Compounds > camptothecin
Page last updated: 2024-08-22

camptothecin and Hepatocellular Carcinoma

camptothecin has been researched along with Hepatocellular Carcinoma in 100 studies

Research

Studies (100)

TimeframeStudies, this research(%)All Research%
pre-19906 (6.00)18.7374
1990's5 (5.00)18.2507
2000's32 (32.00)29.6817
2010's47 (47.00)24.3611
2020's10 (10.00)2.80

Authors

AuthorsStudies
Chen, H; Chen, Q; Guo, X; Lin, T; Liu, J; Wang, G; Xu, Y; Yao, X; Zeng, J; Zhang, XK1
Cetin Atalay, R; Guven, EB; Onder, T; Tuncbilek, M1
He, J; Huang, Y; Ni, P; Tian, H; Zhang, M1
Chen, Y; Pan, J; Qing, C; Sun, Y; Tian, Y; Zhang, Y; Zhou, H; Zhu, Q1
Cao, P; Cheng, Y; Cui, J; Fan, S; Li, Y; Shang, Y; Yin, X; Zhang, H1
Chakraborty, K; Dhara, S1
Fu, W; Kai, GY; Li, L; Liu, XF; Liu, YQ; Peng, LZ; Xu, CR; Zhang, M; Zhang, ZJ; Zhu, LZ1
Chang, S; Chen, F; Li, G; Li, X; Liu, Q; Meng, F; Sun, L; Wang, H; Zhang, J1
Ali, SA; Atya, HB; Elkateb, AS; Nofal, S1
Bai, YP; Li, L; Liu, YQ; Luo, HB; Peng, LZ; Wang, ZP; Xu, CR; Yan, JX; Yang, CJ; Zhang, M; Zhang, ZJ; Zhu, LZ1
Honma, T; Imai, M; Ishikawa, T; Iwanaga, A; Jimbo, R; Kobayashi, Y; Sano, T; Sato, R; Sato, T; Yokoyama, J1
Chen, J; Du, D; Liu, C; Wu, Y1
Emami, J; Hasanzadeh, F; Maghzi, P; Mirian, M; Rostami, M; Sadeghi, H1
Bud Nelson, M; Chen, F; Feng, B; Pi, J; Qu, W; Wang, H; Xue, P; Zhang, Q; Zhao, R; Zhu, J1
Gu, JH; Ling, JJ; Xie, B; Xie, Y; Zhu, HM1
Bi, X; Chen, J; Gao, X; Li, H; Ma, P; Sun, Y; Zhang, Y; Zhu, H1
Chen, X; Ding, J; Li, D; Li, J; Liu, T; Xu, W; Zhang, YS1
Cui, R; Dong, Y; Fan, H; Gu, J; Jia, Y; Li, Y; Liu, C; Ma, X; Miao, R; Niu, W; Qu, K; Ren, L; Wang, H; Wang, Z; Zhang, J; Zhang, X1
Chu, B; Hu, D; Lei, M; Qian, Z; Qu, Y; Wang, F; Wang, M; Wei, X; Zha, R; Zhong, L1
Ding, R; Li, Z; Wang, J; Wang, M; Zhao, Z; Zhu, X1
Boukouris, AE; Buitrago-Molina, LE; Hegermann, J; Kirstein, MM; Kühnel, F; Manns, MP; Marhenke, S; Orlik, J; Pothiraju, D; Schütt, J; Vogel, A1
Deng, Y; Ge, Y; Meng, L; Yu, X; Zhang, Y; Zhao, X; Zu, Y1
Thomas, AL; Walter, H1
Ahn, JS; Jeon, JR; Paik, SW; Park, CK; Park, TK; Sinn, DH; Yoo, HS1
Chen, J; Chen, S; Xi, W; Xu, W; Yin, G1
Duan, Y; Gong, T; Liu, P; Sun, X; Wang, Q; Zhang, Z1
Liu, Z; Xiong, X; Yan, B; Yang, A; Zhou, M1
Chen, X; Gan, Y; Jia, Z; Li, FF; Li, J; Zhang, XX; Zhao, YN1
Guo, B; Liu, J; Song, L; Wu, J; Zhao, DY1
Choi, YH; Hyun, JW; Jayasooriya, RG; Kim, GY1
Ardelt, MA; Brandl, L; De Toni, EN; Ehrlich, SM; Gerbes, AL; Kirchner, T; Lehr, T; Liebl, J; Mayr, D; Vollmar, AM; Zahler, S1
Du, F; Gu, M; Guan, J; He, C; Jiang, R1
Ashton, A; Gupta, S; Kaseb, A; Odisio, BC; Tam, AL; Vauthey, JN; Wallace, MJ; Wei, W; Yan, Y1
Li, FY; Liu, L; Liu, ZQ; Lu, L; Peng, XJ; Qi, XX; Shi, J; Wang, Y; Zhou, FY; Zhou, J1
Cao, Y; Chen, D; Chen, S; He, H; Huang, X; Lei, S; Liu, M; Luo, S; Mukerabigwi, JF; Wen, Z; Zhang, Y1
Jian, C; Pei-hua, L; Xiao-chun, Y; Xu, L; Yuan-run, Z1
Chen, M; He, Q; Luo, P; Peng, X; Shao, J; Xu, L; Xu, Z; Yang, B; Zhu, H; Zhu, Y1
Chang, LL; Dai, XY; Gai, RH; He, QJ; Wang, DD; Yang, B; Zhou, TY; Zhu, DF; Zhu, H; Zhuang, LH1
Chen, M; He, Q; Li, G; Luo, P; Shao, J; Xu, L; Xu, Z; Yan, H; Yang, B; Zhu, Y1
Fu, YR; Qiu, ZY; Yan, YR2
Georgiades, CC; Geschwind, JF; Hong, K; Lee, KH; Liapi, E1
Guo, C; Guo, X; Hu, Z; Li, J; Qiu, L; Ying, K; Yu, Q; Zhang, J1
Chen, LH; Guan, J; Li, QS; Sun, HW; Wei, CJ; Zheng, XK1
Chiang, PC; Guh, JH; Hsu, JL1
Fujiki, R; Kitamura, T; Matsui, O; Motoo, Y; Mouri, H; Ohtsubo, K; Okai, T; Sanada, J; Sawabu, N; Tokuuye, K; Tsuchiyama, T; Watanabe, H; Yamaguchi, Y1
Gu, J; Han, HB; Hu, MH; Li, JY; Wang, Y; Xie, Y; Xing, BC; Xu, XL; Xu, ZL; Zhang, ZQ; Zhao, W1
Abe, M; Harada, M; Itou, M; Kawaguchi, T; Koga, H; Kuromatsu, R; Okuda, K; Sakata, M; Sata, M; Sumie, S; Taniguchi, E; Ueno, T; Yamagishi, S1
Gong, T; Liu, J; Ren, K; Shi, SJ; Sun, X; Wei, W; Zhang, XN; Zhang, ZR; Zhao, D1
Hao, C; Ji, B; Liu, Y; Lu, G; Wang, G; Wei, F1
Berrevoet, F; Bocchetti, T; de Hemptinne, B; Ricciardi, S; Rogiers, X; Sainz-Barriga, M; Troisi, RI; Van Huysse, J; Vandenbossche, B; Vinci, A1
Chen, X; Li, X; Li, Z; Liu, X; Qian, Z; Wei, Y; Yi, T; Zhao, X; Zhong, Q; Zhou, L; Zhou, S1
Dou, KF; Liu, WH; Song, WJ; Zhang, FQ; Zhang, Y1
Chang, S; Chen, Z; Gu, Z; He, B; Lu, J; Nie, Y; Xie, L; Zheng, S; Zou, S1
Abdulghani, J; Allen, JE; Dicker, DT; Dolloff, NG; El-Deiry, WS; Gallant, JN; Hong, B; Katz, SI; Navaraj, A; Smith, CD; Wang, W1
Huang, A; Niu, J; Ping, Q; Sang, X; Su, Z; Sun, M; Xiao, Y; You, W; Yuan, D1
Agostini, V; Biasco, G; Bolondi, L; Borghi, A; Brandi, G; Cappelli, A; Costantini, S; Danesi, R; Derenzini, E; Di Paolo, A; Fanello, S; Giampalma, E; Golfieri, R; Mirarchi, MG; Pini, P; Piscaglia, F1
Feng, G; Liang, B; Liang, H; Qian, J; Wang, Y; Zhao, H; Zheng, C1
Kalokairinou, M; Malagari, K; Marinis, A; Moschouris, H; Papadaki, MG; Stamatiou, K1
Deng, X; Jiang, C; Li, Q; Qiu, W; Zhang, L; Zhao, T; Zhu, Q; Zu, Y1
Fu, H; Grieves, JL; La Perle, KM; McCarty, DM; Rosas, LE; Zaraspe, K1
Jia, G; Li, X; Luo, X; Song, H; Xu, G; Yan, S; Yang, S1
Ambudkar, SV; Bhatnagar, J; Chen, JJ; Chen, WM; Chen, ZS; Lan, P; Ruan, ZX; Shu, C; Sodani, K; Wang, J; Xiao, ZJ; Ye, WC; Zhang, DM1
Barsotti, AM; Breuhahn, K; Bussemaker, HJ; Coutavas, E; Fazollahi, M; Giles, KM; Grunwald, D; Hess, J; Leedman, PJ; Longerich, T; Neumann, O; Ouwehand, A; Powers, MA; Prives, C; Pusterla, T; Schirmacher, P; Singer, RH; Singer, S; Zhao, R1
Gemici, C; Uygur-Bayramiçli, O1
Choi, SH; Hong, SY; Hyung, WJ; Jung, HC; Kim, KS; Lee, MH; Noh, SH; Roh, JK1
Cui, Y; Li, WH; Zhu, JR1
Alajati, A; Ganslmayer, M; Hahn, EG; Herold, C; Lüders, M; Neureiter, D; Ocker, M; Schuppan, D; Zopf, S1
Harada, N; Hatano, E; Ikai, I; Koizumi, N; Nitta, T; Shimahara, Y; Tada, M; Taura, K1
Beurel, E; Blivet-Van Eggelpoël, MJ; Cadoret, A; Capeau, J; Desbois-Mouthon, C; Kornprobst, M1
Fu, ZD; Li, DZ; Liu, HY; Pan, XD; Wang, CY; Wu, S1
Chen, T; Chu, ZH; Liu, JP; Ou, QJ; Wang, J; Zhao, HY1
Cai, W; Chen, JP; Li, XY; Wu, XY; Yao, DF; Yu, JW; Yu, ZJ; Yuan, HX; Yuan, Y1
Fuke, H; Inoue, T; Miyashita, K; Nakano, T; Saitou, Y; Shiraki, K; Sugimoto, K; Yamaguchi, Y; Yamanaka, Y1
Boige, V; Debaere, T; Ducreux, M; Hannoun, L; Hebbar, M; Magherini, E; Malka, D; Mignard, D; Poynard, T; Taïeb, J1
Gao, K; Li, X; Pan, J1
Feng, LF; Lei, XY; Liao, DF; Tang, SS; Zhong, M; Zhu, BY1
Shi, D; Song, X; Yan, B; Yang, D; Yang, J1
Kobayashi, S; Kumai, T; Matsumoto, N; Nakaya, S; Takeba, Y; Tsuzuki, Y; Yanagida, Y1
Asakura, T; Kobayashi, S; Kumai, T; Matsumoto, N; Nakano, H; Nakaya, S; Ohtsubo, T; Sekine, S; Takeba, Y; Tsuzuki, Y; Yanagida, Y1
Meric, JB1
Fukuda, S; Kojiro, M; Nakashima, O; Ookawa, K; Sakata, Y; Suto, K; Takahata, T; Tamura, Y; Tanaka, M; Tateishi, T; Yano, H1
Yan, JB1
Khaoustov, VI; Krishnan, B; Mearns, M; Noda, A; Ozer, A; Slagle, BL; Smith, JR; Yoffe, B1
Yu, ZJ1
Kato, M; Suzuki, A1
Adjei, PN; Gores, GJ; Kaufmann, SH; Leung, WY; Mao, F1
Hashimoto, A; Matsuura, T; Murakami, K; Saiki, I; Sakukawa, R; Sano, M; Yamada, Y; Yonekura, K1
Fujikawa, K; Ito, M; Ito, T; Moriyama, M; Nakano, T; Shiraki, K; Sugimoto, K; Suzuki, A; Takase, K; Yamanaka, T1
Azoulay, D; Duclos-Vallée, JC; Goldwasser, F; Gornet, JM1
Xu, B; Zhang, XW1
Kelsen, DP; Kemeny, NE; O'Reilly, EM; Raeburn, L; Saltz, LB; Sanz-Altamira, PM; Schwartz, GK; Steger, CM; Stuart, KE1
Jiang, JF; Xu, B; Zhang, XW1
Liu, J; Xu, B; Zhou, JJ1
Xu, B; Zhang, X; Zhou, Y1
Cotezee, ML; Klein, K; Ove, P; Sartiano, GP1
Coetzee, ML; Klein, K; Ove, P; Sartiano, GP1
Ling, HY; Wang, NZ; Zhu, HZ1
Becker, JE; Bushnell, DE; Potter, VR1
Hunter, GR; Kalf, GF; Morris, HP1

Reviews

2 review(s) available for camptothecin and Hepatocellular Carcinoma

ArticleYear
Drug-eluting particles for interventional pharmacology.
    Techniques in vascular and interventional radiology, 2007, Volume: 10, Issue:4

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Colorectal Neoplasms; Doxorubicin; Drug Carriers; Humans; Irinotecan; Liver Neoplasms; Lung Neoplasms; Microspheres

2007
[Angiogenesis targeting in gastro-intestinal cancers].
    Bulletin du cancer, 2007, Volume: 94, Issue:7 Suppl

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Carcinoma, Hepatocellular; Colorectal Neoplasms; Esophageal Neoplasms; Fluorouracil; Gastrointestinal Neoplasms; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Neovascularization, Pathologic; Organoplatinum Compounds; Oxaliplatin; Pancreatic Neoplasms; Stomach Neoplasms

2007

Trials

5 trial(s) available for camptothecin and Hepatocellular Carcinoma

ArticleYear
Clinical therapeutic effect and biological monitoring of p53 gene in advanced hepatocellular carcinoma.
    American journal of clinical oncology, 2014, Volume: 37, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Ascites; Camptothecin; Carcinoma, Hepatocellular; Catheters, Indwelling; Chemoembolization, Therapeutic; Female; Genes, p53; Genetic Therapy; Humans; Iliac Artery; Infusions, Intra-Arterial; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Prospective Studies; Treatment Outcome

2014
A phase I study of continuous hepatic arterial infusion of Irinotecan in patients with locally advanced hepatocellular carcinoma.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2011, Volume: 43, Issue:12

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Catheterization; Diarrhea; Disease-Free Survival; Female; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Irinotecan; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Treatment Outcome

2011
Evaluation of HCPTd1,d14-double passaged intervening chemotherapy protocol for hepatocellular carcinoma.
    World journal of gastroenterology, 2005, Sep-07, Volume: 11, Issue:33

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cisplatin; Drug Administration Schedule; Female; Fluorouracil; Hepatic Artery; Humans; Liver Neoplasms; Male; Middle Aged; Portal Vein; Treatment Outcome

2005
Irinotecan as first-line chemotherapy in patients with advanced hepatocellular carcinoma: a multicenter phase II study with dose adjustment according to baseline serum bilirubin level.
    European journal of cancer (Oxford, England : 1990), 2006, Volume: 42, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Agents, Phytogenic; Bilirubin; Biomarkers; Camptothecin; Carcinoma, Hepatocellular; Disease Progression; Dose-Response Relationship, Drug; Female; Humans; Irinotecan; Liver Cirrhosis; Liver Neoplasms; Male

2006
A phase II study of irinotecan in patients with advanced hepatocellular carcinoma.
    Cancer, 2001, Jan-01, Volume: 91, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Diarrhea; Fatigue; Female; Humans; Irinotecan; Liver Neoplasms; Male; Middle Aged; Nausea; Neutropenia; Prognosis; Treatment Outcome; Vomiting

2001

Other Studies

93 other study(ies) available for camptothecin and Hepatocellular Carcinoma

ArticleYear
A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.
    Bioorganic & medicinal chemistry letters, 2012, Mar-01, Volume: 22, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; G2 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; Liver Neoplasms; M Phase Cell Cycle Checkpoints; Orchidaceae; Resveratrol; Stilbenes

2012
Synthesis of novel 6-(4-substituted piperazine-1-yl)-9-(β-D-ribofuranosyl)purine derivatives, which lead to senescence-induced cell death in liver cancer cells.
    Journal of medicinal chemistry, 2012, Apr-12, Volume: 55, Issue:7

    Topics: Adenosine; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p15; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Purine Nucleosides; Retinoblastoma Protein; Structure-Activity Relationship

2012
CD147 Monoclonal Antibody Targeted Reduction-Responsive Camptothecin Polyphosphoester Nanomedicine for Drug Delivery in Hepatocellular Carcinoma Cells.
    ACS applied bio materials, 2021, 05-17, Volume: 4, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Basigin; Biocompatible Materials; Camptothecin; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Immunoconjugates; Liver Neoplasms; Materials Testing; Molecular Structure; Nanomedicine; Particle Size; Prodrugs

2021
9-Nitro-20(S)-carbonate-camptothecin (NCP4), a novel prodrug of 9-nitrocamptothecin (9-NC), exhibits potent chemotherapeutic efficacy and improved safety against hepatocarcinoma.
    European journal of pharmacology, 2022, May-15, Volume: 923

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carbonates; Carcinoma, Hepatocellular; Humans; Lactones; Liver Neoplasms; Mice; Prodrugs

2022
Fluorescent Imaging-Guided Chemo- and Photodynamic Therapy of Hepatocellular Carcinoma with HCPT@NMOFs-RGD Nanocomposites.
    International journal of nanomedicine, 2022, Volume: 17

    Topics: Animals; Camptothecin; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Mice; Nanocomposites; Oligopeptides; Photochemotherapy; Zebrafish

2022
Apoptotic effect of sulfated galactofucan from marine macroalga Turbinaria ornata on hepatocellular and ductal carcinoma cells.
    Phytochemistry, 2022, Volume: 203

    Topics: Apoptosis; Camptothecin; Carcinoma, Ductal; Carcinoma, Hepatocellular; Fucose; Galactose; Hep G2 Cells; Humans; Isothiocyanates; Liver Neoplasms; Phaeophyceae; Polysaccharides; Seaweed; Sulfates; Tumor Suppressor Protein p53

2022
Anti-tumor effects and mechanism of a novel camptothecin derivative YCJ100.
    Life sciences, 2022, Dec-15, Volume: 311, Issue:Pt A

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Topoisomerases, Type I; Female; Humans; Liver Neoplasms; Mice; Molecular Docking Simulation; Pancreatic Neoplasms; Topoisomerase I Inhibitors; Topotecan; Xenograft Model Antitumor Assays

2022
Camptothecin improves sorafenib sensitivity by inhibiting Nrf2‑ARE pathway in hepatocellular carcinoma.
    Oncology reports, 2023, Volume: 49, Issue:3

    Topics: Animals; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Resistance, Neoplasm; Liver Neoplasms; Mice; NAD; NF-E2-Related Factor 2; Oxidoreductases; Quinones; Rabbits; Sorafenib

2023
Camptothecin Sensitizes Hepatocellular Carcinoma Cells to Sorafenib- Induced Ferroptosis Via Suppression of Nrf2.
    Inflammation, 2023, Volume: 46, Issue:4

    Topics: Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Ferroptosis; Humans; Iron; Kelch-Like ECH-Associated Protein 1; Liver Neoplasms; NF-E2-Related Factor 2; Sorafenib

2023
Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I.
    Bioorganic chemistry, 2023, Volume: 139

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; DNA Topoisomerases, Type I; Humans; Liver Neoplasms; Mice; Topoisomerase I Inhibitors; Topotecan

2023
Prognostic Value of TACE With Irinotecan-loaded Drug-eluting Beads (DEBIRI) in Patients With Liver Metastases from Unresectable Colorectal Cancer.
    Anticancer research, 2023, Volume: 43, Issue:8

    Topics: Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Colorectal Neoplasms; Female; Humans; Irinotecan; Liver Neoplasms; Male; Prognosis; Topoisomerase I Inhibitors; Treatment Outcome

2023
Preparation of PLGA microspheres loaded with 10-hydroxycamptothecin and arsenic trioxide and their treatment for rabbit hepatocellular carcinoma.
    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2021, Volume: 165, Issue:1

    Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Camptothecin; Carcinoma, Hepatocellular; Disease Models, Animal; Liver Neoplasms; Microspheres; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits

2021
PLGA-PEG-RA-based polymeric micelles for tumor targeted delivery of irinotecan.
    Pharmaceutical development and technology, 2018, Volume: 23, Issue:1

    Topics: Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Hep G2 Cells; HT29 Cells; Humans; Irinotecan; Lactic Acid; Liver Neoplasms; Micelles; Nanoparticles; Particle Size; Polyethylene Glycols; Polyglactin 910; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Tretinoin

2018
Camptothecin suppresses NRF2-ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs.
    British journal of cancer, 2017, Nov-07, Volume: 117, Issue:10

    Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carboxylic Ester Hydrolases; Carcinoma, Hepatocellular; Drug Resistance, Neoplasm; Female; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; NF-E2-Related Factor 2; Xenograft Model Antitumor Assays

2017
Hydroxycamptothecin liposomes based on thermal and magnetic dual-responsive system: preparation, in vitro and in vivo antitumor activity, microdialysis-based tumor pharmacokinetics.
    Journal of drug targeting, 2018, Volume: 26, Issue:4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Humans; Liposomes; Liver Neoplasms; Magnetics; Male; Mice; Microdialysis; Rats; Rats, Sprague-Dawley; Temperature

2018
Enhanced anti-hepatocarcinoma efficacy by GLUT1 targeting and cellular microenvironment-responsive PAMAM-camptothecin conjugate.
    Drug delivery, 2018, Volume: 25, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cellular Microenvironment; Dendrimers; Drug Delivery Systems; Drug Liberation; Glucose Transporter Type 1; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice; Particle Size; Polyethylene Glycols; Rats; Rats, Sprague-Dawley

2018
Locally Deployable Nanofiber Patch for Sequential Drug Delivery in Treatment of Primary and Advanced Orthotopic Hepatomas.
    ACS nano, 2018, 07-24, Volume: 12, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Drug Delivery Systems; Drug Implants; Female; Liver Neoplasms; Mice, Inbred BALB C; Nanofibers; Polyphenols

2018
Prognostic predictors for patients with hepatocellular carcinoma receiving adjuvant transcatheter arterial chemoembolization.
    European journal of gastroenterology & hepatology, 2019, Volume: 31, Issue:7

    Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Chemotherapy, Adjuvant; Disease-Free Survival; Epirubicin; Female; Fluorouracil; gamma-Glutamyltransferase; Hepatectomy; Hepatitis B, Chronic; Humans; Hypertension, Portal; Leukocyte Count; Liver Neoplasms; Lymphocyte Count; Male; Middle Aged; Monocytes; Neoplasm Staging; Neutrophils; Prognosis; Proportional Hazards Models; Retrospective Studies; Survival Rate; Tumor Burden

2019
Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for "on-demand" drug delivery.
    Journal of controlled release : official journal of the Controlled Release Society, 2019, 02-28, Volume: 296

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; Cell Line; Drug Delivery Systems; Drug Liberation; Gels; Hydrogen-Ion Concentration; Liver Neoplasms; Male; Methacrylates; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Oxidation-Reduction; Polymers; Prodrugs

2019
Design and Synthesis of Galactose-Biotin Lipid Materials for Liposomes to Promote the Hepatoma Cell-Targeting Effect.
    Journal of pharmaceutical sciences, 2019, Volume: 108, Issue:9

    Topics: Antineoplastic Agents; Asialoglycoprotein Receptor; Biotin; Camptothecin; Carcinoma, Hepatocellular; Drug Carriers; Drug Liberation; Drug Screening Assays, Antitumor; Galactose; Hep G2 Cells; Hepatocytes; Humans; Lipids; Liposomes; Liver Neoplasms; Particle Size

2019
Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma.
    Liver international : official journal of the International Association for the Study of the Liver, 2013, Volume: 33, Issue:5

    Topics: Aminopyridines; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Camptothecin; Carcinoma, Hepatocellular; Cell Cycle; Cell Line; Cell Respiration; Cisplatin; Doxorubicin; Everolimus; Humans; Imidazoles; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Irinotecan; Liver Neoplasms; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinolines; Sirolimus; TOR Serine-Threonine Kinases

2013
Preparation of 10-hydroxycamptothecin-loaded glycyrrhizic acid-conjugated bovine serum albumin nanoparticles for hepatocellular carcinoma-targeted drug delivery.
    International journal of nanomedicine, 2013, Volume: 8

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Cattle; Cell Line, Tumor; Drug Carriers; Glycyrrhizic Acid; Hemolysis; Humans; Liver Neoplasms; Nanoparticles; Particle Size; Rabbits; Serum Albumin, Bovine

2013
Liver resection following FOLFOXIRI plus bevacizumab: a detailed pathological review.
    British journal of cancer, 2013, Jun-25, Volume: 108, Issue:12

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Fluorouracil; Hepatectomy; Humans; Leucovorin; Liver; Liver Neoplasms; Organoplatinum Compounds

2013
Hepatoid adenocarcinoma of the stomach: an unusual case of elevated alpha-fetoprotein with prior treatment for hepatocellular carcinoma.
    Clinical and molecular hepatology, 2013, Volume: 19, Issue:2

    Topics: Adenocarcinoma; Aged; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Chemotherapy, Adjuvant; Fluorouracil; Gastroscopy; Humans; Leucovorin; Liver Neoplasms; Lymph Nodes; Lymphatic Metastasis; Male; Recurrence; Silicates; Stomach Neoplasms; Titanium; Tomography, X-Ray Computed

2013
Uptake mechanism and endosomal fate of drug-phospholipid lipid nanoparticles in subcutaneous and in situ hepatoma.
    Journal of biomedical nanotechnology, 2014, Volume: 10, Issue:6

    Topics: Animals; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Diffusion; Endosomes; Liposomes; Male; Mice; Mice, Inbred C57BL; Nanocapsules; Organ Specificity; Phospholipids; Tissue Distribution

2014
Preparation of camptothecin-loaded targeting nanoparticles and their antitumor effects on hepatocellular carcinoma cell line H22.
    Drug delivery, 2016, Volume: 23, Issue:5

    Topics: Antineoplastic Agents; Biotin; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Humans; Nanoparticles; Polymers; Solubility; Tissue Distribution; Xenograft Model Antitumor Assays

2016
[Antitumor efficacy of irinotecan-loaded galactosyl modified lipid bilayer-coated mesoporous silica nanoparticles against hepatocellular carcinoma cells].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Drug Carriers; Drug Delivery Systems; Humans; Irinotecan; Lipid Bilayers; Liver Neoplasms; Nanoparticles; Particle Size; Silicon Dioxide

2014
Chemotherapy for transarterial chemoembolization in patients with unresectable hepatocellular carcinoma.
    World journal of gastroenterology, 2014, Aug-21, Volume: 20, Issue:31

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Deoxycytidine; Disease Progression; Doxorubicin; Female; Fluorouracil; Gemcitabine; Humans; Irinotecan; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome

2014
Camptothecin sensitizes human hepatoma Hep3B cells to TRAIL-mediated apoptosis via ROS-dependent death receptor 5 upregulation with the involvement of MAPKs.
    Environmental toxicology and pharmacology, 2014, Volume: 38, Issue:3

    Topics: Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; MAP Kinase Signaling System; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand

2014
Targeting cyclin dependent kinase 5 in hepatocellular carcinoma--A novel therapeutic approach.
    Journal of hepatology, 2015, Volume: 63, Issue:1

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Liver Neoplasms; Mice; Mice, SCID; Purines; RNA, Neoplasm; Roscovitine; Treatment Outcome

2015
The clinical application of 320-detector row CT in transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma.
    La Radiologia medica, 2015, Volume: 120, Issue:8

    Topics: Adult; Aged; Angiography, Digital Subtraction; Biopsy; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Contrast Media; Doxorubicin; Ethiodized Oil; Female; Humans; Iopamidol; Liver Neoplasms; Male; Middle Aged; Prospective Studies; Radiographic Image Interpretation, Computer-Assisted; Radiography, Interventional; Tegafur; Tomography, X-Ray Computed

2015
Transarterial hepatic chemoembolization with 70-150 µm drug-eluting beads: assessment of clinical safety and liver toxicity profile.
    Journal of vascular and interventional radiology : JVIR, 2015, Volume: 26, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bile Duct Diseases; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Doxorubicin; Drug Carriers; Female; Humans; Infarction; Irinotecan; Liver Neoplasms; Male; Middle Aged; Particle Size; Patient Safety; Portal Vein; Retrospective Studies; Risk Assessment; Risk Factors; Texas; Time Factors; Treatment Outcome; Tumor Burden; Venous Thrombosis

2015
Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Adult; Camptothecin; Carcinoma, Hepatocellular; Genistein; Glucuronosyltransferase; Humans; Inactivation, Metabolic; Irinotecan; Liver Neoplasms; Male; Metabolic Clearance Rate; Microsomes, Liver; Middle Aged; Propofol; Tamoxifen; Zidovudine

2015
Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance.
    Journal of drug targeting, 2016, Volume: 24, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Drug Resistance, Multiple; Glucans; Hep G2 Cells; Humans; Lipids; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nanostructures; Particle Size; Soybean Oil; Xylans

2016
[Anticancer effect of SN-38 combined with sorafenib on hepatocellular carcinoma in vitro and its mechanism].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2015, Volume: 44, Issue:5

    Topics: Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Histones; Humans; Irinotecan; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Poly(ADP-ribose) Polymerases; Sorafenib; Tumor Suppressor Protein p53

2015
Gefitinib Synergizes with Irinotecan to Suppress Hepatocellular Carcinoma via Antagonizing Rad51-Mediated DNA-Repair.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; DNA Repair; Drug Resistance, Neoplasm; Drug Synergism; Gefitinib; Hep G2 Cells; Humans; Irinotecan; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Rad51 Recombinase; RNA, Small Interfering; Topoisomerase I Inhibitors

2016
Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells.
    Oncotarget, 2016, Feb-09, Volume: 7, Issue:6

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Cell Nucleus; Cell Proliferation; Drug Resistance, Neoplasm; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Immunoenzyme Techniques; Irinotecan; Liver Neoplasms; Mice; Mice, Nude; Phosphoproteins; Protein Transport; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; YAP-Signaling Proteins

2016
Dasatinib synergises with irinotecan to suppress hepatocellular carcinoma via inhibiting the protein synthesis of PLK1.
    British journal of cancer, 2017, Apr-11, Volume: 116, Issue:8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Proliferation; Dasatinib; Drug Synergism; Female; Flow Cytometry; Humans; Irinotecan; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Polo-Like Kinase 1; Protein Biosynthesis; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2017
[Quantitative analysis of nuclear proteome in apoptosis hepatoma cells induced by hydroxycamptothecin].
    Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology, 2008, Volume: 41, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Gene Expression Regulation; Humans; Molecular Sequence Data; Nuclear Proteins; Proteome

2008
Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells.
    FEBS letters, 2009, Jan-22, Volume: 583, Issue:2

    Topics: Adenine Nucleotide Translocator 3; Antineoplastic Agents; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Humans; Liver Neoplasms; RNA Interference

2009
[Three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for massive primary liver cancer].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2009, Volume: 29, Issue:6

    Topics: Adult; Aged; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Combined Modality Therapy; Female; Fluorouracil; Humans; Imaging, Three-Dimensional; Liver Neoplasms; Male; Middle Aged; Mitomycin; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Conformal; Retrospective Studies; Treatment Outcome

2009
Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 380, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Etoposide; G1 Phase; Heat-Shock Proteins; Humans; Liver Neoplasms; Tunicamycin

2009
Advanced hepatocellular carcinoma treated effectively with irinotecan via hepatic arterial infusion followed by proton beam therapy.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2009, Volume: 15, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Combined Modality Therapy; Humans; Hyperthermia, Induced; Infusions, Intra-Arterial; Irinotecan; Liver Neoplasms; Male; Middle Aged; Proton Therapy; Survivors

2009
The properties of tumor-initiating cells from a hepatocellular carcinoma patient's primary and recurrent tumor.
    Carcinogenesis, 2010, Volume: 31, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Cell Adhesion; Cisplatin; Comparative Genomic Hybridization; Doxorubicin; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression Profiling; Humans; Liver Neoplasms, Experimental; Male; Mice; Mice, SCID; Middle Aged; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Oligonucleotide Array Sequence Analysis; Paclitaxel; Poly(ADP-ribose) Polymerases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2010
Pigment epithelium-derived factor inhibits lysosomal degradation of Bcl-xL and apoptosis in HepG2 cells.
    The American journal of pathology, 2010, Volume: 176, Issue:1

    Topics: Apoptosis; bcl-X Protein; Camptothecin; Carcinoma, Hepatocellular; Cell Cycle; Cyclophilins; Densitometry; Eye Proteins; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Hep G2 Cells; Humans; Leupeptins; Liver; Liver Neoplasms; Lysosomes; Macrolides; Nerve Growth Factors; Protein Processing, Post-Translational; Recombinant Proteins; RNA, Messenger; Serpins

2010
Lipid nanoparticles loaded with 10-hydroxycamptothecin-phospholipid complex developed for the treatment of hepatoma in clinical application.
    Journal of drug targeting, 2010, Volume: 18, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Female; Hep G2 Cells; Humans; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Particle Size; Phospholipids; Tissue Distribution

2010
Synergistic effect of celecoxib on TRAIL-induced apoptosis in hepatocellular carcinoma cells.
    Cancer investigation, 2010, Volume: 28, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Caspase 8; Celecoxib; Cisplatin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Hep G2 Cells; Humans; Liver Neoplasms; Pyrazoles; Recombinant Proteins; Sulfonamides; TNF-Related Apoptosis-Inducing Ligand

2010
Evolution of laparoscopic left lateral sectionectomy without the Pringle maneuver: through resection of benign and malignant tumors to living liver donation.
    Surgical endoscopy, 2011, Volume: 25, Issue:1

    Topics: Adenocarcinoma; Adenoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Loss, Surgical; Camptothecin; Carcinoma, Hepatocellular; Combined Modality Therapy; Disease-Free Survival; Female; Fluorouracil; Follow-Up Studies; Gastrointestinal Stromal Tumors; Hepatectomy; Humans; Laparoscopy; Length of Stay; Leucovorin; Liver Neoplasms; Liver Transplantation; Living Donors; Male; Melanoma; Middle Aged; Organoplatinum Compounds; Postoperative Complications; Retrospective Studies; Tissue and Organ Harvesting

2011
In vivo antitumor and antimetastatic activities of camptothecin encapsulated with N-trimethyl chitosan in a preclinical mouse model of liver cancer.
    Cancer letters, 2010, Nov-01, Volume: 297, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Chemistry, Pharmaceutical; Chitosan; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Female; Liver Neoplasms; Lymphangiogenesis; Lymphatic Metastasis; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; RNA, Messenger; Time Factors; Tumor Burden; Vascular Endothelial Growth Factor D

2010
Differentiation-inducing activity of hydroxycamptothecin on cancer stem-like cells derived from hepatocellular carcinoma.
    Digestive diseases and sciences, 2011, Volume: 56, Issue:8

    Topics: Albumins; alpha-Fetoproteins; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tumor; Flow Cytometry; Hepatocyte Nuclear Factor 4; Humans; Liver Neoplasms; MicroRNAs; Neoplastic Stem Cells; Side-Population Cells

2011
Characterization of 9-nitrocamptothecin liposomes: anticancer properties and mechanisms on hepatocellular carcinoma in vitro and in vivo.
    PloS one, 2011, Volume: 6, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Stability; Female; Gene Expression Regulation, Neoplastic; Humans; Liposomes; Liver Neoplasms; Mice; Solubility; Ultrasonics; Water; Xenograft Model Antitumor Assays

2011
Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents.
    Cancer biology & therapy, 2011, Aug-01, Volume: 12, Issue:3

    Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Camptothecin; Carcinoma, Hepatocellular; Cell Death; Cell Nucleus; Cytoplasm; Deoxycytidine; Doxorubicin; Drug Synergism; Etoposide; Female; Fluorouracil; Gemcitabine; Genes, p53; Humans; Irinotecan; Liver Neoplasms; Mice; Microtubule-Associated Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins c-bcl-2; Pyridines; Quinacrine; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Small Interfering; Sorafenib; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2011
Effect of octreotide-polyethylene glycol(100) monostearate modification on the pharmacokinetics and cellular uptake of nanostructured lipid carrier loaded with hydroxycamptothecine.
    Molecular pharmaceutics, 2011, Oct-03, Volume: 8, Issue:5

    Topics: Animals; Antineoplastic Agents; Biological Transport; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemical Phenomena; Delayed-Action Preparations; Drug Carriers; Half-Life; Humans; Ligands; Lipids; Liver Neoplasms; Male; Nanostructures; Neoplasm Proteins; Octreotide; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin

2011
Hepatocellular necrosis, apoptosis, and proliferation after transcatheter arterial embolization or chemoembolization in a standardized rabbit model.
    Journal of vascular and interventional radiology : JVIR, 2011, Volume: 22, Issue:11

    Topics: Alanine Transaminase; Angiography, Digital Subtraction; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Aspartate Aminotransferases; Camptothecin; Carcinoma, Hepatocellular; Cell Proliferation; Chemoembolization, Therapeutic; Embolization, Therapeutic; Hepatic Artery; In Situ Nick-End Labeling; Iodized Oil; Ki-67 Antigen; Liver Function Tests; Liver Neoplasms, Experimental; Liver Regeneration; Magnetic Resonance Imaging; Necrosis; Polyvinyl Alcohol; Rabbits; Time Factors; Tomography, X-Ray Computed; Tumor Necrosis Factor-alpha

2011
Contrast-enhanced ultrasonography with intraarterial administration of SonoVue for guidance of transarterial chemoembolization: an initial experience.
    Medical ultrasonography, 2011, Volume: 13, Issue:4

    Topics: Aged; Aged, 80 and over; Angiography, Digital Subtraction; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cholangiocarcinoma; Contrast Media; Doxorubicin; Feasibility Studies; Female; Humans; Injections, Intra-Arterial; Irinotecan; Liver Neoplasms; Male; Microspheres; Middle Aged; Phospholipids; Prospective Studies; Sulfur Hexafluoride; Treatment Outcome; Ultrasonography, Interventional

2011
Camptothecin-20(s)-O-[N-(3'α,12'α-dihydroxy-24'-carbonyl-5'β-cholan)]-lysine, a novel camptothecin analogue, induces apoptosis towards hepatocellular carcinoma SMMC-7721 cells.
    Molecules (Basel, Switzerland), 2011, Sep-13, Volume: 16, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Calcium; Camptothecin; Carcinoma, Hepatocellular; Caspase 3; Caspase 9; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species

2011
Patterns of scAAV vector insertion associated with oncogenic events in a mouse model for genotoxicity.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2012, Volume: 20, Issue:11

    Topics: Animals; Base Sequence; Camptothecin; Carcinoma, Hepatocellular; Dependovirus; DNA Damage; Female; Fibroblast Growth Factor 10; Fibroblast Growth Factor 3; Genetic Vectors; Genome, Viral; Hepatectomy; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, SCID; Molecular Sequence Data; Mutagenesis, Insertional; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; SOS1 Protein; Transcriptional Activation; Virus Integration

2012
Promoted antitumor activities of acid-labile electrospun fibers loaded with hydroxycamptothecin via intratumoral implantation.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012, Volume: 82, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzaldehydes; Camptothecin; Carcinoma, Hepatocellular; Electrochemistry; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Lactates; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Molecular Weight; Polyethylene Glycols; Survival Rate; Tumor Microenvironment

2012
BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo.
    Molecular pharmaceutics, 2012, Nov-05, Volume: 9, Issue:11

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Breast Neoplasms; Calcium Channel Blockers; Camptothecin; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Cisplatin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Fluorescent Antibody Technique; Humans; In Vitro Techniques; Irinotecan; KB Cells; Liver Neoplasms; Male; Mice; Mice, Nude; Models, Molecular; Molecular Docking Simulation; Paclitaxel; Piperidines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triterpenes; Verapamil

2012
Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes.
    Molecular cell, 2012, Dec-14, Volume: 48, Issue:5

    Topics: 14-3-3 Proteins; 3' Untranslated Regions; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Binding Sites; Camptothecin; Carcinoma, Hepatocellular; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Exosomes; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice; Mice, Knockout; Nuclear Pore Complex Proteins; RNA Interference; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Messenger; Time Factors; Transfection; Tumor Suppressor Protein p53

2012
Is liver disease an octreotide side effect?
    Journal of clinical gastroenterology, 2003, Volume: 37, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Hepatocellular; Drug Administration Schedule; Female; Fluorouracil; Gastrointestinal Agents; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Octreotide

2003
Adeno-associated virus mediated endostatin gene therapy in combination with topoisomerase inhibitor effectively controls liver tumor in mouse model.
    World journal of gastroenterology, 2004, Apr-15, Volume: 10, Issue:8

    Topics: Adenoviridae; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Combined Modality Therapy; Drug Synergism; Endostatins; Endothelium, Vascular; Enzyme Inhibitors; Etoposide; Gene Expression; Genetic Therapy; Humans; Liver Neoplasms; Mice; Sarcoma; Survival Rate; Topoisomerase Inhibitors; Umbilical Veins

2004
[Methylated oligonucleotide inhibiting expression of human MRP2 and reversing multidrug resistance in hepatocellular carcinoma Cell HepG2].
    Ai zheng = Aizheng = Chinese journal of cancer, 2004, Volume: 23, Issue:8

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Carboplatin; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Methylation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epirubicin; Humans; Inhibitory Concentration 50; Liver Neoplasms; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Oligonucleotides; RNA, Messenger; Transfection

2004
The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells.
    Journal of cancer research and clinical oncology, 2005, Volume: 131, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Caspases; Down-Regulation; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Fluorouracil; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Irinotecan; Liver Neoplasms; Membrane Potentials; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Skin; Tumor Cells, Cultured; Vorinostat

2005
Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38, an active form of CPT-11, in human hepatoma cells.
    International journal of oncology, 2005, Volume: 26, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Drug Resistance, Neoplasm; Humans; Irinotecan; Liver Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tumor Cells, Cultured

2005
GSK-3beta reactivation with LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis.
    International journal of oncology, 2005, Volume: 27, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Chromones; Cytochromes c; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Etoposide; fas Receptor; Flow Cytometry; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; Serine; Transfection; Tumor Suppressor Protein p53

2005
Synthesis and antitumor activity of A-ring modified hexacyclic analogues of camptothecin.
    Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:3

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Female; Humans; Irinotecan; Liver Neoplasms; Mice; Neoplasm Transplantation; Polycyclic Compounds

2005
[Application of adenosine triphosphate tumor chemosensitive assay system to individual chemotherapy for hepatocellular carcinoma].
    Ai zheng = Aizheng = Chinese journal of cancer, 2005, Volume: 24, Issue:8

    Topics: Adenosine Triphosphate; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Deoxycytidine; Disease-Free Survival; Drug Screening Assays, Antitumor; Female; Gemcitabine; Humans; Irinotecan; Liver Neoplasms; Male; Middle Aged; Paclitaxel; Postoperative Period; Remission Induction; Sensitivity and Specificity; Survival Rate

2005
Targeting of X-linked inhibitor of apoptosis protein or survivin by short interfering RNAs sensitize hepatoma cells to TNF-related apoptosis-inducing ligand- and chemotherapeutic agent-induced cell death.
    Oncology reports, 2005, Volume: 14, Issue:5

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Carcinoma, Hepatocellular; Down-Regulation; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Ligands; Liver Neoplasms; Membrane Glycoproteins; Microtubule-Associated Proteins; Neoplasm Proteins; Proteins; RNA, Small Interfering; Survivin; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; X-Linked Inhibitor of Apoptosis Protein

2005
[Effect of hydroxycamptothecin on apoptosis-inducing factor (AIF) expression and on AIF translocation in human hepatocellular cancer cell SMMC-7721].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2006, Volume: 14, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Inducing Factor; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Translocation, Genetic

2006
Gamma-pyranone derivatives and other constituents from Erigeron annuus.
    Die Pharmazie, 2006, Volume: 61, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Erigeron; Flavanones; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Pyrones; Tumor Cells, Cultured

2006
Bcl-XL small interfering RNA enhances sensitivity of Hepg2 hepatocellular carcinoma cells to 5-fluorouracil and hydroxycamptothecin.
    Acta biochimica et biophysica Sinica, 2006, Volume: 38, Issue:10

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; bcl-X Protein; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Fluorouracil; Humans; Liver Neoplasms; RNA, Messenger; RNA, Small Interfering

2006
Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2.
    Molecular pharmacology, 2007, Volume: 72, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Antiviral Agents; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Clopidogrel; Dose-Response Relationship, Drug; Female; Hepatocytes; Humans; Interleukin-6; Irinotecan; Liver Neoplasms; Male; Middle Aged; Oseltamivir; Platelet Aggregation Inhibitors; RNA, Messenger; Ticlopidine

2007
Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis.
    Journal of pharmacological sciences, 2007, Volume: 104, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; DNA Probes; Electrophoretic Mobility Shift Assay; Humans; In Situ Nick-End Labeling; Irinotecan; Liver Neoplasms; Oligonucleotides; Tumor Suppressor Protein p53

2007
Irinotecan-induced apoptosis is inhibited by increased P-glycoprotein expression and decreased p53 in human hepatocellular carcinoma cells.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; In Situ Nick-End Labeling; Irinotecan; Liver Neoplasms; Microscopy, Fluorescence; Oligonucleotides; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Tumor Suppressor Protein p53

2007
Chemosensitivity determinants of irinotecan hydrochloride in hepatocellular carcinoma cell lines.
    Basic & clinical pharmacology & toxicology, 2008, Volume: 102, Issue:4

    Topics: Acridines; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Flavanones; Gene Expression Regulation, Neoplastic; Glucuronosyltransferase; Humans; Inhibitory Concentration 50; Irinotecan; Liver Neoplasms; Neoplasm Proteins; RNA, Messenger; Tetrahydroisoquinolines; Transfection

2008
[Analysis of the effect of camptothecin as an adjunct treatment of primary liver cancer (author's transl)].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 1980, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Aged; Camptothecin; Carcinoma, Hepatocellular; Child; Child, Preschool; Female; Humans; Infant; Liver Neoplasms; Male; Middle Aged

1980
Induction of senescent cell-derived inhibitor of DNA synthesis gene, SDI1, in hepatoblastoma (HepG2) cells arrested in the G2-phase of the cell cycle by 9-nitrocamptothecin.
    Laboratory investigation; a journal of technical methods and pathology, 1995, Volume: 73, Issue:1

    Topics: Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA; G2 Phase; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1995
[Chinese material medica combined with cisplatin and lipiodol through transcatheter arterial embolization in the treatment of primary hepatoma].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1993, Volume: 13, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Cantharidin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cisplatin; Female; Hepatic Artery; Humans; Immunotherapy, Adoptive; Iodized Oil; Liver Neoplasms; Male; Middle Aged

1993
Chemotherapeutic agent CPT-11 induces the new expression of the apoptosis initiator to the cytoplasm.
    Experimental cell research, 1996, Aug-25, Volume: 227, Issue:1

    Topics: Amino Acid Sequence; Animals; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Caspase 1; Cell Extracts; Cell Nucleus; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Dactinomycin; DNA; Humans; Irinotecan; Liver; Liver Neoplasms; Male; Molecular Sequence Data; Oligopeptides; Protein Synthesis Inhibitors; Rats; Tumor Cells, Cultured

1996
Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32.
    The Journal of clinical investigation, 1996, Dec-01, Volume: 98, Issue:11

    Topics: Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Caspase 1; Caspase 3; Caspases; Cell Line; Cysteine Endopeptidases; Endopeptidases; Enzyme Inhibitors; Etoposide; Humans; Kinetics; Liver Neoplasms; Protease Inhibitors; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1996
4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) inhibits the intrahepatic spread of hepatocellular carcinoma and prolongs the life-span of tumor-bearing animals.
    Clinical & experimental metastasis, 1998, Volume: 16, Issue:7

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Benzoates; Body Weight; Camptothecin; Carcinoma, Hepatocellular; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Mice, Nude; Molecular Structure; Neoplasm Invasiveness; Proto-Oncogene Proteins c-met; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; Specific Pathogen-Free Organisms; Survival Rate; Trimethylsilyl Compounds; Tumor Cells, Cultured

1998
Chemotherapeutic agents augment TRAIL-induced apoptosis in human hepatocellular carcinoma cell lines.
    Hepatology (Baltimore, Md.), 2000, Volume: 32, Issue:3

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Carcinoma, Hepatocellular; Dactinomycin; Doxorubicin; Humans; Liver Neoplasms; Membrane Glycoproteins; NF-kappa B; Receptors, Tumor Necrosis Factor; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2000
Complete remission of unresectable hepatocellular carcinoma on healthy liver by the combination of aggressive surgery and high-dose-intensity chemotherapy by CPT-11.
    Anti-cancer drugs, 2000, Volume: 11, Issue:8

    Topics: alpha-Fetoproteins; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Combined Modality Therapy; DNA Topoisomerases, Type I; Female; Hepatectomy; Humans; Irinotecan; Liver Neoplasms; Middle Aged; Remission Induction

2000
Differential regulation of P53, c-Myc, Bcl-2, Bax and AFP protein expression, and caspase activity during 10-hydroxycamptothecin-induced apoptosis in Hep G2 cells.
    Anti-cancer drugs, 2000, Volume: 11, Issue:9

    Topics: alpha-Fetoproteins; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Camptothecin; Carcinoma, Hepatocellular; Caspase 1; Caspase 3; Caspases; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2000
Differentiation-inducing action of 10-hydroxycamptothecin on human hepatoma Hep G2 cells.
    Acta pharmacologica Sinica, 2000, Volume: 21, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Cell Differentiation; Humans; Liver Neoplasms; Proliferating Cell Nuclear Antigen; Telomerase; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2000
Relationship between lactone ring forms of HCPT and their antitumor activities.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:9

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Female; Humans; Lactones; Liver Neoplasms; Mice; Sarcoma 180; Tumor Cells, Cultured

2001
Differentiation of human hepatoma Hep G2 cells induced by 10-hydroxycamptothecin.
    Chinese medical journal, 2000, Volume: 113, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Cell Differentiation; Humans

2000
Effect of camptothecin and adriamycin on bleomycin-induced tritiated thymidine triphosphate incorporation in a rat nuclear system.
    Journal of the National Cancer Institute, 1977, Volume: 58, Issue:5

    Topics: Animals; Bleomycin; Camptothecin; Carcinoma, Hepatocellular; Cell Nucleus; DNA; DNA Repair; DNA, Neoplasm; Doxorubicin; Drug Interactions; In Vitro Techniques; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Rats; Thymidine Monophosphate; Thymine Nucleotides

1977
The effect of several antitumor agents on 3H-TTP incorporation in host liver and hepatoma nuclei.
    Oncology, 1977, Volume: 34, Issue:2

    Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Camptothecin; Carcinoma, Hepatocellular; Cell Nucleus; Daunorubicin; DNA; DNA, Neoplasm; DNA, Single-Stranded; Doxorubicin; In Vitro Techniques; Liver; Liver Neoplasms; Male; Mitomycins; Neoplasms, Experimental; Plicamycin; Rats; Thymidine

1977
[Preliminary study of traditional Chinese medicine-Western medicine treatment of patients with primary liver carcinoma].
    Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1989, Volume: 9, Issue:6

    Topics: Adjuvants, Immunologic; Adult; Camptothecin; Carcinoma, Hepatocellular; Cimetidine; Drugs, Chinese Herbal; Female; Fluorouracil; Humans; Levamisole; Liver Neoplasms; Male; Middle Aged

1989
The role of messenger RNA in tyrosine aminotransferase superinduction: effects of camptothecin on hepatoma cells in culture.
    Biochemical and biophysical research communications, 1974, Feb-04, Volume: 56, Issue:3

    Topics: Animals; Camptothecin; Carcinoma, Hepatocellular; Cells, Cultured; Dactinomycin; Deoxyadenosines; Enzyme Induction; Hydrocortisone; Insulin; Liver; Liver Neoplasms; Neoplasms, Experimental; Protein Biosynthesis; Rats; RNA, Messenger; Time Factors; Tyrosine Transaminase

1974
Partial characterization of the DNA-dependent DNA polymerases of rat liver and hepatoma.
    Cancer research, 1973, Volume: 33, Issue:5

    Topics: Animals; Camptothecin; Carcinoma, Hepatocellular; Cell Fractionation; Cell Nucleus; DNA Nucleotidyltransferases; DNA, Neoplasm; Dose-Response Relationship, Drug; Ethidium; Hydroxymercuribenzoates; Liver; Liver Neoplasms; Male; Mitochondria, Liver; Rats; Sodium Chloride; Templates, Genetic; Tritium

1973