 Cells; Humans; Leukemia; Nuclear Proteins; RNA, Messenger; Serine Proteinase Inhibitors; Transcription Factor CHOP; Transcription Factors; Tumor Cells, Cultured

1997
Altered formation of topotecan-stabilized topoisomerase I-DNA adducts in human leukemia cells.
    Blood, 1997, Mar-15, Volume: 89, Issue:6

    Topics: Antineoplastic Agents; Camptothecin; DNA Adducts; DNA Topoisomerases, Type I; DNA, Neoplasm; Drug Resistance, Neoplasm; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Humans; Leukemia; Prospective Studies; Topotecan

1997
Mechanisms of resistance in a human cell line exposed to sequential topoisomerase poisoning.
    Cancer research, 1997, Nov-15, Volume: 57, Issue:22

    Topics: Antineoplastic Agents; Camptothecin; Cell Nucleus; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Etoposide; Humans; Leukemia; Phenotype; Point Mutation; RNA, Messenger; Tumor Cells, Cultured

1997
Irinotecan: a review of the initial phase I trials.
    Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:8 Suppl 6

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; France; Hodgkin Disease; Humans; Irinotecan; Japan; Leukemia; Lymphoma, Non-Hodgkin; United States

1998
Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells.
    The Journal of clinical investigation, 1998, Dec-01, Volume: 102, Issue:11

    Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Camptothecin; Catalase; Cell Differentiation; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Etoposide; Flow Cytometry; Granulomatous Disease, Chronic; Humans; Hydrogen Peroxide; Leukemia; Membrane Glycoproteins; Monocytes; NADPH Oxidase 2; NADPH Oxidases; Neoplasm Proteins; Neutrophils; NF-kappa B; Pyrrolidines; Reactive Oxygen Species; Staurosporine; Thiocarbamates; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Ultraviolet Rays

1998
Modulation of 9-nitrocamptothecin-induced apoptosis by hyperthermia in human leukemia HL-60 cells.
    Anti-cancer drugs, 1999, Volume: 10, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Flow Cytometry; HL-60 Cells; Humans; Hyperthermia, Induced; Leukemia

1999
Flow cytometry detection of caspase 3 activation in preapoptotic leukemic cells.
    Cytometry, 2000, Jun-01, Volume: 40, Issue:2

    Topics: Adult; Annexin A5; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Apoptosis; Biomarkers; Blotting, Western; Bone Marrow Cells; Camptothecin; Caspase 3; Caspase 7; Caspases; Daunorubicin; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Idarubicin; Leukemia; Peptide Hydrolases; Protein Binding; U937 Cells

2000
Measurement of the ADP:ATP ratio in human leukaemic cell lines can be used as an indicator of cell viability, necrosis and apoptosis.
    Journal of immunological methods, 2000, Jun-23, Volume: 240, Issue:1-2

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Apoptosis; Camptothecin; Cell Death; Cell Survival; Dexamethasone; Energy Metabolism; HL-60 Cells; Humans; In Situ Nick-End Labeling; Jurkat Cells; Leukemia; Microscopy, Fluorescence; Necrosis; U937 Cells

2000
Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue.
    Cancer research, 1992, Apr-15, Volume: 52, Issue:8

    Topics: Acute Disease; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Camptothecin; CHO Cells; Cricetinae; DNA Topoisomerases, Type I; DNA, Neoplasm; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Flow Cytometry; Leukemia; Membrane Glycoproteins; Quinidine; Topotecan; Tumor Cells, Cultured

1992
Studies of the differentiation properties of camptothecin in the human leukaemic cells K562.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:11

    Topics: Camptothecin; Cell Differentiation; Dose-Response Relationship, Drug; Down-Regulation; Globins; Humans; Leukemia; Lymphocytes, Null; Methotrexate; Mitosis; RNA, Messenger; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1991
Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis.
    Cancer research, 1992, Feb-15, Volume: 52, Issue:4

    Topics: Actin Cytoskeleton; Aphidicolin; Camptothecin; Cell Death; Cell Line; Cell Survival; Cytochalasin B; Humans; Ionomycin; Kinetics; Leukemia; Tetradecanoylphorbol Acetate; Ultraviolet Rays

1992
An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Drug Evaluation; Female; Humans; Irinotecan; Leukemia; Lymphoma; Male; Middle Aged

1990
Induction of differentiation of human and mouse myeloid leukemia cells by camptothecin.
    Biochemical and biophysical research communications, 1990, Jan-15, Volume: 166, Issue:1

    Topics: Animals; Biomarkers; Camptothecin; Cell Differentiation; Cell Line; Humans; Kinetics; Leukemia; Leukemia, Experimental; Mice; Phagocytosis; Receptors, Fc; Time Factors; Tumor Cells, Cultured

1990