Page last updated: 2024-08-22

camptothecin and Genome Instability

camptothecin has been researched along with Genome Instability in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	11 (28.21)	29.6817
2010's	24 (61.54)	24.3611
2020's	4 (10.26)	2.80

Authors

Authors	Studies
He, BM; Lei, L; Li, X; Liu, ZQ; Luo, C; Mei, C; Tan, LM; Xu, XJ; Yin, JY; Zhang, W; Zhou, HH	1
Gao, Y; Hua, Y; Mao, S; Shi, R; Song, S; Tian, B; Wang, L; Wang, Y; Xiao, Y; Xu, H; Xu, X; Zhao, Y	1
Al-Natour, Z; Chalissery, J; Hassan, AH	1
Choi, SY; Kang, HJ; Kwon, HM; Lee-Kwon, W; Ye, BJ	1
Korbel, JO; Mardin, BR; Onishi-Seebacher, M; Segura-Wang, M; Stütz, AM	1
Huang, SN; Jinks-Robertson, S; Pommier, Y; Sloan, R	1
Chen, G; Chen, J; Li, T; Liu, W; Liu, X; Qiao, Y; Shi, X; Shi, Y; Sun, Y; Wan, J; Wang, F; Wang, H; Xie, H; Xie, T; Zeng, Q; Zhou, L	1
Andrews, JF; Gassman, NR; Sobol, RW; Sonavane, M; Sykora, P	1
Alfano, L; Altieri, A; Bini, L; Caporaso, A; Dell'Aquila, M; Giordano, A; Landi, C; Pentimalli, F	1
Cristini, A; Favre, G; Faye, JC; Guirouilh-Barbat, J; Lemarié, A; Lopez, BS; Mamouni, K; Monferran, S; Sordet, O	1
Asaithamby, A; Bhattacharya, S; Chen, DJ; Kobayashi, J; Mori, E; Mukherjee, S; Su, F; Yang, Y; Yannone, SM	1
Chen, Y; Lai, Y; Li, X; Nan, A; Xiao, Y	1
Andersen, SL; Jinks-Robertson, S; Petes, TD; Sloan, RS	1
Aguilera, A; García-Rodríguez, N; Stuckey, R; Wellinger, RE	1
Franchitto, A; Iannascoli, C; Murfuni, I; Palermo, V; Pichierri, P	1
Kim, N; Owiti, N; Yadav, P	1
Johnstone, E; Kerr, D; Midgley, R; Swanton, C; Tomlinson, I; Walther, A	1
Takeda, S; Takenaka, K; Wang, X	1
Baulch, JE; Dziegielewski, J; Goetz, W; Grdina, DJ; Morgan, WF; Murley, JS	1
Lenz, HJ; Winder, T	1
Choudhary, C; Jackson, SP; Kaidi, A; Weinert, BT	1
Adamson, B; Bredemeyer, AL; Ciccia, A; Elledge, SJ; Gygi, SP; Harper, JW; Lydeard, JR; O'Connell, BC; Schlabach, M; Sowa, ME	1
Lou, H; Lu, X; Luo, G	1
Blain, SW; Ye, W	1
Cavenee, WK; Furnari, FB; Huang, JW; Li, M; Mitchell, PS; Taniguchi, T; Tewari, M; Wang, Y; Zhou, X	1
Bohr, VA; Frøhlich, R; Patro, BS; Stevnsner, T	1
Bellot, GL; Koh, D; Tan, WH; Tay, LL; Wang, X	1
Dray, E; Fox, D; Islam, MN; Klein, H; Paquet, N; Sung, P; Wang, W; Zheng, XF	1
Burma, S; Costelloe, T; Dubois, K; Khadaroo, B; Llorente, B; Louge, R; Martini, E; Mukherjee, B; Thierry, A; Tomimatsu, N; van Attikum, H; Wiegant, WW	1
Boige, V; Borrini, F; Ducreux, M; Fallik, D; Jacob, S; Miquel, C; Praz, F; Sabourin, JC; Viguier, J	1
Grem, JL	1
Kusano, K; Maeda, T; Ogawa, HI; Ohba, H; Usui, T; Yamana, Y	1
Dendouga, N; Gao, H; Janicot, M; McGowan, CH; Moechars, D; Vialard, J	1
Cordell, HJ; Johnson, RT; Leonard, JC; Mullinger, AM; Schmidt, J	1
Bertrand, P; Boudsocq, F; Canitrot, Y; Capp, JP; Cazaux, C; Hoffmann, JS; Laroche-Clary, A; Lopez, BS; Pourquier, P	1
Bonner, WM; Dhar, PK; Kikuchi, K; Kohzaki, M; Nakano, A; Nakayama, T; Pilch, DR; Redon, C; Sonoda, E; Takami, Y; Takeda, S; Watanabe, M; Zhao, GY	1
Hatanaka, A; Kikuchi, K; Kohzaki, M; Sale, JE; Shinagawa, H; Sonoda, E; Szüts, D; Takeda, S; Vu Trung, N; Watanabe, M; Yamazoe, M	1
Bernal, JA; Espina, A; Méndez-Vidal, C; Pintor-Toro, JA; Roche, M; Tortolero, M	1
Boubriak, I; Clancy, DJ; Cox, LS; Saunders, RD	1

Reviews

5 review(s) available for camptothecin and Genome Instability

Article	Year
The role of single strand break repair pathways in cellular responses to camptothecin induced DNA damage. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 125 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Survival; DNA Breaks, Single-Stranded; DNA Damage; DNA Repair; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Genomic Instability; Humans; Protein Binding; Signal Transduction; Topoisomerase I Inhibitors	2020
Genetic prognostic and predictive markers in colorectal cancer. Nature reviews. Cancer, 2009, Volume: 9, Issue:7 Topics: beta Catenin; Biomarkers, Tumor; Camptothecin; Capecitabine; Chromosomes, Human, Pair 18; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Gene Expression Profiling; Genes, APC; Genes, p53; Genomic Instability; Humans; Irinotecan; Microsatellite Instability; Mutation; Organoplatinum Compounds; Oxaliplatin; Pharmacogenetics; Prognosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); ras Proteins	2009
Molecular predictive and prognostic markers in colon cancer. Cancer treatment reviews, 2010, Volume: 36, Issue:7 Topics: Camptothecin; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); ErbB Receptors; Genes, ras; Genomic Instability; Humans; Irinotecan; Loss of Heterozygosity; Organoplatinum Compounds; Oxaliplatin; Polymorphism, Genetic; Prognosis; Thymidylate Synthase	2010
A Blm-Recql5 partnership in replication stress response. Journal of molecular cell biology, 2011, Volume: 3, Issue:1 Topics: Camptothecin; DNA Damage; DNA Replication; Genomic Instability; Humans; RecQ Helicases; Sister Chromatid Exchange; Topoisomerase Inhibitors	2011
Intratumoral molecular or genetic markers as predictors of clinical outcome with chemotherapy in colorectal cancer. Seminars in oncology, 2005, Volume: 32, Issue:1 Topics: Antineoplastic Agents; Camptothecin; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Genes, p53; Genes, ras; Genomic Instability; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Prodrugs; Thymidylate Synthase	2005

Other Studies

34 other study(ies) available for camptothecin and Genome Instability

Article	Year
Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability. American journal of physiology. Cell physiology, 2020, 10-01, Volume: 319, Issue:4 Topics: Camptothecin; Cell Cycle Proteins; DNA Damage; DNA Repair; DNA Replication; Exonucleases; Flap Endonucleases; Genome, Human; Genomic Instability; Humans; Hydroxyurea; Mitomycin; Multiprotein Complexes; Proliferating Cell Nuclear Antigen; Protein Processing, Post-Translational; Succinic Acid; SUMO-1 Protein; Sumoylation; Ultraviolet Rays	2020
Fun30 chromatin remodeler helps in dealing with torsional stress and camptothecin-induced DNA damage. Yeast (Chichester, England), 2021, Volume: 38, Issue:2 Topics: Camptothecin; Chromatin; Chromatin Assembly and Disassembly; DNA Damage; DNA, Fungal; Genomic Instability; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Stress, Physiological; Torsion, Mechanical; Transcription Factors	2021
PARP1-mediated PARylation of TonEBP prevents R-loop-associated DNA damage. DNA repair, 2021, Volume: 104 Topics: Camptothecin; Cell Line; DNA; DNA Damage; DNA Replication; DNA, Single-Stranded; Genomic Instability; HEK293 Cells; Hep G2 Cells; Humans; Poly (ADP-Ribose) Polymerase-1; Poly ADP Ribosylation; R-Loop Structures; Transcription Factors; Transcription, Genetic	2021
Systematic Identification of Determinants for Single-Strand Annealing-Mediated Deletion Formation in G3 (Bethesda, Md.), 2017, 10-05, Volume: 7, Issue:10 Topics: Camptothecin; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Fungal; DNA, Single-Stranded; Doxorubicin; Gene Expression Profiling; Genomic Instability; Hydroxyurea; Methyl Methanesulfonate; Mutagens; Mutation; Nucleic Acid Synthesis Inhibitors; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors	2017
Effects of camptothecin or TOP1 overexpression on genetic stability in Saccharomyces cerevisiae. DNA repair, 2017, Volume: 59 Topics: Camptothecin; DNA Damage; DNA Topoisomerases, Type I; DNA, Fungal; DNA, Ribosomal; Gene Expression Regulation, Fungal; Genomic Instability; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins	2017
ZNF830 mediates cancer chemoresistance through promoting homologous-recombination repair. Nucleic acids research, 2018, 02-16, Volume: 46, Issue:3 Topics: Animals; Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Binding Sites; Camptothecin; Carrier Proteins; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA, Neoplasm; Drug Resistance, Neoplasm; Endodeoxyribonucleases; Epithelial Cells; Female; Genomic Instability; Humans; Hydroxyurea; Kruppel-Like Transcription Factors; Lung Neoplasms; Mice; Mice, Nude; Nuclear Proteins; Osteoblasts; Phosphorylation; Protein Binding; Recombinational DNA Repair; Stomach Neoplasms; Survival Analysis; Xenograft Model Antitumor Assays	2018
Camptothecin Efficacy to Poison Top1 Is Altered by Bisphenol A in Mouse Embryonic Fibroblasts. Chemical research in toxicology, 2018, 06-18, Volume: 31, Issue:6 Topics: Animals; Antineoplastic Agents, Phytogenic; Benzhydryl Compounds; Camptothecin; Cell Nucleus; Cell Survival; DNA; DNA Adducts; DNA Breaks, Double-Stranded; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Fibroblasts; Genomic Instability; Mice; Phenols; Topoisomerase I Inhibitors	2018
Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation. Nucleic acids research, 2019, 05-07, Volume: 47, Issue:8 Topics: Antineoplastic Agents; Camptothecin; Checkpoint Kinase 1; Chromatin; DNA; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA, Single-Stranded; Genome, Human; Genomic Instability; HeLa Cells; Heterogeneous Nuclear Ribonucleoprotein D0; Heterogeneous-Nuclear Ribonucleoprotein D; Heterogeneous-Nuclear Ribonucleoprotein U; Histones; Humans; Nucleic Acid Conformation; Nucleic Acid Hybridization; Phosphorylation; Phthalazines; Piperazines; Recombinational DNA Repair; Replication Protein A; Ribonuclease H; RNA Polymerase II; RNA, Small Interfering	2019
RhoB promotes γH2AX dephosphorylation and DNA double-strand break repair. Molecular and cellular biology, 2014, Volume: 34, Issue:16 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Checkpoint Kinase 2; Chromosome Aberrations; DNA Breaks, Double-Stranded; DNA Repair; ELAV Proteins; Genomic Instability; HCT116 Cells; Histones; Humans; Mice; Mice, Knockout; Phosphorylation; Protein Binding; Protein Phosphatase 2; rhoB GTP-Binding Protein; RNA Interference; RNA-Binding Proteins; RNA, Small Interfering; Topoisomerase I Inhibitors	2014
Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress. Cell reports, 2014, Nov-20, Volume: 9, Issue:4 Topics: Animals; Camptothecin; Cell Cycle Proteins; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; DNA; DNA Breaks, Double-Stranded; DNA Replication; DNA-Binding Proteins; Exodeoxyribonucleases; Genomic Instability; Humans; Mice; Models, Biological; MRE11 Homologue Protein; Nuclear Proteins; Protein Transport; Rad51 Recombinase; RecQ Helicases; Replication Protein A; Stress, Physiological; Structure-Activity Relationship; Werner Syndrome Helicase	2014
PP2A-B56ϵ complex is involved in dephosphorylation of γ-H2AX in the repair process of CPT-induced DNA double-strand breaks. Toxicology, 2015, May-04, Volume: 331 Topics: Active Transport, Cell Nucleus; Camptothecin; Cell Cycle; Cell Proliferation; DNA Breaks, Double-Stranded; DNA Repair; Dose-Response Relationship, Drug; Genomic Instability; HEK293 Cells; Histones; Humans; Phosphorylation; Protein Phosphatase 2; RNA Interference; Signal Transduction; Time Factors; Topoisomerase I Inhibitors; Transfection	2015
Genome-destabilizing effects associated with top1 loss or accumulation of top1 cleavage complexes in yeast. PLoS genetics, 2015, Volume: 11, Issue:4 Topics: Camptothecin; Crossing Over, Genetic; DNA Topoisomerases, Type I; Genome, Fungal; Genomic Instability; Mutation; RNA, Ribosomal; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Topoisomerase I Inhibitors	2015
Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system. Proceedings of the National Academy of Sciences of the United States of America, 2015, May-05, Volume: 112, Issue:18 Topics: Bacterial Proteins; Camptothecin; Carcinogenesis; Cell Cycle; Cell Separation; Chromosomes; DNA; DNA Copy Number Variations; DNA Replication; DNA, Ribosomal; Electrophoresis, Gel, Two-Dimensional; Flow Cytometry; Gene Dosage; Genomic Instability; Humans; Hydroxyurea; Luminescent Proteins; Methyl Methanesulfonate; Mutation; Replication Origin; Ribonuclease H; RNA; Saccharomyces cerevisiae	2015
The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation. Nucleic acids research, 2015, Nov-16, Volume: 43, Issue:20 Topics: Camptothecin; Cell Line, Transformed; DNA Helicases; DNA Replication; DNA-Binding Proteins; DNA, Single-Stranded; Exodeoxyribonucleases; Genomic Instability; Humans; Mutation; Poly(ADP-ribose) Polymerases; Protein Structure, Tertiary; RecQ Helicases; Topoisomerase I Inhibitors	2015
The role of topoisomerase I in suppressing genome instability associated with a highly transcribed guanine-rich sequence is not restricted to preventing RNA:DNA hybrid accumulation. Nucleic acids research, 2016, Jan-29, Volume: 44, Issue:2 Topics: Camptothecin; DNA Replication; DNA Topoisomerases, Type I; DNA, Fungal; Escherichia coli Proteins; G-Quadruplexes; Genetic Complementation Test; Genomic Instability; Guanine; Immunoglobulin Switch Region; Nucleic Acid Hybridization; Recombination, Genetic; Ribonuclease H; RNA, Fungal; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic	2016
PTIP promotes DNA double-strand break repair through homologous recombination. Genes to cells : devoted to molecular & cellular mechanisms, 2010, Volume: 15, Issue:3 Topics: Animals; B-Lymphocytes; Camptothecin; Carrier Proteins; Chickens; Diketopiperazines; DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Gene Knockdown Techniques; Genomic Instability; HeLa Cells; Homologous Recombination; Humans; Molecular Sequence Data; Nuclear Proteins; Piperazines; Topoisomerase Inhibitors	2010
Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells. Radiation research, 2010, Volume: 173, Issue:2 Topics: Amifostine; Animals; Camptothecin; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; DNA-Binding Proteins; Genomic Instability; Humans; Hydroxyurea; Mercaptoethylamines; Rad51 Recombinase; Radiation-Protective Agents; Reactive Oxygen Species; Recombination, Genetic; RNA Interference	2010
RETRACTED: Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science (New York, N.Y.), 2010, 09-10, Volume: 329, Issue:5997 Topics: Acetylation; Animals; Camptothecin; Carrier Proteins; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; DNA; DNA Breaks, Double-Stranded; DNA Repair; DNA, Single-Stranded; Endodeoxyribonucleases; Genomic Instability; Humans; Mice; Mutant Proteins; Niacinamide; Nuclear Proteins; Protein Binding; Recombination, Genetic; Sirtuins	2010
A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Molecular cell, 2010, Nov-24, Volume: 40, Issue:4 Topics: Camptothecin; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; DNA-Directed DNA Polymerase; Drug Resistance, Neoplasm; Genetic Testing; Genome, Human; Genomic Instability; HeLa Cells; Histones; Humans; Intracellular Signaling Peptides and Proteins; Multienzyme Complexes; NF-kappa B; Nuclear Proteins; Phosphorylation; Protein Binding; Recombination, Genetic; Replication Protein A; Reproducibility of Results; RNA, Small Interfering; Stress, Physiological; Tumor Suppressor p53-Binding Protein 1	2010
Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage. Apoptosis : an international journal on programmed cell death, 2011, Volume: 16, Issue:5 Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Caffeine; Camptothecin; Cell Cycle Proteins; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebral Cortex; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; DNA-Binding Proteins; Female; Genes, p53; Genomic Instability; Neurons; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tumor Suppressor Proteins	2011
MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression. Molecular cancer research : MCR, 2011, Volume: 9, Issue:8 Topics: Camptothecin; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Survival; Cisplatin; DNA Damage; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Genomic Instability; HeLa Cells; Humans; MicroRNAs; Neoplasms; Nuclear Proteins; Radiation, Ionizing; RNA-Binding Proteins; Stress, Physiological	2011
WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes. Journal of cell science, 2011, Dec-01, Volume: 124, Issue:Pt 23 Topics: Ataxia Telangiectasia Mutated Proteins; Camptothecin; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Chromatin; Chromatin Immunoprecipitation; DNA Damage; DNA Replication; DNA, Single-Stranded; Exodeoxyribonucleases; Gene Expression Regulation, Enzymologic; Gene Knockdown Techniques; Genomic Instability; Humans; Hydroxyurea; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; RecQ Helicases; RNA, Small Interfering; S Phase Cell Cycle Checkpoints; Topoisomerase I Inhibitors; Werner Syndrome Helicase	2011
Reliability of tumor primary cultures as a model for drug response prediction: expression profiles comparison of tissues versus primary cultures from colorectal cancer patients. Journal of cancer research and clinical oncology, 2012, Volume: 138, Issue:3 Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cisplatin; Colorectal Neoplasms; Deoxycytidine; Down-Regulation; Doxorubicin; Etoposide; Floxuridine; Fluorescent Antibody Technique; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomic Instability; Humans; Irinotecan; Metaphase; Paclitaxel; Polymerase Chain Reaction; Predictive Value of Tests; Protein Array Analysis; Reproducibility of Results; Tegafur; Tissue Array Analysis; Tumor Cells, Cultured; Up-Regulation; Uracil	2012
A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization. The Journal of biological chemistry, 2012, Jul-06, Volume: 287, Issue:28 Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; BRCA2 Protein; Camptothecin; Cell Line, Tumor; DNA Replication; Genomic Instability; HEK293 Cells; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Protein Structure, Tertiary; Rad51 Recombinase; Recombination, Genetic; RecQ Helicases; Sequence Homology, Amino Acid	2012
The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection. Nature, 2012, Sep-27, Volume: 489, Issue:7417 Topics: Camptothecin; Cell Line; Cell Survival; Chromatin Assembly and Disassembly; DNA; DNA Breaks, Double-Stranded; DNA Helicases; DNA Repair; Exodeoxyribonucleases; Genomic Instability; Histones; Homologous Recombination; Humans; Mutation; Nucleosomes; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors	2012
Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. Cancer research, 2003, Sep-15, Volume: 63, Issue:18 Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Base Pair Mismatch; bcl-2-Associated X Protein; Camptothecin; Carrier Proteins; Colorectal Neoplasms; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Exons; Female; Gene Deletion; Genomic Instability; Humans; Irinotecan; Male; Middle Aged; Mismatch Repair Endonuclease PMS2; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; Predictive Value of Tests; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2	2003
Regulation of homologous integration in yeast by the DNA repair proteins Ku70 and RecQ. Molecular genetics and genomics : MGG, 2005, Volume: 273, Issue:2 Topics: Camptothecin; DNA Helicases; DNA Primers; DNA Repair; DNA-Binding Proteins; Gene Targeting; Genomic Instability; Mutation; Plasmids; Recombination, Genetic; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins	2005
Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Molecular and cellular biology, 2005, Volume: 25, Issue:17 Topics: Animals; Camptothecin; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; DNA Damage; DNA-Binding Proteins; Endonucleases; Fibroblasts; Genomic Instability; Mice; Rad51 Recombinase; Saccharomyces cerevisiae Proteins	2005
Genome instability in ataxia telangiectasia (A-T) families: camptothecin-induced damage to replicating DNA discriminates between obligate A-T heterozygotes, A-T homozygotes and controls. Bioscience reports, 2004, Volume: 24, Issue:6 Topics: Ataxia Telangiectasia; Camptothecin; Cell Line; DNA Damage; DNA Repair; DNA Replication; Genomic Instability; Heterozygote; Homozygote; Humans; In Situ Hybridization, Fluorescence; In Vitro Techniques; Lymphocytes; Mutation	2004
The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells. Nucleic acids research, 2006, Volume: 34, Issue:10 Topics: Animals; Base Sequence; Camptothecin; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Damage; DNA Polymerase beta; DNA Repair; DNA-Directed DNA Polymerase; Genomic Instability; Molecular Sequence Data; Mutation; Radiation, Ionizing; Recombination, Genetic; Saccharomyces cerevisiae Proteins	2006
Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair. DNA repair, 2007, Mar-01, Volume: 6, Issue:3 Topics: Animals; Avian Proteins; Camptothecin; Cells, Cultured; Chickens; DNA Damage; DNA Repair; DNA-Binding Proteins; Enzyme Inhibitors; Gamma Rays; Genomic Instability; Histones; Models, Genetic; Rad51 Recombinase; Recombination, Genetic; Transfection	2007
Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse. Molecular and cellular biology, 2007, Volume: 27, Issue:8 Topics: Adenosine Triphosphatases; Animals; Camptothecin; Chickens; Cisplatin; Crossing Over, Genetic; DNA Damage; DNA Helicases; DNA Replication; DNA-Binding Proteins; Fanconi Anemia Complementation Group C Protein; Gamma Rays; Gene Deletion; Gene Targeting; Genomic Instability; Methyl Methanesulfonate; Models, Genetic; Molecular Sequence Data; Mutation; RecQ Helicases; Ultraviolet Rays; Vertebrates	2007
Proliferative potential after DNA damage and non-homologous end joining are affected by loss of securin. Cell death and differentiation, 2008, Volume: 15, Issue:1 Topics: Base Sequence; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromosome Aberrations; DNA; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Doxorubicin; Genomic Instability; Humans; Molecular Sequence Data; Neoplasm Proteins; RNA, Small Interfering; Securin	2008
Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity. Aging cell, 2008, Volume: 7, Issue:3 Topics: Alleles; Amino Acid Sequence; Animals; Camptothecin; Drosophila melanogaster; Exodeoxyribonucleases; Genomic Instability; Humans; Molecular Sequence Data; Mutation; Protein Conformation; Protein Structure, Tertiary; Recombination, Genetic; RecQ Helicases; Sequence Alignment; Sequence Homology, Amino Acid; Werner Syndrome; Werner Syndrome Helicase	2008