camptothecin has been researched along with Disease Models, Animal in 163 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.23) | 18.7374 |
| 1990's | 10 (6.13) | 18.2507 |
| 2000's | 54 (33.13) | 29.6817 |
| 2010's | 82 (50.31) | 24.3611 |
| 2020's | 15 (9.20) | 2.80 |
| Authors | Studies |
|---|---|
| Bordignon, A; Cieckiewicz, E; Di Giovanni, N; Frédérich, M; Hoareau, F; Illien, B; Jansen, O; Ledoux, A; Marvilliers, A; Pendeville, H; Quetin-Leclercq, J; St-Gelais, A | 1 |
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Abu, YF; Chen, C; Meng, J; Ramakrishnan, S; Roy, S; Tao, J; Xie, Y; Yan, Y; Zhang, Y; Zhou, Y | 1 |
| Chen, Y; Du, C; Jiang, X; Li, S; Luo, Y; Wang, Y; Wu, L; Xie, Y; Zhang, R | 1 |
| Chen, Y; Gao, Y; Hu, X; Li, C; Li, L; Ren, Z; Tong, W; Wang, J; Wang, X; Yao, W; Zhang, P | 1 |
| Agatsuma, T; Iwata, TN; Sugihara, K; Wada, T | 1 |
| Brenner, AJ; Chiou, J; Gruslova, A; Pandey, R; Tiziani, S | 1 |
| Chen, J; Du, D; Liu, C; Wu, Y | 1 |
| Abe, S; Hatano, A; Ikeda, Y; Izumi, T; Miyamoto, L; Okuno, H; Tsuchihashi, Y; Tsuchiya, K; Tsunematsu, H; Yamane, M; Yasuoka, T | 1 |
| Li, QY; Qi, L; Xiao, LX; Yu, ED; Yue, HL; Zhang, XL; Zhou, YQ | 1 |
| Bou, LB; Cochran, JH; Emmerton, KK; Farr, LM; Jeffrey, SC; Jin, S; Lau, UY; Lyski, RD; Meyer, DW; Okeley, NM; Ortiz, DJ; Ryan, MC; Senter, PD; Simmons, JK; Snead, KM; Trueblood, ES; Zapata, F; Zaval, MC | 1 |
| Gilkeson, GS; Helke, KL; Oates, JC; Wang, X; Zhang, XK | 1 |
| Botella, P; Checa-Chavarria, E; Fernández, E; Martinez Navarrete, G; Rivero-Buceta, E; Sanchez Martos, MA; Soto-Sánchez, C | 1 |
| Gao, Y; Yin, M; Zeng, X; Zhang, H; Zhang, J | 1 |
| Hamada, A; Hasegawa, K; Jikoh, T; Nishikawa, T; Ogitani, Y; Ohuchi, M; Sugihara, K; Suzuki, M; Tamura, K; Teishikata, T; Yagishita, S; Yatabe, Y; Yonemori, K | 1 |
| Chen, T; Jiang, Y; Li, G; Liu, K; Qi, Z; Wang, Y; Xiao, H; Yu, W | 1 |
| Chen, J; Han, W; Lambesis, KT; Le, KT; Little, N; Lu, J; Scott, AJ; Wang, Z | 1 |
| Kandasamy, R; Natesan, S; Palanichamy, R; Ponnusamy, C; Sugumaran, A; Thiagarajan, V | 1 |
| Allan, S; Byrne, JA; Cheung, L; Eden, GL; Flemming, CL; Fletcher, JI; Gamble, LD; Gifford, AJ; Haber, M; Hanssen, KM; Henderson, MJ; Murray, J; Norris, MD; Ruhle, M; Saletta, F; Schuetz, JD; Tan, A; Tivnan, A; Truong, AM; Valli, E; Yu, DMT | 1 |
| He, W; Hu, X; Jiang, W; Li, Z; Liu, R; Luan, Y; Zhang, D; Zhang, J | 1 |
| Ebadi, M; Field, CJ; Lehner, R; Mazurak, VC | 1 |
| Agatsuma, T; Ishida, S; Ishii, C; Iwata, TN; Ogitani, Y; Wada, T | 1 |
| Dong, Z; Guo, Y; Han, M; Wang, T; Wang, X; Wang, Y; Zhao, S | 1 |
| Chen, Q; Han, MK; Kang, Y; Merlin, D; Viennois, E; Wan, Y; Wang, L; Xiao, B; Zhang, Y; Zhang, Z | 1 |
| Dong, Z; Guo, Y; Han, M; Qiu, H; Wang, T; Wang, X; Wang, Y | 1 |
| Chen, H; Du, W; Li, G; Li, M; Liang, X; Yang, W; Zhang, C; Zhang, W | 1 |
| Ahmad, E; Dai, Z; Gan, Y; Guo, S; He, S; Li, Y; Miao, Y; Shi, X; Song, W; Tian, F; Wang, R; Wu, Z; Yi, X; Yu, M; Zhang, X; Zhu, C | 1 |
| Guo, Q; Liu, J; Ni, B; Yang, J; Zhou, W; Zhu, L | 1 |
| Allen, TM; Anantha, M; Bally, MB; Dos Santos, N; Harasym, N; Hare, JI; Neijzen, RW; Waterhouse, DN; Webb, MS | 1 |
| Fu, Z; Wang, X; Yin, H; Zhang, X | 1 |
| Ebara, K; Ichimura, E; Miyakawa, Y; Miyazaki, O; Morino, T; Nagai, D; Nakajima, N; Okamoto, K; Onda, T; Sekine, K | 1 |
| Jie, J; Liu, Z; Tian, B; Yang, Y; Zhang, X; Zhou, M | 1 |
| Hasegawa, M; Hattori, S; Ide, H; Kikuchi, E; Miyajima, A; Oya, M; Yasumizu, Y | 1 |
| Boelsterli, UA; Mani, S; Redinbo, MR | 1 |
| D'Incalci, M; Grohar, PJ; Helman, LJ; Mendoza, A; Pommier, Y; Segars, LE; Yeung, C | 1 |
| Dou, W; Hu, J; Sun, J; Zhao, Y | 1 |
| Benković, V; Blažević, AS; Knežević, AH; Lisičić, D; Mihaljević, J; Oršolić, N; Ðikić, D | 1 |
| Chen, YL; Chiang, JH; Chueh, FS; Chung, JG; Hsueh, SC; Lee, CS; Lu, CC; Lu, HF; Yang, JS | 1 |
| Fujii, H; Horie, H; Inoue, T; Kotake, K; Miyakura, Y; Sato, F; Sugano, K; Tahara, M; Yasuda, Y | 1 |
| Guo, X; Han, J; Hou, ZQ; Wang, YG | 1 |
| Kanazawa, T; Morisaki, K; Suzuki, S; Takashima, Y | 1 |
| Cai, J; Chen, H; Feng, X; He, J; Hu, J; Li, X; Liang, Y; Sun, Y; Sun, Z; Wang, J; Xiao, H; Xiong, C; Yan, L; Yu, H | 1 |
| Doherty, GA; Lee, CS; Ryan, EJ | 1 |
| Ahmad, S; Kong, R; Liu, T; Phan, AT; Scott, JE; Williams, AL; Wong, ST; Yeh, LA; Zhao, H; Zhu, X | 1 |
| Hongeng, S; Manaspon, C; Nasongkla, N; Nittayacharn, P | 1 |
| Anantha, M; Bally, MB; Harasym, N; Manisali, I; Masin, D; Osooly, M; Ostlund, C; Santos, ND; Strutt, D; Sutherland, BW; Waterhouse, DN; Webb, MS; Wehbe, M | 1 |
| Aragão, KS; Costa, ML; de Almeida, PR; de Castro Brito, GA; de Mesquita Neto, JW; de Sá Grassi, L; de Souza, MH; Leite, LL; Lima-Júnior, RC; Marques-Neto, RD; Medeiros, RP; Nunes, LG; Ribeiro, RA | 1 |
| Al-Azri, AR; Bowen, JM; Gibson, RJ; Keefe, DM; Logan, RM; Stringer, AM | 1 |
| Hayashi, A; Higashi, Y; Hori, Y; Kishimoto, K; Maeda, N; Morii, E; Ohashi, F; Osuga, K; Tanaka, K; Tomiyama, N | 1 |
| Choi, KC; Kim, SU; Yi, BR | 1 |
| Alferiev, IS; Brodeur, GM; Chorny, M; Croucher, JL; Iyer, R; Kolla, V; Levy, RJ; Mangino, JL | 1 |
| Bellemann, N; Gnutzmann, DM; Gockner, TL; Kauczor, HU; Köhler, K; Kortes, N; Krone, D; Mechel, J; Mokry, T; Radeleff, BA; Schmitz, A; Sommer, CM; Stampfl, U | 1 |
| Hakamada, K; Hui, FM; Kijima, H; Kudo, D; Miura, T; Morohashi, S; Nanashima, N; Sawano, T; Shimizu, T; Tsuchida, S; Yamada, T | 1 |
| Chen, TC; Golden, EB; Gong, A; Hofman, FM; Howard, A; Jhaveri, N; Louie, SG; Schönthal, AH; Sivakumar, W; Torres, S; Vaikari, VP; Wang, W | 1 |
| Calderon, RI; Cruz, RE; Drummond, DC; Fitzgerald, JB; Hall, CP; Hindle, A; Kang, MH; Ko, W; Lee, JS; Makena, MR; Paz, N; Reynolds, CP; Song, MM; Triche, TJ; Wang, J | 1 |
| Frese, S; Frese-Schaper, M; Keil, A; Körner, M; Schmid, RA; Steiner, SK | 1 |
| Atyabi, F; Dinarvand, M; Dinarvand, R; Esmaeili, A; Kiani, M; Mirzaie, Z; Mirzazadeh, F; Soleimani, M | 1 |
| Bernardi, R; Coltella, N; Ponente, M; Ponzoni, M; Valsecchi, R | 1 |
| Bijman-Lagcher, W; de Bruin, RW; Huisman, SA; IJzermans, JN; Smits, R | 1 |
| Guo, GL; Schumacher, JD | 1 |
| Adkins, CE; Eldon, MA; Hoch, U; Hye, T; Lockman, PR; Mohammad, AS; Mohan, NK; Nounou, MI; Terrell-Hall, T | 1 |
| Abe, Y; Ashida, S; Honda, T; Kasuya, Y; Masuda, T; Miyazaki, H; Morita, K; Naito, H; Nakada, T; Ogitani, Y; Yamaguchi, J; Yoshida, M | 1 |
| Alfranca, G; Cui, D; de la Fuente, JM; Jiang, X; Pan, F; Yang, Y; Yue, C; Zhang, C | 1 |
| Arantes, RM; Bastos, RW; Cardoso, VN; Cartelle, CT; França, CS; Generoso, SV; Martins, FS; Moreira, LM; Neves, MJ; Nicoli, JR; Pedroso, SH; Vieira, AT | 1 |
| Bardelli, A; Bonaldi, T; Cancelliere, C; Conte, A; Cuomo, A; Di Fiore, PP; Magni, E; Penna, G; Pozzi, C; Ravenda, PS; Rescigno, M; Sigismund, S; Silvola, A; Spadoni, I; Zampino, MG | 1 |
| Cardillo, TM; Chang, CH; Goldenberg, DM; Liu, D; Wang, Y; Zalath, M | 1 |
| Dai, B; Fleming, JB; Kang, Y; Li, X; Perez, MVR; Pratt, M; Roife, D | 1 |
| Caron, NS; Deng, Y; Ehrnhoefer, DE; Hayden, MR; Qiu, X; Tsang, M | 1 |
| Guo, B; Qian, SY; Sun, M; Yang, X; Zhang, Q | 1 |
| Huang, YC; Lee, WH; Liu, SC; Liu, SJ; Su, CH; Tseng, YY; Wang, YC; Yang, ST | 1 |
| Baumgart, JT; Edessa, LD; Helman, LJ; Heske, CM; Lee, S; Mendoza, A; Neckers, L; Proia, DA; Trepel, J | 1 |
| Krishnan, V; Liem, N; Peethala, PC; Subhash, VV; Tan, SH; Yan, FL; Yeo, MS; Yong, WP | 1 |
| Frese, S; Hall, SR; Herrmann, M; Keil, A; Körner, M; Schmid, RA | 1 |
| Carter, KA; Geng, J; Lovell, JF; Luo, D; Ortega, J; Razi, A; Shao, S | 1 |
| Aragão, KS; da Silveira Bitencourt, F; de Alencar, NM; de Castro Brito, GA; de Figueiredo, IS; de Freitas, AP; Lima-Júnior, RC; Luz, PB; Magalhães, PJ; Ramos, MV; Ribeiro, RA | 1 |
| Bosserhoff, A; Dietrich, P; Hellerbrand, C; Koch, A; Lee, S; Luehrmann, A; Mahli, A; Müller, M; Saugspier, M; Schulze-Luehrmann, J; Sommer, J; Thasler, R; Thasler, WE | 1 |
| Hormozi, L; Parker, L; Song, J; Tanouye, MA | 1 |
| He, QJ; Lu, W; Luo, PH; Tu, CX; Wu, HH; Yang, B; Yang, XC; Zhou, XL; Zhu, DF; Zhu, H | 1 |
| Bernheim, J; Buchbut, D; Goldiner, I; Inbar, M; Ish-Shalom, M; Keizman, D; Klein, B; Konikoff, F; Leikin-Frenkel, A; Maimon, N | 1 |
| Simanek, EE; Venditto, VJ | 1 |
| Baltes, S; Brinker, T; Freund, I; Lewis, AL; Nolte, I | 1 |
| Hasegawa, G; Hoffman, RM; Iijima, H; Ishihara, Y; Kobayashi, T; Matsunaga, K; Sato, A; Suzuki, T; Yang, M | 1 |
| Bankiewicz, KS; Berger, MS; Bringas, JR; Dickinson, PJ; Drummond, DC; Forsayeth, J; Higgins, RJ; Kirpotin, DB; Krauze, MT; Larson, RF; LeCouteur, RA; Noble, CO; Park, JW; Yamashita, Y | 1 |
| Basse, PH; Donnelly, MK; Eiseman, JL; Joseph, E; Parise, RA; Rice, PM; Shurer, J; Strychor, S; Tonda, ME; Yu, NY; Zamboni, BA; Zamboni, WC | 1 |
| Becherini, P; Cilli, M; Emionite, L; Greenberger, LM; Horak, ID; Loi, M; Pastorino, F; Ponzoni, M; Ribatti, D; Sapra, P | 1 |
| Kenmotsu, H; Kinoshita, T; Koga, Y; Kuroda, J; Matsumura, Y; Ohkohchi, N; Takahashi, A; Yasunaga, M | 1 |
| Chen, X; Du, L; He, X; Li, X; Li, Z; Qian, Z; Wei, Y; Wen, Y; Zhao, X; Zhou, L | 1 |
| Adachi, S; Hiraumi, Y; Itoh, K; Matsubara, H; Naka, N; Nakahata, T; Sano, K; Watanabe, K; Watanabe, M; Yoshioka, K; Yui, Y | 1 |
| Koo, OM; Onyüksel, H; Rubinstein, I | 1 |
| Nirmala, P; Ramanathan, M | 1 |
| Al-Dasooqi, N; Bowen, JM; Gibson, RJ; Keefe, DM; Logan, RM; Stringer, AM | 1 |
| Cardillo, TM; Goldenberg, DM; Govindan, SV; Sharkey, RM; Trisal, P | 1 |
| Liu, J; Ni, B; Yang, J; Zhou, W; Zhu, L | 1 |
| Chang, Q; Chestnut, BA; Lesuisse, C; Martin, LJ; Price, A; Wong, M | 1 |
| Brito, GA; Cunha, FQ; Figueiredo, AA; Freitas, HC; Leite, CA; Lima-Júnior, RC; Marques-Neto, RD; Medeiros, RP; Melo, ML; Oriá, RB; Ribeiro, RA; Souza, MH; Vale, ML; Wong, DV | 1 |
| Balivada, S; Basel, MT; Bossmann, SH; Pyle, MM; Seo, GM; Shrestha, TB; Tamura, M; Troyer, DL | 1 |
| An, S; Hwang, YJ; Jeon, GS; Jung, MK; Kim, KY; Kowall, N; Lee, J; Ouchi, M; Ouchi, T; Ryu, H | 1 |
| Agrawal, S; Lindsey, JR; Nan, L; Wang, H; Yu, D; Zhang, R | 1 |
| Boven, E; Erkelens, CA; Pinedo, HM; Schlüper, HM; Tohgo, A; van Hattum, AH | 1 |
| Hojo, K; Maekawa, R; Maki, H; Sawada, TY; Tanaka, H; Yoshioka, T | 1 |
| Chen, HZ; Chen, Y; Ding, XQ; Kong, QY; Wang, AX | 1 |
| Bouvet, M; Hoffman, RM; Moossa, AR; Nassirpour, R; Sun, FX; Tohgo, A; Yagi, S | 1 |
| Luan, LB; Wei, KB; Yu, WP; Zhu, JB | 1 |
| McLeod, HL; Watters, JW | 1 |
| Chen, LM; Ding, Y; Fu, LW; Liang, YJ; Pan, QC; Xiong, HY; Yang, XP | 1 |
| Chai, LP; Su, ZZ; Xian, ZX | 1 |
| Bendele, R; Brown, E; Emerson, DL; Giles, FJ; Gray, A; Hart, K; LeRay, JD; Meyer, D; Pelanne, M; Tomkinson, B | 1 |
| Carano, RA; Koeppen, H; Ross, AL; Ross, J; Schwall, RH; Van Bruggen, N; Williams, SP | 1 |
| Morotomi, M; Nomoto, K; Takahashi, T | 1 |
| Burt, HM; Cashman, J; Gleave, J; Jackson, JK; Springate, C | 1 |
| D'Haene, N; Darro, F; Gaussin, JF; Kiss, R; Mathieu, A; Penant, S; Remmelink, M; Salmon, I; Van Ginckel, R | 1 |
| Ahmad, I; Ali, S; Chien, PY; Lei, S; Sheikh, S; Zhang, A | 1 |
| Fujiwara, Y; Fukushima, S; Hirohashi, K; Lee, S; Morimura, K; Osugi, H; Suehiro, S; Takemura, M | 1 |
| Akbulut, H; Deisseroth, A; Maynard, J; Pizzorno, G; Tang, Y; Zhang, L | 1 |
| Hutton, WC; Kim, KS; Li, J; Park, JS; Yoon, ST | 1 |
| Beretta, GL; Brigliadori, G; Corna, E; De Cesare, M; Fabbri, F; Ricotti, L; Rosetti, M; Supino, R; Tesei, A; Ulivi, P; Zoli, W; Zunino, F | 1 |
| Hoffman, RM | 1 |
| Cai, SR; Church, RD; Culverhouse, R; Garbow, JR; McLeod, HL; Shannon, WD; Zhang, W | 1 |
| Jiang, W; Larrick, JW; Li, L; Wang, Y | 1 |
| Handa, O; Higashihara, H; Ishikawa, T; Kokura, S; Naito, Y; Nakabe, N; Sakamoto, N; Takagi, T; Yoshida, N; Yoshikawa, T | 1 |
| Cheng, J; Davis, ME; Khin, KT; Schluep, T | 1 |
| Kiselyov, A | 1 |
| Bonhoure, E; Calvet, C; Cuvillier, O; Doumerc, N; Garcia, V; Golzio, M; Malavaud, B; Mazerolles, C; Pchejetski, D; Rischmann, P; Teissié, J | 1 |
| Beck, S; Bourquin, C; Endres, S; Hartmann, G; Schreiber, S | 1 |
| Bartlett, DW; Cheng, J; Davis, ME; Heidel, JD; Hollister, B; Hwang, J; Schluep, T | 1 |
| Berrocal, DH; Gelpi, RJ; González, GE; Grinfeld, LR; Morales, C | 1 |
| Chung, MK; Han, SS; Kim, JC | 1 |
| Liang, H | 1 |
| Alvarez-Silva, M; da Costa, R; de Faria, TJ; Dora, CL; Fernandes, D; Lemos-Senna, E; Stimamiglio, M; Trentin, AG | 1 |
| Hasegawa, F; Komatsu, T; Nishio, K; Ochiya, T; Takeshita, F; Takigahira, M; Yanagihara, K | 1 |
| Butler, RN; Davidson, GP; Howarth, GS; Tooley, KL | 1 |
| Boelsterli, UA; Chan, E; Chan, SY; Duan, W; Ee, PL; Hu, ZP; Huang, M; Koh, HL; Sheu, FS; Wang, JC; Xu, AL; Yang, XX; Zhang, Q; Zhou, SF; Zhu, YZ | 1 |
| Gupta, AA; Pappo, AS | 1 |
| Archer, GE; Chewning, TA; Friedman, HS; McLendon, RE; Ochiai, H; Pernell, CT; Sampson, JH | 1 |
| Aoyagi, Y; Enomoto, T; Nakajima, M; Noguchi, M; Oda, T; Ohkohchi, N; Satake, M; Sugiura, S | 1 |
| Azrak, RG; Cao, S; Combs, GF; Durrani, FA; Fakih, M; Pendyala, L; Prey, J; Rustum, YM; Smith, PF | 1 |
| Cao, S; Creaven, PJ; Durrani, FA; Iyer, RV; Javle, MM; Lawrence, DD; Noel, DC; Pendyala, L; Rustum, YM; Smith, PF | 1 |
| Chamberlain, MC; Chen, TC; Gupta, V; Hofman, FM; Liebes, LF; Samuelson, CG; Schönthal, AH; Su, YS | 1 |
| Chen, GQ; Guo, M; Liu, W; Yu, Y; Zhu, YS | 1 |
| Brito, GA; Carvalho, SB; Cunha, FQ; Melo, ML; Ribeiro, RA; Silva, JV; Soares, PM; Soares, RC; Souza, MH; Vale, ML | 1 |
| Chen, LD; Li, PC; Li, Y; Zheng, F | 1 |
| Alvarez, E; Bowen, JM; Finnie, J; Gibson, RJ; Keefe, DM | 1 |
| Alvarez Silva, M; Fernandes, D; Hangai, M; Lemos-Senna, E; Loch-Neckel, G; Nemen, D; Puhl, AC; Santos Silva, MC; Stimamiglio, MA | 1 |
| Hamaguchi, T; Kano, Y; Kato, K; Koizumi, F; Matsumura, Y; Nakajima, TE; Shimada, Y; Shirao, K; Yamada, Y; Yasunaga, M | 1 |
| Greenberger, LM; Horak, ID; Kraft, P; Longley, C; Malaby, J; Mehlig, M; Sapra, P; Zhao, H | 1 |
| Tanaka, T; Umesaki, N; Utsunomiya, H; Utsunomiya, T | 1 |
| Huang, T | 1 |
| Giovanella, BC; Harris, N; Natelson, E; Stehlin, JS; Vardeman, D | 1 |
| Danks, MK; Houghton, JA; Houghton, PJ; Luo, X; Stewart, CF; Thompson, J; Zamboni, WC | 1 |
| Cheshire, PJ; Houghton, JA; Houghton, PJ; Luo, X; Richmond, L; Stewart, CF; Thompson, J; Zamboni, WC | 1 |
| Brumfield, A; Dookeran, KA; Rubin, JT | 1 |
| Black, JD; Cao, S; Rustum, YM; Troutt, AB | 1 |
| Houghton, PJ; Stewart, CF; Thompson, J | 1 |
| Chuang, N; Cohen, HW; O'Leary, JJ; Potmesil, M; Ren, CJ; Shapiro, RL | 1 |
| Beran, M; Jeha, S; Kantarjian, H; O'Brien, S; Vitek, L | 1 |
| Bailly, C; Bigg, DC; Camara, J; Dassonneville, L; Demarquay, D; Kasprzyk, PG; Kiss, R; Lavergne, O; Lesueur-Ginot, L | 1 |
| Gliniak, B; Le, T | 1 |
| Bastow, KF; Chang, JY; Chen, HX; Cheng, YC; Fu, Q; Guan, J; Guo, X; Jiang, Z; Lee, KH; Wang, HK; Zhu, XK | 1 |
| Ikeda, T; Mitani, N; Murakami, K; Saiki, I; Yamaura, T | 1 |
| Bergeron, MG; Désormeaux, A; Marquis, JF; Olivier, M; Proulx, ME | 1 |
| Blumenthal, RD; Goldenberg, DM; Lew, W; Modrak, DE; Rodriguez, MD | 1 |
| Kline, I | 1 |
8 review(s) available for camptothecin and Disease Models, Animal
| Article | Year |
|---|---|
Understanding and modulating mammalian-microbial communication for improved human health.
Topics: Animals; Anti-Inflammatory Agents; Camptothecin; Disease Models, Animal; Enteritis; Eosinophilia; Gastritis; Gastrointestinal Tract; Glucuronidase; Humans; Irinotecan; Lipopolysaccharides; Mammals; Microbiota | 2014 |
Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cell Death; Colorectal Neoplasms; Diarrhea; Disease Models, Animal; Fluorouracil; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; Inflammation; Intestinal Mucosa; Irinotecan; Mucositis; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin | 2014 |
Mechanistic review of drug-induced steatohepatitis.
Topics: Amiodarone; Animals; Camptothecin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fatty Liver; Hepatocytes; Humans; Irinotecan; Lipid Metabolism; Liver; Methotrexate; Mitochondria, Liver; Organoplatinum Compounds; Oxaliplatin; Perhexiline; Tamoxifen; Tetracycline; Valproic Acid | 2015 |
Cancer therapies utilizing the camptothecins: a review of the in vivo literature.
Topics: Animals; Antineoplastic Agents; Camptothecin; Clinical Trials as Topic; Disease Models, Animal; Humans; Neoplasms | 2010 |
Cancer pharmacogenomics: current and future applications.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Dihydrouracil Dehydrogenase (NADP); Disease Models, Animal; DNA Adducts; DNA Repair; Fluorouracil; Glucuronosyltransferase; Glutathione Transferase; Humans; Irinotecan; Mercaptopurine; Methyltransferases; Neoplasms; Organoplatinum Compounds; Oxidoreductases; Pharmacogenetics; Polymorphism, Genetic; Thymidylate Synthase | 2003 |
New drugs for the treatment of metastatic or refractory soft tissue sarcomas in children.
Topics: Animals; Camptothecin; Child; Disease Models, Animal; Drug Design; Enzyme Inhibitors; Humans; Irinotecan; Rhabdomyosarcoma; Sarcoma; Survival Rate; Topoisomerase I Inhibitors; Topotecan | 2006 |
Protocols for the treatment of human tumor xenografts with camptothecins.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Protocols; Disease Models, Animal; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Transplantation, Heterologous | 1996 |
Animal models for studying the action of topoisomerase I targeted drugs.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Division; Disease Models, Animal; Enzyme Inhibitors; Humans; Molecular Structure; Neoplasms, Experimental; Rodentia; Topoisomerase I Inhibitors; Transplantation, Heterologous | 1998 |
1 trial(s) available for camptothecin and Disease Models, Animal
| Article | Year |
|---|---|
Celecoxib and mucosal protection: translation from an animal model to a phase I clinical trial of celecoxib, irinotecan, and 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Celecoxib; Colorectal Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluorouracil; Glucuronates; Humans; Intestinal Mucosa; Irinotecan; Leucovorin; Male; Maximum Tolerated Dose; Mucositis; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazoles; Rats; Rats, Inbred F344; Sulfonamides | 2007 |
154 other study(ies) available for camptothecin and Disease Models, Animal
| Article | Year |
|---|---|
Antimalarial Activities of Alkyl Cyclohexenone Derivatives Isolated from the Leaves of Poupartia borbonica.
Topics: Anacardiaceae; Animals; Antimalarials; Belgium; Cyclohexanones; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Flavonoids; HeLa Cells; Humans; Inhibitory Concentration 50; Malaria; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Parasitic Sensitivity Tests; Plant Leaves; Plasmodium berghei; Plasmodium falciparum; Quercetin; Zebrafish | 2017 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Opioid-induced microbial dysbiosis disrupts irinotecan (CPT-11) metabolism and increases gastrointestinal toxicity in a murine model.
Topics: Analgesics, Opioid; Animals; Antineoplastic Agents, Phytogenic; Bacteria; Camptothecin; Disease Models, Animal; Dysbiosis; Glucuronidase; Humans; Irinotecan; Male; Mice; Mice, Inbred C57BL; Morphine Derivatives; Neoplasms; RNA, Ribosomal, 16S | 2023 |
Synthesis and biological evaluation of novel SN38-glucose conjugate for colorectal cancer treatment.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Delivery Systems; Humans; Irinotecan | 2023 |
A nanomedicine based on stoichiometric coordination of camptothecin and organoplatinum (II) for synergistic antitumor therapy.
Topics: Animals; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Female; Glutathione; Humans; Hydrogen Peroxide; Mice; Nanomedicine; Polymers | 2023 |
[Fam-] trastuzumab deruxtecan (DS-8201a)-induced antitumor immunity is facilitated by the anti-CTLA-4 antibody in a mouse model.
Topics: Animals; Antibodies; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Camptothecin; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; CTLA-4 Antigen; Disease Models, Animal; Female; Humans; Immunity, Innate; Immunoconjugates; Mice; Receptor, ErbB-2; Trastuzumab | 2019 |
Stable Isotope Dilution LC-HRMS Assay To Determine Free SN-38, Total SN-38, and SN-38G in a Tumor Xenograft Model after Intravenous Administration of Antibody-Drug Conjugate (Sacituzumab Govitecan).
Topics: Administration, Intravenous; Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Immunoconjugates; Indicator Dilution Techniques; Irinotecan; Mass Spectrometry; Mice; Mice, SCID; Molecular Structure; Neoplasms, Experimental | 2020 |
Preparation of PLGA microspheres loaded with 10-hydroxycamptothecin and arsenic trioxide and their treatment for rabbit hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Camptothecin; Carcinoma, Hepatocellular; Disease Models, Animal; Liver Neoplasms; Microspheres; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits | 2021 |
Novel Hydrophilic Camptothecin Derivatives Conjugated to Branched Glycerol Trimer Suppress Tumor Growth without Causing Diarrhea in Murine Xenograft Models of Human Lung Cancer.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Diarrhea; Disease Models, Animal; Glycerol; Heterografts; Humans; Hydrophobic and Hydrophilic Interactions; Irinotecan; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microsomes, Liver; Rats, Sprague-Dawley; Xenograft Model Antitumor Assays | 2020 |
Liver injury in septic mice were suppressed by a camptothecin-bile acid conjugate via inhibiting NF-κB signaling pathway.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Blotting, Western; Camptothecin; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Liver Diseases; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Peroxidase; Sepsis; Signal Transduction | 2020 |
Development of Novel Antibody-Camptothecin Conjugates.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; Camptothecin; Disease Models, Animal; Female; Humans; Mice; Rats; Rats, Sprague-Dawley | 2021 |
Camptothecin and Topotecan, Inhibitors of Transcription Factor Fli-1 and Topoisomerase, Markedly Ameliorate Lupus Nephritis in (NZB × NZW)F1 Mice and Reduce the Production of Inflammatory Mediators in Human Renal Cells.
Topics: Animals; Autoantibodies; Camptothecin; Cytokines; Disease Models, Animal; Female; Humans; Inflammation Mediators; Kidney; Lupus Nephritis; Proteinuria; Proto-Oncogene Protein c-fli-1; Topoisomerase Inhibitors; Topotecan | 2021 |
Development of a Prodrug of Camptothecin for Enhanced Treatment of Glioblastoma Multiforme.
Topics: Animals; Antineoplastic Agents; Apoptosis; Astrocytes; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Glioblastoma; Humans; Male; Primary Cell Culture; Prodrugs; Rats; Solubility; Stereotaxic Techniques | 2021 |
Target identification and drug discovery by data-driven hypothesis and experimental validation in ovarian endometriosis.
Topics: Adult; Animals; Camptothecin; Disease Models, Animal; Drug Discovery; Endometriosis; Endometrium; Female; Humans; Inositol 1,4,5-Trisphosphate Receptors; Mice; Mice, Inbred C57BL; Middle Aged; Ovarian Diseases; Signal Transduction | 2021 |
Visualization of Intratumor Pharmacokinetics of [fam-] Trastuzumab Deruxtecan (DS-8201a) in HER2 Heterogeneous Model Using Phosphor-integrated Dots Imaging Analysis.
Topics: Animals; Camptothecin; Disease Models, Animal; Fluorescent Dyes; Humans; Immunoconjugates; Mice; Nanoparticles; Neoplasms; Receptor, ErbB-2; Trastuzumab; Tumor Cells, Cultured | 2021 |
Therapeutic Mechanism and Effect of Camptothecin on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice.
Topics: Animals; Camptothecin; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation; Humans; Inflammation Mediators; Intestinal Mucosa; Lipopolysaccharides; Mice; Mice, Inbred C57BL; RAW 264.7 Cells | 2021 |
Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy.
Topics: Adenocarcinoma; Animals; B7-H1 Antigen; Camptothecin; Colonic Neoplasms; Disease Models, Animal; Drug Therapy; Granzymes; Humans; Immunotherapy; Lipid Bilayers; Melanoma, Experimental; Mice; Nanoparticles; Perforin; Programmed Cell Death 1 Receptor; Sphingomyelins; T-Lymphocytes, Cytotoxic | 2021 |
Chitosan stabilized camptothecin nanoemulsions: Development, evaluation and biodistribution in preclinical breast cancer animal mode.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Cell Survival; Chitosan; Disease Models, Animal; Drug Carriers; Drug Evaluation, Preclinical; Drug Liberation; Drug Stability; Emulsions; Female; Humans; MCF-7 Cells; Mice; Nanoparticles; Tissue Distribution; Xenograft Model Antitumor Assays | 2017 |
Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Camptothecin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Doxycycline; Heterografts; Irinotecan; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Neuroblastoma; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2017 |
Rational Design of a New Self-Codelivery System from Redox-Sensitive Camptothecin-Cytarabine Conjugate Assembly for Effectively Synergistic Anticancer Therapy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line, Tumor; Cytarabine; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Drug Synergism; Female; Glutathione; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; Magnetic Resonance Imaging; Mice; Nanoparticles | 2017 |
Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer.
Topics: Adipocytes; Adipose Tissue; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Size; Colonic Neoplasms; Disease Models, Animal; Fatty Acids; Fatty Acids, Monounsaturated; Fatty Acids, Omega-3; Female; Fluorouracil; Humans; Irinotecan; Lipogenesis; Mitochondria; Mitochondrial Proteins; Phospholipids; Proteome; Rats; Rats, Inbred F344; Triglycerides | 2017 |
A HER2-Targeting Antibody-Drug Conjugate, Trastuzumab Deruxtecan (DS-8201a), Enhances Antitumor Immunity in a Mouse Model.
Topics: Animals; Antibodies, Monoclonal, Humanized; B7-H1 Antigen; Breast Neoplasms; Camptothecin; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoconjugates; Mice; Programmed Cell Death 1 Receptor; Receptor, ErbB-2; Trastuzumab; Xenograft Model Antitumor Assays | 2018 |
Amphiphilic Hybrid Dendritic-Linear Molecules as Nanocarriers for Shape-Dependent Antitumor Drug Delivery.
Topics: Amines; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; Drug Liberation; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred BALB C; Nanospheres; Nanotubes; Neoplasms; Particle Size; Polyethylene Glycols; Rats; Surface-Active Agents; Treatment Outcome | 2018 |
Silencing of Intestinal Glycoprotein CD98 by Orally Targeted Nanoparticles Enhances Chemosensitization of Colon Cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Drug Delivery Systems; Drug Screening Assays, Antitumor; Female; Fusion Regulatory Protein-1; Humans; Intestines; Mice; Mice, Inbred C57BL; Nanoparticles; Neoplasms, Experimental; RNA, Small Interfering | 2018 |
Hydroxycamptothecin nanoparticles based on poly/oligo (ethylene glycol): Architecture effects of nanocarriers on antitumor efficacy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Stability; Drug Storage; Ethylene Glycol; Humans; Injections, Intravenous; Mice; Mice, Inbred BALB C; Molecular Conformation; Nanoparticles; Neoplasms; Particle Size; Rats; Tissue Distribution | 2019 |
Tissue Distribution and Anti-Lung Cancer Effect of 10-Hydroxycamptothecin Combined with Platycodonis Radix and Glycyrrhizae Radix ET Rhizoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Carcinoma, Lewis Lung; Chromatography, Liquid; Cytokines; Disease Models, Animal; Drug Monitoring; Drugs, Chinese Herbal; Glycyrrhiza; Lung Neoplasms; Male; Mice; Plant Roots; Rhizome; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tissue Distribution; Xenograft Model Antitumor Assays | 2019 |
Chain-Length- and Saturation-Tuned Mechanics of Fluid Nanovesicles Direct Tumor Delivery.
Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Proliferation; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Screening Assays, Antitumor; Humans; Liposomes; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Molecular; Nanoparticles; Neoplasms, Experimental; Optical Imaging; Pancreatic Neoplasms; Particle Size; Stress, Mechanical; Surface Properties; Tumor Cells, Cultured | 2019 |
Hydroxycamptothecin liposomes inhibit collagen secretion and induce fibroblast apoptosis in a postlaminectomy rabbit model.
Topics: Animals; Camptothecin; Cicatrix; Collagen; Disease Models, Animal; Drug Delivery Systems; Epidural Space; Fibroblasts; Laminectomy; Liposomes; Magnetic Resonance Imaging; Male; Postoperative Complications; Rabbits; Secretory Pathway; Tissue Adhesions | 2013 |
Treatment of colorectal cancer using a combination of liposomal irinotecan (Irinophore C™) and 5-fluorouracil.
Topics: Animals; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Combinations; Female; Fluorouracil; HT29 Cells; Humans; Irinotecan; Liposomes; Male; Mice; Tumor Burden | 2013 |
A bioengineered metastatic pancreatic tumor model for mechanistic investigation of chemotherapeutic drugs.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bioengineering; Camptothecin; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Female; Fluorouracil; Gemcitabine; Humans; Leucovorin; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Organoplatinum Compounds; Pancreatic Neoplasms; Tissue Scaffolds; Xenograft Model Antitumor Assays | 2013 |
Antimyeloma activity of NK012, a micelle-forming macromolecular prodrug of SN-38, in an orthotopic model.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Irinotecan; Mice; Mice, Inbred NOD; Mice, SCID; Micelles; Multiple Myeloma; Prodrugs; Xenograft Model Antitumor Assays | 2014 |
Carrier-free functionalized multidrug nanorods for synergistic cancer therapy.
Topics: Animals; Camptothecin; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Carriers; Drug Synergism; Drug Therapy, Combination; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; KB Cells; MCF-7 Cells; Methotrexate; Mice; Mice, Inbred BALB C; Nanoparticles; Nanotubes; Neoplasms; Paclitaxel | 2013 |
Therapeutic enhancement of S-1 with CPT-11 through down-regulation of thymidylate synthase in bladder cancer.
Topics: Animals; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Combinations; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Mice; Mice, Nude; Oxonic Acid; RNA Interference; RNA, Small Interfering; Tegafur; Thymidylate Synthase; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2013 |
Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Dioxoles; Disease Models, Animal; DNA Breaks, Double-Stranded; DNA Damage; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Exodeoxyribonucleases; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Irinotecan; Mice; Oncogene Proteins, Fusion; Phenotype; Proto-Oncogene Protein c-fli-1; RecQ Helicases; RNA Interference; RNA-Binding Protein EWS; RNA, Small Interfering; Sarcoma, Ewing; Tetrahydroisoquinolines; Trabectedin; Werner Syndrome Helicase; Xenograft Model Antitumor Assays | 2014 |
A comparison of the effects of topical treatment of calcipotriol, camptothecin, clobetasol and tazarotene on an imiquimod-induced psoriasis-like mouse model.
Topics: Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Animals; Anti-Inflammatory Agents; Calcitriol; Camptothecin; Clobetasol; Dermatologic Agents; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Nicotinic Acids; Psoriasis; Topoisomerase I Inhibitors | 2014 |
Addition of propolis to irinotecan therapy prolongs survival in ehrlich ascites tumor-bearing mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Ehrlich Tumor; Cell Growth Processes; Disease Models, Animal; Drug Synergism; Irinotecan; Male; Mice; Propolis; Survival Analysis | 2014 |
Antitumor effects with apoptotic death in human promyelocytic leukemia HL-60 cells and suppression of leukemia xenograft tumor growth by irinotecan HCl.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Caspase 3; Cell Cycle Proteins; Disease Models, Animal; DNA Damage; Endoplasmic Reticulum Chaperone BiP; G1 Phase Cell Cycle Checkpoints; HL-60 Cells; Humans; Irinotecan; Leukemia, Promyelocytic, Acute; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Confocal; Transplantation, Heterologous | 2015 |
The use of Olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks.
Topics: Animals; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; DNA Breaks, Double-Stranded; DNA Mismatch Repair; DNA Repair; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Profiling; Gene Knockdown Techniques; Humans; Irinotecan; Mice; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerases; Rad51 Recombinase; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
Synthesis and evaluation of hydroxycamptothecin-encapsulated chitosan nanospheres for the treatment of liver cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chitosan; Disease Models, Animal; Drug Compounding; Drug Liberation; Hep G2 Cells; Humans; Liver Neoplasms; Nanospheres; Xenograft Model Antitumor Assays | 2015 |
Prolongation of life in rats with malignant glioma by intranasal siRNA/drug codelivery to the brain with cell-penetrating peptide-modified micelles.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brain; Camptothecin; Cell Line; Cell Line, Tumor; Cell Survival; Cell-Penetrating Peptides; Disease Models, Animal; Glioma; Male; MAP Kinase Kinase Kinases; Micelles; Proto-Oncogene Proteins c-raf; Rats; Rats, Sprague-Dawley; RNA, Small Interfering | 2014 |
The optimal concentration of topical hydroxycamptothecin in preventing intraarticular scar adhesion.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Disease Models, Animal; Femur; Hydroxyproline; Male; Patellofemoral Joint; Rabbits; Random Allocation; Tissue Adhesions | 2014 |
Old drug new use--amoxapine and its metabolites as potent bacterial β-glucuronidase inhibitors for alleviating cancer drug toxicity.
Topics: Amoxapine; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Female; Glycoproteins; Irinotecan; Mice; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Neoplasms; Protective Agents; Protein Binding; Xenograft Model Antitumor Assays | 2014 |
HPLC analysis and extraction method of SN-38 in brain tumor model after injected by polymeric drug delivery system.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Delivery Systems; Irinotecan; Mice, Nude; Polymers | 2014 |
Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cholesterol; Colon; Diarrhea; Disease Models, Animal; Drug Therapy, Combination; Female; Fluorouracil; Intestine, Small; Irinotecan; Liposomes; Nanoparticles; Phosphatidylcholines; Rats, Sprague-Dawley | 2014 |
Chemotherapy-associated steatohepatitis induced by irinotecan: a novel animal model.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents, Phytogenic; Aspartate Aminotransferases; Camptothecin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fatty Liver; Humans; Interleukin-1beta; Irinotecan; Liver; Male; Mice; Peroxidase; Time Factors; Tumor Necrosis Factor-alpha; Weight Loss | 2014 |
Involvement of matrix metalloproteinases (MMP-3 and MMP-9) in the pathogenesis of irinotecan-induced oral mucositis.
Topics: Analysis of Variance; Animals; Atrophy; Camptothecin; Disease Models, Animal; Female; Immunohistochemistry; Irinotecan; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Mouth Mucosa; Random Allocation; Rats; Stomatitis; Tongue | 2015 |
In vivo evaluation of irinotecan-loaded QuadraSphere microspheres for use in chemoembolization of VX2 liver tumors.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chemoembolization, Therapeutic; Disease Models, Animal; Female; Irinotecan; Liver Neoplasms, Experimental; Microspheres; Rabbits; Tomography, X-Ray Computed; Treatment Outcome | 2014 |
Co-treatment with therapeutic neural stem cells expressing carboxyl esterase and CPT-11 inhibit growth of primary and metastatic lung cancers in mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylesterase; Cell Growth Processes; Cell Line, Tumor; Disease Models, Animal; Humans; Irinotecan; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Neural Stem Cells; Random Allocation; Xenograft Model Antitumor Assays | 2014 |
Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Humans; Irinotecan; Mice; Mice, Nude; Nanoparticles; Neuroblastoma; Prodrugs; Tissue Distribution; Xenograft Model Antitumor Assays | 2015 |
Evaluation of the plasmatic and parenchymal elution kinetics of two different irinotecan-loaded drug-eluting embolics in a pig model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chemoembolization, Therapeutic; Disease Models, Animal; Female; Irinotecan; Liver Neoplasms; Swine | 2015 |
Fatty acid synthase-positive hepatocytes and subsequent steatosis in rat livers by irinotecan.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Disease Models, Animal; Fatty Acid Synthases; Fatty Liver; Hepatocytes; Immunohistochemistry; Irinotecan; Liver; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction | 2015 |
Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Bevacizumab; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Dendritic Cells; Disease Models, Animal; Drug Delivery Systems; Drug Therapy, Combination; Glioma; Humans; Irinotecan; Mice; Platelet Endothelial Cell Adhesion Molecule-1; Time Factors; Xenograft Model Antitumor Assays | 2015 |
Activity of MM-398, nanoliposomal irinotecan (nal-IRI), in Ewing's family tumor xenografts is associated with high exposure of tumor to drug and high SLFN11 expression.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Drug Combinations; Female; Gene Expression; Humans; Irinotecan; Liposomes; Macrophages; Mice; Nuclear Proteins; Sarcoma, Ewing; Sucrose; Tissue Distribution; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
The Topoisomerase I Inhibitor Irinotecan and the Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Furamidine Synergistically Suppress Murine Lupus Nephritis.
Topics: Animals; Benzamidines; Camptothecin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Female; Immunomodulation; Irinotecan; Lupus Nephritis; Mice; Mice, Inbred NZB; Phosphoric Diester Hydrolases; Topoisomerase I Inhibitors; Treatment Outcome | 2015 |
Oral delivery of nanoparticles containing anticancer SN38 and hSET1 antisense for dual therapy of colon cancer.
Topics: Administration, Oral; Animals; Camptothecin; Cell Line, Tumor; Chitosan; Colonic Neoplasms; Disease Models, Animal; Drug Carriers; Drug Liberation; Drug Stability; Histone-Lysine N-Methyltransferase; Humans; Irinotecan; Mice; Nanoparticles; Oligonucleotides, Antisense; Spectroscopy, Fourier Transform Infrared; Xenograft Model Antitumor Assays | 2015 |
Synergistic Leukemia Eradication by Combined Treatment with Retinoic Acid and HIF Inhibition by EZN-2208 (PEG-SN38) in Preclinical Models of PML-RARα and PLZF-RARα-Driven Leukemia.
Topics: Animals; Arsenic Trioxide; Arsenicals; Camptothecin; Cell Differentiation; Cell Movement; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Promyelocytic, Acute; Mice; Mutation; Neoplasm Proteins; Oncogene Proteins, Fusion; Oxides; Polyethylene Glycols; Tretinoin | 2015 |
Fasting protects against the side effects of irinotecan but preserves its anti-tumor effect in Apc15lox mutant mice.
Topics: Adenomatous Polyposis Coli Protein; Animals; Camptothecin; Cell Proliferation; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Fasting; G2 Phase Cell Cycle Checkpoints; Irinotecan; Mice; Mice, Inbred C57BL; Mice, Knockout; S Phase Cell Cycle Checkpoints; Topoisomerase I Inhibitors | 2015 |
NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blood-Brain Barrier; Brain; Brain Neoplasms; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Drug Monitoring; Female; Humans; Irinotecan; Luminescent Measurements; Mice; Molecular Structure; Permeability; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Injections, Intraventricular; Mammary Neoplasms, Experimental; Mice; Molecular Conformation; Structure-Activity Relationship; Trastuzumab | 2016 |
Near-Infrared Light Triggered ROS-activated Theranostic Platform based on Ce6-CPT-UCNPs for Simultaneous Fluorescence Imaging and Chemo-Photodynamic Combined Therapy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Chlorophyllides; Disease Models, Animal; Drug Carriers; Drug Therapy; Humans; Infrared Rays; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Optical Imaging; Photochemotherapy; Porphyrins; Radiation-Sensitizing Agents; Reactive Oxygen Species; Theranostic Nanomedicine; Treatment Outcome | 2016 |
Saccharomyces cerevisiae UFMG A-905 treatment reduces intestinal damage in a murine model of irinotecan-induced mucositis.
Topics: Animals; Camptothecin; Disease Models, Animal; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Irinotecan; Jejunum; Lipid Peroxidation; Male; Mice; Mucositis; Oxidative Stress; Probiotics; Saccharomyces cerevisiae; Weight Loss | 2016 |
The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Calreticulin; Camptothecin; Cell Death; Cell Line, Tumor; Cetuximab; Colorectal Neoplasms; Dendritic Cells; Disease Models, Animal; Endoplasmic Reticulum Stress; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; Indoles; Irinotecan; Leucovorin; Mice; Panitumumab; Phagocytosis; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Pyridones; Pyrimidinones; Sulfonamides; Unfolded Protein Response; Vemurafenib; X-Box Binding Protein 1 | 2016 |
Combining ABCG2 Inhibitors with IMMU-132, an Anti-Trop-2 Antibody Conjugate of SN-38, Overcomes Resistance to SN-38 in Breast and Gastric Cancers.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Camptothecin; Cell Adhesion Molecules; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Flow Cytometry; Gene Expression; Humans; Immunoconjugates; Inhibitory Concentration 50; Irinotecan; Mice; Stomach Neoplasms; Xenograft Model Antitumor Assays | 2016 |
Ex Vivo Testing of Patient-Derived Xenografts Mirrors the Clinical Outcome of Patients with Pancreatic Ductal Adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Camptothecin; Carcinoma, Pancreatic Ductal; Deoxycytidine; Disease Models, Animal; Disease-Free Survival; Female; Gemcitabine; Heterografts; Humans; Irinotecan; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Pancreatic Neoplasms; Retrospective Studies; Xenograft Model Antitumor Assays | 2016 |
Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons.
Topics: Animals; Antineoplastic Agents, Phytogenic; bcl-2-Associated X Protein; Camptothecin; Caspase 6; Cerebral Cortex; COS Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Down Syndrome; Gene Expression Regulation; Humans; Huntingtin Protein; Mice; Mice, Transgenic; Mutation; Neurons; Protein Synthesis Inhibitors; Quinolones; Time Factors; Tosylphenylalanyl Chloromethyl Ketone | 2016 |
Vitamin D Enhances the Efficacy of Irinotecan through miR-627-Mediated Inhibition of Intratumoral Drug Metabolism.
Topics: Animals; Camptothecin; Cell Line, Tumor; Cytochrome P-450 CYP3A; Disease Models, Animal; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Male; Mice; MicroRNAs; Neoplasms; Pharmacogenetics; RNA Interference; Vitamin D; Xenograft Model Antitumor Assays | 2016 |
Advanced interstitial chemotherapy combined with targeted treatment of malignant glioma in rats by using drug-loaded nanofibrous membranes.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bibenzyls; Brain; Brain Neoplasms; Camptothecin; Cisplatin; Disease Models, Animal; Drug Delivery Systems; Ethylnitrosourea; Glioblastoma; Glioma; Humans; Irinotecan; Lactic Acid; Male; Nanofibers; Neurosurgical Procedures; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Tumor Burden | 2016 |
STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Child; Disease Models, Animal; DNA Damage; Drug Evaluation, Preclinical; Female; HSP90 Heat-Shock Proteins; Humans; Irinotecan; Mice; Mice, Knockout; Mice, SCID; Resorcinols; Rhabdomyosarcoma; Sarcoma, Ewing; Topoisomerase I Inhibitors; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
ATM Expression Predicts Veliparib and Irinotecan Sensitivity in Gastric Cancer by Mediating P53-Independent Regulation of Cell Cycle and Apoptosis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Ataxia Telangiectasia Mutated Proteins; Benzimidazoles; Camptothecin; Cell Cycle; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression; Histones; Humans; Inhibitory Concentration 50; Irinotecan; Oncogene Protein p21(ras); Phosphorylation; Proto-Oncogene Proteins; Stomach Neoplasms; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2016 |
Suppression of lupus nephritis and skin lesions in MRL/lpr mice by administration of the topoisomerase I inhibitor irinotecan.
Topics: Animals; Antibodies, Antinuclear; Camptothecin; Disease Models, Animal; DNA; Enzyme-Linked Immunosorbent Assay; Enzyme-Linked Immunospot Assay; Female; Flow Cytometry; Irinotecan; Kidney; Lupus Nephritis; Mice; Mice, Inbred MRL lpr; Random Allocation; Skin; Topoisomerase I Inhibitors | 2016 |
Sphingomyelin Liposomes Containing Porphyrin-phospholipid for Irinotecan Chemophototherapy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Disease Models, Animal; Drug Carriers; Heterografts; Infrared Rays; Irinotecan; Liposomes; Mice; Pancreatic Neoplasms; Phospholipids; Porphyrins; Sphingomyelins; Treatment Outcome | 2016 |
Side-Effects of Irinotecan (CPT-11), the Clinically Used Drug for Colon Cancer Therapy, Are Eliminated in Experimental Animals Treated with Latex Proteins from Calotropis procera (Apocynaceae).
Topics: Animals; Apocynaceae; Calotropis; Camptothecin; Colonic Neoplasms; Disease Models, Animal; Irinotecan; Latex; Male; Mice | 2017 |
ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Autophagy; Camptothecin; Disease Models, Animal; Fatty Liver; Hepatocytes; Humans; In Vitro Techniques; Irinotecan; Liver Neoplasms; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Preoperative Care | 2018 |
DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Bromates; Camptothecin; Disease Models, Animal; DNA Topoisomerases, Type I; Drosophila; Drosophila Proteins; Drug Administration Schedule; Electric Stimulation; Electroshock; Enzyme Inhibitors; Epilepsy; Evoked Potentials; Motor Neurons; Muscle, Skeletal; Mutation; Paralysis; Seizures; Topoisomerase I Inhibitors; Valproic Acid | 2008 |
Antimetastatic activity of MONCPT in preclinical melanoma mice model.
Topics: Animals; Camptothecin; Cell Adhesion; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Separation; Disease Models, Animal; Drug Screening Assays, Antitumor; Extracellular Signal-Regulated MAP Kinases; Female; Green Fluorescent Proteins; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Transduction, Genetic; Vascular Endothelial Growth Factor A | 2010 |
An animal model for chemotherapy-associated steatohepatitis and its prevention by the oral administration of fatty acid bile acid conjugate.
Topics: Animals; Bile Acids and Salts; Camptothecin; Disease Models, Animal; Fatty Acids; Fatty Liver; Irinotecan; Mice; Mice, Inbred C57BL; Organoplatinum Compounds; Oxaliplatin | 2010 |
Doxorubicin and irinotecan drug-eluting beads for treatment of glioma: a pilot study in a rat model.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Camptothecin; Disease Models, Animal; Doxorubicin; Drug Carriers; Drug Delivery Systems; Female; Glioma; Injections, Intralesional; Irinotecan; Male; Microspheres; Pilot Projects; Rats; Survival Analysis | 2010 |
The combination of 5-FU, leucovorin and CPT-11 (FOLFIRI) prolongs survival through inhibition of metastasis in an orthotopic model of colon cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Fluorouracil; Green Fluorescent Proteins; Humans; Leucovorin; Lymphatic Metastasis; Mice; Mice, Nude; Survival Rate; Treatment Outcome; Whole Body Imaging; Xenograft Model Antitumor Assays | 2010 |
Canine spontaneous glioma: a translational model system for convection-enhanced delivery.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Convection; Disease Models, Animal; Dogs; Drug Delivery Systems; Glioma; Irinotecan; Liposomes; Magnetic Resonance Imaging; Nanoparticles | 2010 |
Tumor disposition of pegylated liposomal CKD-602 and the reticuloendothelial system in preclinical tumor models.
Topics: Animals; Area Under Curve; Camptothecin; Chromatography, Liquid; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Mass Spectrometry; Mice; Mononuclear Phagocyte System; Topoisomerase I Inhibitors; Xenograft Model Antitumor Assays | 2011 |
Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor.
Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Female; Humans; Irinotecan; Mice; Mice, Nude; Neoplasms, Experimental; Neovascularization, Pathologic; Neuroblastoma; Polyethylene Glycols; Survival Rate; Topoisomerase I Inhibitors | 2010 |
Detailed distribution of NK012, an SN-38-incorporating micelle, in the liver and its potent antitumor effects in mice bearing liver metastases.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Proliferation; Chromatography, High Pressure Liquid; Colonic Neoplasms; Disease Models, Animal; Humans; Irinotecan; Kaplan-Meier Estimate; Liver; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2010 |
The antitumor and antimetastatic effects of N-trimethyl chitosan-encapsulated camptothecin on ovarian cancer with minimal side effects.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line, Tumor; Chitosan; Disease Models, Animal; Female; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Nude; Neovascularization, Pathologic; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Xenograft Model Antitumor Assays | 2010 |
Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM8.
Topics: Animals; Camptothecin; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Irinotecan; Lung Neoplasms; Mesoderm; Mice; Mice, Inbred C3H; Osteosarcoma; Signal Transduction | 2010 |
Actively targeted low-dose camptothecin as a safe, long-acting, disease-modifying nanomedicine for rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Camptothecin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Immunohistochemistry; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; Micelles; Nanoparticles; Radiography; Topoisomerase I Inhibitors; Treatment Outcome; Vasoactive Intestinal Peptide | 2011 |
Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Camptothecin; Colorectal Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Irinotecan; Kaempferols; Lipid Peroxidation; Male; Rats; Rats, Wistar; Species Specificity | 2011 |
Selection of housekeeping genes for gene expression studies in a rat model of irinotecan-induced mucositis.
Topics: 14-3-3 Proteins; Actins; Animals; Camptothecin; Colon; Disease Models, Animal; Gene Expression Regulation; Glyceraldehyde-3-Phosphate Dehydrogenases; Irinotecan; Jejunum; Male; Matrix Metalloproteinase 2; Molecular Chaperones; Mucositis; Rats; Succinate Dehydrogenase; Ubiquitin C; Up-Regulation | 2011 |
Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys.
Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Camptothecin; Cell Adhesion Molecules; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Immunoconjugates; Immunoglobulin G; Irinotecan; Macaca fascicularis; Male; Mice; Mice, Nude; Models, Biological; Monkey Diseases; Neoplasms, Glandular and Epithelial; Treatment Outcome; Xenograft Model Antitumor Assays | 2011 |
Application of liposome-encapsulated hydroxycamptothecin in the prevention of epidural scar formation in New Zealand white rabbits.
Topics: Animals; Camptothecin; Cicatrix; Disease Models, Animal; Drug Carriers; Epidural Space; Intervertebral Disc; Intervertebral Disc Displacement; Laminectomy; Liposomes; Lumbar Vertebrae; Rabbits; Tissue Adhesions; Wound Healing | 2011 |
Epigenetic regulation of motor neuron cell death through DNA methylation.
Topics: 5-Methylcytosine; Age Factors; Amyloid Precursor Protein Secretases; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Aspartic Acid Endopeptidases; Camptothecin; Caspase 3; Cell Line, Transformed; Central Nervous System; Cytosine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Enzyme Inhibitors; Epigenomics; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Humans; Indoles; Mice; Mice, Transgenic; Motor Neurons; Mutation; Phthalimides; Propionates; RNA, Small Interfering; Sciatic Neuropathy; Superoxide Dismutase; Transfection; Tryptophan; Up-Regulation | 2011 |
Involvement of nitric oxide on the pathogenesis of irinotecan-induced intestinal mucositis: role of cytokines on inducible nitric oxide synthase activation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cytokines; Disease Models, Animal; Enzyme Activation; Immunohistochemistry; Intestinal Mucosa; Irinotecan; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucositis; Nitric Oxide; Nitric Oxide Synthase Type II | 2012 |
A cell-delivered and cell-activated SN38-dextran prodrug increases survival in a murine disseminated pancreatic cancer model.
Topics: Animals; Camptothecin; Dextrans; Disease Models, Animal; Irinotecan; Mice; Pancreatic Neoplasms; Prodrugs; Rabbits | 2012 |
Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of γ-H2AX and DNA damage responses in Huntington's disease.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein; Camptothecin; Cell Cycle Proteins; Cell Nucleus; Disease Models, Animal; DNA Damage; DNA-Binding Proteins; Enzyme Activation; Histones; Huntington Disease; Mice; Models, Biological; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Signal Transduction; Subcellular Fractions; Time Factors; Tumor Suppressor Proteins | 2012 |
Anti-tumor efficacy of a novel antisense anti-MDM2 mixed-backbone oligonucleotide in human colon cancer models: p53-dependent and p53-independent mechanisms.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Colorectal Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Mice; Mice, Nude; Neoplasm Proteins; Neoplasm Transplantation; Nuclear Proteins; Oligonucleotides, Antisense; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Survival Rate; Treatment Outcome; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
The activity profile of the hexacyclic camptothecin derivative DX-8951f in experimental human colon cancer and ovarian cancer.
Topics: Animals; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Camptothecin; Cell Division; Cisplatin; Colonic Neoplasms; Disease Models, Animal; Female; Humans; Membrane Glycoproteins; Mice; Mice, Nude; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Ovarian Neoplasms; Sulfhydryl Reagents; Tetraspanin 29; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles; Xenograft Model Antitumor Assays | 2002 |
Augmented anti-metastatic efficacy of a selective matrix metalloproteinase inhibitor, MMI-166, in combination with CPT-11.
Topics: Animals; Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Disease Models, Animal; Humans; Irinotecan; Liver Neoplasms; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Sulfonamides; Transplantation, Heterologous | 2002 |
[Anticancer effect of hydroxycampothecin on oral squamous carcinoma cell line].
Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Carcinoma, Squamous Cell; Cell Cycle; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred BALB C; Mouth Neoplasms; Neoplasm Transplantation; Neoplasms, Experimental; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2002 |
Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model.
Topics: Animals; Camptothecin; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Mice; Mice, Nude; Neoplasm Metastasis; Pancreatic Neoplasms; Tumor Cells, Cultured | 2003 |
[Studies on the preparation of camptothecin niosomes].
Topics: Acrylic Resins; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cholesterol; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Mice; Neoplasm Transplantation; Particle Size; Sarcoma 180; Surface-Active Agents; Tumor Cells, Cultured | 2002 |
[Experimental studies on treatment of nasopharyngeal carcinoma with combination regimen of hydroxycamptothecin and etoposide].
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Etoposide; Mice; Mice, Inbred BALB C; Mice, Nude; Nasopharyngeal Neoplasms; Neoplasm Transplantation; Neoplasms, Experimental; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2003 |
[Inhibition of hydroxycamptothecin on laryngeal squamous carcinoma cell line].
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carcinoma, Squamous Cell; Disease Models, Animal; Flow Cytometry; Laryngeal Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; S Phase; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2003 |
OSI-211, a novel liposomal topoisomerase I inhibitor, is active in SCID mouse models of human AML and ALL.
Topics: Animals; Antineoplastic Agents; Camptothecin; Disease Models, Animal; Drug Evaluation; Female; Humans; Leukemia, Myeloid, Acute; Mice; Mice, SCID; Neoplasm Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation, Heterologous; Tumor Cells, Cultured | 2003 |
Quantification of tumor tissue populations by multispectral analysis.
Topics: Adipose Tissue; Animals; Antineoplastic Agents, Phytogenic; Apoptosis Regulatory Proteins; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; fas Receptor; Female; Humans; Irinotecan; Ligands; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Mice; Mice, Nude; Necrosis; Neoplasm Transplantation; Remission Induction; Skin Neoplasms; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Topoisomerase I Inhibitors; Transplantation, Heterologous; Tumor Necrosis Factor-alpha | 2004 |
A novel mouse model of rectal cancer established by orthotopic implantation of colon cancer cells.
Topics: Animals; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Humans; Irinotecan; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Rectal Neoplasms; Transplantation, Heterologous | 2004 |
Camptothecin-loaded films for the prevention of postsurgical adhesions.
Topics: Animals; Body Weight; Camptothecin; Cecum; Disease Models, Animal; Elasticity; Inflammation; Postoperative Complications; Rats; Rats, Sprague-Dawley; Time Factors; Tissue Adhesions; Wound Healing | 2004 |
Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resista
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cyclooxygenase 2; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Intramolecular Oxidoreductases; Irinotecan; Isoenzymes; Liver Neoplasms; Lung Neoplasms; Membrane Proteins; Mice; Mice, Nude; Neoplasm Proteins; Organoplatinum Compounds; Ornithine Decarboxylase; Oxaliplatin; Paclitaxel; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Survival Rate; Transplantation, Heterologous; Vault Ribonucleoprotein Particles | 2004 |
Enhanced therapeutic efficacy of a novel liposome-based formulation of SN-38 against human tumor models in SCID mice.
Topics: Animals; Biomedical Enhancement; Camptothecin; Cell Line, Tumor; Clinical Trials, Phase I as Topic; Colonic Neoplasms; Disease Models, Animal; Drug Carriers; Female; HT29 Cells; Humans; Injections, Intravenous; Irinotecan; Liposomes; Mice; Mice, SCID; Technology, Pharmaceutical; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2004 |
Suppressive effect of CPT-11 on rat esophageal tumorigenesis induced by N-nitrosomethylbenzylamine.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Squamous Cell; Dimethylnitrosamine; Disease Models, Animal; DNA, Single-Stranded; Esophageal Neoplasms; Immunohistochemistry; Irinotecan; Male; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Tumor Suppressor Protein p53 | 2004 |
Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms.
Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Camptothecin; Carboxylesterase; Cell Line, Tumor; Combined Modality Therapy; Cytosine Deaminase; Disease Models, Animal; Drug Delivery Systems; Female; Fluorouracil; Genetic Therapy; Genetic Vectors; Humans; Inhibitory Concentration 50; Irinotecan; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasms, Glandular and Epithelial; Promoter Regions, Genetic; Ribosomes; RNA, Messenger; Thymidylate Synthase; Time Factors; Transcription, Genetic | 2004 |
Disc degeneration in the rabbit: a biochemical and radiological comparison between four disc injury models.
Topics: Animals; Apoptosis; Arthrography; Camptothecin; Disease Models, Animal; Enzyme Inhibitors; Female; Glycosaminoglycans; Intervertebral Disc; Intervertebral Disc Displacement; Magnetic Resonance Imaging; Needles; Rabbits; Reproducibility of Results; Sulfates; Water; Wounds, Stab | 2005 |
Cellular basis of antiproliferative and antitumor activity of the novel camptothecin derivative, gimatecan, in bladder carcinoma models.
Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Camptothecin; Disease Models, Animal; DNA Topoisomerases, Type I; Down-Regulation; Female; Humans; Mice; Mice, Nude; Protease Inhibitors; Pyrazines; RNA, Messenger; S Phase; Topoisomerase I Inhibitors; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2005 |
Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Camptothecin; Cisplatin; Colonic Neoplasms; Cytosine; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Fluorouracil; Green Fluorescent Proteins; Humans; Immunotherapy; Interferons; Liposomes; Liver; Liver Neoplasms; Luminescent Proteins; Lung Neoplasms; Male; Metalloproteases; Mice; Mice, Inbred C57BL; Mice, Nude; Mice, Transgenic; Microscopy, Fluorescence; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Oligonucleotides, Antisense; Pancreatic Neoplasms; Prostatic Neoplasms; Red Fluorescent Protein | 2005 |
A mouse model for developing treatment for secondary liver tumors.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Humans; Immunohistochemistry; Irinotecan; Liver; Liver Neoplasms; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Neoplasm Metastasis; Time Factors | 2005 |
Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Docosahexaenoic Acids; Drug Design; Drug Screening Assays, Antitumor; Humans; Leukemia L1210; Mice; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship | 2005 |
The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-kappaB.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antipyrine; Apoptosis; Blotting, Western; Camptothecin; Caspase 3; Caspases; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Edaravone; Electrophoretic Mobility Shift Assay; Free Radical Scavengers; In Situ Nick-End Labeling; Irinotecan; Lung Neoplasms; Male; Mice; NF-kappa B; Reactive Oxygen Species | 2005 |
Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor-bearing mice.
Topics: Animals; Area Under Curve; beta-Cyclodextrins; Camptothecin; Chromatography, High Pressure Liquid; Colonic Neoplasms; Disease Models, Animal; Female; Half-Life; Humans; Injections, Intraperitoneal; Injections, Intravenous; Mice; Mice, Nude; Polymers; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2006 |
Drug Discovery Technology and Development 2005 - IBC's Tenth World Congress. Cancer mouse models and other techniques for improved prediction of efficacy.
Topics: Angiogenesis Inhibitors; Animals; Boronic Acids; Bortezomib; Camptothecin; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Forecasting; Gemcitabine; Green Fluorescent Proteins; Humans; Image Enhancement; Irinotecan; Luminescent Proteins; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Pyrazines; Red Fluorescent Protein; Technology, Pharmaceutical; Treatment Outcome | 2005 |
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Ceramides; Disease Models, Animal; Docetaxel; Flow Cytometry; Green Fluorescent Proteins; Humans; Lysophospholipids; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; RNA Interference; Sphingosine; Taxoids; Tumor Cells, Cultured | 2005 |
Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; CpG Islands; Dendritic Cells; Disease Models, Animal; Female; Fluorouracil; Humans; Immunotherapy; Irinotecan; Mice; Mice, Inbred BALB C; Oligonucleotides | 2006 |
Preclinical efficacy of the camptothecin-polymer conjugate IT-101 in multiple cancer models.
Topics: Animals; Breast Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Colorectal Neoplasms; Cyclodextrins; Disease Models, Animal; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Nanotechnology; Pancreatic Neoplasms; Polymers; Sarcoma, Ewing; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2006 |
Irinotecan-eluting stents inhibited neointimal proliferation in hypercholesterolemic rabbit aortas.
Topics: Animals; Aorta, Abdominal; Atherosclerosis; Camptothecin; Cell Proliferation; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Hypercholesterolemia; Inflammation; Irinotecan; Necrosis; Phosphorylcholine; Rabbits; Research Design; Stents; Tunica Intima | 2006 |
Evaluation of the toxic potentials of a new camptothecin anticancer agent CKD-602 on fertility and early embryonic development in rats.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Body Weight; Camptothecin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Embryonic Development; Female; Fertility; Injections, Intravenous; Litter Size; Male; No-Observed-Adverse-Effect Level; Organ Size; Rats; Rats, Sprague-Dawley | 2006 |
Comparison of antitumor activities in tumor xenograft treatment.
Topics: Algorithms; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Disease Models, Animal; Humans; Irinotecan; Mice; Sesquiterpenes; Transplantation, Heterologous; Treatment Outcome | 2007 |
Evaluation of antimetastatic activity and systemic toxicity of camptothecin-loaded microspheres in mice injected with B16-F10 melanoma cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Capsules; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Melanoma; Mice; Microspheres; Neoplasm Metastasis; Neoplasm Transplantation; Particle Size | 2006 |
A photon counting technique for quantitatively evaluating progression of peritoneal tumor dissemination.
Topics: Animals; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Female; Humans; Image Processing, Computer-Assisted; Irinotecan; Luciferases; Mice; Mice, Inbred BALB C; Mice, Nude; Peritoneal Neoplasms; Photons; Stomach Neoplasms; Transfection | 2006 |
A non-invasive method for detection of intestinal mucositis induced by different classes of chemotherapy drugs in the rat.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breath Tests; Camptothecin; Cyclophosphamide; Disease Models, Animal; DNA Topoisomerases, Type I; Doxorubicin; Etoposide; Female; Intestine, Small; Irinotecan; Mucositis; Rats; Sucrase; Sucrose; Topoisomerase I Inhibitors | 2006 |
St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cytokines; Diarrhea; Disease Models, Animal; Down-Regulation; Drug Therapy, Combination; Hypericum; Intestinal Mucosa; Irinotecan; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley | 2006 |
Treatment of neoplastic meningitis with intrathecal 9-nitro-camptothecin.
Topics: Animals; Antineoplastic Agents; Camptothecin; Disease Models, Animal; Glioblastoma; Injections, Spinal; Meningitis; Rats; Rats, Nude | 2006 |
Consistent liver metastases in a rat model by portal injection of microencapsulated cancer cells.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Gemcitabine; Humans; Injections, Intravenous; Irinotecan; Liver Neoplasms, Experimental; Mice; Mice, Nude; Microspheres; Neoplasm Transplantation; Pancreatic Neoplasms; Portal Vein; Rats; Rats, Nude; Transplantation, Heterologous | 2006 |
Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent.
Topics: Administration, Oral; Animals; Bone Marrow; Camptothecin; Cysteine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Irinotecan; Kidney; Kinetics; Liver; Mice; Mice, Nude; Neoplasms; Organoselenium Compounds; Plasma; Selenium; Selenocysteine | 2007 |
Irinotecan: a potential new chemotherapeutic agent for atypical or malignant meningiomas.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Culture Techniques; Cell Line, Tumor; Disease Models, Animal; Irinotecan; Male; Meningioma; Mice; Mice, Nude; Proto-Oncogene Proteins c-bcl-2; Soft Tissue Neoplasms; Subcutaneous Tissue | 2007 |
Therapeutic efficacy of NSC606985, a novel camptothecin analog, in a mouse model of acute promyelocytic leukemia.
Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Disease Models, Animal; Leukemia, Promyelocytic, Acute; Mice | 2007 |
Role of cytokines (TNF-alpha, IL-1beta and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chemokines; Diarrhea; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Injections, Intraperitoneal; Interleukin-1beta; Intestine, Small; Irinotecan; Male; Mice; Mucositis; Pentoxifylline; Peroxidase; Thalidomide; Tumor Necrosis Factor-alpha | 2008 |
Intraperitoneal chemotherapy with hydroxycamptothecin reduces peritoneal carcinomatosis: results of an experimental study.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma; Cell Line, Tumor; Disease Models, Animal; Humans; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Peritoneal Neoplasms; Survival Rate; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays | 2008 |
Establishment of a single-dose irinotecan model of gastrointestinal mucositis.
Topics: Animals; Body Weight; Camptothecin; Diarrhea; Disease Models, Animal; Female; Irinotecan; Mucositis; Neoplasm Transplantation; Organ Size; Rats; Survival Rate | 2007 |
Stealth and non-stealth nanocapsules containing camptothecin: in-vitro and in-vivo activity on B16-F10 melanoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Screening Assays, Antitumor; Female; Injections, Intraperitoneal; Lung Neoplasms; Melanoma, Experimental; Mice; Nanocapsules; Neutropenia; Particle Size; Polyesters; Polyethylene Glycols | 2007 |
Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Cycle; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Synergism; Fluorouracil; Humans; Irinotecan; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Polymers; Transplantation, Heterologous | 2008 |
Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11-refractory model.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Camptothecin; Carcinoma; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Female; Humans; Irinotecan; Mice; Mice, Nude; Models, Biological; Neoplasms; Pancreatic Neoplasms; Polyethylene Glycols; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2008 |
A novel molecular mechanism for anticancer drug-induced ovarian failure: Irinotecan HCl, an anticancer topoisomerase I inhibitor, induces specific FasL expression in granulosa cells of large ovarian follicles to enhance follicular apoptosis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase 3; Disease Models, Animal; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Female; Granulosa Cells; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Irinotecan; Mice; Organ Culture Techniques; Primary Ovarian Insufficiency; Recombinant Proteins; Topoisomerase I Inhibitors; Up-Regulation | 2008 |
[Animal models used to study the therapeutic effect and mechanism of Chinese herbal drugs in the treatment of psoriasis].
Topics: Animals; Camptothecin; China; Disease Models, Animal; Female; Mice; Mitosis; Plants, Medicinal; Psoriasis; Vagina | 1984 |
Schedule-dependent efficacy of camptothecins in models of human cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Irinotecan; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured | 1996 |
Efficacy of oral irinotecan against neuroblastoma xenografts.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Child, Preschool; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Infant; Irinotecan; Mice; Mice, Inbred CBA; Neuroblastoma; Topoisomerase I Inhibitors; Transplantation, Heterologous | 1997 |
A comparison of locoregional depot and systemic preparations of 9-aminocamptothecin for treatment of liver metastases in a rat tumor model: superior antitumor activity of sustained-release preparation.
Topics: Animals; Antineoplastic Agents; Camptothecin; Delayed-Action Preparations; Disease Models, Animal; Drug Delivery Systems; Ethiodized Oil; Liver Neoplasms, Experimental; Rats; Rats, Inbred F344 | 1997 |
Interleukin 15 offers selective protection from irinotecan-induced intestinal toxicity in a preclinical animal model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Colon; Colorectal Neoplasms; Diarrhea; Disease Models, Animal; Drug Interactions; Duodenum; Female; Interleukin-15; Intestinal Mucosa; Irinotecan; Paraffin Embedding; Rats; Rats, Inbred F344 | 1998 |
Antiangiogenic effects of camptothecin analogues 9-amino-20(S)-camptothecin, topotecan, and CPT-11 studied in the mouse cornea model.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cornea; Disease Models, Animal; Fibroblast Growth Factor 2; Irinotecan; Mice; Mice, Inbred Strains; Neovascularization, Pathologic; Neovascularization, Physiologic; Topotecan; Vincristine | 1999 |
Activity of oral and intravenous 9-aminocamptothecin in SCID mice engrafted with human leukemia.
Topics: Acute Disease; Administration, Oral; Animals; Camptothecin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; HLA-DQ alpha-Chains; HLA-DQ Antigens; Humans; Injections, Intravenous; Leukemia, Experimental; Leukemia, Myeloid; Mice; Mice, SCID; Neoplasm Transplantation; Survival Rate | 1998 |
Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Division; Disease Models, Animal; DNA; Drug Screening Assays, Antitumor; Drug Stability; Enzyme Inhibitors; HT29 Cells; Humans; K562 Cells; Lactones; Leukemia L1210; Leukemia, Experimental; Neoplasm Transplantation; Topoisomerase I Inhibitors; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
Tumor necrosis factor-related apoptosis-inducing ligand's antitumor activity in vivo is enhanced by the chemotherapeutic agent CPT-11.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Colonic Neoplasms; Disease Models, Animal; Drug Screening Assays, Antitumor; Drug Synergism; Female; HT29 Cells; Humans; Irinotecan; Membrane Glycoproteins; Mice; Mice, SCID; Neoplasm Transplantation; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 1999 |
Unique biochemical, cytotoxic, and antitumor activity of camptothecin and 4beta-amino-4'-O-demethylepipodophyllotoxin conjugates.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Cycle; Disease Models, Animal; DNA; DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Podophyllotoxin; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2000 |
Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Berberine; Camptothecin; Carcinoma, Lewis Lung; Disease Models, Animal; Female; Irinotecan; Lung Neoplasms; Lymphatic Metastasis; Mediastinal Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Transplantation; Transcription Factor AP-1 | 2001 |
Treatment of visceral leishmaniasis with sterically stabilized liposomes containing camptothecin.
Topics: Animals; Antiprotozoal Agents; Camptothecin; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Drug Stability; Leishmania donovani; Leishmaniasis, Visceral; Liposomes; Mice; Mice, Inbred BALB C; Treatment Outcome | 2001 |
Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Cisplatin; Colonic Neoplasms; Disease Models, Animal; Drug Synergism; Female; Fluorouracil; Humans; Irinotecan; Mice; Mice, Nude; Neoplasm Transplantation; Signal Transduction; Sphingomyelins; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides; Cyclophosphamide; Cytarabine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethylamines; Fluorouracil; Imidazoles; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Oxazines; Piperazines; Procarbazine; Propane; Triazenes | 1974 |