Compounds > camptothecin
Page last updated: 2024-08-22

camptothecin and Cancer of Colon

camptothecin has been researched along with Cancer of Colon in 719 studies

Research

Studies (719)

TimeframeStudies, this research(%)All Research%
pre-19901 (0.14)18.7374
1990's76 (10.57)18.2507
2000's324 (45.06)29.6817
2010's249 (34.63)24.3611
2020's69 (9.60)2.80

Authors

AuthorsStudies
Boehm, JC; Caranfa, MJ; Faucette, LF; Gallagher, G; Hecht, SM; Holden, KG; Jakas, DR; Johnson, RK; Kingsbury, WD; McCabe, FL1
Baguley, BC; Bu, X; Deady, LW; Denny, WA; Finlay, GJ1
Burgess, JP; Fairchild, CR; Farnsworth, NR; Kinghorn, AD; Navarro, HA; Oberlies, NH; Peterson, RW; Pinos, RE; Soejarto, DD; Wall, ME; Wani, MC1
Bandrés, E; Chozas, H; Cordeu, L; Cubedo, E; Echeverría, M; Font, M; García-Foncillas, J; Mendivil, B; Palop, JA; Rebollo, A; Sáenz, X; Sanmartin, C; Victoria Domínguez, M1
Jadegoud, Y; Jayaprakasha, GK; Mandadi, KK; Nagana Gowda, GA; Patil, BS; Poulose, SM1
Bandey, AH; Chashoo, G; Mondhe, D; Qazi, GN; Qazi, NA; Reddy, DM; Sampath Kumar, HM; Sawant, SD; Saxena, A; Saxena, AK; Sethi, VK; Shankar, M; Singh, SK; Srinivas, J; Taneja, SC; Verma, M1
Bielawska-Pohl, A; Duarte, N; Duś, D; Ferreira, MJ; Michalak, K; Paprocka, M; Sroda-Pomianek, K; Wesołowska, O; Wiśniewski, J1
Islam, MS; Kadi, AA; Kwon, Y; Park, S; Rahman, AF; Song, C1
Ali, T; Chai, HB; Inagaki, M; Rakotondraibe, LH; Rapplye, C; Wieboldt, T1
Fujimoto, M; Fukuda, T; Ishibashi, F; Iwao, M; Nanjo, Y; Natsui, Y; Okazaki, F; To, H; Yoshida, K1
Chen, S; Cheng, J; Dong, G; Fang, K; Huang, Y; Li, Y; Sheng, C; Wang, L; Wu, S1
Abdelhameid, MK; Ismail, MM; Mohammed, MR; Noha, RM; Salwa, E1
Hu, X; Jiang, W; Li, J; Li, X; Long, L; Wang, Y; Wang, Z; Yu, Q; Zhang, H1
Callan, B; Callan, JF; Gao, J; Griffith, DM; Logan, KA; Love, M; McHale, AP; McKaig, T; Nesbitt, H; Taylor, M1
Alsrhani, A; Farhana, A; Koh, AE; Kumar Subbiah, S; Mok, PL; Tong, JB1
Arai, H; Battaglin, F; Jayachandran, P; Kawanishi, N; Lenz, HJ; Mancao, C; Millstein, J; Mumenthaler, SM; Parikh, AR; Salhia, B; Soni, S; Wang, J; Xiao, Y; Zhang, W1
Ahn, JB; Beom, SH; Byun, HK; Chang, JS; Kim, HS; Kim, K; Kim, MS; Koom, WS; Lee, J; Park, EJ; Shin, SJ; Yang, G1
Liu, H; Rong, X; Wang, J; Wang, Y; Yu, H; Zhao, J1
Atkins, JN; Bainter, TM; Blanke, CD; Fuchs, CS; Goldberg, RM; Hochster, HS; Innocenti, F; Lenz, HJ; Ma, C; Mayer, RJ; McCleary, NJ; Meyerhardt, JA; Ng, K; Niedzwiecki, D; O'Neil, BH; O'Reilly, EM; Ou, FS; Polite, BN; Venook, AP; Zhang, S1
Chang, TK; Chen, PJ; Chen, YC; Huang, CW; Li, CC; Su, WC; Tsai, HL; Wang, JY; Yin, TC1
Li, N; Nagasaki, Y; Nguyen-Trinh, QN; Trinh, KXT; Trinh, NT; Vo, VT; Vong, LB1
Hong, JY; Jo, H; Kang, WK; Kim, H; Kim, ST; Lee, J; Lee, MS; Lee, YP; Lim, HY; Park, JO; Park, SH; Park, YS1
Ando, M; Bando, H; Honda, K; Kadowaki, S; Kato, K; Masuishi, T; Matsubara, Y; Muro, K; Nakazawa, T; Narita, Y; Nozawa, K; Ogata, T; Tajika, M; Taniguchi, H1
Ahn, MS; Bae, BN; Baik, SH; Beom, SH; Han, SW; Jeon, SY; Jo, HJ; Kang, MH; Kim, DH; Kim, HK; Kim, JG; Kim, JH; Kim, JS; Kim, JY; Lee, MA; Lee, S; Oh, J; Park, I; Park, YS; Shin, SH; Yoon, JA; Zang, DY1
Cai, Z; Jin, L; Kagawa, Y; Makiyama, A; Satake, H; Shinozaki, E; Tanizawa, Y1
Al-Batran, SE; Decker, T; Denzlinger, C; Fischer, LE; Giessen-Jung, C; Heinemann, V; Heinrich, K; Heintges, T; Held, S; Jung, A; Kahl, C; Kaiser, F; Kiani, A; Kirchner, T; Kullmann, F; Lerchenmüller, C; Modest, DP; Peuser, B; Scheithauer, W; Seipelt, G; Stahler, A; Stauch, M; Stintzing, S; Uhlig, J; von Weikersthal, LF; Weiss, L1
Alonso de Castro, B; Cameselle García, S; Carmona Campos, M; Cousillas Castiñeiras, A; De la Cámara Gómez, JC; Fernández-Montes, A; Gómez-Randulfe Rodríguez, MI; González Villarroel, P; Martínez-Lago, N; Méndez Méndez, JC; Romero Reinoso, C; Salgado Fernández, M; Vidal Insua, Y1
Antoniotti, C; Brodskiy, P; Calegari, MA; Carullo, M; Conca, V; Corti, F; Cremolini, C; Elliott, A; Fassan, M; Intini, R; Korn, M; Lenz, HJ; Lonardi, S; Masi, G; Mauri, G; Moretto, R; Pella, N; Pietrantonio, F; Rasola, C; Rossini, D; Salati, M; Sartore-Bianchi, A; Scartozzi, M; Shields, A1
Arai, H; Battaglin, F; Heinemann, V; Jayachandran, P; Kawanishi, N; Lenz, HJ; Millstein, J; Soni, S; Stintzing, S; Wang, J; Yang, Y; Zhang, W1
Liu, JY; Liu, X; Long, YX; Qiu, M; Zhou, YW1
Akazawa, N; Ando, T; Hirata, K; Kagawa, Y; Kato, T; Maeda, H; Mishima, H; Nagasaka, T; Nagata, N; Oba, K; Sakamoto, J; Shiozawa, M; Watanabe, J; Yamada, T; Yokota, M1
Arai, H; Battaglin, F; Cremolini, C; Falcone, A; Heinemann, V; Jayachandran, P; Kawanishi, N; Lenz, HJ; Liu, T; Loupakis, F; Mancao, C; Millstein, J; Shen, L; Soni, S; Stintzing, S; Wang, J; Xiao, Y; Yang, Y; Zhang, W1
Aparicio, J; Capdevila, J; Gallego, RÁ; Galván, P; García de Albeniz, X; Hernandez-Yagüe, X; Hernando, J; Maurel, J; Muñoz Boza, F; Oliveres, H; Páez, D; Richart, P; Riesco-Martinez, MC; Serrano, S; Vera, R; Virgili Manrique, AC1
Li, Y; Shi, W; Wu, D; Yu, H; Zhang, G; Zhao, D; Zhong, B1
Banerjee, A; Chrabaszcz, S; Dhiman, A; Gamblin, TC; Johnston, FM; Klooster, B; Rajeev, R; Turaga, KK; Witmer, HDD1
Gao, L; Liu, X; Ma, X; Ou, K; Wang, Q; Yang, L; Zhang, H1
Blaney, M; Cubillo, A; Kozloff, M; Liang, JT; Lowe, T; Matrana, M; Naumovski, L; Sahtout, M; Strickler, JH; Wainberg, ZA1
Decker, T; Denzlinger, C; Fischer von Weikersthal, L; Gießen-Jung, C; Graeven, U; Heinemann, V; Heinrich, K; Held, S; Jung, A; Kaiser, F; Kirchner, T; Kurreck, A; Modest, DP; Neumann, J; Schenk, M; Schwaner, I; Stahler, A; Stintzing, S1
D'Anastasi, M; Decker, T; Gesenhues, AB; Heinemann, V; Heintges, T; Hesse, N; Hofmann, FO; Holch, JW; Kahl, C; Kaiser, F; Kiani, A; Kullmann, F; Link, H; Modest, DP; Moehler, M; Scheithauer, W; Stintzing, S; von Weikersthal, LF1
Afable, M; Gathirua-Mwangi, W; Khan, T; Wu, Y; Yang, T1
Kazama, H; Terazawa, T; Uetake, H; Watanabe, J; Yamane, S; Yoshino, T1
Hamamoto, Y; Hazama, S; Iida, M; Ioka, T; Kanesada, K; Matsui, H; Nagano, H; Ogihara, H; Shindo, Y; Suzuki, N; Takeda, S; Tokumitsu, Y; Tsunedomi, R; Yoshida, S1
Allegrini, G; Antoniotti, C; Borelli, B; Carullo, M; Citarella, F; Cremolini, C; Dell'Aquila, E; Fulgenzi, CAM; Lonardi, S; Marmorino, F; Masi, G; Nappo, F; Passardi, A; Pietrantonio, F; Rossini, D; Santini, D; Spagnoletti, A; Tamburini, E; Vetere, G; Zaniboni, A1
Bendell, J; Cervantes, A; Chiu, VK; Fakih, M; Falcone, A; Fontaine, M; Grothey, A; Hitron, M; Oh, SC; Shah, MA; Tabernero, J; Taieb, J; Tebbutt, NC; Tomasek, J; Van Cutsem, E; Wu, C; Xu, B; Xu, RH; Yamaguchi, K; Yoshino, T1
Acar, R; Akbas, S; Akinci, MB; Araz, M; Arslan, C; Artac, M; Bahceci, A; Bilgetekin, I; Bilici, A; Cakir, E; Celik, E; Cilbir, E; Cincin, I; Dede, DS; Demirkiran, A; Deniz, GI; Dogan, I; Erdem, D; Erdogan, AP; Eren, OO; Erol, C; Garbioglu, DB; Gulmez, A; Hacibekiroglu, I; Hamdard, J; Hizal, M; Inal, A; Kahraman, S; Kaya, AO; Koca, S; Kubilay, P; Kucukarda, A; Kut, E; Mandel, NM; Menekse, S; Nayir, E; Oksuzoglu, B; On, S; Oyman, A; Ozyukseler, DT; Paydas, S; Sakin, A; Sen, E; Sendur Mehmet, AN; Sevinc, A; Taskaynatan, H; Tastekin, D; Turhal, S; Uncu, D; Yalcin, B; Yildirim, ME1
Alés Díaz, I; Aranda, E; Élez, E; García-Alfonso, P; García-Ortiz, MV; Gómez-España, MA; Graña, B; Grávalos, C; Losa, F; Polo, E; Riesco, MC; Rivera, F; Rodríguez, R; Rodríguez-Ariza, A; Ruiz-Casado, A; Safont, MJ; Salgado, M; Salud, A; Tabernero, JM; Toledano-Fonseca, M; Valladares-Ayerbes, M1
Abad, LP; Aguilera, MJS; Bonastre, MTT; Hernández, IB; Pérez, IP; Raga, MG; Rodríguez, PL; Sosa, MM; Urtasun, JA; Veiga, RC1
Bergamo, F; Conca, V; Cremolini, C; Di Donato, S; Fanotto, V; Fontanini, G; Germani, MM; Giordano, M; Latiano, TP; Lonardi, S; Masi, G; Moretto, R; Niccoli, C; Passardi, A; Pietrantonio, F; Prisciandaro, M; Proietti, A; Tamburini, E; Ugolini, C; Zaniboni, A1
Antoniotti, C; Bensi, M; Bergamo, F; Boccaccino, A; Boquet, I; Catteau, A; Conca, V; Cremolini, C; Galon, J; Giordano, M; Leonetti, S; McGregor, K; Morano, F; Murgioni, S; Nielsen, TJ; Papiani, G; Passardi, A; Pietrantonio, F; Ross, DT; Rossini, D; Salvatore, L; Schweitzer, BL; Seitz, R; Tamburini, E; Varga, MG1
Altucci, L; Anderson, A; Ciardiello, D; Ciardiello, F; Coker, O; De Falco, V; Della Corte, CM; Famiglietti, V; Fowlkes, NW; Kanikarla, P; Kopetz, S; Lee, HM; Martinelli, E; Martini, G; Morris, V; Napolitano, S; Sorokin, A; Tabernero, J; Troiani, T; Villareal, OE; Woods, M1
Cao, J; Ding, Y; Feng, X; Ji, D; Liu, L; Mao, C; Song, L; Song, W; Wu, Y; Xu, N; Zhang, J; Zhang, Y1
Chorawala, MR; Patel, RS; Thakur, A1
Azuma, K; Dote, S; Fujii, R; Fukui, R; Goto, E; Hayasaka, D; Hayashi, Y; Hirabatake, M; Hirata, T; Honda, S; Ikesue, H; Itakura, S; Ito, K; Kataoka, N; Kobayashi, A; Kobayashi, Y; Kohno, E; Makihara, K; Mashimo, K; Meguro, Y; Miyake, M; Miyata, H; Morimoto, N; Nakao, M; Nakata, Y; Negoro, Y; Nishiuma, S; Odaira, N; Shigemori, M; Shimato, A; Shiwaku, E; Suzuki, S; Takagi, M; Takahashi, K; Takahashi, M; Takahashi, Y; Tasaka, M; Tokutome, A; Watanabe, H; Yagisawa, K; Yamaguchi, D; Yamamoto, Y; Yokomizo, A; Yoshino, M1
Bako, E; Ciardiello, F; Di Bartolomeo, M; Elez, E; Fakih, M; Grothey, A; Kawakami, H; Kobayashi, K; Loupakis, F; Masuishi, T; Meinhardt, G; Nishina, T; Okuda, Y; Raghav, K; Rodriguez, J; Saxena, K; Siena, S; Wainberg, Z; Yamaguchi, K; Yoshino, T1
Boccaccino, A; Bustreo, S; Carullo, M; Clavarezza, M; Cremolini, C; Cupini, S; Daniel, F; Libertini, M; Lonardi, S; Morano, F; Niger, M; Palermo, F; Pietrantonio, F; Procaccio, L; Raimondi, A; Rossini, D; Santini, D; Tomasello, G; Zaniboni, A1
Burkart, C; Eucker, J; Fischer von Weikersthal, L; Heinemann, V; Heinrich, K; Kahl, C; Kaiser, F; Karthaus, M; Kasper-Virchow, S; Krammer-Steiner, B; Modest, DP; Müller, C; Pihusch, R; Prager, GW; Reinacher-Schick, A; Schwaner, I; Stauch, M; Stintzing, S; Taieb, J; Tougeron, D1
Chin, K; Fukuda, K; Fukuoka, S; Nakayama, I; Ogura, M; Ooki, A; Osumi, H; Shinozaki, E; Takahari, D; Wakatsuki, T; Yamaguchi, K; Yoshino, K1
Qin, J; Sun, W; Wang, Y; Yin, L; Zhang, K; Zhang, Y1
Armansyah, A; Khoe, LC; Megraini, A; Nadjib, M; Nugraha, RR; Permanasari, VY; Putri, S; Saldi, SRF; Santatiwongchai, B; Sastroasmoro, S; Setiawan, E1
Fukuda, H; Hamaguchi, T; Hashimoto, T; Hironaka, S; Kanemitsu, Y; Kataoka, T; Mizusawa, J; Otsu, S; Takashima, A; Tsukamoto, S1
Hansen, TF; Havelund, BM; Jensen, LH; Lindebjerg, J; Rafaelsen, SR; Raunkilde, L; Thomsen, CB1
Anchisi, S; Bohanes, P; Derigs, HG; Geffriaud-Ricouard, C; Grünberger, B; Gueldner, M; Hofheinz, RD; Piringer, G; Scholten, F; Schwarz, L; Thaler, J; von Moos, R1
Kim, KP; Lee, BK; Yoon, S1
Chiron, M; Denda, T; Esaki, T; Fujii, H; Hamaguchi, T; Itabashi, M; Kajiwara, T; Komatsu, Y; Kudo, T; Moriwaki, T; Nagashima, F; Nakajima, TE; Oki, E; Otsu, S; Sasaki, T; Sato, T; Sugimoto, N; Takahashi, S; Ura, T; Yamazaki, K; Yoshino, T1
Li, Q; Liu, M; Wang, M; Weng, Q; Xiao, L; Xu, J; Zhou, L1
Balcı, NC; İnan, N; Koyuncu Sökmen, B; Namal, E; Öz, A; Server, S1
Aizawa, M; Endo, S; Isohata, N; Nemoto, D; Nemoto, T; Oshibe, I; Saito, T; Soeta, N; Takayanagi, D; Togashi, K; Utano, K1
Akamatsu, H; Fujie, Y; Imasato, M; Kagawa, Y; Kawai, K; Murata, K; Naito, A; Nakaba, H; Ohtsuka, M; Suzuki, Y; Takeda, Y; Takeno, A1
Anderson, CF; Cui, H; Dai, W; Oh, R; Su, H; Wan, F; Wang, F; Wang, Z; Xu, D; Zhang, W; Zheng, M1
Aranda, E; Élez, E; Gallego, J; González, E; Safont, MJ; Salgado, M; Vera, R1
Alberts, SR; Allegra, CJ; Andre, T; Blanke, CD; de Gramont, A; Dixon, JG; Francini, E; George, TJ; Goldberg, RM; Grothey, A; Haller, DG; Kerr, R; Marsoni, S; O'Connell, MJ; Saltz, LB; Seitz, JF; Shi, Q; Taieb, J; Twelves, C; VanCutsem, E; Wagner, AD; Wolmark, N; Yothers, G1
Aoki, I; Bakalova, R; Higashi, T; Lazarova, D; Lefterov, P; Nikolova, B; Semkova, S; Stoyanova, E; Tsoneva, I; Zhelev, Z1
Abnous, K; Alibolandi, M; Babaei, M; Ramezani, M; Sh Saljooghi, A; Taghavi, S; Taghdisi, SM1
Farma, J; Hall, MJ; Jain, R; Luo, B; McGillivray, E; Savage, M1
Kanto, S; Kawabe, A; Okamura, M; Sakikubo, M; Takeji, S; Tatsumi, K; Yasuda, S1
Al-Rajabi, R; Carroll, E; Diab, O; Kasi, A; Melancon, T; Rawlley, B1
Abnous, K; Alibolandi, M; Babaei, M; Ramezani, M; Sanati, S; Taghavi, S; Taghdisi, SM1
Bachet, JB; Bouvier, AM; Jooste, V; Lepage, C; Mas, L1
Anger, F; Germer, CT; Kelm, M; Klein, I; Kunzmann, V; Löb, S; Schlegel, N; Schollbach, J; Wiegering, A1
Abnous, K; Alibolandi, M; Ramezani, M; Taghdisi, SM; Zahiri, M1
Echeverry-Molina, MI; Gómez, M; Guevara-Cuellar, CA; Martínez, P; Soto-Rojas, VE1
Chen, J; Han, W; Lambesis, KT; Le, KT; Little, N; Lu, J; Scott, AJ; Wang, Z1
Bezdenezhnykh, N; Kocherga, R; Kovalova, O; Kudryavets, Y; Lykhova, O; Maksimyak, GI; Vorontsova, A; Zhylchuk, V1
Chen, QK; Chen, XW; Huang, YF; Liao, NZ; Liu, CC; Luo, ZT; Wang, GX; Zhang, WJ; Zhu, DJ1
Adam, R; Barroso, E; Capussotti, L; Elias, D; Giuliante, F; Gruenberger, T; Guglielmi, A; Hubert, C; Innominato, PF; Isoniemi, H; Lapointe, R; Laurent, C; Lin, JK; Lopez-Ben, S; Regimbeau, JM; Skipenko, OG; Yi, B1
Abdel-Rahman, WM; Al-Khayyal, NA; Aravind, SR; Nair, VA; Saber-Ayad, M1
Chen, X; Huang, Y; Luo, Y; Su, P; Wang, G; Wang, Q; Yang, Y; Zhu, D1
He, Y; Jia, B; Lac, D; Lam, KS; Li, Y; Lin, TY; Luo, Y; Xiao, K; Xue, X; Yang, X; Zhang, H1
Chen, Q; Han, MK; Kang, Y; Ma, L; Ma, P; Merlin, D; Xiao, B; Xu, Z1
Alarfaj, AA; Amira, F; Arulselvan, P; Arumugam, R; Benelli, G; Danjuma, L; Fakurazi, S; Hamat, RA; Higuchi, A; Krishnan, P; Kumar, SS; Kumari, S; Munusamy, MA; Murugan, K; Pooi Ling, M; Priya, SP; Rajan, M; Sakinah, S1
Abnous, K; Alibolandi, M; Farzad, SA; Ramezani, M; Rezvani, R; Taghdisi, SM1
Azrumelashvili, T; Chikovani, T; Janikashvili, N; Kikodze, N; Mizandari, M; Paksashvili, N; Pantsulaia, I; Shanava, K1
Chowdhury, R; Francia, G; Gales, D; Manne, U; Miller, S; Samuel, T; Valenzuela, P; Yehualaeshet, T1
Aarthy, T; Mohana Kumara, P; Mulani, FA; Nataraja, KN; Ravikanth, G; Santhoshkumar, TR; Siva, R; Soujanya, KN; Srimany, A; Thulasiram, HV; Uma Shaanker, R1
Blocker, SJ; Chen, W; Douglas, KA; Hendriks, BS; Lalo, E; Lee, H; Polin, LA; Shields, AF1
Fukuda, M; Hosokawa, M; Iwakawa, S; Masuda, A; Tanaka, S; Ueda, K1
Chen, HM; Cheng, AL; Lai, MS; Liang, YH; Shao, YY; Yeh, KH1
Chang, W; Li, R; Liu, W; Shen, Q; Tao, K; Tao, R; Xie, G; Yin, Y; Zhang, P1
Ebadi, M; Field, CJ; Lehner, R; Mazurak, VC1
Crathorne, L; Hoyle, M; Huxley, N; Napier, M; Snowsill, T; Tikhonova, IA; Varley-Campbell, J1
Liu, B; Liu, S1
Anan, C; Katada, E; Mitsui, A; Sasaki, S; Uematsu, N1
Chen, H; Chen, Y; Gu, Y; Hoffman, RM; Li, Y; Wang, H; Wang, W; Wu, M; Xu, M; Yang, Z; Zhu, P1
Conneely, JB; Greally, M; Linehan, A; McCaffrey, JA; O'Keane, C; Pilson, K; Shields, CJ1
Albrecht, MH; Gruber-Rouh, T; Hammerstingl, R; Lahrsow, M; Thompson, ZM; Vogl, TJ1
Cervantes, A; Moreno Vera, S; Peeters, M; Taieb, J1
André, T; Taieb, J1
Chen, Q; Han, MK; Kang, Y; Merlin, D; Viennois, E; Wan, Y; Wang, L; Xiao, B; Zhang, Y; Zhang, Z1
Chen, X; Ju, Y; Su, P; Wang, G; Yang, Y1
Ohara, H; Yamamoto, H1
DE Cesare, M1
Esna-Ashari, O; Fathi-Azarbayjani, A; Kheradmand, F; Malekinejad, H; Mohammadian, M; Rasmi, Y; Zeynali-Moghaddam, S1
Miyagaki, T; Nonogaki, A; Oka, T; Sato, S; Senda, N; Shibata, S; Yoshizaki, A1
Pietrantonio, F3
Kang, Y; Ma, L; Xiao, B; Xie, D; Zhang, X; Zu, M1
Accordino, MK; Hershman, DL; Hillyer, GC; Keller, D; Kiran, RP; Lin, A; Neugut, AI; O'Neil, DS; Raab, GT; Wright, J1
Cao, W; Chen, M; Hu, J; Liang, G; Xiao, Z; Yang, L; Zhao, C; Zheng, H; Zheng, S1
Chen, J; Chen, Q; Gou, S; Kang, Y; Ma, P; Ma, Y; Xiao, B; Zhu, S1
Huang, W; Huang, X; Jin, H; Li, H; Liu, M; Sun, M; Xie, Y; Yan, D; Zhu, T; Zhu, X1
Bang, OS; Hong, S; Kim, HY; Kim, J; Kim, NS; Kim, YA; Shin, S1
Kim, HS; Lee, JJ; Park, IH; Rhee, WJ; Shin, JS1
Chen, P; Gu, N; Ji, M; Sun, C; Wang, Z; Xing, J; Zhang, H; Zhang, X; Zhou, G1
Hamada, T; Ohashi, S; Ohta, K; Taniguchi, E; Yamagami, Y; Yoshikawa, M1
Machado, MA; Makdissi, FF; Surjan, RC1
Bradshaw-Pierce, EL; Eckhardt, SG; Gustafson, DL; Kulikowski, G; Merz, AL; Pitts, TM; Selby, H; Serkova, NJ; Weekes, CD1
Engstrom, PF; Kiel, K1
Diasio, RB1
Benson, AB1
Fujii, H; Horie, H; Inoue, T; Kotake, K; Miyakura, Y; Sugano, K; Tahara, M; Yasuda, Y1
Campolo, F; Dolci, S; Dorio, AS; Graziani, G; Lacal, PM; Leonetti, C; Muzi, A; Porru, M; Praz, F; Tentori, L; Vernole, P1
Chi, AL; Fei, B; Weng, Y1
Huang, S; Park, JM; Sinicrope, FA; Tougeron, D1
Alberts, SR; Blanke, CD; Cassidy, J; Cheung, WY; Kerr, DJ; Meyers, J; O'Connell, M; Sargent, DJ; Shi, Q; Van Cutsem, E; Yothers, G1
Arakawa, Y; Okawa, Y; Ozaki, K; Yamada, H1
Ge, FJ; Lin, L; Liu, ZY; Sharma, MR; Wang, Y; Xu, JM1
Fujiyama, Y; Kaneko, H; Kikuchi, M; Kinoshita, S; Nishizawa, T; Sakuno, T; Suzuki, H; Takahashi, M1
Goi, T; Katayama, K; Koneri, K; Sawai, K; Yamaguchi, A1
Kim, EJ; Kim, HS; Kim, J; Kim, SM; Lee, M; Young Kim, S1
Dent, P1
Zaki, NM1
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Cuzzocrea, S; Dorio, AS; Forini, O; Graziani, G; Lapidus, R; Leonetti, C; Mazzon, E; Muzi, A; Scarsella, M; Tentori, L; Vergati, M; Xu, W; Zhang, J1
Uemura, N; Yamada, Y1
Afchain, P; André, T; de Gramont, A; Segura, C1
Hunter, K; Jones-Bolin, S; Klein-Szanto, A; Ruggeri, B; Zhao, H1
Anazawa, S; Eto, K; Kosuge, M; Mitsuyama, Y; Mouri, T; Ogawa, M; Ushigome, T; Watanabe, M; Yamagata, T; Yanaga, K1
Lu, B; Zhang, Z1
Caciagli, B; Capaccioli, S; Donnini, M; Landini, I; Lapucci, A; Lulli, M; Mazzei, T; Mini, E; Morganti, M; Nobili, S; Papucci, L; Perna, F; Schiavone, N; Sobrero, A; Tempestini, A; Witort, E1
Deguchi, Y; Kaneko, I; Kii, E; Murata, T; Sonoda, K; Tsubono, M; Yasuda, K1
Egami, K; Maruyama, H; Matsutani, T; Miyamoto, M; Sasajima, K; Suzuki, S; Tajiri, T; Yokoyama, T1
Hiro, J; Inoue, Y; Kusunoki, M; Miki, C; Nakatani, K; Nobori, T; Ojima, E; Toiyama, Y; Watanabe, H1
Allaire, N; Amatucci, J; Bailly, V; Bottiglio, C; Browning, JL; Carmillo, A; Crowell, T; Ding, J; Fawell, S; Garber, E; Griffith, L; Heaney, G; Hoffman, R; Jarpe, M; Kelly, R; LePage, D; Lukashev, M; Lukashin, A; Mackay, F; Meier, W; Miatkowski, K; Ngam-ek, A; Perrin, S; Prentice, H; Reff, M; Silverio, E; Szeliga, K; Violette, SM; Wilson, C; Wortham, K; Xu, X; Yang, D; Yang, W; Zeng, W1
Adlakha, A; Allen, JA; Bergethon, PR1
Hamaguchi, T; Kitagawa, M; Koizumi, F; Matsumoto, S; Matsumura, Y; Negishi, T; Onda, T1
Fukushima, M; Hoebe, EK; Peters, GJ; Temmink, OH1
Higa, GM1
Ezumi, K; Fujie, Y; Fukunaga, H; Hata, T; Hirota, S; Ikeda, M; Ikenaga, M; Monden, M; Ohue, M; Sekimoto, M; Seshimo, I; Shingai, T; Takayama, O; Takemasa, I; Yamamoto, H; Yasui, M1
Bucana, CD; Fidler, IJ; Kitadai, Y; Kuwai, T; Nakamura, T; Sasaki, T1
Enomoto, M; Iida, S; Ishiguro, M; Kato, K; Makino, H; Morita, S; Sugihara, K; Takagi, Y; Uetake, H1
Azzariti, A; Han, Y; Li, YM; Li, ZQ; Paradiso, A; Wang, Y; Xu, JM; Yang, WW; Yuan, SJ; Zhao, CH1
Guichard, SM; Hua, ML; Jodrell, DI; Kang, P; Macpherson, JS1
Kitajima, M; Kubota, T; Wada, N1
Hiro, J; Inoue, Y; Kusunoki, M; Miki, C; Ojima, E; Toiyama, Y; Watanabe, H; Yanagi, H1
Honda, K; Kondo, H; Ohura, K; Sumiyoshi, T; Takahari, D; Tanaka, S; Tsuji, Y; Tsushima, T; Yoshizaki, N1
Kabeya, K; Kamoshita, N; Kobayashi, M; Makita, F; Matsuzaki, Y1
Cheng, J; Li, J; Wu, CP; Wu, Q; Xu, LG; Xu, N; Zhang, W; Zhao, ZY1
Hyodo, I1
Wils, J1
André, T; de Gramont, A; Larsen, AK; Louvet, C; Tournigand, C1
Adam, R1
Abbrederis, K; Kremer, M; Schuhmacher, C1
Marshall, JL1
Benson, AB; Mulcahy, MF; Wisinski, KB1
Arima, S; Futami, K; Kamitani, T; Koga, M1
Komatsu, Y1
Aikou, T; Akiyama, S; Akune, S; Che, XF; Firth, SD; Furukawa, T; Ikeda, R; Ishizawa, T; Kitazono, M; Komatsu, M; Mercer, JF; Owatari, S; Takeuchi, T; Tsujikawa, K; Yamamoto, M1
Bayer, W; Hoffmann, D; Wildner, O1
Fakih, MG; Gupta, B; LeVea, C; Litwin, A1
Berglund, A; Brünner, N; Byström, P; Christensen, IJ; Glimelius, B; Nielsen, HJ; Sørensen, NM1
Bosron, WF; Davis, WI; Green, SL; Sanghani, PC; Sanghani, SP; Schiel, MA1
Meropol, NJ1
Boku, N; Yamazaki, K; Yoshino, T1
He, YJ; Jiang, WQ; Li, YH; Luo, HY; Shi, YX; Wang, F; Xu, RH; Zhang, L1
Eguchi, T; Hiro, J; Inoue, Y; Kusunoki, M; Miki, C; Tanaka, K; Toiyama, Y; Yoshiyama, S1
Ishizu, K; Makuuchi, H; Sadahiro, S; Sunose, N; Tsuruo, T; Yamazaki, K; Yamori, T1
Abe, S; Araki, H; Chiba, H; Iyama, S; Kato, J; Murase, K; Niitsu, Y; Nikaido, T; Sagawa, T; Sato, T; Sato, Y; Takayama, T; Wada, Y1
Choi, CH; Han, HK; Han, SI; Jung, GR; Kim, KJ; Lee, TB; Lim, SC1
Czaykowski, PM1
Ballem, N; Berber, E; Parikh, RT; Siperstein, AE1
Chu, E; Grothey, E1
Ciardiello, F; Eckhardt, SG; Gustafson, DL; Henthorn, TK; Lockerbie, O; Long, M; Merz, A; Morrow, M; Serkova, NJ; Troiani, T1
Arnold, D; Lordick, F1
Baracos, VE; Dieleman, LA; Field, CJ; Sawyer, MB; Xue, H1
Alami, N; Belanger, S; Grieshaber, CK; Juste, S; Leyland-Jones, B; Paterson, J1
Fan, D; Fidler, IJ; Kim, JS; Kim, SJ; Kitadai, Y; Kuwai, T; Langley, RR; Nakamura, T; Sasaki, T; Tsan, RZ1
Bandrés, E; Enguita, M; García-Foncillas, J; Garrido, MJ; Moreno, D; Trocóniz, IF1
Berard, E; Colosetti, P; Czerucka, D; Dreano, M; Fenouille, N; Griessinger, E; Hofman, P; Imbert, V; Lagadec, P; Mari, M; Nawrot, MP; Peyron, JF; Rousseau, D1
Arita, A; Fujimoto, M; Mochizuki, K; Sakai, Y1
Wijesinghe, N1
Breil, C; Candeil, L; Conseiller, E; Copois, V; Del Rio, M; Denis, V; Fraslon, C; Gongora, C; Martineau, P; Molina, F; Pau, B; Vezzio, N1
Matsuda, T; Shikata, S1
Baracos, VE; Dieleman, LA; Field, CJ; Murray, D; Sawyer, MB; Xue, H1
Ambrosini, G; Qin, LX; Schwartz, GK; Seelman, SL1
Buchsbaum, DJ; Kim, H; LoBuglio, AF; Nan, L; Oliver, PG; Wang, W; Zhou, T; Zinn, KR1
Inagaki, D; Katayama, K; Oosawa, H; Shiraishi, R; Tanabe, H; Tani, K; Wada, H; Yasuda, S1
Li, S; Wang, A1
Bar-Eli, M; Fan, D; Fidler, IJ; Kerbel, RS; Kim, SJ; Kuwai, T; Nakamura, T; Sasaki, T; Villares, GJ; Wang, H; Zigler, M1
Ferreud, L; Holmlund, B; Sun, XF; Svanvik, J; Wallin, A1
Alami, N; Jerome, L; Leyland-Jones, B; Page, V; Paterson, J; Shiry, L; Yu, Q1
Cheshire, PJ; Danks, MK; Friedman, HS; Hallman, JD; Houghton, JA; Houghton, PJ; Lutz, L1
Astruc, J; Chazottes, E; DePrez, C; Jannot, MC; Kiss, R; Kruczynski, A; Pauwels, O; Yeaton, P1
Choh, H; Kusano, M; Nakao, K; Shibusawa, M; Takada, M; Tsunoda, A; Yokoyama, N; Yoshizawa, H1
Bae, I; Goldwasser, F; Pommier, Y; Torres, K; Valenti, M1
Rivory, LP; Robert, J1
Akiyama, S; Andoh, T; Ito, K; Kodera, Y; Kondou, K; Nagai, S; Nishizawa, M; Satta, T; Takagi, H; Yamauchi, M1
Fujimura, T; Kanno, M; Kurosaka, Y; Miwa, K; Miyazaki, I; Nishimura, G; Satou, T; Sugiyama, K; Yonemura, Y; Yoshimitsu, Y1
Besterman, JM; Brown, HR; Emerson, DL; Evans, MG; Leitner, PP; Luzzio, MJ; Shaffer, JE; Sternbach, DD; Uehling, D; Vuong, A1
Inaba, M; Kawada, S; Mitsuhashi, J; Nakano, H1
Kono, A; Shimazoe, T; Takiguchi, S1
Fujimori, A; Fujimori, Y; Pommier, Y; Tanizawa, A1
Giovanella, BC1
Bissery, MC; Cheshire, PJ; Hallman, JC; Houghton, JA; Houghton, PJ; Mathieu-Boué, A1
Besterman, JM; Croom, DK; Emerson, DL; Evans, MG; Lackey, K; Leitner, PL; Luzzio, MJ; McIntyre, G; Sternbach, DD; Vuong, A; Yates, J1
Terada, K1
Chou, TC; Conti, JA; Gonzalez, C; Huang, Y; Kemeny, NE; Pulliam, S; Saltz, LB; Sun, M; Tong, WP1
Beijnen, JH; Creemers, GJ; Davies, B; de Boer-Dennert, M; McDonald, M; Rosing, H; Schellens, JH; Verweij, J1
Boisseau, M; Bugat, R; Mahjoubi, M1
Keith, WN; McLeod, HL1
Goldwasser, F; Hoki, Y; Jackman, J; Kohn, KW; O'Connor, PM; Pommier, Y; Shimizu, T1
Anderson, RC; Babel, KM; Brat, DJ; Brem, H; Ewend, MG; Pinn, ML; Tabassi, K; Tyler, BM; Williams, JA1
Bae, I; Fornace, AJ; Goldwasser, F; Pommier, Y1
Willson, JK1
Ahmed, AE; Giovanella, BC; Jacob, S; Kozielski, AJ; Liehr, JG; Stehlin, JS1
Adenis, A; Becouarn, Y; Bonneterre, J; Brunet, P; Bugat, R; Burki, F; Conroy, T; Culine, S; Douillard, JY; Extra, JM; Ganem, G; Herait, P; Mahjoubi, M; Marty, M; Merrouche, Y; Mousseau, M; Namer, M; Negrier, S; Rougier, P; Seitz, JF; Suc, E; Ychou, M1
Chen, AY; Liu, LF1
Iino, Y; Kobayashi, I; Maemura, M; Morishita, Y; Ogawa, T; Ohwada, S; Satoh, Y1
Boven, E; Giaccone, G; Hulscher, ST; Jansen, WJ; Pinedo, HM; Zwart, B1
Cowan, KH; Fukuda, M; Ikeda, K; Kohno, S; Matsuo, I; Nakano, R; Narasaki, F; Oka, M; Soda, H; Takatani, H; Terashi, K; Tomonaga, M1
Berger, NA; Gordon, NH; Mackay, W; Whitacre, CM; Zborowska, E1
Kubota, N; Omura, M; Torigoe, S1
Kohlhagen, G; Kohn, KW; Nieves-Neira, W; Pommier, Y; Valenti, M; Wall, ME; Wani, MC1
Egashira, Y; Hirata, I; Katsu, K; Kawabe, S; Nakagawa, K; Nakagawa, Y; Takao, Y; Takiuchi, H1
Fujimori, A; Pommier, Y; Pondarré, C; Strumberg, D; Torres-León, R1
Courtney, A; Cox, J; Meyer, W; Mues, G; Nemunaitis, J1
Aoyagi, K; Aoyagi, Y; Asao, T; Okazaki, S; Sano, M; Utsugi, T; Wierzba, K; Yamada, Y1
Cheshire, PJ; Hanna, SK; Houghton, JA; Houghton, PJ; Luo, X; McGovren, JP; Poquette, C; Richmond, LB; Stewart, CF; Zamboni, WC1
Agrawal, S; Bianco, AR; Bianco, R; Caputo, R; Ciardiello, F; Damiano, V; Jiang, Z; Pepe, S; Pomatico, G; Tortora, G1
Aschele, C; Baldo, C; Bertino, JR; Bornmann, WG; Debernardis, D; Sobrero, AF1
Bierling, P; Bozec, L; Cvitkovic, E; Debat, P; Fromont, P; Lévi, F; Misset, JL1
Bugat, R; Canal, P; Chatelut, E; Guichard, S; Lochon, I; Mahjoubi, M1
McCann, J1
Jimbo, T; Kumazawa, E; Ochi, Y; Tohgo, A1
Bours, V; Fillet, G; Jerusalem, G1
Fidler, IJ; Killion, JJ; Kumar, R; Kuniyasu, H; Shinohara, H1
Fan, S; Gupta, M; Kohn, KW; O'Connor, PM; Pommier, Y; Zhan, Q1
Cheshire, PJ; Hallman, JD; Houghton, JA; Houghton, PJ; Li, Y; Luo, X; Lutz, L1
du Sorbier, BM; Lokiec, F; Sanderink, GJ1
Etienne, MC; Fischel, JL; Formento, JL; Formento, P; Francoual, M; Milano, G; Pavillard, V; Rostagno, P1
Fujikawa, R; Fukushima, J; Goya, T; Koshiishi, Y; Miya, T; Nogami, H1
Amantea, M; Colbern, GT; Dykes, DJ; Engbers, C; Hiller, A; Luzzio, M; Musterer, R; Pegg, E; Saville, R; Uster, P; Weng, S; Working, PK1
Attar, A; Bloch, F; Bruneval, P; Duong Van Huyen, JP; Kreft, C; Levoir, D; Molina, T1
Britten, CD; Eckhardt, SG; Hilsenbeck, SG; MacDonald, JR; Mangold, G; Marty, J; Rowinsky, EK; Von Hoff, DD; Weitman, S1
Berger, NA; Whitacre, CM; Willson, JK; Zborowska, E1
Cvitkovic, E; Goldwasser, F; Raymond, E; Zeghari-Squalli, N1
Ciesielski, MJ; Fenstermaker, RA1
Bugat, R; Canal, P; Chatelut, E; Chevreau, P; Frétigny, E; Guichard, S; Hennebelle, I; Lochon, I; Selves, J; Terret, C1
Fujiwara, T; Fukuda, H; Gamo, M; Ido, T; Ishioka, C; Iwata, R; Kanamaru, R; Murakawa, Y; Yoshioka, T1
Endo, W; Haridas, K; Hausheer, FH; Matsui, S; Rustum, YM; Seetharamulu, P; Wrzosek, C1
Chen, AY; Choy, H; Rothenberg, ML1
Ebuchi, M; Irie, T; Kure, M; Maruyama, M; Nagahama, T; Yoshida, T1
Armand, JP; Bexon, A; Bonnay, M; Ducreux, M; Mahjoubi, M; Méry-Mignard, D; Rougier, P; Seitz, JF; Ychou, M1
Joel, SP; te Poele, RH1
Gliniak, B; Le, T1
Al-Zoubi, A; Boucher, J; Savarese, D1
Ford, HE; Jackman, AL; Kimbell, R1
Hotta, T; Ishimoto, K; Iwahashi, M; Matsuda, K; Tanaka, H; Tani, M; Tanimura, H; Tsunoda, T; Yamaue, H1
Grivicich, I; Mans, DR; Peters, GJ; Schwartsmann, G1
Baars, JJ; Huibregtse, K; Pinedo, HM; Stieltjes, H; Van der Vijgh, WJ; van Groeningen, CJ1
Bigg, DC; Bronckart, Y; Chaboteaux, C; da Costa, PM; Decaestecker, C; Gordover, L; Harper, L; Kiss, R; Lavergne, O; Lesueur-Ginot, L; Malonne, H; Philippart, P1
Chambers, TC; Drake, RR; Jones, KE; McMasters, RA; Moyer, MP; Pitlyk, K; Saylors, RL; Wilbert, TN1
Brendel, MD; Daniel, H; Kuntz, S; Wenzel, U1
Hisano, C; Ishikawa, T; Kaji, Y; Maruyama, T; Masumoto, N; Nakamura, M; Nakano, S; Niho, Y; Ohkuma, K1
Bugat, R; Canal, P; Chatelut, E; Guichard, S; Hennebelle, I; Terret, C1
Boven, E; Hausheer, FH; Pinedo, HM; Schlüper, HM; Van Hattum, AH1
Graeven, U; Schmiegel, W1
Boige, V; Borrini, F; Ducreux, M; Fallik, D; Jacob, S; Praz, F; Sabourin, JC1
Akamatsu, T; Fujimoto, K; Honda, T; Kaneki, T; Kawashima, A; Koizumi, T; Kubo, K; Tsushima, K1
Ebuchi, M; Maruyama, M; Nagahama, T; Yuasa, Y1
Kobayashi, A; Yamaguchi, M1
Cao, Z; Early, J; Giovanella, B; Harris, N; Kozielski, A; Liehr, J; Mendoza, J; Pantazis, P; Stehlin, JS; Vardeman, D1
Gilbert, BE; Giovanella, BC; Kleinerman, ES; Knight, V; Koshkina, NV; Waldrep, JC1
Chow, DS; Giovanella, BC; Gong, L; Wolfe, MD1
Boven, E; Hoogsteen, I; Pinedo, HM; Schlüper, HM; Van Hattum, AH1
Ahmed, F; Cook, T; Gupta, E; Rubin, E; Sinko, P; Vyas, V1
Firby, PS; Horn, L; Li, ML; Moore, MJ1
Dubreuil, A; Etienne, MC; Fischel, JL; Formento, P; Milano, G; Rostagno, P1
Aoki, S; Hamamatsu, C; Hirata, K; Hirayama, T; Kawasaki, H; Matsunaga, T; Nakagawa, N; Nakayama, I; Oono, K; Sasaki, K; Shibata, K; Takaoka, A; Takasaka, H; Yabana, T; Yamamoto, Y1
Astrow, AB; Macdonald, JS1
Bigg, DC; Chyzak, G; Gilbert, C; Larsen, AK; Lavergne, O; Lesueur-Ginot, L; Naguibneva, I; Plisov, SY1
Burger, RA; Danks, MK; Harris, LC; Iyengar, RV; Krull, EJ; Pawlik, CA; Phelps, DA; Potter, PM1
Cao, CX; Dimanche-Boitrel, MT; Nieves-Neira, W; Pommier, Y; Shao, RG; Solary, E1
Benedetti, F; Bertino, J; Fong, Y; Gonen, M; Jarnagin, W; Kemeny, N; Paty, P; Saltz, L; Schwartz, L; Stockman, J; Sullivan, D; Tong, W1
Desai, SD; Li, TK; Liu, LF; Rodriguez-Bauman, A; Rubin, EH1
Choufani, EB; Hartshorn, KL; Lazar, HL1
Boyd, G; Cummings, J; Jodrell, DI; Smyth, JF1
Arnould, S; Bugat, R; Canal, P; Guichard, S; Hennebelle, I1
Baumgartner, G; Cosentini, E; Haberl, I; Hamilton, G; Mallinger, R; Pertschy, P; Teleky, B; Wenzl, E1
Baba, H; Ebuchi, M; Kure, N; Maruyama, M; Nagahama, T; Toukairin, Y1
Fukumoto, S; Habara, K; Iwasaki, T; Kamigaki, T; Ku, Y; Kunimoto, Y; Kuroda, Y; Nakamura, T; Nakamura, Y; Tamura, T1
Bécouarn, Y; Bekradda, M; Coudert, B; Gamelin, E; Germa, C; Krisch, C; Mignard, D; Mousseau, M; Négrier, S; Pierga, JY; Provençal, J; Raoul, JL; Rixe, O1
Araki, Y; Hayashi, A; Ishibashi, N; Kishimoto, Y; Konishi, J; Matono, K; Mituoka, M; Miyagi, Y; Nakagawa, M; Nozoe, Y; Ogata, Y; Sasatomi, T; Shirouzu, K1
Gonen, M; Jung, C; Motwani, M; Schwartz, GK; Shah, MA; She, Y; Sirotnak, FM1
Abrams, SI; Bergmann-Leitner, ES1
Blumenthal, RD; Goldenberg, DM; Lew, W; Modrak, DE; Rodriguez, MD1
Reutova, EV1
Dove, A1
Ashkenazi, A; Fong, S; Lawrence, D; LeBlanc, H; Morlan, J; Schow, P; Schwall, R; Sinicropi, D; Totpal, K; Varfolomeev, E1
Balan, KV; Calabresi, P; Darnowski, JW; Dunaway, S; Han, Z; Hendrickson, EA; Pantazis, P; Sedivy, J; Wei, W; Wyche, JH1
Agrawal, S; Nan, L; Wang, H; Wang, S; Yu, D; Zhang, R1
Chauvier, D; Manfait, M; Morjani, H2
Gwadry, FG; Kohn, KW; Liu, ET; Miller, LD; Pommier, Y; Reinhold, WC; Scherf, U; Smith, LH; Weinstein, JN; Zhou, Y1
Cerna, C; Davidson, KK; Heise, C; Izbicka, E; Kirn, D; Lawrence, RA; Petit, T; Von Hoff, DD1
Brill, S; Halpern, Z; Khaikin, M; Kouniavsky, G; Papa, M; Zippel, D; Zvibel, I1
Boyd, G; Cummings, J; Jodrell, DI; Macpherson, JS; Smith, G; Smyth, JF; Wolf, H1
Boyd, G; Burchell, B; Cummings, J; Ethell, BT; Jodrell, DI; Macpherson, JS; Smyth, JF1
Benchalal, M; Fingerhut, A; Fouere, S; Yahchouchy-Chouillard, E1
Dimitrakopoulos, A; Gennatas, K; Giannopoulos, A; Kosmas, Ch; Koufos, Ch; Macheras, A; Margaris, H; Papalambros, E; Papastratis, G; Polyzos, A; Tsavaris, NB; Tsipras, H; Vadiaka, M1
Aikawa, M; Dupree, K; Escandón, E; Fox, JA; Lowe, J; Sinicropi, D; Totpal, K; Xiang, H1
Agrawal, S; Ball, R; Chen, SF; Dexter, DL; Hollister, BA; Kandimalla, ER; Lombardi, G; Lucas, T; Yu, D1
Agrawal, S; Hang, J; Kandimalla, ER; Li, M; Shi, Z; Wang, H; Yu, D; Zhang, R1
Fujita, M; Kawasaki, M; Shibata, J; Tani, T1
de Bruijn, P; Loos, WJ; Mathijssen, RH; Nooter, K; Sparreboom, A; Verweij, J1
Fujita, M; Kobayashi, I; Miyamoto, Y; Morishita, Y; Owada, S; Taguchi, T; Takeshita, M1
Eguchi, K; Karato, A; Kojima, A; Kunikane, H; Ohe, Y; Ohmatsu, H; Okamoto, H; Sasaki, Y; Shinkai, T; Tamura, T1
Bertrand, R; Kerrigan, D; O'Connor, PM; Pommier, Y1
Cheshire, PJ; Houghton, JA; Houghton, PJ; Myers, L; Stewart, CF; Synold, TW1
Bertrand, R; Goldman, J; Kerrigan, D; Kohn, KW; Nieves-Neira, W; O'Connor, PM; Pommier, Y1
Liu, LF; Oh-hara, T; Sugimoto, Y; Tsukahara, S; Tsuruo, T1
Bertrand, R; Kerrigan, D; Kohn, KW; O'Connor, PM; Pommier, Y1
Giovanella, BC; Liu, LF; Nicholas, AW; Potmesil, M; Silber, R; Stehlin, JS; Wall, ME; Wani, MC1

Reviews

48 review(s) available for camptothecin and Cancer of Colon

ArticleYear
A Systematic Review of Conversion to Resectability in Unresectable Metastatic Colorectal Cancer Chemotherapy Trials.
    American journal of clinical oncology, 2022, 08-01, Volume: 45, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Rectal Neoplasms

2022
A systemic review and meta-analysis of Aflibercept plus FOLFIRI regimen as a second-line treatment for metastatic colorectal cancer: A PRISMA compliant pooled analysis of randomized controlled trials and single arm studies to assess efficacy and safety.
    Critical reviews in oncology/hematology, 2023, Volume: 188

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Placenta Growth Factor; Randomized Controlled Trials as Topic; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Rectal Neoplasms

2023
Phase II biomarker identification study of anti-VEGF agents with FOLFIRI for pretreated metastatic colorectal cancer.
    Future oncology (London, England), 2023, Volume: 19, Issue:23

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers; Camptothecin; Clinical Trials, Phase II as Topic; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Oxaliplatin; Prospective Studies; Rectal Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor D

2023
Controversies in the treatment of RAS wild-type metastatic colorectal cancer.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2021, Volume: 23, Issue:4

    Topics: Advisory Committees; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colon, Ascending; Colon, Transverse; Colonic Neoplasms; Colorectal Neoplasms; Consensus; Delphi Technique; ErbB Receptors; Fluorouracil; Genes, ras; Genotype; Humans; Leucovorin; Liquid Biopsy; Maintenance Chemotherapy; Organoplatinum Compounds; Proto-Oncogene Proteins B-raf; Retreatment

2021
Trifluridine/tipiracil: an emerging strategy for the management of gastrointestinal cancers.
    Future oncology (London, England), 2018, Volume: 14, Issue:16

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Clinical Trials as Topic; Colonic Neoplasms; Docetaxel; Drug Combinations; Fluorouracil; Gastrointestinal Neoplasms; Humans; Immunotherapy; Indoles; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Pyrrolidines; Quality of Life; Taxoids; Thymine; Trifluridine; Uracil

2018
[A case of recurrent colon cancer involved in multiple organs maintaining complete response over the long-term after chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Organoplatinum Compounds; Recurrence; Time Factors

2013
Applications of oral fluoropyrimidines in colon cancer: their role and new directions.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2003, Volume: 1 Suppl 3

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Oxaloacetates; Oxonic Acid; Tegafur; Uracil

2003
TroVax in colorectal cancer.
    Human vaccines & immunotherapeutics, 2014, Volume: 10, Issue:11

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cancer Vaccines; Carcinoembryonic Antigen; Carcinoma, Renal Cell; Colonic Neoplasms; Fluorouracil; Humans; Immunotherapy; Kidney Neoplasms; Leucovorin; Membrane Glycoproteins; Organoplatinum Compounds; Vaccination; Vaccines, DNA; Vaccinia virus

2014
[A Case of Descending Colon Adenocarcinoma with Neuroendocrine Differentiation Successfully Treated with FOLFIRI plus Bevacizumab].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2016, Volume: 43, Issue:1

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biopsy; Camptothecin; Carcinoma, Neuroendocrine; Colon, Descending; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Prognosis

2016
Colon cancer: update on adjuvant therapy.
    Clinical colorectal cancer, 2008, Volume: 7, Issue:3

    Topics: Age Factors; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colonic Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Neoplasm Recurrence, Local; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic

2008
The role of capecitabine in the management of tumors of the digestive system.
    Reviews on recent clinical trials, 2009, Volume: 4, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Extrahepatic; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Cholangiocarcinoma; Colonic Neoplasms; Deoxycytidine; Digestive System Neoplasms; Docetaxel; Esophageal Neoplasms; Fluorouracil; Gallbladder Neoplasms; Humans; Irinotecan; Liver Neoplasms; Organoplatinum Compounds; Oxaliplatin; Pancreatic Neoplasms; Rectal Neoplasms; Stomach Neoplasms; Taxoids; Treatment Outcome; Vascular Endothelial Growth Factor A

2009
Oxaliplatin or irinotecan as adjuvant therapy for colon cancer: the results are in.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Jul-01, Volume: 27, Issue:19

    Topics: Antineoplastic Agents; Camptothecin; Chemotherapy, Adjuvant; Clinical Trials as Topic; Colonic Neoplasms; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic

2009
Efficacy and safety of bevacizumab plus capecitabine and irinotecan regimen for metastatic colorectal cancer.
    Medical oncology (Northwood, London, England), 2010, Volume: 27, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Disease-Free Survival; Fatigue; Female; Fluorouracil; Gastrointestinal Diseases; Hematologic Diseases; Humans; Hypertension; Irinotecan; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Proteins; Rectal Neoplasms; Retrospective Studies; Vascular Endothelial Growth Factor A

2010
Evolving treatment of advanced colon cancer.
    Annual review of medicine, 2009, Volume: 60

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Camptothecin; Capecitabine; Cetuximab; Colonic Neoplasms; Deoxycytidine; Disease Progression; Fluorouracil; Humans; Irinotecan; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin

2009
[Neoadjuvant chemotherapy and pancreatoduodenectomy for locally advanced colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:12

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Organoplatinum Compounds; Pancreaticoduodenectomy

2009
Molecular predictive and prognostic markers in colon cancer.
    Cancer treatment reviews, 2010, Volume: 36, Issue:7

    Topics: Camptothecin; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); ErbB Receptors; Genes, ras; Genomic Instability; Humans; Irinotecan; Loss of Heterozygosity; Organoplatinum Compounds; Oxaliplatin; Polymorphism, Genetic; Prognosis; Thymidylate Synthase

2010
Metastatic colorectal cancer: from improved survival to potential cure.
    Oncology, 2010, Volume: 78, Issue:3-4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Catheter Ablation; Colonic Neoplasms; Female; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Male; Medical Oncology; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Time Factors; Treatment Outcome

2010
Maintenance therapy in colon cancer.
    Cancer treatment reviews, 2010, Volume: 36 Suppl 3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Colonic Neoplasms; Disease Progression; Disease-Free Survival; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Survival Rate

2010
Two or three year disease-free survival (DFS) as a primary end-point in stage III adjuvant colon cancer trials with fluoropyrimidines with or without oxaliplatin or irinotecan: data from 12,676 patients from MOSAIC, X-ACT, PETACC-3, C-06, C-07 and C89803.
    European journal of cancer (Oxford, England : 1990), 2011, Volume: 47, Issue:7

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Clinical Trials, Phase III as Topic; Colonic Neoplasms; Disease-Free Survival; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Proportional Hazards Models; Pyrimidines; Research Design; Time Factors; Treatment Outcome

2011
[A case of irinotecan or panitumumab-induced interstitial pneumonia successfully treated by steroid pulse therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:2

    Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Lung Diseases, Interstitial; Male; Methylprednisolone; Middle Aged; Organoplatinum Compounds; Panitumumab; Tomography, X-Ray Computed

2012
[Recent advances in chemotherapy for digestive cancers with special references to gastric and colonic cancers].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2003, Volume: 100, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colonic Neoplasms; Docetaxel; Drug Administration Schedule; Drug Combinations; Drug Delivery Systems; Fluorouracil; Humans; Irinotecan; Oxonic Acid; Paclitaxel; Pyridines; Stomach Neoplasms; Taxoids; Tegafur

2003
Second-line treatment in advanced colon cancer: are multiple phase II trials informative enough to guide clinical practice?
    Anti-cancer drugs, 2003, Volume: 14, Issue:9

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Clinical Trials, Phase II as Topic; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Practice Guidelines as Topic; Reproducibility of Results

2003
[Chemotherapy for colon cancer].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Tegafur; Treatment Outcome; Uracil

2003
Intergroup trial fails to demonstrate a benefit with the addition of irinotecan to bolus 5-fluorouracil/leucovorin in stage III colon cancer.
    Clinical colorectal cancer, 2004, Volume: 4, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Survival Rate

2004
Advances in colon cancer chemotheapy: nursing implications.
    Home healthcare nurse, 2005, Volume: 23, Issue:3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Cetuximab; Chemotherapy, Adjuvant; Colonic Neoplasms; Community Health Nursing; Deoxycytidine; Drug Monitoring; Fluorouracil; Home Infusion Therapy; Humans; Irinotecan; Nurse's Role; Organoplatinum Compounds; Oxaliplatin; Survival Rate; Treatment Outcome

2005
Adjuvant therapy in colon cancer: which treatment in 2005?
    Annals of oncology : official journal of the European Society for Medical Oncology, 2005, Volume: 16 Suppl 4

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colonic Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Survival Rate

2005
Have we made progress in pharmacogenomics? The implementation of molecular markers in colon cancer.
    Pharmacogenomics, 2005, Volume: 6, Issue:6

    Topics: Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Camptothecin; Colonic Neoplasms; Fluorouracil; Forecasting; Gene Expression Profiling; Genomics; Humans; Irinotecan; Loss of Heterozygosity; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Pharmacogenetics

2005
Recent data with anti-epidermal growth factor receptor antibodies and irinotecan in colon cancer.
    Clinical colorectal cancer, 2005, Volume: 5 Suppl 2

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cetuximab; Colonic Neoplasms; Combined Modality Therapy; ErbB Receptors; Humans; Irinotecan; Panitumumab

2005
[Progression of adjuvant chemotherapy for colon cancer].
    Ai zheng = Aizheng = Chinese journal of cancer, 2005, Volume: 24, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Irinotecan; Leucovorin; Levamisole; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin

2005
Adjuvant therapy for colon cancer 2005: new options in the twenty-first century.
    Surgical oncology clinics of North America, 2006, Volume: 15, Issue:1

    Topics: Antineoplastic Agents; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; History, 20th Century; History, 21st Century; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin

2006
[Molecular targets in colon cancer].
    Therapeutische Umschau. Revue therapeutique, 2006, Volume: 63, Issue:4

    Topics: Angiogenesis Inhibitors; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Camptothecin; Cetuximab; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Colonic Neoplasms; Drug Delivery Systems; ErbB Receptors; Gefitinib; Humans; Imatinib Mesylate; Indoles; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Phthalazines; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Quinolones; Receptors, Platelet-Derived Growth Factor; Receptors, Somatomedin; Signal Transduction; Sirolimus; Sunitinib

2006
[FOLFIRI regimen for metastatic or recurrent colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Clinical Trials, Phase III as Topic; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Randomized Controlled Trials as Topic; Rectal Neoplasms

2006
[Adjuvant treatment of colorectal cancer].
    Bulletin du cancer, 2006, Volume: 93, Issue:7

    Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colonic Neoplasms; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Irinotecan; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Prognosis; Tegafur; Uracil

2006
[Up to date chemotherapy for colon cancer].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2007, Volume: 104, Issue:2

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Leucovorin; Neoplasm Staging; Organoplatinum Compounds; Survival Rate

2007
[Standard chemotherapy for colonic neoplasms].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2007, Feb-10, Volume: 96, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Tegafur; Uracil

2007
Adjuvant treatment of colon cancer: past, present and future.
    Journal of chemotherapy (Florence, Italy), 2007, Volume: 19, Issue:2

    Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colonic Neoplasms; Deoxycytidine; Disease-Free Survival; ErbB Receptors; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Leucovorin; Levamisole; Organoplatinum Compounds; Oxaliplatin; Survival Rate

2007
[Adjuvant chemotherapy for colorectal cancer in Japan-current state and problem areas].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Europe; Evidence-Based Medicine; Fluorouracil; Humans; Irinotecan; Japan; Leucovorin; Neoplasm Staging; Oxonic Acid; Practice Guidelines as Topic; Rectal Neoplasms; Tegafur; United States; Uracil

2007
[Bevacizumab (Avastin)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:8

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Breast Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Colonic Neoplasms; Drug Administration Schedule; Drug Approval; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Lung Neoplasms; Male; Organoplatinum Compounds; Oxaliplatin; Rectal Neoplasms; Vascular Endothelial Growth Factor A

2007
The clinical efficacy of FOLFIRI and bevacizumab in combination as first-line therapy of metastatic colorectal cancer.
    Clinical colorectal cancer, 2007, Volume: 6, Issue:9

    Topics: Age Factors; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Middle Aged; Neoplasm Metastasis; Treatment Outcome; Vascular Endothelial Growth Factor A

2007
[Development of new anti-cancer agents in Europe].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:2

    Topics: Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Europe; Female; France; Humans; Irinotecan; Japan; Lung Neoplasms; Ovarian Neoplasms; Uterine Cervical Neoplasms

1996
Topoisomerase-I inhibitors in the management of colon cancer.
    Annals of the New York Academy of Sciences, 1996, Dec-13, Volume: 803

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Enzyme Inhibitors; Humans; Irinotecan; Topoisomerase I Inhibitors; Topotecan

1996
Design of topoisomerase inhibitors to overcome MDR1-mediated drug resistance.
    Advances in pharmacology (San Diego, Calif.), 1994, Volume: 29B

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma; Colonic Neoplasms; Drug Design; Drug Resistance, Neoplasm; Genes, MDR; Humans; Mice; Mice, Nude; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1994
Cooperative antitumor effect of mixed backbone oligonucleotides targeting protein kinase A in combination with cytotoxic drugs or biologic agents.
    Antisense & nucleic acid drug development, 1998, Volume: 8, Issue:2

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cell Division; Cisplatin; Colonic Neoplasms; Combined Modality Therapy; Cyclic AMP-Dependent Protein Kinases; Doxorubicin; Drug Design; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Fluorouracil; Genetic Therapy; Humans; Methotrexate; Oligonucleotides, Antisense; Ovarian Neoplasms; Paclitaxel; Structure-Activity Relationship; Thionucleotides; Tumor Cells, Cultured; Vincristine

1998
[Drug clinics. How I treat. II. Therapeutic approaches to metastatic colorectal cancer].
    Revue medicale de Liege, 1998, Volume: 53, Issue:6

    Topics: Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Enzyme Inhibitors; Fluorouracil; Hospitalization; Humans; Irinotecan; Leucovorin; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Quality of Life; Quinazolines; Rectal Neoplasms; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors

1998
DNA topoisomerase I-targeting drugs as radiation sensitizers.
    Oncology (Williston Park, N.Y.), 1999, Volume: 13, Issue:10 Suppl 5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Cycle; Colonic Neoplasms; Combined Modality Therapy; DNA Damage; DNA Repair; DNA Topoisomerases, Type I; Enzyme Inhibitors; Female; Head and Neck Neoplasms; Humans; Irinotecan; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Radiation-Sensitizing Agents; Topotecan

1999
Combination of raltitrexed with other cytotoxic agents: rationale and preclinical observations.
    European journal of cancer (Oxford, England : 1990), 1999, Volume: 35 Suppl 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Quinazolines; Thiophenes; Tumor Cells, Cultured

1999
[Colon carcinoma. Consensus of therapeutic strategies].
    Der Internist, 2000, Volume: 41, Issue:9

    Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma; Chemotherapy, Adjuvant; Clinical Trials as Topic; Colonic Neoplasms; Colorectal Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; Germany; Humans; Incidence; Irinotecan; Leucovorin; Lymphatic Metastasis; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Prodrugs

2000
Adjuvant therapy of colon cancer.
    Seminars in oncology, 2001, Volume: 28, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Survival Rate

2001

Trials

66 trial(s) available for camptothecin and Cancer of Colon

ArticleYear
Germline polymorphisms in genes maintaining the replication fork predict the efficacy of oxaliplatin and irinotecan in patients with metastatic colorectal cancer.
    British journal of cancer, 2022, Volume: 126, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers, Tumor; Camptothecin; Cell Cycle Proteins; Colonic Neoplasms; DNA Replication; DNA-Binding Proteins; Female; Fluorouracil; Germ-Line Mutation; Humans; Intracellular Signaling Peptides and Proteins; Leucovorin; Male; Neoplasm Metastasis; Organoplatinum Compounds; Polymorphism, Single Nucleotide; Survival Rate

2022
Impact of omitting fluorouracil from FOLFIRI plus bevacizumab as second-line chemotherapy for patients with metastatic colorectal cancer.
    Journal of cancer research and clinical oncology, 2023, Volume: 149, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Neutropenia; Rectal Neoplasms; Retrospective Studies

2023
Efficacy of FOLFIRI plus cetuximab vs FOLFIRI plus bevacizumab in 1st-line treatment of older patients with RAS wild-type metastatic colorectal cancer: an analysis of the randomised trial FIRE-3.
    British journal of cancer, 2022, Volume: 127, Issue:5

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Rectal Neoplasms; Retrospective Studies

2022
Germline Polymorphisms in Genes Involved in the Antioxidant System Predict the Efficacy of Cetuximab in Metastatic Colorectal Cancer Patients Enrolled in FIRE-3 Trial.
    Clinical colorectal cancer, 2022, Volume: 21, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Bevacizumab; Camptothecin; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Germ Cells; Humans; Leucovorin; Rectal Neoplasms

2022
Multicenter, single-arm, phase II study of the continuous use of panitumumab in combination with FOLFIRI after FOLFOX for RAS wild-type metastatic colorectal cancer: Exploratory sequential examination of acquired mutations in circulating cell-free DNA.
    International journal of cancer, 2022, Dec-15, Volume: 151, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell-Free Nucleic Acids; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Mutation; Panitumumab; Proto-Oncogene Proteins B-raf; Rectal Neoplasms

2022
Randomized phase II trial of FOLFIRI-panitumumab compared with FOLFIRI alone in patients with RAS wild-type circulating tumor DNA metastatic colorectal cancer beyond progression to first-line FOLFOX-panitumumab: the BEYOND study (GEMCAD 17-01).
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2022, Volume: 24, Issue:11

    Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Circulating Tumor DNA; Colonic Neoplasms; Colorectal Neoplasms; Disease Progression; Fluorouracil; Humans; Leucovorin; Panitumumab; Proto-Oncogene Proteins B-raf; Rectal Neoplasms

2022
Efficacy and safety of dilpacimab (ABT-165) versus bevacizumab plus FOLFIRI in metastatic colorectal cancer: a phase II study.
    Future oncology (London, England), 2022, Volume: 18, Issue:27

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Disease-Free Survival; Fluorouracil; Humans; Leucovorin; Rectal Neoplasms

2022
First-line fluoropyrimidine plus bevacizumab followed by irinotecan-escalation versus initial fluoropyrimidine, irinotecan and bevacizumab in patients with metastatic colorectal cancer - Final survival and per-protocol analysis of the randomised XELAVIRI
    European journal of cancer (Oxford, England : 1990), 2022, Volume: 173

    Topics: Aged; Antimetabolites; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Randomized Controlled Trials as Topic; Rectal Neoplasms

2022
Standard diametric versus volumetric early tumor shrinkage as a predictor of survival in metastatic colorectal cancer: subgroup findings of the randomized, open-label phase III trial FIRE-3 / AIO KRK-0306.
    European radiology, 2023, Volume: 33, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Disease-Free Survival; Fluorouracil; Humans; Rectal Neoplasms; Retrospective Studies

2023
Napabucasin Plus FOLFIRI in Patients With Previously Treated Metastatic Colorectal Cancer: Results From the Open-Label, Randomized Phase III CanStem303C Study.
    Clinical colorectal cancer, 2023, Volume: 22, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Rectal Neoplasms

2023
Efficacy and safety of folfiri plus aflibercept in second-line treatment of metastatic colorectal cancer: Real-life data from Turkish oncology group.
    Journal of cancer research and therapeutics, 2022, Volume: 18, Issue:12 Suppl 2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Middle Aged; Rectal Neoplasms; Retrospective Studies

2022
Trop-2 and Nectin-4 immunohistochemical expression in metastatic colorectal cancer: searching for the right population for drugs' development.
    British journal of cancer, 2023, Volume: 128, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Prognosis; Rectal Neoplasms

2023
An Immune-Related Gene Expression Signature Predicts Benefit from Adding Atezolizumab to FOLFOXIRI plus Bevacizumab in Metastatic Colorectal Cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2023, 06-13, Volume: 29, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Rectal Neoplasms; Transcriptome

2023
Suvemcitug as second-line treatment of advanced or metastatic solid tumors and with FOLFIRI for pretreated metastatic colorectal cancer: phase Ia/Ib open label, dose-escalation trials.
    ESMO open, 2023, Volume: 8, Issue:3

    Topics: Antibodies, Monoclonal, Humanized; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Vascular Endothelial Growth Factor A

2023
Adverse events during first-line treatments for mCRC: The Toxicity over Time (ToxT) analysis of three randomised trials.
    European journal of cancer (Oxford, England : 1990), 2023, Volume: 189

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Panitumumab; Rectal Neoplasms

2023
FOLFOXIRI Plus Cetuximab or Bevacizumab as First-Line Treatment of
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023, 09-01, Volume: 41, Issue:25

    Topics: Adenosine Triphosphate; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Prospective Studies; Proto-Oncogene Proteins B-raf; Rectal Neoplasms

2023
Delta tocotrienol as a supplement to FOLFOXIRI in first-line treatment of metastatic colorectal cancer. A randomized, double-blind, placebo-controlled phase II study.
    Acta oncologica (Stockholm, Sweden), 2023, Volume: 62, Issue:9

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Middle Aged; Oxaliplatin; Rectal Neoplasms; Tocotrienols; Young Adult

2023
Intravoxel Incoherent Motion of Colon Cancer Liver Metastases for the Assessment of Response to Antiangiogenic Treatment: Results from a Pilot Study.
    Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2020, Volume: 29, Issue:5

    Topics: Adult; Angiogenesis Inhibitors; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Diffusion Magnetic Resonance Imaging; Female; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Pilot Projects; Prospective Studies

2020
The predictive and prognostic value of sex in early-stage colon cancer: a pooled analysis of 33,345 patients from the ACCENT database.
    Clinical colorectal cancer, 2013, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Fluorouracil; Follow-Up Studies; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Prognosis; Sex Factors; Survival Rate; Young Adult

2013
Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial.
    Journal of the National Cancer Institute, 2013, Dec-04, Volume: 105, Issue:23

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Class I Phosphatidylinositol 3-Kinases; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Irinotecan; Kaplan-Meier Estimate; Leucovorin; Male; Microsatellite Instability; Middle Aged; Multivariate Analysis; Mutation; Neoplasm Staging; Phosphatidylinositol 3-Kinases; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); ras Proteins

2013
A phase II study of combined chemotherapy with 5-week cycles of S-1 and CPT-11 plus bevacizumab in patients with metastatic colon cancer.
    Oncology, 2013, Volume: 85, Issue:6

    Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Drug Combinations; Female; Humans; Irinotecan; Male; Middle Aged; Neoplasm Metastasis; Oxonic Acid; Tegafur

2013
Comparison of FOLFIRI with or without cetuximab in patients with resected stage III colon cancer; NCCTG (Alliance) intergroup trial N0147.
    Clinical colorectal cancer, 2014, Volume: 13, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; Male; Middle Aged; Mutation; Neoplasm Staging; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Survival Rate; Treatment Outcome

2014
CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer.
    Gastroenterology, 2014, Volume: 147, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colectomy; Colonic Neoplasms; CpG Islands; Disease-Free Survival; DNA Methylation; DNA Mismatch Repair; Female; Fluorouracil; Humans; Irinotecan; Kaplan-Meier Estimate; Leucovorin; Male; Middle Aged; Neoplasm Staging; Phenotype; Proportional Hazards Models; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Young Adult

2014
MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Disease-Free Survival; DNA-Binding Proteins; Female; Fluorouracil; Follow-Up Studies; Genetic Association Studies; Humans; Irinotecan; Leucovorin; Male; Middle Aged; MRE11 Homologue Protein; Polymorphism, Single Nucleotide; Prognosis; Treatment Outcome; Young Adult

2014
Prognosis of stage II and III colon cancer treated with adjuvant 5-fluorouracil or FOLFIRI in relation to microsatellite status: results of the PETACC-3 trial.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2015, Volume: 26, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Microsatellite Instability; Microsatellite Repeats; Neoplasm Recurrence, Local

2015
DPYD variants as predictors of 5-fluorouracil toxicity in adjuvant colon cancer treatment (NCCTG N0147).
    Journal of the National Cancer Institute, 2014, Volume: 106, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Diarrhea; Dihydrouracil Dehydrogenase (NADP); Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Genetic Predisposition to Disease; Humans; Leucovorin; Logistic Models; Male; Middle Aged; Nausea; Neoplasm Staging; Neutropenia; Organoplatinum Compounds; Polymorphism, Single Nucleotide; Prospective Studies; Severity of Illness Index; Thrombocytopenia; Valine; Vomiting

2014
Improving the therapeutic index in cancer therapy by using antibody-drug conjugates designed with a moderately cytotoxic drug.
    Molecular pharmaceutics, 2015, Jun-01, Volume: 12, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Bevacizumab; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Female; Humans; Immunoconjugates; Irinotecan; Mice; Mice, Nude; Rabbits

2015
Safety, efficacy, and pharmacokinetics of navitoclax (ABT-263) in combination with irinotecan: results of an open-label, phase 1 study.
    Cancer chemotherapy and pharmacology, 2015, Volume: 76, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Aniline Compounds; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Colonic Neoplasms; Diarrhea; Disease Progression; Dose-Response Relationship, Drug; Febrile Neutropenia; Female; Hematologic Diseases; Humans; Irinotecan; Male; Middle Aged; Neoplasm Proteins; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Salvage Therapy; Sulfonamides; Treatment Outcome

2015
Prospective analysis of UGT1A1 promoter polymorphism for irinotecan dose escalation in metastatic colorectal cancer patients treated with bevacizumab plus FOLFIRI as the first-line setting: study protocol for a randomized controlled trial.
    Trials, 2016, Jan-25, Volume: 17

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Fluorouracil; Glucuronosyltransferase; Humans; Irinotecan; Leucovorin; Neoplasm Metastasis; Outcome Assessment, Health Care; Polymorphism, Genetic; Promoter Regions, Genetic; Prospective Studies

2016
[Irinotecan plus fuorouracil/leucovorin (FOLFIRI) as a second line chemotherapy for refractory or metastatic colorectal cancer].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2008, Volume: 30, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Disease Progression; Female; Fluorouracil; Follow-Up Studies; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neutropenia; Prospective Studies; Rectal Neoplasms; Remission Induction; Survival Rate; Vomiting; Young Adult

2008
Pharmacokinetic and pharmacogenetic determinants of the activity and toxicity of irinotecan in metastatic colorectal cancer patients.
    British journal of cancer, 2008, Oct-21, Volume: 99, Issue:8

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; Carboxylesterase; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Glucuronides; Glucuronosyltransferase; Humans; Irinotecan; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Promoter Regions, Genetic

2008
A phase I study of combination therapy with S-1 and irinotecan (CPT-11) in patients with advanced colorectal cancer.
    Journal of cancer research and clinical oncology, 2009, Volume: 135, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Disease Progression; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Injections, Intravenous; Irinotecan; Male; Middle Aged; Oxonic Acid; Rectal Neoplasms; Tegafur

2009
A phase III randomised trial of LV5FU2 + irinotecan versus LV5FU2 alone in adjuvant high-risk colon cancer (FNCLCC Accord02/FFCD9802).
    Annals of oncology : official journal of the European Society for Medical Oncology, 2009, Volume: 20, Issue:4

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Recurrence; Risk Assessment

2009
Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Apr-10, Volume: 27, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Microsatellite Instability; Middle Aged; Neoplasm Staging; Prognosis; Prospective Studies; Survival Analysis; Young Adult

2009
Randomized phase III trial comparing biweekly infusional fluorouracil/leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Jul-01, Volume: 27, Issue:19

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Kaplan-Meier Estimate; Leucovorin; Male; Middle Aged; Neoplasm Staging

2009
Tissue biomarker development in a multicentre trial context: a feasibility study on the PETACC3 stage II and III colon cancer adjuvant treatment trial.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Sep-01, Volume: 15, Issue:17

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Fluorouracil; Glucuronosyltransferase; Humans; Irinotecan; Microsatellite Instability; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Prospective Studies; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); ras Proteins; Smad4 Protein; Telomerase; Tumor Suppressor Protein p53

2009
[Efficacy of FORFIRI regimen on oxaliplatin-based chemotherapy-failed advanced colorectal cancer].
    Ai zheng = Aizheng = Chinese journal of cancer, 2009, Volume: 28, Issue:9

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Disease Progression; Female; Fluorouracil; Follow-Up Studies; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Nausea; Neoplasm Staging; Neutropenia; Rectal Neoplasms; Remission Induction; Salvage Therapy; Survival Rate; Vomiting; Young Adult

2009
KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Dec-01, Volume: 15, Issue:23

    Topics: Adult; Aged; Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Disease-Free Survival; Female; Genes, ras; Humans; Irinotecan; Male; Microsatellite Repeats; Middle Aged; Mutation; Oncogene Protein p21(ras); Proportional Hazards Models; Treatment Outcome

2009
Phase III trial of irinotecan plus infusional 5-fluorouracil/folinic acid versus irinotecan plus oxaliplatin as first-line treatment of advanced colorectal cancer.
    European journal of cancer (Oxford, England : 1990), 2011, Volume: 47, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Rectal Neoplasms; Young Adult

2011
[Evaluation of bevacizumab combined with irinotecan-based regimen as the first-line treatment for patients with metastatic colorectal cancer].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2010, Volume: 32, Issue:10

    Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; CA-19-9 Antigen; Camptothecin; Carcinoembryonic Antigen; Colonic Neoplasms; Diarrhea; Disease-Free Survival; Female; Fluorouracil; Follow-Up Studies; Humans; Hypertension; Irinotecan; Leucovorin; Male; Middle Aged; Neutropenia; Rectal Neoplasms; Remission Induction; Retrospective Studies; Survival Rate; Young Adult

2010
A randomized phase III trial of adjuvant chemotherapy with irinotecan, leucovorin and fluorouracil versus leucovorin and fluorouracil for stage II and III colon cancer: a Hellenic Cooperative Oncology Group study.
    BMC medicine, 2011, Jan-31, Volume: 9

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Fluorouracil; Greece; Humans; Irinotecan; Kaplan-Meier Estimate; Leucovorin; Male; Middle Aged; Neoplasm Staging; Treatment Outcome; Young Adult

2011
Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Feb-01, Volume: 18, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Irinotecan; Kaplan-Meier Estimate; Leucovorin; Male; Middle Aged; Mutation; Neoplasm Staging; Prognosis; Proportional Hazards Models; Proto-Oncogene Proteins B-raf

2012
Effectiveness of liver metastasectomies in patients with metastatic colorectal cancer treated with FIr-B/FOx triplet chemotherapy plus bevacizumab.
    Clinical colorectal cancer, 2012, Volume: 11, Issue:2

    Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Fluorouracil; Hepatectomy; Humans; Irinotecan; Liver Neoplasms; Male; Metastasectomy; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Treatment Outcome

2012
Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial.
    British journal of cancer, 2012, Mar-13, Volume: 106, Issue:6

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; beta 2-Microglobulin; Biomarkers, Tumor; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Humans; Irinotecan; Kaplan-Meier Estimate; Leucovorin; Male; Microsatellite Instability; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Proportional Hazards Models; Prospective Studies; Treatment Outcome

2012
Anti-EGFR (cetuximab) combined with irinotecan for treatment of elderly patients with metastatic colorectal cancer (mCRC).
    Journal of cancer research and clinical oncology, 2012, Volume: 138, Issue:9

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Camptothecin; Cetuximab; Colonic Neoplasms; Diarrhea; ErbB Receptors; Female; Humans; Irinotecan; Kaplan-Meier Estimate; Male; Neoplasm Metastasis; Rectal Neoplasms; Skin Diseases; Treatment Outcome

2012
Integrated analysis of molecular and clinical prognostic factors in stage II/III colon cancer.
    Journal of the National Cancer Institute, 2012, Nov-07, Volume: 104, Issue:21

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Chemotherapy, Adjuvant; Chromosomes, Human, Pair 18; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Immunohistochemistry; Irinotecan; Kaplan-Meier Estimate; Leucovorin; Loss of Heterozygosity; Male; Microsatellite Instability; Middle Aged; Multivariate Analysis; Mutation; Neoplasm Staging; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); ras Proteins; Research Design; Smad4 Protein

2012
High-dose, single-agent irinotecan as first-line therapy in the treatment of metastatic colorectal cancer.
    Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Diarrhea; Drug Administration Schedule; Enzyme Inhibitors; Female; Follow-Up Studies; Granulocyte Colony-Stimulating Factor; Humans; Irinotecan; Male; Middle Aged; Neoplasm Proteins; Neutropenia; Prodrugs; Rectal Neoplasms; Remission Induction; Safety; Topoisomerase I Inhibitors; Treatment Outcome

2002
A Phase II study of irinotecan in combination with 120-h infusion of 5-fluorouracil in patients with metastatic colorectal carcinoma: Japan Clinical Oncology Group Study (JCOG9703).
    Japanese journal of clinical oncology, 2003, Volume: 33, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Feasibility Studies; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Rectal Neoplasms

2003
Phase I and pharmacokinetic study of intravenous irinotecan plus oral ciclosporin in patients with fuorouracil-refractory metastatic colon cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Mar-15, Volume: 21, Issue:6

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Cyclosporine; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Neoplasm Staging; Treatment Outcome

2003
Two different schedules of irinotecan (CPT-11) in patients with advanced colorectal carcinoma relapsing after a 5-fluorouracil and leucovorin combination. A randomized study.
    Cancer chemotherapy and pharmacology, 2003, Volume: 52, Issue:6

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Karnofsky Performance Status; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Rectal Neoplasms; Topoisomerase I Inhibitors

2003
A phase II study of intravenous exatecan mesylate (DX-8951f) administered daily for five days every three weeks to patients with metastatic adenocarcinoma of the colon or rectum.
    Investigational new drugs, 2004, Volume: 22, Issue:1

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Female; Humans; Male; Middle Aged; Rectal Neoplasms

2004
Combined topoisomerase I inhibition for the treatment of metastatic colon cancer.
    Anti-cancer drugs, 2004, Volume: 15, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Diarrhea; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Infusions, Intravenous; Injections, Intravenous; Irinotecan; Maximum Tolerated Dose; Nausea; Neoplasm Metastasis; Neoplasm Staging; Neutropenia; Patient Selection; Remission Induction; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome; Vomiting

2004
Two schedules of second-line irinotecan for metastatic colon carcinoma.
    Cancer, 2004, Dec-01, Volume: 101, Issue:11

    Topics: Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma; Colonic Neoplasms; Cost Savings; Drug Administration Schedule; Female; Health Care Costs; Humans; Irinotecan; Male; Middle Aged; Quality of Life

2004
A phase I-II, dose-escalating trial of ZD9331 in combination with irinotecan (CPT11) in previously pretreated metastatic colorectal cancer patients.
    Bulletin du cancer, 2004, Volume: 91, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Female; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neutropenia; Quinazolines; Rectal Neoplasms

2004
Phase II study of irinotecan, 5-fluorouracil and leucovorin as first-line therapy for advanced colorectal cancer.
    Japanese journal of clinical oncology, 2005, Volume: 35, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Leukopenia; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Maximum Tolerated Dose; Middle Aged; Rectal Neoplasms; Survival Analysis; Treatment Outcome

2005
Multicenter phase II study of oral capecitabine plus irinotecan as first-line chemotherapy in advanced colorectal cancer: a Korean Cancer Study Group trial.
    Acta oncologica (Stockholm, Sweden), 2005, Volume: 44, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Diarrhea; Disease Progression; Female; Fluorouracil; Follow-Up Studies; Humans; Irinotecan; Male; Middle Aged; Neutropenia; Prodrugs; Rectal Neoplasms; Remission Induction; Survival Rate; Topoisomerase I Inhibitors; Treatment Outcome

2005
[Clinical evaluation of chemotherapy with irinotecan (CPT-11), l-leucovorin (l-LV), 5-fluorouracil (5-FU), and UFT for metastatic or recurrent colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Nausea; Rectal Neoplasms; Survival Rate; Tegafur; Uracil; Vomiting, Anticipatory

2005
[Multicenter phase II study of modified FOLFIRI regimen in the advanced colorectal cancer patient refractory to fluoropyrimidine and oxaliplatin].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2006, Volume: 28, Issue:10

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Diarrhea; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Nausea; Neoplasm Staging; Neutropenia; Organoplatinum Compounds; Oxaliplatin; Prospective Studies; Pyrimidines; Rectal Neoplasms; Remission Induction; Treatment Failure

2006
TIMP-1 is significantly associated with objective response and survival in metastatic colorectal cancer patients receiving combination of irinotecan, 5-fluorouracil, and folinic acid.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Jul-15, Volume: 13, Issue:14

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Carcinoembryonic Antigen; Colonic Neoplasms; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Neoplasm Metastasis; Odds Ratio; Rectal Neoplasms; Survival Analysis; Tissue Inhibitor of Metalloproteinase-1; Treatment Outcome

2007
[Effect of chemotherapy using irinotecan (CPT-11) against recurrent colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Irinotecan; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Rectal Neoplasms

1995
Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor.
    British journal of cancer, 1996, Volume: 73, Issue:10

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Biological Availability; Camptothecin; Carcinoma, Small Cell; Colonic Neoplasms; Cross-Over Studies; Female; Humans; Hydroxy Acids; Lactones; Male; Metabolic Clearance Rate; Middle Aged; Ovarian Neoplasms; Topoisomerase I Inhibitors; Topotecan

1996
Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Diarrhea; Disease Progression; Drug Administration Schedule; Female; Fever; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Neutropenia; Rectal Neoplasms; Remission Induction

1997
Phase I study of hepatic arterial infusion of floxuridine and dexamethasone with systemic irinotecan for unresectable hepatic metastases from colorectal cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, May-15, Volume: 19, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Camptothecin; Carcinoma; Colonic Neoplasms; Cryosurgery; Dexamethasone; Female; Floxuridine; Humans; Irinotecan; Liver Neoplasms; Male; Middle Aged; Tomography, X-Ray Computed

2001
Randomized multicenter phase II study comparing a combination of fluorouracil and folinic acid and alternating irinotecan and oxaliplatin with oxaliplatin and irinotecan in fluorouracil-pretreated metastatic colorectal cancer patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Nov-15, Volume: 19, Issue:22

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Rectal Neoplasms; Survival Rate; Treatment Outcome

2001
Irinotecan (CPT-11) in patients with advanced colon carcinoma relapsing after 5-fluorouracil-leucovorin combination.
    Chemotherapy, 2002, Volume: 48, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Cost-Benefit Analysis; Drug Costs; Drug Resistance, Neoplasm; Female; Fluorouracil; Health Status; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local; Treatment Outcome

2002
Phase I study and pharmacokinetics of CPT-11 with 5-day continuous infusion.
    Journal of the National Cancer Institute, 1992, Jun-17, Volume: 84, Issue:12

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Diarrhea; Drug Evaluation; Esophageal Neoplasms; Humans; Irinotecan; Leukopenia; Lung Neoplasms; Middle Aged; Pharyngeal Neoplasms

1992

Other Studies

605 other study(ies) available for camptothecin and Cancer of Colon

ArticleYear
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:1

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cattle; Cell Line; Colonic Neoplasms; DNA, Superhelical; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Leukemia L1210; Lung Neoplasms; Melanoma, Experimental; Mice; Molecular Structure; Plasmids; Structure-Activity Relationship; Thymus Gland; Topoisomerase I Inhibitors; Transplantation, Heterologous

1991
Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives.
    Journal of medicinal chemistry, 2001, Jun-07, Volume: 44, Issue:12

    Topics: Animals; Antineoplastic Agents; Cell Survival; Colonic Neoplasms; Doxorubicin; Drug Design; Drug Resistance, Neoplasm; Humans; Indicators and Reagents; Isoquinolines; Jurkat Cells; Leukemia P388; Lung Neoplasms; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Conformation; Molecular Structure; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured

2001
Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris.
    Journal of natural products, 2002, Volume: 65, Issue:2

    Topics: Antifungal Agents; Antineoplastic Agents, Phytogenic; Aspergillus niger; Colonic Neoplasms; Diterpenes; Drug Screening Assays, Antitumor; Ecuador; Female; Humans; Inhibitory Concentration 50; KB Cells; Lung Neoplasms; Magnoliopsida; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Ovarian Neoplasms; Plant Leaves; Plant Shoots; Plants, Medicinal; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Tumor Cells, Cultured

2002
Biological profile of new apoptotic agents based on 2,4-pyrido[2,3-d]pyrimidine derivatives.
    Bioorganic & medicinal chemistry, 2007, Feb-15, Volume: 15, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Humans; Pyrimidines; Signal Transduction; Urinary Bladder Neoplasms

2007
Inhibition of colon cancer cell growth and antioxidant activity of bioactive compounds from Poncirus trifoliata (L.) Raf.
    Bioorganic & medicinal chemistry, 2007, Jul-15, Volume: 15, Issue:14

    Topics: Animals; Antioxidants; Carboxylic Acids; Cell Extracts; Cell Line; Cell Proliferation; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Colonic Neoplasms; Esters; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Poncirus; Sitosterols

2007
Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:8

    Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; DNA Fragmentation; Humans; Male; Mice; Neoplasm Transplantation; NF-kappa B; Nitriles; Oxides; Prostatic Neoplasms; Sesquiterpenes; Spiro Compounds; Structure-Activity Relationship

2011
Multidrug resistance reversal and apoptosis induction in human colon cancer cells by some flavonoids present in citrus plants.
    Journal of natural products, 2012, Nov-26, Volume: 75, Issue:11

    Topics: Algorithms; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caspase 3; Citrus; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavanones; Flavones; Flavonoids; Humans; Molecular Structure; Rhodamine 123

2012
Fluorescein hydrazones: A series of novel non-intercalative topoisomerase IIα catalytic inhibitors induce G1 arrest and apoptosis in breast and colon cancer cells.
    European journal of medicinal chemistry, 2017, Jan-05, Volume: 125

    Topics: Animals; Antigens, Neoplasm; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Fluorescein; G1 Phase Cell Cycle Checkpoints; Humans; Hydrazones; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2017
Halogenated Compounds from Directed Fermentation of Penicillium concentricum, an Endophytic Fungus of the Liverwort Trichocolea tomentella.
    Journal of natural products, 2017, 05-26, Volume: 80, Issue:5

    Topics: Benzyl Alcohols; Colonic Neoplasms; Epoxy Compounds; Ethylene Glycols; Fermentation; Halogenation; Hepatophyta; HT29 Cells; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; MCF-7 Cells; Molecular Structure; Penicillium; Xanthones

2017
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
    Bioorganic & medicinal chemistry, 2019, 01-15, Volume: 27, Issue:2

    Topics: Animals; Antineoplastic Agents; Cattle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Coumarins; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Male; Mice, Inbred BALB C; Molecular Structure; Structure-Activity Relationship; Topoisomerase I Inhibitors

2019
Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer.
    Journal of medicinal chemistry, 2020, 01-23, Volume: 63, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Drug Design; G2 Phase; HCT116 Cells; Humans; Mice; Quinazolines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tubulin Modulators; Xenograft Model Antitumor Assays

2020
Design, synthesis and screening of benzimidazole containing compounds with methoxylated aryl radicals as cytotoxic molecules on (HCT-116) colon cancer cells.
    European journal of medicinal chemistry, 2021, Jan-01, Volume: 209

    Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Chromosomal Instability; Colonic Neoplasms; Drug Design; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Radiation-Sensitizing Agents; Tubulin Modulators

2021
Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase-2 for colon cancer therapy.
    European journal of medicinal chemistry, 2022, Oct-05, Volume: 240

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase Inhibitors

2022
A single microbubble formulation carrying 5-fluorouridine, Irinotecan and oxaliplatin to enable FOLFIRINOX treatment of pancreatic and colon cancer using ultrasound targeted microbubble destruction.
    Journal of controlled release : official journal of the Controlled Release Society, 2021, 10-10, Volume: 338

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Mice; Microbubbles; Oxaliplatin; Pancreatic Neoplasms; Treatment Outcome; Uridine

2021
Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells.
    Molecules (Basel, Switzerland), 2021, Sep-06, Volume: 26, Issue:17

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Base Sequence; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Cyclodextrins; DNA Polymerase III; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Binding Proteins; Drug Compounding; Drug Liberation; Epigenesis, Genetic; Gene Expression Regulation; Gene Library; HMGB1 Protein; Humans; Magnetic Iron Oxide Nanoparticles; Nanocapsules; Nucleoproteins

2021
Metastasis-Directed Radiotherapy for Oligoprogressive or Oligopersistent Metastatic Colorectal Cancer.
    Clinical colorectal cancer, 2022, Volume: 21, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Prospective Studies; Rectal Neoplasms

2022
Efficacy of apatinib combined with FOLFIRI in the first-line treatment of patients with metastatic colorectal cancer.
    Investigational new drugs, 2022, Volume: 40, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Pyridines; Rectal Neoplasms

2022
Age and comorbidity association with survival outcomes in metastatic colorectal cancer: CALGB 80405 analysis.
    Journal of geriatric oncology, 2022, Volume: 13, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Comorbidity; Fluorouracil; Humans; Leucovorin; Rectal Neoplasms; Treatment Outcome

2022
Comparison of
    Oncology research, 2022, May-04, Volume: 29, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Glucuronosyltransferase; Humans; Irinotecan; Leucovorin; Retrospective Studies

2022
A silica-based antioxidant nanoparticle for oral delivery of Camptothecin which reduces intestinal side effects while improving drug efficacy for colon cancer treatment.
    Acta biomaterialia, 2022, 04-15, Volume: 143

    Topics: Animals; Antioxidants; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Colorectal Neoplasms; Endothelial Cells; Mice; Nanoparticles; Reactive Oxygen Species; Silicon Dioxide

2022
A Comparison of Folinic Acid, Fluorouracil and Irinotecan (FOLFIRI) plus Bevacizumab and FOLFIRI plus Aflibercept as Second-line Treatment for Metastatic Colorectal Cancer.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2022, Volume: 34, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Neoplasm Metastasis; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Rectal Neoplasms

2022
Safety and effectiveness of aflibercept in combination with FOLFIRI in Korean patients with metastatic colorectal cancer who received oxaliplatin-containing regimen.
    Journal of cancer research and clinical oncology, 2023, Volume: 149, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Male; Oxaliplatin; Rectal Neoplasms; Republic of Korea

2023
Real-World Data Analysis of Second-Line Antiangiogenic Targeted Treatments Following Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies and First-Line FOLFOX for Patients with Metastatic Colorectal Cancer.
    Advances in therapy, 2022, Volume: 39, Issue:6

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Data Analysis; Female; Fluorouracil; Humans; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Retrospective Studies

2022
Efficacy and safety of FOLFIRI/aflibercept (FA) in an elderly population with metastatic colorectal cancer (mCRC) after failure of an oxaliplatin-based regimen.
    PloS one, 2022, Volume: 17, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Oxaliplatin; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Rectal Neoplasms; Retrospective Studies

2022
Benefit from upfront FOLFOXIRI and bevacizumab in BRAFV600E-mutated metastatic colorectal cancer patients: does primary tumour location matter?
    British journal of cancer, 2022, Volume: 127, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Organoplatinum Compounds; Rectal Neoplasms

2022
Tumor calcification is associated with better survival in metastatic colorectal cancer patients treated with bevacizumab plus chemotherapy.
    Future oncology (London, England), 2022, Volume: 18, Issue:22

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Rectal Neoplasms; Retrospective Studies

2022
Genetic variants involved in the cGAS-STING pathway predict outcome in patients with metastatic colorectal cancer: Data from FIRE-3 and TRIBE trials.
    European journal of cancer (Oxford, England : 1990), 2022, Volume: 172

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Interferons; Leucovorin; Membrane Proteins; Nucleotidyltransferases; Rectal Neoplasms

2022
A novel irinotecan derivative ZBH-1207 with different anti-tumor mechanism from CPT-11 against colon cancer cells.
    Molecular biology reports, 2022, Volume: 49, Issue:9

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Caspase 3; Cell Line, Tumor; Colonic Neoplasms; Humans; Irinotecan; Poly(ADP-ribose) Polymerase Inhibitors

2022
Safety and efficacy of irinotecan, oxaliplatin, and capecitabine (XELOXIRI) regimen with or without targeted drugs in patients with metastatic colorectal cancer: a retrospective cohort study.
    BMC cancer, 2022, Jul-21, Volume: 22, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Longitudinal Studies; Organoplatinum Compounds; Oxaliplatin; Rectal Neoplasms; Retrospective Studies

2022
Real-world overall survival of patients receiving cetuximab in later lines of treatment for metastatic colorectal cancer.
    Future oncology (London, England), 2022, Volume: 18, Issue:29

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Rectal Neoplasms; Retrospective Studies

2022
Aflibercept with FOLFIRI in Japanese patients with metastatic colorectal cancer: results of a post-marketing surveillance.
    International journal of clinical oncology, 2023, Volume: 28, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; East Asian People; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Product Surveillance, Postmarketing; Receptors, Vascular Endothelial Growth Factor; Rectal Neoplasms

2023
Association between a single nucleotide polymorphism in the R3HCC1 gene and irinotecan toxicity.
    Cancer medicine, 2023, Volume: 12, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Neutropenia; Pancreatic Neoplasms; Polymorphism, Single Nucleotide; Rectal Neoplasms

2023
Bone metastases are associated with worse prognosis in patients affected by metastatic colorectal cancer treated with doublet or triplet chemotherapy plus bevacizumab: a subanalysis of the TRIBE and TRIBE2 trials.
    ESMO open, 2022, Volume: 7, Issue:6

    Topics: Bevacizumab; Bone Neoplasms; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Prognosis; Quality of Life

2022
A signature of circulating microRNAs predicts the response to treatment with FOLFIRI plus aflibercept in metastatic colorectal cancer patients.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 159

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Circulating MicroRNA; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; MicroRNAs; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Rectal Neoplasms

2023
Maintenance of angiogenesis inhibition with aflibercept after progression to bevacizumab in metastatic colorectal cancer: real life study in the Valencian community.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2023, Volume: 25, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Hypertension; Leucovorin; Middle Aged; Neoplasm Metastasis; Recombinant Fusion Proteins; Rectal Neoplasms; Retrospective Studies

2023
Antitumor Efficacy of Dual Blockade with Encorafenib + Cetuximab in Combination with Chemotherapy in Human BRAFV600E-Mutant Colorectal Cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2023, 06-13, Volume: 29, Issue:12

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Mice; Xenograft Model Antitumor Assays

2023
Impact of prior bevacizumab therapy on the incidence of ramucirumab-induced proteinuria in colorectal cancer: a multi-institutional cohort study.
    International journal of clinical oncology, 2023, Volume: 28, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Incidence; Leucovorin; Proteinuria; Ramucirumab; Rectal Neoplasms

2023
Final results of DESTINY-CRC01 investigating trastuzumab deruxtecan in patients with HER2-expressing metastatic colorectal cancer.
    Nature communications, 2023, 06-07, Volume: 14, Issue:1

    Topics: Antibodies, Monoclonal, Humanized; Breast Neoplasms; Camptothecin; Colonic Neoplasms; Female; Humans; Immunoconjugates; Receptor, ErbB-2; Rectal Neoplasms; Trastuzumab

2023
Single-organ pulmonary metastasis is a favorable prognostic factor in metastatic colorectal cancer patients treated with FOLFIRI and vascular endothelial growth factor inhibitors.
    BMC cancer, 2023, Jul-06, Volume: 23, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Lung Neoplasms; Neoplasm Metastasis; Prognosis; Rectal Neoplasms; Retrospective Studies; Vascular Endothelial Growth Factor A

2023
Carboxymethylcellulose based self-healing hydrogel with coupled DOX as Camptothecin loading carrier for synergetic colon cancer treatment.
    International journal of biological macromolecules, 2023, Sep-30, Volume: 249

    Topics: Camptothecin; Carboxymethylcellulose Sodium; Colonic Neoplasms; Doxorubicin; Drug Carriers; Drug Liberation; Humans; Hydrogels

2023
Cetuximab as first-line treatment for metastatic colorectal cancer (mCRC): a model-based economic evaluation in Indonesia setting.
    BMC cancer, 2023, Aug-08, Volume: 23, Issue:1

    Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Cost-Benefit Analysis; Fluorouracil; Humans; Indonesia; Leucovorin; Oxaliplatin; Rectal Neoplasms

2023
Quality of life, effectiveness, and safety of aflibercept plus FOLFIRI in older patients with metastatic colorectal cancer: An analysis of the prospective QoLiTrap study.
    Journal of geriatric oncology, 2023, Volume: 14, Issue:8

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Prospective Studies; Quality of Life; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Rectal Neoplasms

2023
Caffeine enhances chemosensitivity to irinotecan in the treatment of colorectal cancer.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 121

    Topics: Adenocarcinoma; Caffeine; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Colorectal Neoplasms; DNA; Humans; Irinotecan

2023
Exploration of potential prognostic biomarkers in aflibercept plus FOLFIRI in Japanese patients with metastatic colorectal cancer.
    Cancer science, 2019, Volume: 110, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asian People; Biomarkers, Tumor; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Insulin-Like Growth Factor Binding Protein 1; Interleukin-8; Japan; Kallikreins; Leucovorin; Placenta Growth Factor; Prognosis; Progression-Free Survival; Prospective Studies; Pulmonary Surfactant-Associated Protein D; Receptor for Advanced Glycation End Products; Receptors, Tumor Necrosis Factor, Type II; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Rectal Neoplasms; Regression Analysis; Tenascin; Tissue Inhibitor of Metalloproteinase-1; Vascular Endothelial Growth Factor Receptor-1

2019
Mechanism of a Novel Camptothecin-Deoxycholic Acid Derivate Induced Apoptosis against Human Liver Cancer HepG2 Cells and Human Colon Cancer HCT116 Cells.
    Recent patents on anti-cancer drug discovery, 2019, Volume: 14, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Deoxycholic Acid; HCT116 Cells; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species

2019
[Two Cases of Advanced Colorectal Cancer Achieving Complete Response by FOLFOXIRI plus Bevacizumab-A Case Report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2019, Volume: 46, Issue:13

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Organoplatinum Compounds; Rectal Neoplasms

2019
[A Case of Complete Pathological Response in a Patient with Advanced Ascending Colon Cancer That Invaded the Liver and Duodenum after FOLFOXIRI plus Bevacizumab Chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2020, Volume: 47, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colon, Ascending; Colonic Neoplasms; Duodenum; Female; Fluorouracil; Humans; Leucovorin; Liver; Organoplatinum Compounds

2020
Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel.
    Nature biomedical engineering, 2020, Volume: 4, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Delivery Systems; Female; Hydrogels; Immunotherapy; Mice, Inbred BALB C; Mice, Inbred C57BL; Nanotubes; Tumor Microenvironment

2020
Sex and Adverse Events of Adjuvant Chemotherapy in Colon Cancer: An Analysis of 34 640 Patients in the ACCENT Database.
    Journal of the National Cancer Institute, 2021, 04-06, Volume: 113, Issue:4

    Topics: Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Body Mass Index; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colonic Neoplasms; Databases, Factual; Diarrhea; Female; Fluorouracil; Humans; Leucovorin; Leukopenia; Logistic Models; Male; Middle Aged; Nausea; Nervous System Diseases; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Sex Factors; Stomatitis; Thrombocytopenia; Vomiting

2021
Redox-related Molecular Mechanism of Sensitizing Colon Cancer Cells to Camptothecin Analog SN38.
    Anticancer research, 2020, Volume: 40, Issue:9

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA Damage; Drug Resistance, Neoplasm; Drug Synergism; Fluorescent Antibody Technique; Glutathione; Humans; Models, Biological; Oxidation-Reduction; Reactive Oxygen Species

2020
Targeted rod-shaped mesoporous silica nanoparticles for the co-delivery of camptothecin and survivin shRNA in to colon adenocarcinoma in vitro and in vivo.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2020, Volume: 156

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; CHO Cells; Colonic Neoplasms; Cricetinae; Cricetulus; Drug Delivery Systems; Female; Humans; Mice; Mice, Inbred BALB C; Nanoparticles; Nanotubes; Porosity; RNA, Small Interfering; Silicon Dioxide; Survivin

2020
Pathologic Complete Response in Patient With ATM Mutation After Neoadjuvant FOLFOXIRI Plus Panitumumab Therapy for Locally Advanced Colon Cancer: A Case Report.
    Clinical colorectal cancer, 2021, Volume: 20, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Ataxia Telangiectasia Mutated Proteins; Camptothecin; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Mutation; Neoadjuvant Therapy; Organoplatinum Compounds; Panitumumab; Treatment Outcome

2021
[A Case of Neoadjuvant Chemotherapy with Modified FOLFOXIRI plus Bevacizumab for Transverse Colon Cancer with Invasion of the Gastric Antrum].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2020, Volume: 47, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colon, Transverse; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Male; Neoadjuvant Therapy; Organoplatinum Compounds; Pyloric Antrum

2020
Dual deficiency of DPD and UGT1A1 in a case of colon cancer.
    Pharmacogenomics, 2020, Volume: 21, Issue:18

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Glucuronosyltransferase; Humans; Irinotecan; Leucovorin; Middle Aged; Mutation; Tomography, X-Ray Computed

2020
Fabrication of anionic dextran-coated micelles for aptamer targeted delivery of camptothecin and survivin-shRNA to colon adenocarcinoma.
    Gene therapy, 2022, Volume: 29, Issue:1-2

    Topics: Adenocarcinoma; Animals; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Dextrans; Drug Delivery Systems; Mice; Micelles; Polyesters; RNA, Small Interfering; Survivin

2022
Chemotherapy of metastatic colon cancer in France: A population-based study.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2021, Volume: 53, Issue:10

    Topics: Adenocarcinoma; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; France; Humans; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Palliative Care; Registries; Retrospective Studies

2021
Prognostic impact of additive chemotherapy after curative resection of metachronous colorectal liver metastasis: a single-centre retrospective study.
    BMC cancer, 2021, May-03, Volume: 21, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Hepatectomy; Humans; Kaplan-Meier Estimate; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Prognosis; Proportional Hazards Models; Rectal Neoplasms; Retrospective Studies; Risk Factors; Survival Rate; Time Factors

2021
Fabrication of versatile targeted lipopolymersomes for improved camptothecin efficacy against colon adenocarcinoma in vitro and in vivo.
    Expert opinion on drug delivery, 2021, Volume: 18, Issue:9

    Topics: Adenocarcinoma; Camptothecin; Colonic Neoplasms; Drug Delivery Systems; Humans

2021
Optimal Allocation of Chemotherapy Schemes for Metastatic Colon Cancer in Colombia.
    Value in health regional issues, 2021, Volume: 26

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colombia; Colonic Neoplasms; Colorectal Neoplasms; Humans

2021
Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy.
    Nature nanotechnology, 2021, Volume: 16, Issue:10

    Topics: Adenocarcinoma; Animals; B7-H1 Antigen; Camptothecin; Colonic Neoplasms; Disease Models, Animal; Drug Therapy; Granzymes; Humans; Immunotherapy; Lipid Bilayers; Melanoma, Experimental; Mice; Nanoparticles; Perforin; Programmed Cell Death 1 Receptor; Sphingomyelins; T-Lymphocytes, Cytotoxic

2021
Effect of antitumor drugs in low concentrationson the biological, immunophenotypic and cytogenetic characteristics of human colon cancer cells in vitro.
    Experimental oncology, 2017, Volume: 39, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Cadherins; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cisplatin; Colonic Neoplasms; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Endonucleases; Epithelial-Mesenchymal Transition; HT29 Cells; Humans; Hyaluronan Receptors; Immunohistochemistry; Immunophenotyping; Interferons; Irinotecan; Snail Family Transcription Factors; Time Factors; Vimentin

2017
Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway.
    Oncotarget, 2017, Jun-20, Volume: 8, Issue:25

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Calcium; Camptothecin; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Curcumin; Drug Synergism; Drug Therapy, Combination; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Humans; Irinotecan; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Transcription Factor CHOP

2017
Resection of colorectal liver metastases after second-line chemotherapy: is it worthwhile? A LiverMetSurvey analysis of 6415 patients.
    European journal of cancer (Oxford, England : 1990), 2017, Volume: 78

    Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Catheter Ablation; Cetuximab; Colonic Neoplasms; Disease Progression; Disease-Free Survival; Female; Hepatectomy; Humans; Irinotecan; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Panitumumab; Postoperative Care; Preoperative Care; Prospective Studies; Rectal Neoplasms; Registries

2017
Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations.
    World journal of gastroenterology, 2017, May-21, Volume: 23, Issue:19

    Topics: Animals; Axl Receptor Tyrosine Kinase; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Doxorubicin; Fluorouracil; Gene Expression Regulation, Neoplastic; Gene Silencing; HCT116 Cells; HeLa Cells; Humans; Irinotecan; MCF-7 Cells; Mice, Knockout; Mutation; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; RNA, Small Interfering; Signal Transduction; Treatment Outcome; Tumor Suppressor Protein p53

2017
Epithelial-mesenchymal transition and cancer stem cell-like phenotype induced by Twist1 contribute to acquired resistance to irinotecan in colon cancer.
    International journal of oncology, 2017, Volume: 51, Issue:2

    Topics: Camptothecin; Cell Movement; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Neoplasm Invasiveness; Neoplastic Stem Cells; Nuclear Proteins; RNA, Small Interfering; Transfection; Twist-Related Protein 1

2017
Sub-100nm, long tumor retention SN-38-loaded photonic micelles for tri-modal cancer therapy.
    Journal of controlled release : official journal of the Controlled Release Society, 2017, 09-10, Volume: 261

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Combined Modality Therapy; Drug Delivery Systems; HT29 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Irinotecan; Male; Mice; Mice, Nude; Micelles; Nanoparticles; Particle Size; Photons; Photosensitizing Agents; Phototherapy; Rats; Rats, Sprague-Dawley; Time Factors; Xenograft Model Antitumor Assays

2017
iRGD-functionalized PEGylated nanoparticles for enhanced colon tumor accumulation and targeted drug delivery.
    Nanomedicine (London, England), 2017, Volume: 12, Issue:16

    Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Carriers; Drug Liberation; Female; Humans; Mice; Nanoparticles; Oligopeptides; Particle Size; Polyglycolic Acid; Surface Properties; Tissue Distribution

2017
Efficiency of newly formulated camptothecin with β-cyclodextrin-EDTA-Fe
    Scientific reports, 2017, 09-08, Volume: 7, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; beta-Cyclodextrins; Camptothecin; Colonic Neoplasms; Edetic Acid; Ferric Compounds; G1 Phase; HT29 Cells; Humans; Nanoconjugates

2017
Tetrac-conjugated polymersomes for integrin-targeted delivery of camptothecin to colon adenocarcinoma in vitro and in vivo.
    International journal of pharmaceutics, 2017, Oct-30, Volume: 532, Issue:1

    Topics: Adenocarcinoma; Animals; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Delivery Systems; Female; HT29 Cells; Humans; Integrin alphaVbeta3; Mice; Mice, Inbred BALB C; Thyroxine

2017
Long-term survival in a patient with low-level inflammatory markers and liver metastasis, converted resectable by TACE.
    Immunotherapy, 2017, Volume: 9, Issue:13

    Topics: Adenocarcinoma; Adult; Biomarkers; Camptothecin; Capecitabine; Chemoembolization, Therapeutic; Colectomy; Colonic Neoplasms; Fluorouracil; Hepatectomy; Humans; Inflammation Mediators; Irinotecan; Leucovorin; Liver Neoplasms; Male; Microspheres; Organoplatinum Compounds; Oxaliplatin; Remission Induction

2017
Bromoethylindole (BEI-9) redirects NF-κB signaling induced by camptothecin and TNFα to promote cell death in colon cancer cells.
    Apoptosis : an international journal on programmed cell death, 2017, Volume: 22, Issue:12

    Topics: Apoptosis; bcl-X Protein; Camptothecin; Caspases; Cell Cycle; Cell Death; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Humans; Indoles; NF-kappa B; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha

2017
Camptothecin-producing endophytic bacteria from Pyrenacantha volubilis Hook. (Icacinaceae): A possible role of a plasmid in the production of camptothecin.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2017, Dec-01, Volume: 36

    Topics: Antineoplastic Agents; Bacillus; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Endophytes; Fruit; Humans; Magnoliopsida; Plant Leaves; Plasmids; RNA, Ribosomal, 16S; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2017
Liposomal
    Theranostics, 2017, Volume: 7, Issue:17

    Topics: Animals; Bevacizumab; Camptothecin; Colonic Neoplasms; Copper Radioisotopes; HT29 Cells; Humans; Irinotecan; Liposomes; Mice; Mice, SCID; Positron-Emission Tomography; Vascular Endothelial Growth Factor A

2017
Monophosphorylation by deoxycytidine kinase affects apparent cellular uptake of decitabine in HCT116 colon cancer cells.
    Drug metabolism and pharmacokinetics, 2017, Volume: 32, Issue:6

    Topics: Antimetabolites, Antineoplastic; Azacitidine; Camptothecin; Colonic Neoplasms; Cytarabine; Decitabine; Deoxycytidine; Deoxycytidine Kinase; Equilibrative Nucleoside Transporter 1; Etoposide; Gemcitabine; HCT116 Cells; Humans; Irinotecan; Phosphorylation

2017
Irinotecan and Oxaliplatin Might Provide Equal Benefit as Adjuvant Chemotherapy for Patients with Resectable Synchronous Colon Cancer and Liver-confined Metastases: A Nationwide Database Study.
    Anticancer research, 2017, Volume: 37, Issue:12

    Topics: Aged; Antineoplastic Agents; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Databases, Factual; Female; Humans; Irinotecan; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Organoplatinum Compounds; Outcome Assessment, Health Care; Oxaliplatin; Proportional Hazards Models; Retrospective Studies; Taiwan

2017
Wee1 inhibition can suppress tumor proliferation and sensitize p53 mutant colonic cancer cells to the anticancer effect of irinotecan.
    Molecular medicine reports, 2018, Volume: 17, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; DNA Damage; Enzyme Inhibitors; Humans; Irinotecan; Mutation; Nuclear Proteins; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Tumor Suppressor Protein p53

2018
Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer.
    Lipids in health and disease, 2017, Dec-19, Volume: 16, Issue:1

    Topics: Adipocytes; Adipose Tissue; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Size; Colonic Neoplasms; Disease Models, Animal; Fatty Acids; Fatty Acids, Monounsaturated; Fatty Acids, Omega-3; Female; Fluorouracil; Humans; Irinotecan; Lipogenesis; Mitochondria; Mitochondrial Proteins; Phospholipids; Proteome; Rats; Rats, Inbred F344; Triglycerides

2017
Economic Analysis of First-Line Treatment with Cetuximab or Panitumumab for RAS Wild-Type Metastatic Colorectal Cancer in England.
    PharmacoEconomics, 2018, Volume: 36, Issue:7

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Cost-Benefit Analysis; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Models, Economic; Organoplatinum Compounds; Panitumumab; Proto-Oncogene Proteins p21(ras); Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Survival Analysis

2018
Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Mar-09, Volume: 24

    Topics: Apoptosis; Camptothecin; Cell Cycle Checkpoints; Cell Movement; Colonic Neoplasms; DNA Damage; Down-Regulation; G2 Phase; Gene Expression Regulation, Neoplastic; HCT116 Cells; Histones; Humans; Irinotecan; Lentivirus; Membrane Potential, Mitochondrial; Mitosis; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Transduction, Genetic; Tumor Suppressor Proteins

2018
Posterior Reversible Encephalopathy Syndrome after a Variety of Combined Chemotherapies Containing Bevacizumab for Metastatic Colon Cancer.
    Internal medicine (Tokyo, Japan), 2018, Aug-15, Volume: 57, Issue:16

    Topics: Adult; Antineoplastic Agents, Immunological; Bevacizumab; Camptothecin; Capecitabine; Colonic Neoplasms; Female; Humans; Irinotecan; Leucovorin; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Posterior Leukoencephalopathy Syndrome; Treatment Outcome

2018
Ethanolic Extract of Traditional Chinese Medicine (TCM) Gamboge Inhibits Colon Cancer
    Anticancer research, 2018, Volume: 38, Issue:4

    Topics: Animals; Apoptosis; Camptothecin; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Ethanol; Fluorouracil; Garcinia; Humans; Immunohistochemistry; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Plant Extracts; Random Allocation; Wnt Signaling Pathway; Xenograft Model Antitumor Assays

2018
Indolent Nodal Relapse of Colon Carcinoma with Associated Tumor Thrombus Invading the Superior Mesenteric Vein.
    Journal of gastrointestinal cancer, 2019, Volume: 50, Issue:3

    Topics: Adenocarcinoma, Mucinous; Anticoagulants; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colectomy; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Lymph Nodes; Lymphatic Metastasis; Male; Mesenteric Veins; Mesentery; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Organoplatinum Compounds; Positron Emission Tomography Computed Tomography; Thrombectomy; Treatment Outcome; Venous Thrombosis

2019
Survival of patients with non-resectable, chemotherapy-resistant colorectal cancer liver metastases undergoing conventional lipiodol-based transarterial chemoembolization (cTACE) palliatively versus neoadjuvantly prior to percutaneous thermal ablation.
    European journal of radiology, 2018, Volume: 102

    Topics: Ablation Techniques; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemoembolization, Therapeutic; Cisplatin; Colonic Neoplasms; Colorectal Neoplasms; Deoxycytidine; Disease-Free Survival; Ethiodized Oil; Female; Gemcitabine; Humans; Hyperthermia, Induced; Irinotecan; Laser Therapy; Liver Neoplasms; Male; Microwaves; Middle Aged; Mitomycin; Neoadjuvant Therapy; Palliative Care; Prognosis; Rectal Neoplasms; Retrospective Studies; Survival Rate; Treatment Outcome; Young Adult

2018
[IDEA study (International Duration Evaluation of Adjuvant Chemotherapy) for patients with stage III colon cancer: Possibility of reducing to 3 months treatment for 60% of the patients!]
    Bulletin du cancer, 2018, Volume: 105, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Colonic Neoplasms; Disease-Free Survival; Drug Administration Schedule; Equivalence Trials as Topic; Fluorouracil; Humans; Leucovorin; Neoplasm Staging; Organoplatinum Compounds; Rectal Neoplasms; Treatment Outcome

2018
Silencing of Intestinal Glycoprotein CD98 by Orally Targeted Nanoparticles Enhances Chemosensitization of Colon Cancer.
    ACS nano, 2018, 06-26, Volume: 12, Issue:6

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Drug Delivery Systems; Drug Screening Assays, Antitumor; Female; Fusion Regulatory Protein-1; Humans; Intestines; Mice; Mice, Inbred C57BL; Nanoparticles; Neoplasms, Experimental; RNA, Small Interfering

2018
Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells.
    International journal of oncology, 2018, Volume: 53, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Camptothecin; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Curcumin; Drug Resistance, Neoplasm; Humans; Irinotecan; Neoplastic Stem Cells; Spheroids, Cellular

2018
[Five-Year Survival of Two Patients with Para-Aortic Lymph Node Metastasis Treated with Four FOLFOX6and Four FOLFIRI Courses in Combination with Bevacizumab].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2018, Volume: 45, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Aorta; Bevacizumab; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Lymphatic Metastasis; Middle Aged; Organoplatinum Compounds; Time Factors; Treatment Outcome

2018
High Efficacy of Intravenous Gimatecan on Human Tumor Xenografts.
    Anticancer research, 2018, Volume: 38, Issue:10

    Topics: Administration, Oral; Animals; Apoptosis; Astrocytoma; Bone Neoplasms; Camptothecin; Cell Proliferation; Colonic Neoplasms; Female; Humans; Mice; Mice, Nude; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2018
A molecular basis for the synergy between 17‑allylamino‑17‑demethoxy geldanamycin with Capecitabine and Irinotecan in human colorectal cancer cells through VEFG and MMP-9 gene expression.
    Gene, 2019, Feb-05, Volume: 684

    Topics: Antineoplastic Combined Chemotherapy Protocols; Benzoquinones; Camptothecin; Capecitabine; Colonic Neoplasms; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Gene Expression; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Irinotecan; Lactams, Macrocyclic; Matrix Metalloproteinase 9; Neovascularization, Pathologic; Vascular Endothelial Growth Factor A

2019
Case of purpuric drug eruption probably induced by panitumumab.
    The Journal of dermatology, 2019, Volume: 46, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Camptothecin; Colonic Neoplasms; Drug Eruptions; Female; Fluorouracil; Humans; Leucovorin; Lung Neoplasms; Middle Aged; Panitumumab; Prednisolone; Purpura; Skin; Staphylococcal Skin Infections; Staphylococcus aureus; Vasculitis, Leukocytoclastic, Cutaneous

2019
[Treatment with FOLFIRI plus aflibercept in a patient with RAS and BRAF wild-type, right-sided colon cancer and potentially resectable liver metastases].
    Recenti progressi in medicina, 2018, Volume: 109, Issue:11

    Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Organoplatinum Compounds; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Treatment Outcome

2018
[Perioperative treatment with FOLFIRI plus aflibercept in a patient with RAS and BRAF wild-type, left-sided colon cancer, with early relapse following adjuvant oxaliplatin- based treatment due to potentially resectable liver metastases].
    Recenti progressi in medicina, 2018, Volume: 109, Issue:11

    Topics: Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Oxaliplatin; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins

2018
[Second-line treatment with FOLFIRI plus aflibercept in a patient with right-sided, BRAF mutated metastatic colon cancer.]
    Recenti progressi in medicina, 2018, Volume: 109, Issue:11

    Topics: Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Lymphatic Metastasis; Mutation; Proto-Oncogene Proteins B-raf; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins

2018
Chondroitin sulfate-functionalized polymeric nanoparticles for colon cancer-targeted chemotherapy.
    Colloids and surfaces. B, Biointerfaces, 2019, May-01, Volume: 177

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Proliferation; Cell Survival; Chondroitin Sulfates; Colonic Neoplasms; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Hydrodynamics; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasms, Experimental; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Surface Properties; Tumor Cells, Cultured

2019
FOLFOX and FOLFIRI Use in Stage IV Colon Cancer: Analysis of SEER-Medicare Data.
    Clinical colorectal cancer, 2019, Volume: 18, Issue:2

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Utilization; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Leucovorin; Male; Medicare; Neoplasm Staging; Organoplatinum Compounds; Progression-Free Survival; SEER Program; United States

2019
Acid-responsive nanoparticles as a novel oxidative stress-inducing anticancer therapeutic agent for colon cancer.
    International journal of nanomedicine, 2019, Volume: 14

    Topics: Acids; Acrolein; Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dextrans; Drug Delivery Systems; Drug Liberation; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Female; Humans; Hydrogen-Ion Concentration; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Oxidative Stress; Proton Magnetic Resonance Spectroscopy; Rats, Sprague-Dawley; Reactive Oxygen Species

2019
Modulation of drug release by decoration with Pluronic F127 to improve anti-colon cancer activity of electrospun fibrous meshes.
    Materials science & engineering. C, Materials for biological applications, 2019, Volume: 99

    Topics: Adsorption; Animals; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Liberation; Mice; Poloxamer; Polylactic Acid-Polyglycolic Acid Copolymer; Proteins; Temperature; Tissue Engineering; Water; Wettability; X-Ray Diffraction

2019
ROS-responsive nanoparticles based on amphiphilic hyperbranched polyphosphoester for drug delivery: Light-triggered size-reducing and enhanced tumor penetration.
    Biomaterials, 2019, Volume: 211

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chlorophyllides; Colonic Neoplasms; Delayed-Action Preparations; Drug Delivery Systems; HT29 Cells; Humans; Light; Mice, Nude; Nanoparticles; Photosensitizing Agents; Porphyrins; Reactive Oxygen Species

2019
A new herbal formula BP10A exerted an antitumor effect and enhanced anticancer effect of irinotecan and oxaliplatin in the colon cancer PDTX model.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 116

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Death; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drugs, Chinese Herbal; Humans; Irinotecan; Male; Mice, Inbred BALB C; Mice, Nude; Oxaliplatin; Phytotherapy; Xenograft Model Antitumor Assays

2019
HMGB1 modulates the balance between senescence and apoptosis in response to genotoxic stress.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:10

    Topics: Animals; Apoptosis; Camptothecin; Cell Line, Tumor; Cells, Cultured; Cellular Senescence; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Doxorubicin; Fibroblasts; HMGB1 Protein; Humans; Melanoma; Mice

2019
Novel lipophilic SN38 prodrug forming stable liposomes for colorectal carcinoma therapy.
    International journal of nanomedicine, 2019, Volume: 14

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Colonic Neoplasms; Drug Liberation; Female; HT29 Cells; Humans; Irinotecan; Lipids; Liposomes; Mice, Nude; Molecular Dynamics Simulation; Nanoparticles; Prodrugs; Rats, Sprague-Dawley; Solubility; Tissue Distribution; Xenograft Model Antitumor Assays

2019
ALPPS procedure with the use of pneumoperitoneum.
    Annals of surgical oncology, 2013, Volume: 20, Issue:5

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Fluorouracil; Hepatectomy; Humans; Leucovorin; Ligation; Liver Neoplasms; Neoadjuvant Therapy; Organoplatinum Compounds; Pneumoperitoneum, Artificial; Portal Vein

2013
Utilization of quantitative in vivo pharmacology approaches to assess combination effects of everolimus and irinotecan in mouse xenograft models of colorectal cancer.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Colonic Neoplasms; Drug Synergism; Everolimus; Female; Humans; Immunosuppressive Agents; Irinotecan; Metabolome; Mice; Mice, Nude; Mutation; Neoplasm Transplantation; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); ras Proteins; Sirolimus; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2013
Update: NCCN colon and rectal cancer clinical practice guidelines.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2004, Volume: 2 Suppl 3

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Chemoradiotherapy; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Organoplatinum Compounds; Practice Guidelines as Topic; Radiotherapy, Adjuvant; Rectal Neoplasms

2004
Selecting regimens in advanced colon cancer.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2004, Volume: 2 Suppl 3

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin

2004
Cell diameter measurements obtained with a handheld cell counter could be used as a surrogate marker of G2/M arrest and apoptosis in colon cancer cell lines exposed to SN-38.
    Biochemical and biophysical research communications, 2013, May-17, Volume: 434, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Count; Cell Proliferation; Cell Size; Cell Survival; Colonic Neoplasms; Cytological Techniques; Dose-Response Relationship, Drug; G2 Phase Cell Cycle Checkpoints; HCT116 Cells; HT29 Cells; Humans; Irinotecan; Microscopy, Fluorescence; Reproducibility of Results

2013
Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan.
    International journal of oncology, 2013, Volume: 43, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Camptothecin; Checkpoint Kinase 1; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Irinotecan; MutL Protein Homolog 1; Nuclear Proteins; Phosphorylation; Poly(ADP-ribose) Polymerase Inhibitors; Protein Kinases; Topoisomerase I Inhibitors

2013
Hydroxycamptothecin induces apoptosis and inhibits tumor growth in colon cancer by the downregulation of survivin and XIAP expression.
    World journal of surgical oncology, 2013, May-30, Volume: 11

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Cell Proliferation; Colonic Neoplasms; Female; Humans; Inhibitor of Apoptosis Proteins; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Survivin; Tumor Cells, Cultured; X-Linked Inhibitor of Apoptosis Protein

2013
MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Benzofurans; Camptothecin; Cell Death; Cell Nucleus; Cell Survival; Colonic Neoplasms; DNA Damage; DNA Mismatch Repair; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Fluorescent Antibody Technique; Fluorouracil; Gene Knockdown Techniques; HCT116 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Irinotecan; MutL Protein Homolog 1; MutS Homolog 3 Protein; Nuclear Proteins; Organoplatinum Compounds; Oxaliplatin; Rad51 Recombinase

2013
Three missense mutations of DNA topoisomerase I in highly camptothecin-resistant colon cancer cell sublines.
    Oncology reports, 2013, Volume: 30, Issue:3

    Topics: Apoptosis; ATP-Binding Cassette Transporters; Blotting, Western; Camptothecin; Carbazoles; Cell Cycle; Cell Proliferation; Colonic Neoplasms; DNA Topoisomerases, Type I; DNA, Neoplasm; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Mutation, Missense; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Topoisomerase I Inhibitors; Tumor Cells, Cultured

2013
Severe irinotecan-induced toxicity in a patient with UGT1A1 28 and UGT1A1 6 polymorphisms.
    World journal of gastroenterology, 2013, Jun-28, Volume: 19, Issue:24

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Diarrhea; Dose-Response Relationship, Drug; Fluorouracil; Glucuronosyltransferase; Heterozygote; Humans; Irinotecan; Leucovorin; Male; Neutropenia; Polymorphism, Genetic; Severity of Illness Index; Treatment Outcome

2013
[A case of metastatic colon cancer effectively treated by XELOX and IRIS].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Oxaloacetates; Oxonic Acid; Tegafur; Tomography, X-Ray Computed

2013
Partial response after transcatheter arterial infusion chemotherapy in a patient with systemic chemotherapy-resistant unresectable colon cancer and hepatic metastasis: (case report).
    World journal of surgical oncology, 2013, Aug-17, Volume: 11, Issue:1

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Failure; Liver Neoplasms; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Prognosis; Remission Induction; Tomography, X-Ray Computed

2013
Mitogen-activated protein kinase phosphatase-1 inhibition and sustained extracellular signal-regulated kinase 1/2 activation in camptothecin-induced human colon cancer cell death.
    Cancer biology & therapy, 2013, Volume: 14, Issue:11

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Caco-2 Cells; Camptothecin; Colonic Neoplasms; Dual Specificity Phosphatase 1; Enzyme Activation; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Proteasome Endopeptidase Complex

2013
ERK plays the baddie (again).
    Cancer biology & therapy, 2013, Volume: 14, Issue:11

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Camptothecin; Colonic Neoplasms; Dual Specificity Phosphatase 1; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3

2013
Augmented cytotoxicity of hydroxycamptothecin-loaded nanoparticles in lung and colon cancer cells by chemosensitizing pharmaceutical excipients.
    Drug delivery, 2014, Volume: 21, Issue:4

    Topics: Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Cytotoxins; Drug Carriers; Excipients; HT29 Cells; Humans; Lung Neoplasms; Nanoparticles

2014
Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs.
    Toxicology in vitro : an international journal published in association with BIBRA, 2013, Volume: 27, Issue:8

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Antineoplastic Agents; Apoptosis; Caco-2 Cells; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Interactions; Extracellular Signal-Regulated MAP Kinases; Fluorouracil; Humans; Nicotine; Proto-Oncogene Proteins c-akt

2013
RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients.
    BMC cancer, 2013, Oct-08, Volume: 13

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Cytokine Receptor gp130; Female; Gene Expression; Humans; Interleukin-6; Janus Kinases; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Phosphatidylethanolamine Binding Protein; Phosphorylation; Prognosis; Protein Binding; Signal Transduction; STAT3 Transcription Factor; Transcription, Genetic; Tumor Burden

2013
Dual roles for splice variants of the glucuronidation pathway as regulators of cellular metabolism.
    Molecular pharmacology, 2014, Volume: 85, Issue:1

    Topics: Alternative Splicing; Antineoplastic Agents; Camptothecin; Catalase; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Gene Expression Profiling; Gene Knockdown Techniques; Glucuronosyltransferase; Humans; Irinotecan; Isoenzymes; Oxidative Stress; Peroxiredoxins; Reactive Oxygen Species; RNA, Small Interfering

2014
A circadian clock transcription model for the personalization of cancer chronotherapy.
    Cancer research, 2013, Dec-15, Volume: 73, Issue:24

    Topics: Animals; ARNTL Transcription Factors; Camptothecin; Chronotherapy; Circadian Clocks; Colonic Neoplasms; Female; Gene Expression Regulation, Neoplastic; Irinotecan; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Models, Biological; Nuclear Receptor Subfamily 1, Group D, Member 1; Period Circadian Proteins; Precision Medicine; RNA, Messenger; Topoisomerase I Inhibitors

2013
Different effects of epigenetic modifiers on the cytotoxicity induced by 5-fluorouracil, irinotecan or oxaliplatin in colon cancer cells.
    Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Decitabine; DNA; DNA Modification Methylases; Drug Synergism; Epigenesis, Genetic; Fluorouracil; HCT116 Cells; Histone Deacetylase Inhibitors; HT29 Cells; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin

2014
Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB.
    Molecular medicine reports, 2014, Volume: 9, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Berberine; Camptothecin; Colonic Neoplasms; Down-Regulation; Doxorubicin; Fluorouracil; HCT116 Cells; Humans; Inhibitor of Apoptosis Proteins; Irinotecan; NF-kappa B; RNA Interference; RNA, Small Interfering; Survivin; Transcription Factor RelA

2014
Comparison of the effects of photon versus carbon ion irradiation when combined with chemotherapy in vitro.
    Radiation oncology (London, England), 2013, Nov-06, Volume: 8

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Carbon; Cell Cycle; Cell Line, Tumor; Cell Separation; Chemoradiotherapy; Cisplatin; Colonic Neoplasms; Deoxycytidine; Dose-Response Relationship, Radiation; Drug Screening Assays, Antitumor; Flow Cytometry; Gemcitabine; Glioblastoma; Humans; Ions; Lung Neoplasms; Paclitaxel; Pancreatic Neoplasms; Photons; Propidium; Radiotherapy; Relative Biological Effectiveness; Time Factors

2013
Trends in treatment and survival in older patients presenting with stage IV colorectal cancer.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2014, Volume: 18, Issue:2

    Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Humans; Irinotecan; Male; Medicare; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Rectal Neoplasms; Registries; Survival Rate; Time Factors; United States

2014
[Efficacy and safety of bevacizumab (BEV) plus chemotherapeutic agents in the treatment of metastatic colorectal cancer, mCRC].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2013, Volume: 35, Issue:8

    Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Disease-Free Survival; Female; Fluorouracil; Follow-Up Studies; Hemorrhage; Humans; Hypertension; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxaloacetates; Proteinuria; Rectal Neoplasms; Remission Induction; Young Adult

2013
A case of liver fibrosis with splenomegaly after oxaliplatin-based adjuvant chemotherapy for colon cancer.
    Journal of Korean medical science, 2013, Volume: 28, Issue:12

    Topics: Actins; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Humans; Hypertension, Portal; Immunohistochemistry; Leucovorin; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Platelet Endothelial Cell Adhesion Molecule-1; Splenomegaly; Thrombocytopenia; Tomography, X-Ray Computed

2013
[A case of multiple skin metastases from cancer of the descending colon responding to FOLFIRI/cetuximab therapy].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2014, Volume: 111, Issue:1

    Topics: Adenocarcinoma; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Fatal Outcome; Female; Fluorouracil; Humans; Leucovorin; Middle Aged; Skin Neoplasms

2014
IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice.
    Mucosal immunology, 2014, Volume: 7, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Irinotecan; Mice; Mice, Inbred BALB C; Mucositis; Receptors, Interleukin; Recombinant Proteins

2014
Irinotecan-induced immune thrombocytopenia.
    The American journal of the medical sciences, 2014, Volume: 347, Issue:2

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Bevacizumab; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Middle Aged; Platelet Count; Thrombocytopenia

2014
The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells.
    Oncology research, 2013, Volume: 21, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Caco-2 Cells; Camptothecin; Colonic Neoplasms; Drug Synergism; Female; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; Irinotecan; Mice; Mice, Inbred BALB C; Mice, Nude; Organoplatinum Compounds; Oxaliplatin; Random Allocation; Receptors, TNF-Related Apoptosis-Inducing Ligand; Sirtuin 1; Sirtuin 2; Sirtuins; Up-Regulation; Xenograft Model Antitumor Assays

2013
Curable patient with metastatic colorectal cancer: balancing effective therapies and toxicities.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Apr-01, Volume: 32, Issue:10

    Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colectomy; Colonic Neoplasms; Colonoscopy; Female; Fluorouracil; Hepatectomy; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Magnetic Resonance Imaging; Neoadjuvant Therapy; Positron-Emission Tomography

2014
The use of Olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:5

    Topics: Animals; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; DNA Breaks, Double-Stranded; DNA Mismatch Repair; DNA Repair; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Profiling; Gene Knockdown Techniques; Humans; Irinotecan; Mice; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerases; Rad51 Recombinase; Tumor Burden; Xenograft Model Antitumor Assays

2014
A systemic analysis of S-1 regimens for treatment of patients with colon cancer.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Tegafur; Treatment Outcome

2014
Resistance to irinotecan (CPT-11) activates epidermal growth factor receptor/nuclear factor kappa B and increases cellular metastasis and autophagy in LoVo colon cancer cells.
    Cancer letters, 2014, Jul-10, Volume: 349, Issue:1

    Topics: Autophagy; beta Catenin; Camptothecin; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; ErbB Receptors; Humans; I-kappa B Kinase; Irinotecan; Neoplasm Metastasis; NF-kappa B; Signal Transduction; Topoisomerase I Inhibitors; Wnt Proteins

2014
The key role of calreticulin in immunomodulation induced by chemotherapeutic agents.
    International journal of clinical oncology, 2015, Volume: 20, Issue:2

    Topics: Animals; Antigens, Surface; Antineoplastic Agents; Apoptosis; Calreticulin; Camptothecin; Carcinoma, Lewis Lung; CD3 Complex; Cell Line, Tumor; Cell Survival; Cisplatin; Colonic Neoplasms; Deoxycytidine; Female; Fluorouracil; Gemcitabine; Histocompatibility Antigens Class I; Humans; Immunomodulation; Lymphocyte Count; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitomycin; Mitoxantrone; Neoplasm Transplantation; Neoplasms, Experimental; Protein Transport; T-Lymphocytes; Tumor Microenvironment

2015
Chemosensitivity of resistant colon cancer cell lines to lobaplatin, heptaplatin, and dicycloplatin.
    International journal of clinical pharmacology and therapeutics, 2014, Volume: 52, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; Cisplatin; Colonic Neoplasms; Cyclobutanes; Dose-Response Relationship, Drug; Drug Combinations; Drug Resistance, Neoplasm; Enzyme-Linked Immunosorbent Assay; Glutamates; Humans; Inhibitory Concentration 50; Irinotecan; Malonates; Organoplatinum Compounds; Oxaliplatin

2014
Colon cancer, version 3.2014.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2014, Volume: 12, Issue:7

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Cetuximab; Colonic Neoplasms; Deoxycytidine; Disease Progression; Fluorouracil; GTP Phosphohydrolases; Humans; Leucovorin; Liver Neoplasms; Membrane Proteins; Organoplatinum Compounds; Oxaloacetates; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); ras Proteins; Treatment Outcome

2014
Pseudocirrhosis after anti-EGFR-based neoadjuvant therapy for hepatic metastasis from colon cancer: a different point of view.
    Clinical colorectal cancer, 2014, Volume: 13, Issue:3

    Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Cetuximab; Chemotherapy, Adjuvant; Colonic Neoplasms; Deoxycytidine; ErbB Receptors; Fluorouracil; Humans; Leucovorin; Liver Cirrhosis; Liver Neoplasms; Male; Neoadjuvant Therapy; Organoplatinum Compounds; Oxaliplatin

2014
Variable NF-κB pathway responses in colon cancer cells treated with chemotherapeutic drugs.
    BMC cancer, 2014, Aug-18, Volume: 14

    Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Erlotinib Hydrochloride; Fluorouracil; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; NF-kappa B; Organoplatinum Compounds; Oxaliplatin; Phleomycins; Quinazolines; Signal Transduction

2014
Tissue penetration and activity of camptothecins in solid tumor xenografts.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:11

    Topics: Animals; Camptothecin; Cell Proliferation; Colonic Neoplasms; Female; HCT116 Cells; HT29 Cells; Humans; Mice; Mice, Inbred NOD; Topoisomerase I Inhibitors; Xenograft Model Antitumor Assays

2014
Development and validation of an ultra-high performance LC-MS/MS assay for intracellular SN-38 in human solid tumour cell lines: comparison with a validated HPLC-fluorescence method.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Oct-15, Volume: 969

    Topics: Acetonitriles; Camptothecin; Cell Line, Tumor; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Stability; HCT116 Cells; HT29 Cells; Humans; Intracellular Space; Irinotecan; Least-Squares Analysis; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Tandem Mass Spectrometry

2014
The power of genes: a case of unusually severe systemic toxicity after localized hepatic chemoembolization with irinotecan-eluted microspheres for metastatic colon cancer.
    The Annals of pharmacotherapy, 2014, Volume: 48, Issue:12

    Topics: Aged, 80 and over; Antineoplastic Agents, Phytogenic; Camptothecin; Chemoembolization, Therapeutic; Colonic Neoplasms; Female; Glucuronosyltransferase; Humans; Irinotecan; Liver Neoplasms; Microspheres; Mutation; Neutropenia; Polymorphism, Genetic

2014
Adaptation of international guidelines for metastatic colorectal cancer: an asian consensus.
    Clinical colorectal cancer, 2014, Volume: 13, Issue:3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Asia; Bevacizumab; Camptothecin; Capecitabine; Cetuximab; Colonic Neoplasms; Combined Modality Therapy; Deoxycytidine; Drug Combinations; ErbB Receptors; Fluorouracil; Guideline Adherence; Humans; Leucovorin; Liver Neoplasms; Lung Neoplasms; Magnetic Resonance Imaging; Metastasectomy; Neoplasm Staging; Organoplatinum Compounds; Oxaloacetates; Oxonic Acid; Panitumumab; Practice Guidelines as Topic; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Rectal Neoplasms; Tegafur; Tomography, X-Ray Computed

2014
Hyaluronic acid decorated lipid nanocarrier for MDR modulation and CD-44 targeting in colon adenocarcinoma.
    International journal of biological macromolecules, 2015, Volume: 72

    Topics: Adenocarcinoma; Camptothecin; Colonic Neoplasms; Coumarins; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Hyaluronan Receptors; Hyaluronic Acid; Irinotecan; Lipids; Nanoparticles; Thiazoles

2015
Preclinical activity of nanoliposomal irinotecan is governed by tumor deposition and intratumor prodrug conversion.
    Cancer research, 2014, Dec-01, Volume: 74, Issue:23

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma; Colonic Neoplasms; Female; HT29 Cells; Humans; Irinotecan; Liposomes; Mice; Mice, Inbred NOD; Mice, SCID; Prodrugs; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2014
Aspirin and COX-2 inhibitor use in patients with stage III colon cancer.
    Journal of the National Cancer Institute, 2015, Volume: 107, Issue:1

    Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; Disease-Free Survival; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Odds Ratio; Prospective Studies; Sex Factors; Treatment Outcome

2015
Synthesis and biological evaluation of novel 10-substituted-7-ethyl-10-hydroxycamptothecin (SN-38) prodrugs.
    Molecules (Basel, Switzerland), 2014, Nov-27, Volume: 19, Issue:12

    Topics: Animals; Camptothecin; Cell Death; Cell Line, Tumor; Cell Proliferation; Cholinesterase Inhibitors; Colonic Neoplasms; Drug Stability; Humans; Hydrogen-Ion Concentration; Irinotecan; Mice, Nude; Prodrugs; Xenograft Model Antitumor Assays

2014
Irinophore C™, a lipid nanoparticulate formulation of irinotecan, improves vascular function, increases the delivery of sequentially administered 5-FU in HT-29 tumors, and controls tumor growth in patient derived xenografts of colon cancer.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, Feb-10, Volume: 199

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Blood Vessels; Camptothecin; Cell Line, Tumor; Chemistry, Pharmaceutical; Colonic Neoplasms; Drug Delivery Systems; Fluorouracil; HT29 Cells; Humans; Irinotecan; Mice; Mice, Inbred NOD; Mice, SCID; Nanostructures; Regional Blood Flow; Xenograft Model Antitumor Assays

2015
The number of intestinal bacteria is not critical for the enhancement of antitumor activity and reduction of intestinal toxicity of irinotecan by the Chinese herbal medicine PHY906 (KD018).
    BMC complementary and alternative medicine, 2014, Dec-15, Volume: 14

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Bacteria; Camptothecin; Colonic Neoplasms; Drugs, Chinese Herbal; Female; Granulocyte Colony-Stimulating Factor; Humans; Intestinal Mucosa; Intestines; Irinotecan; Mice; Neutrophil Infiltration; Phytotherapy; Receptors, G-Protein-Coupled; RNA, Messenger; Tumor Necrosis Factor-alpha; Weight Loss

2014
XELOX plus bevacizumab vs. FOLFIRI plus bevacizumab treatment for first-line chemotherapy in metastatic colon cancer: a retrospective study of the Anatolian Society of Medical Oncology.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:23

    Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Bone Neoplasms; Camptothecin; Capecitabine; Carcinoma; Colonic Neoplasms; Deoxycytidine; Female; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Oxaloacetates; Retrospective Studies; Treatment Outcome

2014
Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival.
    Cancer science, 2015, Volume: 106, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; beta-Thromboglobulin; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Disease-Free Survival; Female; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Organoplatinum Compounds; Receptors, CXCR4; Receptors, Interleukin-8B; Signal Transduction

2015
Prognostic factors and the role of adjuvant chemotherapy in post-curative surgery for Dukes B and C colon cancers and survival outcomes: a Malaysian experience.
    Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:6

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Fluorouracil; Follow-Up Studies; Humans; Irinotecan; Leucovorin; Lymphatic Metastasis; Malaysia; Male; Middle Aged; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Postoperative Period; Prognosis; Retrospective Studies; Survival Rate; Young Adult

2015
[Management for adverse events associated with FOLFIRI plus cetuximab or panitumumab].
    Nihon rinsho. Japanese journal of clinical medicine, 2015, Volume: 73 Suppl 2

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Panitumumab

2015
[Tumor lysis syndrome after FOLFIRI+cetuximab for ascending colon cancer].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2015, Volume: 112, Issue:4

    Topics: Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colon, Ascending; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Tumor Lysis Syndrome

2015
Oral delivery of nanoparticles containing anticancer SN38 and hSET1 antisense for dual therapy of colon cancer.
    International journal of biological macromolecules, 2015, Volume: 78

    Topics: Administration, Oral; Animals; Camptothecin; Cell Line, Tumor; Chitosan; Colonic Neoplasms; Disease Models, Animal; Drug Carriers; Drug Liberation; Drug Stability; Histone-Lysine N-Methyltransferase; Humans; Irinotecan; Mice; Nanoparticles; Oligonucleotides, Antisense; Spectroscopy, Fourier Transform Infrared; Xenograft Model Antitumor Assays

2015
Functional-segregated coumarin-containing telodendrimer nanocarriers for efficient delivery of SN-38 for colon cancer treatment.
    Acta biomaterialia, 2015, Volume: 21

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Coumarins; Dendrimers; Drug Carriers; Humans; Irinotecan; Molecular Dynamics Simulation; Nanostructures

2015
Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer.
    Biomaterials, 2015, Volume: 55

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Azoxymethane; Camptothecin; Cell Line, Tumor; Colitis; Colonic Neoplasms; Dextrans; Drug Delivery Systems; Drug Screening Assays, Antitumor; Endoscopy; Free Radical Scavengers; Inflammation; Irinotecan; Male; Mice; Mice, Inbred ICR; Nanomedicine; Nanoparticles; Neoplasms, Experimental; Nitrogen Oxides; Oxidation-Reduction; Reactive Oxygen Species; Sulfates

2015
Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Sep-15, Volume: 21, Issue:18

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Female; Fluorouracil; Genes, Dominant; HT29 Cells; Humans; Immunohistochemistry; Irinotecan; Mice; Mice, SCID; Mitogen-Activated Protein Kinase 8; Organoplatinum Compounds; Oxaliplatin; Protein Kinase Inhibitors; Transfection; Xenograft Model Antitumor Assays

2015
Association between mismatch repair gene and irinotecan-based chemotherapy in metastatic colon cancer.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:12

    Topics: Adaptor Proteins, Signal Transducing; Aged; Camptothecin; Colonic Neoplasms; Disease-Free Survival; DNA Mismatch Repair; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Irinotecan; Male; Middle Aged; MutL Protein Homolog 1; MutS Homolog 2 Protein; Nuclear Proteins; Prognosis; Thymidylate Synthase; Treatment Outcome

2015
SW480 colorectal cancer cells that naturally express Lgr5 are more sensitive to the most common chemotherapeutic agents than Lgr5-negative SW480 cells.
    Anti-cancer drugs, 2015, Volume: 26, Issue:9

    Topics: Antineoplastic Agents; Camptothecin; Cell Adhesion; Cell Count; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Fluorouracil; Humans; Irinotecan; Neoplastic Stem Cells; Organoplatinum Compounds; Oxaliplatin; Receptors, G-Protein-Coupled; Transfection

2015
Vatalanib sensitizes ABCB1 and ABCG2-overexpressing multidrug resistant colon cancer cells to chemotherapy under hypoxia.
    Biochemical pharmacology, 2015, Sep-01, Volume: 97, Issue:1

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HEK293 Cells; Humans; Irinotecan; Isoenzymes; Neoplasm Proteins; Phthalazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins

2015
[Rapidly Growing Interval Colon Cancer].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2015, Volume: 65, Issue:5

    Topics: Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colonoscopy; Female; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lung Neoplasms; Middle Aged; Positron-Emission Tomography; Tomography, X-Ray Computed

2015
Topoisomerase-I PS506 as a Dual Function Cancer Biomarker.
    PloS one, 2015, Volume: 10, Issue:8

    Topics: Amino Acid Sequence; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Colonic Neoplasms; DNA Topoisomerases, Type I; Female; Gene Expression; Humans; Irinotecan; Lung; Lung Neoplasms; Molecular Sequence Data; Neoplasms; Ovarian Neoplasms; Phosphorylation; Serine; Topotecan

2015
An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer.
    Oncotarget, 2015, Sep-22, Volume: 6, Issue:28

    Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Camptothecin; Cell Adhesion Molecules; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Epithelial Cell Adhesion Molecule; Flow Cytometry; Fluorouracil; HCT116 Cells; Humans; Irinotecan; Leucovorin; Mice, Inbred NOD; Mice, SCID; Molecular Targeted Therapy; Vitamin B Complex; Xenograft Model Antitumor Assays

2015
Fasting protects against the side effects of irinotecan treatment but does not affect anti-tumour activity in mice.
    British journal of pharmacology, 2016, Volume: 173, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Line, Tumor; Colonic Neoplasms; Diarrhea; Fasting; Glucuronides; Irinotecan; Leukopenia; Liver; Male; Mice, Inbred BALB C; RNA, Messenger; Treatment Outcome; Tumor Burden; Weight Loss

2016
Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design.
    Oncotarget, 2015, Nov-03, Volume: 6, Issue:34

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Cell Cycle; Cell Line, Tumor; Checkpoint Kinase 1; Colonic Neoplasms; Drug Design; Drug Synergism; Female; Humans; Indoles; Irinotecan; Mice; Mice, Nude; Protein Kinase Inhibitors; Protein Kinases; Pyridones; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2015
Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy.
    Nanoscale, 2015, Nov-14, Volume: 7, Issue:42

    Topics: Animals; Caco-2 Cells; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Curcumin; Drug Carriers; Drug Synergism; Humans; Hyaluronic Acid; Immunoglobulin G; Lactic Acid; Male; Melphalan; Mice; Mice, Inbred C57BL; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers

2015
Anti-cancer effects of 2-oxoquinoline derivatives on the HCT116 and LoVo human colon cancer cell lines.
    Molecular medicine reports, 2015, Volume: 12, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 3; Cell Line, Tumor; Colonic Neoplasms; Extracellular Signal-Regulated MAP Kinases; Fluorouracil; HCT116 Cells; Humans; Irinotecan; JNK Mitogen-Activated Protein Kinases; Myeloid Cell Leukemia Sequence 1 Protein; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Quinolones

2015
Synergistic Effect of SN-38 in Combination with Cetuximab on Angiogenesis and Cancer Cell Invasion.
    Anticancer research, 2015, Volume: 35, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Camptothecin; Cell Adhesion; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Cetuximab; Colonic Neoplasms; Drug Synergism; Flow Cytometry; Human Umbilical Vein Endothelial Cells; Humans; Irinotecan; Neoplasm Invasiveness; Neovascularization, Pathologic; Phosphorylation; Signal Transduction

2015
Development and characterization of pH responsive polymeric nanoparticles of SN-38 for colon cancer.
    Artificial cells, nanomedicine, and biotechnology, 2016, Volume: 44, Issue:8

    Topics: Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Carriers; Humans; Hydrogen-Ion Concentration; Irinotecan; Nanoparticles

2016
DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Apr-01, Volume: 22, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; Biomarkers; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; DNA Topoisomerases, Type I; Female; Gene Dosage; Gene Expression; Humans; In Situ Hybridization, Fluorescence; Irinotecan; Kaplan-Meier Estimate; Male; Neoplasm Staging; Prognosis; RNA, Messenger; Topoisomerase I Inhibitors

2016
Chemotherapeutic agents attenuate CXCL12-mediated migration of colon cancer cells by selecting for CXCR4-negative cells and increasing peptidase CD26.
    BMC cancer, 2015, Nov-10, Volume: 15

    Topics: Animals; Camptothecin; Carcinogenesis; Cell Lineage; Cell Movement; Chemokine CXCL12; Colonic Neoplasms; Dipeptidyl Peptidase 4; Fluorouracil; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Hyaluronan Receptors; Irinotecan; Mice; Neoplasm Metastasis; Receptors, CXCR4; Xenograft Model Antitumor Assays

2015
Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner.
    Oncotarget, 2015, Dec-29, Volume: 6, Issue:42

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Chemokines; Chemoradiotherapy; Colonic Neoplasms; Computational Biology; Cytokines; Databases, Genetic; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HCT116 Cells; Heterozygote; Humans; Inhibitory Concentration 50; Irinotecan; MicroRNAs; Mutation; Radiation Dosage; Signal Transduction; Time Factors; Transfection; Tumor Suppressor Protein p53

2015
Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenicals; Azepines; Camptothecin; Celecoxib; Cell Line, Tumor; Cisplatin; Colonic Neoplasms; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; p38 Mitogen-Activated Protein Kinases; Stomach Neoplasms; Sulfides; Triazoles; Tumor Suppressor Protein p53

2015
Improving Antitumor Activity with N-Trimethyl Chitosan Entrapping Camptothecin in Colon Cancer and Lung Cancer.
    Journal of nanoscience and nanotechnology, 2015, Volume: 15, Issue:9

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chitosan; Colonic Neoplasms; Drug Carriers; Female; Lung Neoplasms; Mice; Mice, Inbred BALB C

2015
[Efficacy and safety of antivascular drugs after anti-EFGR: aflibercept after cetuximab, a clinical case].
    Recenti progressi in medicina, 2015, Volume: 106, Issue:12

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Disease Progression; ErbB Receptors; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Organoplatinum Compounds; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Treatment Outcome

2015
Regorafenib as a potential adjuvant chemotherapy agent in disseminated small colon cancer: Drug selection outcome of a novel screening system using nanoimprinting 3-dimensional culture with HCT116-RFP cells.
    International journal of oncology, 2016, Volume: 48, Issue:4

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cell Culture Techniques; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Screening Assays, Antitumor; Fluorouracil; HCT116 Cells; Humans; Irinotecan; Luminescent Proteins; Mice; Organoplatinum Compounds; Oxaliplatin; Panitumumab; Phenylurea Compounds; Pyridines; Red Fluorescent Protein; Xenograft Model Antitumor Assays

2016
Synthesis and Antitumor Properties of BQC-Glucuronide, a Camptothecin Prodrug for Selective Tumor Activation.
    Molecular pharmaceutics, 2016, Apr-04, Volume: 13, Issue:4

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Female; Glucuronidase; Glucuronides; Humans; Irinotecan; Mice; Mice, Inbred BALB C; Prodrugs; Topotecan

2016
Effect of fermentation parameters, elicitors and precursors on camptothecin production from the endophyte Fusarium solani.
    Bioresource technology, 2016, Volume: 206

    Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Endophytes; Ethanol; Female; Fermentation; Fusarium; Humans; Hydrogen-Ion Concentration; Industrial Microbiology; Temperature

2016
Complete regression of xenograft tumors using biodegradable mPEG-PLA-SN38 block copolymer micelles.
    Colloids and surfaces. B, Biointerfaces, 2016, Jun-01, Volume: 142

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Carriers; Drug Liberation; Female; HCT116 Cells; Hepatocytes; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Injections, Subcutaneous; Irinotecan; Mice; Mice, Nude; Micelles; Particle Size; Polyesters; Polyethylene Glycols; Structure-Activity Relationship; Treatment Outcome; Xenograft Model Antitumor Assays

2016
Calculated Log D Is Inversely Correlated With Select Camptothecin Clearance and Efficacy in Colon Cancer Xenografts.
    Journal of pharmaceutical sciences, 2016, Volume: 105, Issue:4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Colon; Colonic Neoplasms; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Xenograft Model Antitumor Assays

2016
Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations.
    Journal of experimental & clinical cancer research : CR, 2016, Mar-31, Volume: 35

    Topics: Benzodioxoles; Binding Sites; Camptothecin; Cell Line, Tumor; Chromosome Deletion; Colonic Neoplasms; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Epirubicin; Etoposide; Gene Dosage; Guanidines; HCT116 Cells; HT29 Cells; Humans; Hydrazones; Irinotecan; Isoquinolines; Mutation

2016
Inhibition of NF-κB and metastasis in irinotecan (CPT-11)-resistant LoVo colon cancer cells by thymoquinone via JNK and p38.
    Environmental toxicology, 2017, Volume: 32, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Benzoquinones; Camptothecin; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Humans; Irinotecan; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Transcription Factor RelA

2017
Cell Line Derived 5-FU and Irinotecan Drug-Sensitivity Profiles Evaluated in Adjuvant Colon Cancer Trial Data.
    PloS one, 2016, Volume: 11, Issue:5

    Topics: Camptothecin; Cell Line, Tumor; Chemotherapy, Adjuvant; Clinical Trials as Topic; Cohort Studies; Colonic Neoplasms; Disease-Free Survival; Drug Evaluation, Preclinical; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Prognosis

2016
Drug penetration and metabolism in 3D cell cultures treated in a 3D printed fluidic device: assessment of irinotecan via MALDI imaging mass spectrometry.
    Proteomics, 2016, Volume: 16, Issue:11-12

    Topics: Camptothecin; Cell Culture Techniques; Colonic Neoplasms; HCT116 Cells; Humans; Irinotecan; Lab-On-A-Chip Devices; Printing, Three-Dimensional; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spheroids, Cellular

2016
Colonic perforation following endoscopic mucosal resection in a patient on bevacizumab treatment.
    Endoscopy, 2016, Volume: 48 Suppl 1

    Topics: Adenocarcinoma; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Diseases; Colonic Neoplasms; Colonic Polyps; Colonoscopy; Endoscopic Mucosal Resection; Female; Fluorouracil; Humans; Intestinal Perforation; Irinotecan; Leucovorin

2016
Primary cultures of human colon cancer as a model to study cancer stem cells.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:9

    Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Colorectal Neoplasms; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Irinotecan; Mice; Neoplastic Stem Cells; Octamer Transcription Factor-3; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2016
Bevacizumab in colorectal cancer: it should have worked.
    The Lancet. Oncology, 2016, Volume: 17, Issue:11

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Organoplatinum Compounds

2016
Prognostic Significance of MicroRNA-21 Expression in Patients with Unresectable Metastatic Colon Cancer.
    Anticancer research, 2016, Volume: 36, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; MicroRNAs; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Prognosis; Real-Time Polymerase Chain Reaction

2016
Late-stage inhibition of autophagy enhances calreticulin surface exposure.
    Oncotarget, 2016, Dec-06, Volume: 7, Issue:49

    Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Calreticulin; Camptothecin; Cell Membrane; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Fluorouracil; HCT116 Cells; Humans; Intracellular Signaling Peptides and Proteins; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Phosphorylation; Protein Transport; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases

2016
Side-Effects of Irinotecan (CPT-11), the Clinically Used Drug for Colon Cancer Therapy, Are Eliminated in Experimental Animals Treated with Latex Proteins from Calotropis procera (Apocynaceae).
    Phytotherapy research : PTR, 2017, Volume: 31, Issue:2

    Topics: Animals; Apocynaceae; Calotropis; Camptothecin; Colonic Neoplasms; Disease Models, Animal; Irinotecan; Latex; Male; Mice

2017
TNF Signaling through RIP1 Kinase Enhances SN38-Induced Death in Colon Adenocarcinoma.
    Molecular cancer research : MCR, 2017, Volume: 15, Issue:4

    Topics: Adenocarcinoma; Animals; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Female; HCT116 Cells; HT29 Cells; Humans; Irinotecan; Mice; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Tumor Necrosis Factor-alpha

2017
Smart AS1411-aptamer conjugated pegylated PAMAM dendrimer for the superior delivery of camptothecin to colon adenocarcinoma in vitro and in vivo.
    International journal of pharmaceutics, 2017, Mar-15, Volume: 519, Issue:1-2

    Topics: Adenocarcinoma; Animals; Aptamers, Nucleotide; Camptothecin; Cell Line, Tumor; CHO Cells; Colon; Colonic Neoplasms; Cricetulus; Dendrimers; Drug Carriers; Drug Delivery Systems; HT29 Cells; Humans; Mice; Mice, Inbred BALB C; Nanoparticles; Nucleolin; Oligodeoxyribonucleotides; Phosphoproteins; RNA-Binding Proteins

2017
[A case of interstitial pneumonia induced by S-1/irinotecan combination therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2008, Volume: 35, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Combinations; Humans; Irinotecan; Liver Neoplasms; Lung Diseases, Interstitial; Male; Oxonic Acid; Tegafur; Tomography, X-Ray Computed; Treatment Failure

2008
Efficacy of the combined use of bevacizumab and irinotecan as a postoperative adjuvant chemotherapy in colon carcinoma.
    Oncology reports, 2008, Volume: 20, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bevacizumab; Camptothecin; Cell Proliferation; Chemotherapy, Adjuvant; Colonic Neoplasms; Humans; Immunoenzyme Techniques; Irinotecan; Lung Neoplasms; Male; Neovascularization, Pathologic; Postoperative Care; Rats; Rats, Inbred F344; Rats, Nude; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2008
Anti-proliferative and pro-apoptotic effect of CPT13, a novel camptothecin analog, on human colon cancer HCT8 cell line.
    Chemico-biological interactions, 2008, Nov-25, Volume: 176, Issue:2-3

    Topics: Apoptosis; Camptothecin; Caspase 3; Caspase 8; Cell Cycle; Cell Nucleus; Cell Proliferation; Cell Survival; Chromatin; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Activation; Flow Cytometry; Humans; Membrane Potential, Mitochondrial; Microscopy, Atomic Force; Molecular Conformation; Tumor Cells, Cultured

2008
Synergism of CPT-11 and Apo2L/TRAIL against two differentially sensitive human colon tumor xenografts.
    Oncology, 2008, Volume: 74, Issue:3-4

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Colonic Neoplasms; Combined Modality Therapy; Drug Synergism; Gene Expression Regulation, Neoplastic; Genetic Therapy; Humans; Immunoenzyme Techniques; In Situ Nick-End Labeling; Irinotecan; Mice; Mice, SCID; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2008
Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Sep-01, Volume: 14, Issue:17

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; DNA-Binding Proteins; Humans; Irinotecan; Mice; Mice, Nude; Microsatellite Instability; MRE11 Homologue Protein; Mutation; Thymidine; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays

2008
[Three cases with liver metastasis from gastric or colon cancer successfully treated with S-1 combined with CPT- 11].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2008, Volume: 35, Issue:9

    Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Combinations; Female; Humans; Irinotecan; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Stomach Neoplasms; Tegafur; Tomography, X-Ray Computed

2008
Synchronous hepatic metastases from colon cancer: changing treatment strategies and results of surgical intervention.
    Annals of surgical oncology, 2009, Volume: 16, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Carcinoembryonic Antigen; Colonic Neoplasms; Combined Modality Therapy; Female; Humans; Irinotecan; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Prognosis; Retrospective Studies; Survival Rate; Treatment Outcome

2009
Sequential or combination chemotherapy for a patient with mCRC?
    Cancer treatment reviews, 2008, Volume: 34 Suppl 2

    Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male

2008
Effect of interleukins response to ECM-induced acquisition of drug resistance in MCF-7 cells.
    Experimental oncology, 2008, Volume: 30, Issue:4

    Topics: Antineoplastic Agents; Breast Neoplasms; Camptothecin; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Drug Resistance, Neoplasm; Extracellular Matrix; Female; Fluorescent Antibody Technique; Humans; Interleukins; Lung Neoplasms; Paclitaxel

2008
Can cetuximab affect paraneoplastic myopathy?
    Journal of neuro-oncology, 2009, Volume: 93, Issue:3

    Topics: Adenocarcinoma; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Candidiasis; Cetuximab; Colonic Neoplasms; Humans; Irinotecan; Klebsiella Infections; Liver Neoplasms; Male; Methylprednisolone; Middle Aged; Muscular Diseases; Paraneoplastic Syndromes; Tuberculosis

2009
Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Feb-15, Volume: 15, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Irinotecan; Male; MAP Kinase Signaling System; Mice; Phosphatidylinositol 3-Kinases; Protein Kinases; Proto-Oncogene Proteins c-akt; Sirolimus; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2009
Single and combined supplementation of glutamine and n-3 polyunsaturated fatty acids on host tolerance and tumour response to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11)/5-fluorouracil chemotherapy in rats bearing Ward colo
    The British journal of nutrition, 2009, Volume: 102, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Body Weight; Camptothecin; Colonic Neoplasms; Combined Modality Therapy; Diarrhea; Dietary Supplements; Fatty Acids, Omega-3; Female; Fluorouracil; Glutamine; Immune Tolerance; Irinotecan; Leukocyte Count; Nutritional Status; Rats; Rats, Inbred F344; Treatment Failure; Xenograft Model Antitumor Assays

2009
[A case of ascending colon cancer with local recurrence responding completely to alternating modified-FOLFOX6 and FOLFIRI regimens(modified-FIREFOX regimen)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Middle Aged; Organoplatinum Compounds; Positron-Emission Tomography; Recurrence; Remission Induction; Tomography, X-Ray Computed

2009
Dual chemotherapy and photodynamic therapy in an HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles.
    Biomaterials, 2009, Volume: 30, Issue:21

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Female; HT29 Cells; Humans; Immunohistochemistry; Irinotecan; Mice; Mice, Inbred BALB C; Micelles; Molecular Structure; Photochemotherapy; Polymers; Porphyrins; Xenograft Model Antitumor Assays

2009
Successful and well-tolerated second line therapy with cetuximab, irinotecan, and raltitrexed in progressive liver disease due to metastatic colon cancer.
    Journal of gastrointestinal cancer, 2008, Volume: 39, Issue:1-4

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Humans; Irinotecan; Liver Diseases; Liver Neoplasms; Male; Quinazolines; Thiophenes

2008
A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.
    Cancer prevention research (Philadelphia, Pa.), 2009, Volume: 2, Issue:6

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Screening Assays, Antitumor; Humans; Irinotecan; Male; Maximum Tolerated Dose; Mice; Mice, Nude; Models, Molecular; Neoplasm Proteins; Protein Conformation; Sulindac; Xenograft Model Antitumor Assays

2009
Molecular mechanisms of sequence-dependent antitumor effects of SN-38 and 5-fluorouracil combination therapy against colon cancer cells.
    Anticancer research, 2009, Volume: 29, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Camptothecin; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Flow Cytometry; Fluorouracil; G1 Phase; G2 Phase; Humans; Irinotecan; Thymidylate Synthase; Tumor Cells, Cultured

2009
The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38.
    International journal of cancer, 2009, Dec-15, Volume: 125, Issue:12

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Camptothecin; Cell Cycle; Cell Proliferation; Chromatography, Liquid; Colonic Neoplasms; Colony-Forming Units Assay; Drug Synergism; ErbB Receptors; Flow Cytometry; Humans; Irinotecan; Lapatinib; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Quinazolines; Receptor, ErbB-2; Stomach Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2009
Upregulation of glycolytic enzymes in proteins secreted from human colon cancer cells with 5-fluorouracil resistance.
    Electrophoresis, 2009, Volume: 30, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Down-Regulation; Drug Resistance, Neoplasm; Female; Fluorouracil; Glycolysis; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Proteins; Proteome; Pyruvate Kinase; Reproducibility of Results; Up-Regulation

2009
Acquired Fanconi syndrome after treatment with capecitabine, irinotecan, and bevacizumab.
    The Annals of pharmacotherapy, 2009, Volume: 43, Issue:7

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Fanconi Syndrome; Female; Fluorouracil; Humans; Irinotecan

2009
[A case of hyperammonemia with encephalopathy related to FOLFIRI chemotherapy for advanced colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Consciousness Disorders; Fluorouracil; Humans; Hyperammonemia; Irinotecan; Leucovorin; Male; Middle Aged

2009
Differentiation-related gene-1 decreases Bim stability by proteasome-mediated degradation.
    Cancer research, 2009, Aug-01, Volume: 69, Issue:15

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Camptothecin; Colonic Neoplasms; DNA, Antisense; Down-Regulation; GTP-Binding Proteins; HCT116 Cells; Humans; Irinotecan; Membrane Proteins; Proteasome Endopeptidase Complex; Protein Binding; Proto-Oncogene Proteins; RNA, Small Interfering

2009
Irinotecan use during pregnancy.
    Obstetrics and gynecology, 2009, Volume: 114, Issue:2 Pt 2

    Topics: Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Female; Humans; Irinotecan; Krukenberg Tumor; Ovarian Neoplasms; Pregnancy; Pregnancy Complications, Neoplastic; Prenatal Care

2009
Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts.
    Macromolecular bioscience, 2009, Nov-10, Volume: 9, Issue:11

    Topics: Animals; Antineoplastic Agents; Biocompatible Materials; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; Female; Humans; Male; Materials Testing; Methacrylates; Mice; Mice, Nude; Molecular Structure; Neoplasm Transplantation; Polymers; Survival Rate; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2009
[A case of advanced colon cancer treated with preoperative chemotherapy (IRIS) leading to clinical complete response].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:8

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Humans; Irinotecan; Lymphatic Metastasis; Male; Preoperative Care; Rectal Neoplasms; Tegafur; Treatment Outcome

2009
[Effectiveness of S-1 plus CPT-11 therapy for an elderly patient with recurrent colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:8

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colectomy; Colonic Neoplasms; Humans; Irinotecan; Lymph Node Excision; Male; Neoplasm Recurrence, Local; Tegafur

2009
[Clinical significance of a transient increase in carcinoembryonic antigen and carbohydrate antigen 19-9 in patients with metastatic colorectal cancer receiving chemotherapy].
    Ai zheng = Aizheng = Chinese journal of cancer, 2009, Volume: 28, Issue:9

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; CA-19-9 Antigen; Camptothecin; Capecitabine; Carcinoembryonic Antigen; Child; Colonic Neoplasms; Deoxycytidine; Disease Progression; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Oxaloacetates; Rectal Neoplasms; Remission Induction; Young Adult

2009
CEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Oct-01, Volume: 15, Issue:19

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Camptothecin; Carcinoembryonic Antigen; Carcinoma; Colonic Neoplasms; Drug Delivery Systems; Female; GPI-Linked Proteins; Humans; Immunoconjugates; Irinotecan; Mice; Mice, Nude; Models, Biological; Pancreatic Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2009
NCCN guideline updates: colon and rectal cancers, version 1.2004.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2004, Volume: 2, Issue:4

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Organoplatinum Compounds; Rectal Neoplasms

2004
The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells.
    International journal of oncology, 2009, Volume: 35, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Camptothecin; Cell Adhesion; Cell Survival; Colonic Neoplasms; Drug Synergism; HT29 Cells; Humans; Irinotecan; Protein Kinase C; Sphingosine

2009
Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs.
    Journal of natural products, 2009, Volume: 72, Issue:11

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cardenolides; Colonic Neoplasms; Digitoxin; Digoxin; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Irinotecan; NF-kappa B; Proscillaridin; Strophanthins

2009
[Huge ascending colon carcinoma, treated successfully with S-1 plus CPT-11, followed by significant tumor reduction and curative resection--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:11

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colectomy; Colonic Neoplasms; Colonoscopy; Combined Modality Therapy; Drug Combinations; Female; Humans; Irinotecan; Oxonic Acid; Tegafur; Tomography, X-Ray Computed

2009
[Efficacy of cetuximab combined with chemotherapy on advanced colorectal cancer: a report of 53 cases].
    Ai zheng = Aizheng = Chinese journal of cancer, 2009, Volume: 28, Issue:12

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Combined Modality Therapy; Diarrhea; Exanthema; Female; Follow-Up Studies; Humans; Irinotecan; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neutropenia; Organoplatinum Compounds; Oxaliplatin; Prognosis; Proportional Hazards Models; Rectal Neoplasms; Remission Induction; Retrospective Studies

2009
[Combination with SN-38 on human colon cancer LoVo cells].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2009, Volume: 31, Issue:10

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Bevacizumab; Camptothecin; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Irinotecan; RNA, Messenger; Signal Transduction; Time Factors; Vascular Endothelial Growth Factor A

2009
[A case of advanced right colonic cancer successfully treated by surgery and post operative chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:12

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Combined Modality Therapy; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Organoplatinum Compounds; Oxonic Acid; Postoperative Period; Tegafur

2009
[Extended lymphadenectomy for gastric regional lymph node metastasis from transverse colon cancer--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colon, Transverse; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Organoplatinum Compounds; Stomach

2009
[Ovarian metastasis after complete response of colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:12

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Humans; Hysterectomy; Leucovorin; Middle Aged; Organoplatinum Compounds; Ovarian Neoplasms; Ovariectomy

2009
En bloc resection for right colon cancer directly invading duodenum or pancreatic head.
    Yonsei medical journal, 2009, Dec-31, Volume: 50, Issue:6

    Topics: Adult; Aged; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Duodenal Neoplasms; Duodenum; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Pancreas; Pancreatic Neoplasms; Retrospective Studies; Treatment Outcome

2009
Expression of HSP27, HSP72 and MRP proteins in in vitro co-culture of colon tumour cell spheroids with normal cells after incubation with rhTGF- beta1 and/or CPT-11.
    Journal of biosciences, 2009, Volume: 34, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Camptothecin; Coculture Techniques; Colonic Neoplasms; HSP27 Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Humans; Interleukin-6; Irinotecan; Nitric Oxide; Recombinant Proteins; Spheroids, Cellular; Transforming Growth Factor beta1; Tumor Cells, Cultured

2009
MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil.
    Cancer biology & therapy, 2010, Apr-01, Volume: 9, Issue:7

    Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Capecitabine; Caspases; Cell Cycle Proteins; Cell Proliferation; Colonic Neoplasms; Deoxycytidine; DNA Damage; Doxorubicin; Flow Cytometry; Fluorouracil; Glutamates; Guanine; Histones; Humans; Immunoenzyme Techniques; Mitomycin; Nuclear Proteins; Pemetrexed; Phosphorylation; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Rats; Rats, Inbred F344; Rats, Nude; Xenograft Model Antitumor Assays

2010
Gene expression profile of colon cancer cell lines treated with SN-38.
    Chemotherapy, 2010, Volume: 56, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Oligonucleotide Array Sequence Analysis

2010
[A case of colon cancer with multiple liver metastases responding ot S-1 as third-line treatment following FOLFIRI and FOLFOX].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Camptothecin; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Combinations; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Organoplatinum Compounds; Oxonic Acid; Salvage Therapy; Tegafur; Tomography, X-Ray Computed

2010
[Allicin enhances cytotoxicity of CPT-11 to colon cancer LoVo cell in vitro].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009, Volume: 34, Issue:23

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disulfides; Humans; Irinotecan; Models, Biological; Sulfinic Acids

2009
Irinotecan in the adjuvant treatment of colon cancer: is the story finished or does personalized therapy open new opportunities?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Apr-20, Volume: 28, Issue:12

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Clinical Trials, Phase III as Topic; Colonic Neoplasms; Disease-Free Survival; Humans; Irinotecan; Patient Selection; Precision Medicine; Randomized Controlled Trials as Topic; Survival Analysis; Treatment Outcome

2010
The combination of 5-FU, leucovorin and CPT-11 (FOLFIRI) prolongs survival through inhibition of metastasis in an orthotopic model of colon cancer.
    Anticancer research, 2010, Volume: 30, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Fluorouracil; Green Fluorescent Proteins; Humans; Leucovorin; Lymphatic Metastasis; Mice; Mice, Nude; Survival Rate; Treatment Outcome; Whole Body Imaging; Xenograft Model Antitumor Assays

2010
Cytotoxic drugs up-regulate epidermal growth factor receptor (EGFR) expression in colon cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent cell-mediated-cytotoxicity (ADCC).
    European journal of cancer (Oxford, England : 1990), 2010, Volume: 46, Issue:9

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibody-Dependent Cell Cytotoxicity; Antineoplastic Agents; Blotting, Western; Camptothecin; Cell Line, Tumor; Cetuximab; Colonic Neoplasms; Deoxycytidine; Drug Synergism; ErbB Receptors; Fluorouracil; Gemcitabine; Genes, ras; Humans; Irinotecan; Killer Cells, Lymphokine-Activated; Mutation; Panitumumab; Up-Regulation

2010
[Survey on the compliance of patients with continuous infusion of 5-fluorouracil via portable infusion pumps].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Humans; Infusion Pumps; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Seasons; Surveys and Questionnaires

2010
[A case of fluoropyrimidine-resistant recurrent colon cancer successfully treated with weekly administration of irinotecan].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:4

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Resistance, Neoplasm; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Neoplasm Staging; Recurrence; Tegafur; Tomography, X-Ray Computed; Uracil

2010
Effects of potential calcium sensing receptor inducers on promoting chemosensitivity of human colon carcinoma cells.
    International journal of oncology, 2010, Volume: 36, Issue:6

    Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Calcitriol; Camptothecin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression; Humans; Immunoprecipitation; Lentinan; Leucovorin; Receptors, Calcium-Sensing; Transcription, Genetic; Transfection

2010
Oxidative stress-based cytotoxicity of delphinidin and cyanidin in colon cancer cells.
    Archives of biochemistry and biophysics, 2010, Sep-01, Volume: 501, Issue:1

    Topics: Anthocyanins; Antioxidants; Apoptosis; Caco-2 Cells; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Glutathione; Glutathione Reductase; Humans; Oxidants; Oxidative Stress

2010
The importance of release of proinflammatory cytokines, ROS, and NO in different stages of colon carcinoma growth and metastasis after treatment with cytotoxic drugs.
    Oncology research, 2010, Volume: 18, Issue:9

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Coculture Techniques; Colon; Colonic Neoplasms; Cytokines; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Nitric Oxide; Reactive Oxygen Species; Spheroids, Cellular

2010
Glutathione modulators reverse the pro-tumour effect of growth factors enhancing WiDr cell response to chemotherapeutic agents.
    Anticancer research, 2010, Volume: 30, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Camptothecin; Cell Growth Processes; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Epidermal Growth Factor; Fluorouracil; Glutathione; Hepatocyte Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Pyrrolidonecarboxylic Acid; Thiazolidines; Vascular Endothelial Growth Factor A

2010
Janus-activated kinases and signal transducer and activator of transcription control tumor growth response to camptothecin in human colon cancer cells.
    Cancer biology & therapy, 2010, Aug-15, Volume: 10, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA Repair; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Fluorescent Antibody Technique; Gene Expression; Humans; Janus Kinase 2; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; STAT Transcription Factors

2010
[A case of ascending colon cancer with unresectable distant metastases treated by systemic chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:6

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colonoscopy; Combined Modality Therapy; Fatal Outcome; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Organoplatinum Compounds; Tomography, X-Ray Computed

2010
Hepatocyte growth factor (HGF), heat shock proteins (HSPs) and multidrug resistance protein (MRP) expression in co-culture of colon tumor spheroids with normal cells after incubation with interleukin-1beta (IL-1beta) and/or camptothecin (CPT-11).
    Indian journal of experimental biology, 2010, Volume: 48, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Camptothecin; Cell Line, Tumor; Coculture Techniques; Colon; Colonic Neoplasms; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fluorescent Antibody Technique, Indirect; Heat-Shock Proteins; Hepatocyte Growth Factor; Humans; Interleukin-1beta; Neoplasm Staging; Spheroids, Cellular

2010
Detailed distribution of NK012, an SN-38-incorporating micelle, in the liver and its potent antitumor effects in mice bearing liver metastases.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Oct-01, Volume: 16, Issue:19

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Proliferation; Chromatography, High Pressure Liquid; Colonic Neoplasms; Disease Models, Animal; Humans; Irinotecan; Kaplan-Meier Estimate; Liver; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2010
Irinotecan overcomes the resistance to 5-fluorouracil in human colon cancer xenografts by down-regulation of intratumoral thymidylate synthase.
    Oncology reports, 2010, Volume: 24, Issue:4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Camptothecin; Colonic Neoplasms; Down-Regulation; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Humans; Irinotecan; Mice; Mice, Nude; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Prodrugs; Tegafur; Thymidylate Synthase; Xenograft Model Antitumor Assays

2010
Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1.
    Apoptosis : an international journal on programmed cell death, 2011, Volume: 16, Issue:1

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Caco-2 Cells; Camptothecin; Caspases; Cell Line, Transformed; Colonic Neoplasms; DNA Fragmentation; DNA-Binding Proteins; E2F1 Transcription Factor; Gene Expression; Humans; Imidazoles; Nuclear Proteins; Piperazines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-mdm2; RNA, Small Interfering; Tumor Protein p73; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2011
Genome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors.
    Cancer research, 2010, Oct-15, Volume: 70, Issue:20

    Topics: Alternative Splicing; Antineoplastic Agents, Phytogenic; Camptothecin; Cisplatin; Colonic Neoplasms; DNA Topoisomerases, Type I; DNA-Binding Proteins; Down-Regulation; Exons; Genetic Variation; Genome-Wide Association Study; Humans; Models, Statistical; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA Polymerase II; RNA Splicing; RNA, Small Interfering; Vinblastine

2010
[A case of colon cancer with multiple lung metastases responding completely to FOLFIRI and FOLFOX therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:9

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Lung Neoplasms; Male; Organoplatinum Compounds; Positron-Emission Tomography; Tomography, X-Ray Computed

2010
Acute thrombocytopenia: an unusual complication occurring after drug-eluting microspheres transcatheter hepatic chemoembolization.
    Cardiovascular and interventional radiology, 2011, Volume: 34 Suppl 2

    Topics: Acute Disease; Adenocarcinoma; Antineoplastic Agents; Camptothecin; Chemoembolization, Therapeutic; Colonic Neoplasms; Follow-Up Studies; Humans; Irinotecan; Leukocyte Count; Liver Neoplasms; Male; Microspheres; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Platelet Count; Sigmoid Neoplasms; Thrombocytopenia

2011
High antimetastatic efficacy of MEN4901/T-0128, a novel camptothecin carboxymethyldextran conjugate.
    The Journal of surgical research, 2011, Volume: 171, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Body Weight; Camptothecin; Colonic Neoplasms; Dextrans; Dose-Response Relationship, Drug; Green Fluorescent Proteins; HT29 Cells; Humans; Irinotecan; Mice; Mice, Nude; Prodrugs; Topotecan; Xenograft Model Antitumor Assays

2011
A retrospective observational study on the safety and efficacy of first-line treatment with bevacizumab combined with FOLFIRI in metastatic colorectal cancer.
    British journal of cancer, 2010, Nov-09, Volume: 103, Issue:10

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Disease Progression; Drug Tolerance; Female; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms; Retrospective Studies; Safety; Spain; Treatment Outcome

2010
[A case of high CEA colon cancer responding to neoadjuvant chemotherapy with FOLFIRI].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoembryonic Antigen; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Remission Induction

2010
Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts.
    Oncology reports, 2010, Volume: 24, Issue:6

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma; Colonic Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; HCT116 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Irinotecan; Mice; Mice, Nude; Models, Biological; Naphthalenes; Organoplatinum Compounds; Oxaliplatin; Xenograft Model Antitumor Assays

2010
The histone deacetylase inhibitor PXD101 increases the efficacy of irinotecan in in vitro and in vivo colon cancer models.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Female; HCT116 Cells; Histone Deacetylase Inhibitors; HT29 Cells; Humans; Hydroxamic Acids; Irinotecan; Mice; Mice, Nude; Prodrugs; Random Allocation; Sulfonamides; Topoisomerase I Inhibitors; Tumor Burden; Whole Body Imaging; Xenograft Model Antitumor Assays

2011
Pancreatic metastasis from colon carcinoma treated with radiotherapy with palliative benefit.
    JOP : Journal of the pancreas, 2010, Nov-09, Volume: 11, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Pain; Palliative Care; Pancreatic Neoplasms; Radiotherapy, Adjuvant; Treatment Outcome

2010
In vivo imaging of early stage apoptosis by measuring real-time caspase-3/7 activation.
    Apoptosis : an international journal on programmed cell death, 2011, Volume: 16, Issue:2

    Topics: Animals; Apoptosis; Blotting, Western; Camptothecin; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dacarbazine; Enzyme Activation; Firefly Luciferin; Flow Cytometry; Glioblastoma; Humans; Luminescent Measurements; Luminescent Proteins; Mice; Mice, Nude; Oligopeptides; Staining and Labeling; Temozolomide; Xenograft Model Antitumor Assays

2011
[Risk associated with severe hematological toxicity in patients with advanced or recurrent colonic cancer receiving combination chemotherapy of S-1 and irinotecan hydrochloride].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:11

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Combinations; Female; Hematologic Diseases; Humans; Irinotecan; Male; Neoplasm Recurrence, Local; Oxonic Acid; Risk Factors; Tegafur

2010
Targeting the p38 MAPK pathway inhibits irinotecan resistance in colon adenocarcinoma.
    Cancer research, 2011, Feb-01, Volume: 71, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Female; Fluorouracil; HCT116 Cells; Humans; Imidazoles; Immunohistochemistry; Irinotecan; Isoenzymes; Leucovorin; MAP Kinase Signaling System; Mice; Mice, Nude; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Xenograft Model Antitumor Assays

2011
[Efficacy of cetuximab combined with chemotherapy for patients with advanced colorectal cancer and unclear K-ras status].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2010, Volume: 32, Issue:10

    Topics: Acneiform Eruptions; Adenocarcinoma; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Diarrhea; Disease-Free Survival; Female; Follow-Up Studies; Humans; Irinotecan; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neutropenia; Organoplatinum Compounds; Oxaliplatin; ras Proteins; Rectal Neoplasms; Remission Induction; Survival Rate

2010
Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells.
    Investigational new drugs, 2012, Volume: 30, Issue:3

    Topics: Acridones; Antineoplastic Agents; Camptothecin; Cell Cycle Checkpoints; Cell Survival; Chromones; Cisplatin; Colonic Neoplasms; Comet Assay; DNA-Activated Protein Kinase; Drug Synergism; HCT116 Cells; HT29 Cells; Humans; Irinotecan; Morpholines; Organoplatinum Compounds; Protein Kinase Inhibitors; Pyridines; Topoisomerase I Inhibitors

2012
A patient with metastatic colon cancer to the liver presenting with cardiac arrest status post receiving combination irinotecan-panitumumab: a case report.
    Journal of experimental therapeutics & oncology, 2010, Volume: 8, Issue:4

    Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Heart Arrest; Humans; Irinotecan; Liver Neoplasms; Male; Middle Aged; Panitumumab

2010
[An elderly colon cancer patient with hepatic, lunge and peritoneal metastases was treated by hepatic arterial infusion and systemic chemotherapy-a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:12

    Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Colonic Neoplasms; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Neoadjuvant Therapy; Organoplatinum Compounds

2010
[A surgical (right lobectomy) case of liver metastasis of colon cancer after chemotherapy using mFOLFIRI and cetuximab].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:12

    Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Combined Modality Therapy; Fluorouracil; Hepatectomy; Humans; Leucovorin; Liver Neoplasms; Male

2010
Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells.
    Molecular nutrition & food research, 2011, Volume: 55 Suppl 1

    Topics: Anthocyanins; Antineoplastic Agents, Phytogenic; Camptothecin; Cell-Free System; Colonic Neoplasms; DNA; DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Doxorubicin; HT29 Cells; Humans; Plant Extracts; Vaccinium myrtillus

2011
DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Apr-15, Volume: 17, Issue:8

    Topics: Acridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Cell Cycle; Cell Survival; Cells, Cultured; Colonic Neoplasms; DNA Damage; Drug Synergism; G-Quadruplexes; HCT116 Cells; HT29 Cells; Humans; Irinotecan; Male; Mice; Mice, Nude; Telomere; Topoisomerase I Inhibitors; Treatment Outcome; Xenograft Model Antitumor Assays

2011
[Analysis of gene expression patterns in an irinotecan-resistance colon cancer cell by cDNA microarray].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2011, Volume: 42, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Humans; Irinotecan; Oligonucleotide Array Sequence Analysis; Transcriptome; Zinc Fingers

2011
[A case of drug-induced lung injury associated with chemotherapy (FOLFOX6, FOLFIRI, Bevacizumab) for an advanced colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:1

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Fatal Outcome; Female; Fluorouracil; Humans; Leucovorin; Lung Injury; Neoplasm Staging; Organoplatinum Compounds; Tomography, X-Ray Computed

2011
RNA interference (RNAi) of Ufd1 protein can sensitize a hydroxycamptothecin-resistant colon cancer cell line SW1116/HCPT to hydroxycamptothecin.
    Journal of digestive diseases, 2011, Volume: 12, Issue:2

    Topics: Adaptor Proteins, Vesicular Transport; Antineoplastic Agents, Phytogenic; Blotting, Western; Camptothecin; Caspase 3; Caspases, Initiator; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Humans; Intracellular Signaling Peptides and Proteins; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference

2011
[A case of drug-induced interstitial pneumonia caused by S-1 and CPT-11 combination therapy for advanced colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Combinations; Fatal Outcome; Female; Humans; Irinotecan; Lung Diseases, Interstitial; Neoplasm Staging; Oxonic Acid; Tegafur; Tomography, X-Ray Computed

2011
Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells.
    The American journal of pathology, 2011, Volume: 178, Issue:4

    Topics: Animals; Antigens; Antineoplastic Agents; Benzimidazoles; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Etoposide; Humans; Irinotecan; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; Peptides; T-Lymphocytes, Cytotoxic

2011
Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan.
    Gastroenterology, 2011, Volume: 141, Issue:1

    Topics: Adenocarcinoma; Aldehyde Dehydrogenase; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers, Tumor; Blotting, Western; Camptothecin; Cell Differentiation; Colonic Neoplasms; Cyclosporins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Irinotecan; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Spheroids, Cellular; Time Factors; Topoisomerase I Inhibitors; Tumor Burden; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2011
Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment.
    BMC medical genomics, 2011, May-11, Volume: 4

    Topics: Animals; Camptothecin; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Interactions; Drugs, Chinese Herbal; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Immunity; Immunohistochemistry; Inflammation; Irinotecan; Liver; Macrophages; Medicine, Chinese Traditional; Mice; Organ Size; Polymerase Chain Reaction; Reproducibility of Results; RNA, Messenger; Signal Transduction; Spleen; Tumor Microenvironment

2011
Anti-tumor activity of liposome encapsulated fluoroorotic acid as a single agent and in combination with liposome irinotecan.
    Journal of controlled release : official journal of the Controlled Release Society, 2011, Aug-10, Volume: 153, Issue:3

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Survival; Colonic Neoplasms; Drug Combinations; Drug Compounding; Drug Synergism; HT29 Cells; Humans; Irinotecan; Liposomes; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Nude; Orotic Acid; Particle Size; Survival Analysis; Treatment Outcome; Xenograft Model Antitumor Assays

2011
Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1.
    Cancer research, 2011, Aug-01, Volume: 71, Issue:15

    Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Camptothecin; CDC2 Protein Kinase; Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Fluorouracil; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitor of Apoptosis Proteins; Irinotecan; Mice; Mice, Nude; Neoplasm Proteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-myb; Pyrimidines; Recombinant Proteins; RNA, Small Interfering; Thiazoles; TNF-Related Apoptosis-Inducing Ligand; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2011
Association between deficient mismatch repair system and efficacy to irinotecan-containing chemotherapy in metastatic colon cancer.
    Cancer science, 2011, Volume: 102, Issue:9

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Disease-Free Survival; DNA Mismatch Repair; Female; Humans; Irinotecan; Male; Microsatellite Instability; Middle Aged; MutL Protein Homolog 1; MutS Homolog 2 Protein; Nuclear Proteins; Prognosis; Treatment Outcome

2011
Fatal infusion reaction to cetuximab: the need for predictive risk factors and safer patient selection.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Aug-10, Volume: 29, Issue:23

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Camptothecin; Cetuximab; Colonic Neoplasms; Fatal Outcome; Genotype; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Patient Selection; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Risk Factors

2011
Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells.
    Molecular cancer, 2011, Jul-06, Volume: 10

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma; Cell Line, Tumor; Colonic Neoplasms; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic; HCT116 Cells; Hep G2 Cells; Humans; Inactivation, Metabolic; Irinotecan; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Signal Transduction; Up-Regulation; Xenobiotics

2011
Clinical and radiological response with FOLFOXIRI and bevacizumab as third-line therapy after mFOLFOX6 and FOLFIRI failure.
    Anti-cancer drugs, 2011, Volume: 22 Suppl 2

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lung Neoplasms; Middle Aged; Organoplatinum Compounds; Treatment Outcome

2011
Comparative effectiveness of different chemotherapeutic regimens on survival of people aged 66 and older with stage III colon cancer: a "real world" analysis using Surveillance, Epidemiology, and End Results-Medicare data.
    Journal of the American Geriatrics Society, 2011, Volume: 59, Issue:9

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Comparative Effectiveness Research; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Organoplatinum Compounds; Oxaliplatin; Proportional Hazards Models; Retrospective Studies; SEER Program; Survival Analysis; Treatment Outcome; United States

2011
RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors.
    Current cancer drug targets, 2011, Volume: 11, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Gene Transfer Techniques; Genetic Therapy; Humans; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Neoplasm Proteins; RNA Interference; RNA, Small Interfering; Topoisomerase Inhibitors

2011
Identification of a potent epigenetic biomarker for resistance to camptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer.
    International journal of oncology, 2012, Volume: 40, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Caco-2 Cells; Camptothecin; Case-Control Studies; Cell Line, Tumor; Colonic Neoplasms; DNA Methylation; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Fluorouracil; Gene Knockdown Techniques; HCT116 Cells; Humans; Irinotecan; Male; Membrane Proteins; Middle Aged; Organoplatinum Compounds; Oxaliplatin; RNA, Messenger

2012
[A case of undifferentiated colon cancer responding to FOLFIRI therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:9

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fatal Outcome; Fluorouracil; Humans; Leucovorin; Male; Tomography, X-Ray Computed

2011
MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment.
    European journal of pharmacology, 2011, Nov-16, Volume: 670, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biphenyl Compounds; Breast Neoplasms; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Doxorubicin; Drug Synergism; Female; Genomics; Humans; Irinotecan; Kinetics; Multidrug Resistance-Associated Proteins; Necrosis; Neoplasm Proteins; Signal Transduction; Tetrahydroisoquinolines; Topotecan

2011
MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells.
    Stem cells (Dayton, Ohio), 2011, Volume: 29, Issue:11

    Topics: Antineoplastic Agents; Blotting, Western; Camptothecin; Cell Line; Colonic Neoplasms; Cyclooxygenase 2; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Irinotecan; MicroRNAs; Neoplastic Stem Cells; Reverse Transcriptase Polymerase Chain Reaction

2011
Comparative and cost-effectiveness of oxaliplatin-based or irinotecan-based regimens compared with 5-fluorouracil/leucovorin alone among US elderly stage IV colon cancer patients.
    Cancer, 2012, Jun-15, Volume: 118, Issue:12

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Cost-Benefit Analysis; Disease-Free Survival; Female; Fluorouracil; Health Care Costs; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Quality-Adjusted Life Years; Survival Analysis

2012
MicroRNA 506 regulates expression of PPAR alpha in hydroxycamptothecin-resistant human colon cancer cells.
    FEBS letters, 2011, Nov-16, Volume: 585, Issue:22

    Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; PPAR alpha; Reverse Transcriptase Polymerase Chain Reaction

2011
Liver metastasis from colonic adenocarcinoma presenting as nephrolithiasis: computed tomography findings.
    The Israel Medical Association journal : IMAJ, 2011, Volume: 13, Issue:10

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Diagnosis, Differential; Female; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Middle Aged; Nephrolithiasis; Tomography, X-Ray Computed

2011
Soluplus--solubilized citrated camptothecin--a potential drug delivery strategy in colon cancer.
    AAPS PharmSciTech, 2012, Volume: 13, Issue:1

    Topics: Caco-2 Cells; Camptothecin; Citric Acid; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Delivery Systems; Humans; Solubility; X-Ray Diffraction

2012
[mFOLFOX6 and FOLFIRI/bevacizumab treatment in a patient on hemodialysis with metastatic colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:12

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Humans; Kidney Failure, Chronic; Leucovorin; Middle Aged; Organoplatinum Compounds; Peritoneal Dialysis; Peritoneal Neoplasms

2011
Pharmacokinetics and antitumor efficacy of XMT-1001, a novel, polymeric topoisomerase I inhibitor, in mice bearing HT-29 human colon carcinoma xenografts.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, May-01, Volume: 18, Issue:9

    Topics: Acetals; Animals; Camptothecin; Chromatography, Liquid; Colonic Neoplasms; DNA Topoisomerases, Type I; Female; Humans; Irinotecan; Mice; Mice, Nude; Polymers; Tandem Mass Spectrometry; Tissue Distribution; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2012
Injectable poly(organophosphazene)-camptothecin conjugate hydrogels: synthesis, characterization, and antitumor activities.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012, Volume: 81, Issue:3

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Stability; Drug Storage; Female; Glycine; Humans; Hydrogels; Injections; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Organophosphorus Compounds; Phase Transition; Polymers; Temperature; Xenograft Model Antitumor Assays

2012
The role of autophagic cell death and apoptosis in irinotecan-treated p53 null colon cancer cells.
    Anti-cancer agents in medicinal chemistry, 2013, Volume: 13, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; HCT116 Cells; HT29 Cells; Humans; Irinotecan; Tumor Suppressor Protein p53

2013
Combination of gastrin-releasing peptide antagonist with cytotoxic agents produces synergistic inhibition of growth of human experimental colon cancers.
    Cell cycle (Georgetown, Tex.), 2012, Jul-01, Volume: 11, Issue:13

    Topics: Animals; Antineoplastic Agents; Bombesin; Camptothecin; Cell Cycle Checkpoints; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Gastrin-Releasing Peptide; HCT116 Cells; HT29 Cells; Humans; Irinotecan; Male; Mice; Mice, Nude; Peptide Fragments; Receptors, Bombesin; Transplantation, Heterologous

2012
Gef gene therapy enhances the therapeutic efficacy of cytotoxics in colon cancer cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2012, Volume: 66, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; Bacterial Toxins; Camptothecin; Cell Survival; Colonic Neoplasms; Combined Modality Therapy; Escherichia coli Proteins; Fluorouracil; Genetic Therapy; Humans; Irinotecan; Membrane Proteins; Organoplatinum Compounds; Oxaliplatin

2012
Colon cancer cell chemosensitisation by fish oil emulsion involves apoptotic mitochondria pathway.
    The British journal of nutrition, 2013, Apr-14, Volume: 109, Issue:7

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Combined Modality Therapy; Dietary Supplements; Drug Resistance, Neoplasm; Emulsions; Fatty Acids, Omega-3; Fish Oils; Fluorouracil; Food-Drug Interactions; Humans; Irinotecan; Membrane Potential, Mitochondrial; Mitochondria; Organoplatinum Compounds; Oxaliplatin; Triglycerides

2013
[A case of colon cancer with chronic renal dysfunction responding to effective retreatment with FOLFIRI].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:8

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Kidney Failure, Chronic; Leucovorin; Male; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Salvage Therapy; Tomography, X-Ray Computed

2012
The synergistic effects of low-dose irinotecan and TRAIL on TRAIL-resistant HT-29 colon carcinoma in vitro and in vivo.
    International journal of molecular medicine, 2012, Volume: 30, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; bcl-2-Associated X Protein; Camptothecin; Carcinoma; Caspase 9; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Female; HT29 Cells; Humans; Irinotecan; Mice; Mice, Nude; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand; Tumor Burden; Xenograft Model Antitumor Assays

2012
Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E inhibition.
    International journal of cancer, 2013, Feb-01, Volume: 132, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Benzamides; Biomarkers, Tumor; Bridged Bicyclo Compounds, Heterocyclic; Camptothecin; Cell Line, Tumor; Cell Proliferation; Chromosomal Proteins, Non-Histone; Colonic Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Irinotecan; Lung Neoplasms; M Phase Cell Cycle Checkpoints; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Neuroblastoma; Pancreatic Neoplasms; RNA Interference; RNA, Small Interfering; Sarcosine; Temozolomide

2013
Current stages of adjuvant treatment of colon cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23 Suppl 10

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Neoplasm Staging; Organoplatinum Compounds; Survival Analysis

2012
The PARP inhibitor ABT-888 synergizes irinotecan treatment of colon cancer cell lines.
    Investigational new drugs, 2013, Volume: 31, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzimidazoles; Blotting, Western; Camptothecin; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Flow Cytometry; Humans; Irinotecan; Poly(ADP-ribose) Polymerase Inhibitors; Tumor Cells, Cultured

2013
[A case of unresectable multiple hepatic metastases from ascending colon cancer successfully treated with panitumumab and FOLFIRI(5-FU/LV/irinotecan)therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:10

    Topics: Aged; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Panitumumab; Tomography, X-Ray Computed

2012
GHRH antagonist when combined with cytotoxic agents induces S-phase arrest and additive growth inhibition of human colon cancer.
    Cell cycle (Georgetown, Tex.), 2012, Nov-15, Volume: 11, Issue:22

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cisplatin; Colonic Neoplasms; Fluorouracil; Growth Hormone-Releasing Hormone; HCT116 Cells; HT29 Cells; Humans; Irinotecan; Mice; Mice, Nude; S Phase Cell Cycle Checkpoints; Sermorelin; Transplantation, Heterologous

2012
Bevacizumab-containing chemotherapy is safe in patients with unresectable metastatic colorectal cancer and a synchronous asymptomatic primary tumor.
    Japanese journal of clinical oncology, 2013, Volume: 43, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Colonic Neoplasms; Combined Modality Therapy; Deoxycytidine; Female; Fluorouracil; Follow-Up Studies; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Staging; Neoplasms, Multiple Primary; Organoplatinum Compounds; Oxaliplatin; Prognosis; Rectal Neoplasms; Retrospective Studies; Survival Rate; Young Adult

2013
KRAS mutation is a predictor of oxaliplatin sensitivity in colon cancer cells.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA-Binding Proteins; Endonucleases; Fluorouracil; Humans; Irinotecan; Mutation; Organoplatinum Compounds; Oxaliplatin; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins

2012
Polymorphisms of the UDP-glucuronosyl transferase 1A genes are associated with adverse events in cancer patients receiving irinotecan-based chemotherapy.
    The Tohoku journal of experimental medicine, 2013, Volume: 229, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Diarrhea; Drug-Related Side Effects and Adverse Reactions; Female; Genetic Predisposition to Disease; Glucuronosyltransferase; Humans; Irinotecan; Isoenzymes; Lung Neoplasms; Male; Middle Aged; Neoplasms; Neutropenia; Pharmacogenetics; Polymorphism, Genetic; Stomach Neoplasms

2013
KML001 displays vascular disrupting properties and irinotecan combined antitumor activities in a murine tumor model.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arsenites; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; Drug Synergism; Human Umbilical Vein Endothelial Cells; Humans; Irinotecan; Mice; Neoplasms, Experimental; Neovascularization, Pathologic; Sodium Compounds; Telomere

2013
Concurrent chemotherapy inhibits herpes simplex virus-1 replication and oncolysis.
    Cancer gene therapy, 2013, Volume: 20, Issue:2

    Topics: Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Combined Modality Therapy; Fluorouracil; Herpesvirus 1, Human; Humans; Irinotecan; Methotrexate; NF-kappa B; Oncolytic Virotherapy; Oncolytic Viruses; Pancreatic Neoplasms; Transcriptional Activation; Tumor Necrosis Factor-alpha; Virus Replication

2013
Irinotecan during pregnancy in metastatic colon cancer.
    Tumori, 2012, Volume: 98, Issue:6

    Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cesarean Section; Colectomy; Colonic Neoplasms; Disease Progression; Female; Fluorouracil; Gestational Age; Humans; Infant, Newborn; Irinotecan; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Pregnancy; Pregnancy Complications, Neoplastic; Pregnancy Outcome; Treatment Failure

2012
Combined colonic cancer treatment with vitamin D analogs and irinotecan or oxaliplatin.
    Anticancer research, 2013, Volume: 33, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Dihydroxycholecalciferols; Female; HT29 Cells; Humans; Irinotecan; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Organoplatinum Compounds; Oxaliplatin; Signal Transduction; Vitamin D; Xenograft Model Antitumor Assays

2013
Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells.
    International journal of oncology, 2002, Volume: 21, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Division; Cell Survival; Colonic Neoplasms; DNA, Neoplasm; Drug Interactions; Female; Fluorouracil; Glutamates; Guanine; HT29 Cells; Humans; Irinotecan; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Organoplatinum Compounds; Oxaliplatin; Pemetrexed; Transplantation, Heterologous

2002
Drg1, a novel target for modulating sensitivity to CPT-11 in colon cancer cells.
    Cancer research, 2002, Jul-15, Volume: 62, Issue:14

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Colonic Neoplasms; DNA, Antisense; DNA, Complementary; Drug Synergism; Flavonoids; GTP-Binding Proteins; Humans; Irinotecan; Male; Mice; Mice, Nude; Piperidines; Prodrugs; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2002
Influence of G2 arrest on the cytotoxicity of DNA topoisomerase inhibitors toward human carcinoma cells with different p53 status.
    Acta biochimica Polonica, 2002, Volume: 49, Issue:1

    Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Camptothecin; Carcinoma; Cell Cycle; Colonic Neoplasms; Etoposide; Humans; Staurosporine; Topoisomerase Inhibitors; Tumor Suppressor Protein p53

2002
Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status.
    International journal of cancer, 2002, Sep-01, Volume: 101, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Blotting, Western; Caffeine; Camptothecin; Carrier Proteins; CDC2 Protein Kinase; Cell Cycle; Colonic Neoplasms; Drug Resistance, Neoplasm; Flow Cytometry; Gene Deletion; Humans; Irinotecan; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2002
Functional expression of tumor necrosis factor-related apoptosis-inducing ligand in human colonic adenocarcinoma cells.
    Laboratory investigation; a journal of technical methods and pathology, 2002, Volume: 82, Issue:9

    Topics: Adenocarcinoma; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Colonic Neoplasms; Doxorubicin; HT29 Cells; Humans; Interferon-alpha; Interferon-gamma; Jurkat Cells; Membrane Glycoproteins; NF-kappa B; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha

2002
Contribution of apoptosis in the cytotoxicity of the oxaliplatin-irinotecan combination in the HT29 human colon adenocarcinoma cell line.
    Biochemical pharmacology, 2002, Oct-15, Volume: 64, Issue:8

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Cycle; Cell Division; Cell Survival; Colonic Neoplasms; Drug Interactions; Flow Cytometry; HT29 Cells; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Peptide Hydrolases; Poly(ADP-ribose) Polymerases

2002
The activity profile of the hexacyclic camptothecin derivative DX-8951f in experimental human colon cancer and ovarian cancer.
    Biochemical pharmacology, 2002, Oct-15, Volume: 64, Issue:8

    Topics: Animals; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Camptothecin; Cell Division; Cisplatin; Colonic Neoplasms; Disease Models, Animal; Female; Humans; Membrane Glycoproteins; Mice; Mice, Nude; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Ovarian Neoplasms; Sulfhydryl Reagents; Tetraspanin 29; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles; Xenograft Model Antitumor Assays

2002
Secreted and tumour targeted human carboxylesterase for activation of irinotecan.
    British journal of cancer, 2002, Sep-09, Volume: 87, Issue:6

    Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents, Phytogenic; Blotting, Western; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Adhesion Molecules; Cell Division; Chlorocebus aethiops; Colonic Neoplasms; COS Cells; Drug Screening Assays, Antitumor; Gene Expression Regulation; Humans; Immunoenzyme Techniques; Irinotecan; Lymphokines; Plasmids; Polymerase Chain Reaction; Prodrugs; Sialoglycoproteins; Tumor Cells, Cultured

2002
Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice.
    Cancer research, 2002, Oct-15, Volume: 62, Issue:20

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Immunohistochemistry; Irinotecan; Membrane Glycoproteins; Mice; Mice, SCID; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays

2002
Augmented anti-metastatic efficacy of a selective matrix metalloproteinase inhibitor, MMI-166, in combination with CPT-11.
    Clinical & experimental metastasis, 2002, Volume: 19, Issue:6

    Topics: Animals; Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Disease Models, Animal; Humans; Irinotecan; Liver Neoplasms; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Sulfonamides; Transplantation, Heterologous

2002
[Two patients with recurrent colon cancer who underwent surgery following a combination of irinotecan and UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:11

    Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Fluorouracil; Humans; Irinotecan; Leucovorin; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Tegafur; Uracil

2002
Combination of 5-fluorouracil and irinotecan on modulation of thymidylate synthase and topoisomerase I expression and cell cycle regulation in human colon cancer LoVo cells: clinical relevance.
    Clinical colorectal cancer, 2002, Volume: 2, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; Humans; In Vitro Techniques; Irinotecan; Thymidylate Synthase; Topoisomerase I Inhibitors; Tumor Cells, Cultured

2002
Prognostic role of serum vascular endothelial growth factor, basic fibroblast growth factor and nitric oxide in patients with colorectal carcinoma.
    Cytokine, 2002, Nov-24, Volume: 20, Issue:4

    Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Carcinoembryonic Antigen; Chemotherapy, Adjuvant; Cisplatin; Colonic Neoplasms; Colorectal Neoplasms; Disease-Free Survival; Endothelial Growth Factors; Female; Fibroblast Growth Factor 2; Fluorouracil; Follow-Up Studies; Humans; Intercellular Signaling Peptides and Proteins; Irinotecan; Leucovorin; Life Tables; Lymphokines; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neovascularization, Pathologic; Nitrates; Nitric Oxide; Organoplatinum Compounds; Oxaliplatin; Prognosis; Proportional Hazards Models; Rectal Neoplasms; Survival Analysis; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
Antisense protein kinase A RIalpha acts synergistically with hydroxycamptothecin to inhibit growth and induce apoptosis in human cancer cells: molecular basis for combinatorial therapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Blotting, Western; Camptothecin; Carrier Proteins; Cell Division; Colonic Neoplasms; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; Cyclic AMP-Dependent Protein Kinases; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Humans; Male; Oligonucleotides; Oligonucleotides, Antisense; Oligoribonucleotides, Antisense; Prostatic Neoplasms; Protein Isoforms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Up-Regulation

2003
Weekly hepatic arterial infusion of 5-fluorouracil and subsequent systemic chemotherapy for liver metastases from colorectal cancer.
    Japanese journal of clinical oncology, 2003, Volume: 33, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leukopenia; Liver Neoplasms; Male; Middle Aged; Nausea; Rectal Neoplasms; Retrospective Studies; Survival Analysis; Thrombocytopenia; Vomiting, Anticipatory

2003
Irinotecan (CPT11) plus high-dose 5-fluorouracil (5-FU) and leucovorin (LV) as salvage therapy for metastatic colorectal cancer (MCRC) after failed oxaliplatin plus 5-FU and LV: a pilot study in Taiwan.
    Japanese journal of clinical oncology, 2003, Volume: 33, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Irinotecan; Leucovorin; Leukopenia; Middle Aged; Nausea; Pilot Projects; Rectal Neoplasms; Salvage Therapy; Survival Analysis; Treatment Outcome; Vomiting, Anticipatory

2003
[A case of irinotecan-resistant colon cancer responding to chronotherapy with oxaliplatin, 5-FU, l-LV].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:4

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Chronotherapy; Colonic Neoplasms; Drug Evaluation; Drug Resistance, Neoplasm; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Organoplatinum Compounds; Oxaliplatin

2003
[A case of colon cancer with liver metastases and lymph node metastases successfully treated with surgery followed by CPT-11 and 5-FU chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:5

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Aorta, Abdominal; Camptothecin; Colonic Neoplasms; Combined Modality Therapy; Female; Fluorouracil; Gastrectomy; Humans; Irinotecan; Liver Neoplasms; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Middle Aged

2003
Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11.
    British journal of cancer, 2003, Jun-16, Volume: 88, Issue:12

    Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Camptothecin; Cell Division; Colonic Neoplasms; Endothelial Growth Factors; HT29 Cells; Humans; Intercellular Signaling Peptides and Proteins; Irinotecan; Lymphokines; Mice; Mice, Nude; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2003
Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.
    International journal of cancer, 2003, Sep-20, Volume: 106, Issue:5

    Topics: Apoptosis; bcl-X Protein; Camptothecin; Caspase 3; Caspases; Colonic Neoplasms; Cytochrome c Group; DNA Primers; Down-Regulation; Enzyme Activation; Free Radical Scavengers; HT29 Cells; Humans; Immunoblotting; Membrane Potentials; Mitochondria; Mutation; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Penicillamine; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Superoxides; Tumor Suppressor Protein p53

2003
Precursor peptide progastrin(1-80) reduces apoptosis of intestinal epithelial cells and upregulates cytochrome c oxidase Vb levels and synthesis of ATP.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 285, Issue:6

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase 3; Caspase 9; Caspases; Cell Line; Colonic Neoplasms; Electron Transport Complex IV; Enzyme Activation; Gastrins; Intestinal Mucosa; Mitochondria; Promoter Regions, Genetic; Protein Precursors; Rats; RNA, Messenger; Up-Regulation

2003
Epidermal growth factor receptor inhibition induces trichomegaly.
    Acta oncologica (Stockholm, Sweden), 2003, Volume: 42, Issue:4

    Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Diagnosis, Differential; ErbB Receptors; Eyelashes; Female; Humans; Irinotecan; Liver Neoplasms; Neoplasm Metastasis

2003
Second-line chemotherapy with low-dose CPT-11 and cisplatin for colorectal cancer resistant to 5-FU-based chemotherapy.
    Cancer chemotherapy and pharmacology, 2003, Volume: 52, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colonic Neoplasms; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Neoplasm Metastasis; Remission Induction

2003
[Effect of the change of caspase-3 activity on the neoadjuvant chemotherapy-induced apoptosis of large-intestinal carcinoma cells].
    Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 2003, Volume: 28, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Caspase 3; Caspases; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged

2003
Advances in colon cancer.
    Drug news & perspectives, 2003, Volume: 16, Issue:5

    Topics: Camptothecin; Colonic Neoplasms; Drug Combinations; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Pyridines; Treatment Outcome

2003
PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:9

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Cycle; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Diterpenes; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Epoxy Compounds; Humans; Irinotecan; Lung Neoplasms; Mice; Mice, Nude; Phenanthrenes; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2003
Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Oct-15, Volume: 9, Issue:13

    Topics: Blotting, Northern; Blotting, Western; Brain; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Line, Tumor; Colon; Colonic Neoplasms; DNA Topoisomerases, Type I; Electrophoresis, Polyacrylamide Gel; Female; Humans; Hydrolases; Hydrolysis; Irinotecan; Liver; Male; Reverse Transcriptase Polymerase Chain Reaction; RNA; Umbelliferones

2003
A prodrug strategy using ONYX-015-based replicating adenoviruses to deliver rabbit carboxylesterase to tumor cells for conversion of CPT-11 to SN-38.
    Cancer research, 2003, Oct-15, Volume: 63, Issue:20

    Topics: Adenoviridae; Animals; Camptothecin; Carboxylesterase; Colonic Neoplasms; Female; Humans; Irinotecan; Mice; Mice, Nude; Prodrugs; Rabbits; Transgenes; Virus Replication; Xenograft Model Antitumor Assays

2003
c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis.
    British journal of cancer, 2003, Nov-03, Volume: 89, Issue:9

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumor; Blotting, Western; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc

2003
Ex vivo analysis of topotecan: advancing the application of laboratory-based clinical therapeutics.
    British journal of cancer, 2003, Nov-03, Volume: 89, Issue:9

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; In Vitro Techniques; Irinotecan; Lethal Dose 50; Lung Neoplasms; Male; Neoplasms; Prostatic Neoplasms; Topotecan; Tumor Cells, Cultured

2003
Enhancement of in vivo antitumor activity of classical anticancer agents by combination with the new, glutathione-interacting DNA minor groove-binder, brostallicin.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Nov-01, Volume: 9, Issue:14

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Colonic Neoplasms; DNA; Doxorubicin; Female; Glutathione; Glutathione Transferase; Guanidines; Irinotecan; Leukemia L1210; Lung Neoplasms; Mice; Mice, Inbred DBA; Mice, Nude; Pyrroles; Transplantation, Heterologous

2003
[Experimental study on intraperitoneal versus intravenous CPT-11 for peritoneal seeding and liver metastasis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:11

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Female; Infusions, Intravenous; Injections, Intraperitoneal; Irinotecan; Liver Neoplasms; Mice; Mice, Inbred BALB C; Peritoneal Neoplasms

2003
[A case of resected spinal metastasis following colectomy and hepatectomy for descending colon carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:11

    Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Fluorouracil; Hepatectomy; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Spinal Neoplasms

2003
Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Dec-09, Volume: 100, Issue:25

    Topics: Adenoviridae; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Base Pair Mismatch; bcl-2-Associated X Protein; Camptothecin; Carcinoma; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Death; Cell Line; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA Repair; Enzyme Inhibitors; Etoposide; Flow Cytometry; Humans; Irinotecan; Luciferases; Membrane Glycoproteins; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; RNA, Small Interfering; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53

2003
Thrombospondin-1 plus irinotecan: a novel antiangiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice.
    Cancer chemotherapy and pharmacology, 2004, Volume: 53, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; Cells, Cultured; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; HT29 Cells; Humans; Irinotecan; Kinetics; Mice; Mice, Nude; Thrombospondin 1; Xenograft Model Antitumor Assays

2004
Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins.
    Biochemical pharmacology, 2004, Jan-01, Volume: 67, Issue:1

    Topics: Anthraquinones; Antigens, CD; Antineoplastic Agents, Phytogenic; Biological Transport; Camptothecin; Carrier Proteins; Colonic Neoplasms; Drug Interactions; Drug Resistance; Glucuronides; HT29 Cells; Humans; Irinotecan; Membrane Glycoproteins; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Propionates; Quinolines; Tetraspanin 29; Tumor Cells, Cultured; Tyrosine

2004
Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2003, Volume: 7, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Folic Acid; Hepatectomy; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Neoadjuvant Therapy; Postoperative Complications; Retrospective Studies

2003
Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives.
    Cancer research, 2003, Dec-01, Volume: 63, Issue:23

    Topics: Anthraquinones; Biopsy; Camptothecin; Catalysis; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Food Additives; Glucuronides; Glucuronosyltransferase; Humans; Irinotecan; Isoenzymes; Propofol; Topoisomerase I Inhibitors; Tyrosine

2003
Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin.
    Cancer research, 2003, Dec-15, Volume: 63, Issue:24

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Base Pair Mismatch; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; DNA Repair; Fluorouracil; Gene Expression Profiling; Humans; Oligonucleotide Array Sequence Analysis; Predictive Value of Tests; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Suppressor Protein p53

2003
Biweekly irinotecan plus bolus 5-fluorouracil and folinic acid in patients with advanced stage colorectal cancer.
    Japanese journal of clinical oncology, 2003, Volume: 33, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Rectal Neoplasms; Survival Analysis

2003
Chemoembolization of rat liver metastasis with irinotecan and quantification of tumor cell reduction.
    Journal of cancer research and clinical oncology, 2004, Volume: 130, Issue:4

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Chemoembolization, Therapeutic; Colonic Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; Irinotecan; Luminescent Measurements; Male; Microspheres; Rats; Rats, Inbred Strains

2004
Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.
    Carcinogenesis, 2004, Volume: 25, Issue:5

    Topics: Antioxidants; Apoptosis; Ascorbic Acid; bcl-X Protein; Camptothecin; Caspase 3; Caspases; Colonic Neoplasms; Down-Regulation; Flavones; Flavonoids; Free Radical Scavengers; HT29 Cells; Humans; Hydroxyl Radical; Immunoblotting; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; Superoxides

2004
Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents.
    Cancer research, 2004, Feb-01, Volume: 64, Issue:3

    Topics: Antineoplastic Agents; Camptothecin; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Female; Fluorouracil; HCT116 Cells; Humans; Irinotecan; Models, Biological; Ovarian Neoplasms; Paclitaxel

2004
Quantification of tumor tissue populations by multispectral analysis.
    Magnetic resonance in medicine, 2004, Volume: 51, Issue:3

    Topics: Adipose Tissue; Animals; Antineoplastic Agents, Phytogenic; Apoptosis Regulatory Proteins; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; fas Receptor; Female; Humans; Irinotecan; Ligands; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Mice; Mice, Nude; Necrosis; Neoplasm Transplantation; Remission Induction; Skin Neoplasms; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Topoisomerase I Inhibitors; Transplantation, Heterologous; Tumor Necrosis Factor-alpha

2004
ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan-treated metastases.
    International journal of cancer, 2004, May-10, Volume: 109, Issue:6

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Colon; Colonic Neoplasms; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Liver Neoplasms; Neoplasm Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm

2004
[A case report of colon cancer with liver and lung metastases responding to combination chemotherapy with l-LV, 5-fluorouracil and CPT-11].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Tumor Cells, Cultured

2004
[A case of highly advanced ascending colon cancer with multiple bone and liver metastases and pleuritis carcinomatosa treated with pharmacokinetic modulating chemotherapy and low-dose CPT-11].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Pleurisy; Quality of Life; Tegafur; Uracil

2004
Selective modulation of the therapeutic efficacy of anticancer drugs by selenium containing compounds against human tumor xenografts.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Apr-01, Volume: 10, Issue:7

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Squamous Cell; Cell Line, Tumor; Colonic Neoplasms; Cysteine; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Irinotecan; Maximum Tolerated Dose; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Organoselenium Compounds; Radiation-Sensitizing Agents; Selenium; Selenocysteine; Selenomethionine; Time Factors

2004
[A case of colon carcinoma with unresectable multiple liver metastases responding to various combined chemotherapies centering on hepatic arterial infusion therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:5

    Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Quality of Life

2004
The schedule-dependent enhanced cytotoxic activity of 7-ethyl-10-hydroxy-camptothecin (SN-38) in combination with Gefitinib (Iressa, ZD1839).
    Biochemical pharmacology, 2004, Jul-01, Volume: 68, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Cell Cycle; Cell Division; Colonic Neoplasms; DNA Topoisomerases, Type I; Drug Synergism; ErbB Receptors; Gefitinib; HT29 Cells; Humans; Irinotecan; Quinazolines; Signal Transduction; Tumor Cells, Cultured

2004
Two new drugs for colon cancer.
    The Medical letter on drugs and therapeutics, 2004, Jun-07, Volume: 46, Issue:1184

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Humans; Irinotecan; Lung Neoplasms; Pancreatic Neoplasms

2004
Complete remission of primary colon cancer in a metastatic patient treated with CPT-11 plus capecitabine.
    International journal of colorectal disease, 2004, Volume: 19, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Disease-Free Survival; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Treatment Outcome

2004
Reactivation of hepatitis C virus after chemotherapy for colon cancer.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2004, Volume: 16, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma; Colonic Neoplasms; Fluorouracil; Hepatitis C; Humans; Immunocompromised Host; Irinotecan; Leucovorin; Male; Recurrence

2004
Irinotecan chemotherapy associated with transient dysarthria and aphasia.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Volume: 15, Issue:7

    Topics: Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Aphasia; Camptothecin; Colonic Neoplasms; Dysarthria; Fluorouracil; Humans; Infusion Pumps; Irinotecan; Male

2004
Effects of oxaliplatin and CPT-11 on cytotoxicity and nucleic acid incorporation of the fluoropyrimidines.
    Journal of cancer research and clinical oncology, 2004, Volume: 130, Issue:8

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Irinotecan; Nucleic Acids; Organoplatinum Compounds; Oxaliplatin; Uridine

2004
[A case of hepatic metastasis from colon cancer successfully treated with 5-FU, levofolinate (l-LV) and low-dose CPT-11].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:8

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colectomy; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Remission Induction

2004
Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastroph
    Cancer research, 2004, Sep-15, Volume: 64, Issue:18

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Colonic Neoplasms; DNA Damage; DNA Replication; Drug Administration Schedule; Drug Synergism; Enzyme Inhibitors; G2 Phase; HCT116 Cells; Humans; Irinotecan; Microscopy, Fluorescence; Mitosis; S Phase; Staurosporine; Topoisomerase I Inhibitors; Transfection; Tumor Suppressor Protein p53

2004
[A case of metastatic liver tumor from colorectal carcinoma--continued arterial infusion chemotherapy through a microcatheter located in replaced right hepatic artery].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:9

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Catheters, Indwelling; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male

2004
[A case of 5-FU-resistant recurrent colon cancer treated with low-dose CPT-11/CDDP on an outpatient basis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:9

    Topics: Adult; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Fluorouracil; Humans; Irinotecan; Male; Quality of Life

2004
Cytotoxic effect of different camptothecin formulations on human colon carcinoma in vitro.
    Anti-cancer drugs, 2004, Volume: 15, Issue:9

    Topics: Camptothecin; Chemistry, Pharmaceutical; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HT29 Cells; Humans

2004
Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin.
    The Journal of biological chemistry, 2004, Dec-24, Volume: 279, Issue:52

    Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cisplatin; Colonic Neoplasms; Cytarabine; DNA; DNA Adducts; DNA Topoisomerases, Type I; Drug Synergism; Enzyme Inhibitors; Female; Humans; Models, Molecular; Ovarian Neoplasms; Platinum Compounds; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured

2004
Enhanced therapeutic efficacy of a novel liposome-based formulation of SN-38 against human tumor models in SCID mice.
    Anti-cancer drugs, 2004, Volume: 15, Issue:8

    Topics: Animals; Biomedical Enhancement; Camptothecin; Cell Line, Tumor; Clinical Trials, Phase I as Topic; Colonic Neoplasms; Disease Models, Animal; Drug Carriers; Female; HT29 Cells; Humans; Injections, Intravenous; Irinotecan; Liposomes; Mice; Mice, SCID; Technology, Pharmaceutical; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2004
[Successful treatment of liver metastasis and extrahepatic metastasis with hepatic arterial infusion of CDDP, CPT-11, and 5-FU].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:11

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colonic Neoplasms; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Rectal Neoplasms

2004
Functional expression of TWEAK in human colonic adenocarcinoma cells.
    International journal of oncology, 2005, Volume: 26, Issue:1

    Topics: Adenocarcinoma; Antibodies; Apoptosis Regulatory Proteins; Camptothecin; Carrier Proteins; Cell Membrane; Colonic Neoplasms; Culture Media, Conditioned; Cytokine TWEAK; Endothelial Cells; Genes, Reporter; Humans; Luciferases; Neovascularization, Pathologic; NF-kappa B; Receptors, Tumor Necrosis Factor; RNA, Messenger; Tumor Necrosis Factors; TWEAK Receptor

2005
Carcinoembryonic antigen antibody inhibits lung metastasis and augments chemotherapy in a human colonic carcinoma xenograft.
    Cancer immunology, immunotherapy : CII, 2005, Volume: 54, Issue:4

    Topics: Animals; Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Carcinoembryonic Antigen; Carcinoma, Signet Ring Cell; Cell Proliferation; Colonic Neoplasms; Combined Modality Therapy; Complement System Proteins; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Irinotecan; Lung Neoplasms; Mice; Mice, Nude; Survival Rate; Transplantation, Heterologous

2005
Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL.
    Cancer research, 2004, Dec-15, Volume: 64, Issue:24

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Camptothecin; Colonic Neoplasms; Drug Synergism; Female; HCT116 Cells; Humans; Irinotecan; Janus Kinase 2; Liver Neoplasms; Membrane Glycoproteins; Mice; Mice, Nude; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; TNF-Related Apoptosis-Inducing Ligand; Topoisomerase I Inhibitors; Transfection; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; X-Linked Inhibitor of Apoptosis Protein; Xenograft Model Antitumor Assays

2004
Synergistic antitumor activity of capecitabine in combination with irinotecan.
    Clinical colorectal cancer, 2005, Volume: 4, Issue:5

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Irinotecan; Maximum Tolerated Dose; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thiophenes

2005
Importance of preclinical investigations of the integration of capecitabine into polychemotherapy regimens.
    Clinical colorectal cancer, 2005, Volume: 4, Issue:5

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Irinotecan; Maximum Tolerated Dose; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thiophenes

2005
Antitumour activity of XR5944 in vitro and in vivo in combination with 5-fluorouracil and irinotecan in colon cancer cell lines.
    British journal of cancer, 2005, Feb-28, Volume: 92, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; Irinotecan; Mice; Mice, Nude; Phenazines; Transplantation, Heterologous

2005
Inhibitory effects of asiatic acid and CPT-11 on growth of HT-29 cells.
    The journal of medical investigation : JMI, 2005, Volume: 52, Issue:1-2

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase 3; Caspases; Cell Division; Colonic Neoplasms; HT29 Cells; Humans; Irinotecan; Pentacyclic Triterpenes; Triterpenes

2005
Adenoviral vector-mediated expression of a gene encoding secreted, EpCAM-targeted carboxylesterase-2 sensitises colon cancer spheroids to CPT-11.
    British journal of cancer, 2005, Mar-14, Volume: 92, Issue:5

    Topics: Adenoviridae; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylesterase; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genetic Vectors; Humans; Irinotecan; Ovarian Neoplasms

2005
HERG K+ channel expression-related chemosensitivity in cancer cells and its modulation by erythromycin.
    Cancer chemotherapy and pharmacology, 2005, Volume: 56, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Biomarkers; Breast Neoplasms; Camptothecin; Carcinoma; Colonic Neoplasms; Coloring Agents; Drug Interactions; Drug Resistance, Neoplasm; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression Profiling; Humans; Lung Neoplasms; Paclitaxel; Potassium Channels, Voltage-Gated; Tetrazolium Salts; Thiazoles; Transfection; Vincristine

2005
Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model.
    Cancer research, 2005, May-01, Volume: 65, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Growth Processes; Colonic Neoplasms; ErbB Receptors; Growth Substances; HT29 Cells; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Irinotecan; Male; Mice; Mice, Nude; Neoplasm Metastasis; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purines; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Xenograft Model Antitumor Assays

2005
The irinotecan/5-fluorouracil combination induces apoptosis and enhances manganese superoxide dismutase activity in HT-29 human colon carcinoma cells.
    Chemotherapy, 2005, Volume: 51, Issue:2-3

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Colonic Neoplasms; Drug Synergism; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Fluorouracil; HT29 Cells; Humans; Irinotecan; Superoxide Dismutase

2005
Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy.
    The Journal of clinical investigation, 2005, Volume: 115, Issue:6

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Mice; Mice, Nude; Neoplasms, Experimental; Oligonucleotide Array Sequence Analysis; Osteonectin; Transplantation, Heterologous

2005
Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy.
    Methods in molecular medicine, 2005, Volume: 111

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Camptothecin; Cisplatin; Colonic Neoplasms; Cytosine; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Fluorouracil; Green Fluorescent Proteins; Humans; Immunotherapy; Interferons; Liposomes; Liver; Liver Neoplasms; Luminescent Proteins; Lung Neoplasms; Male; Metalloproteases; Mice; Mice, Inbred C57BL; Mice, Nude; Mice, Transgenic; Microscopy, Fluorescence; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Oligonucleotides, Antisense; Pancreatic Neoplasms; Prostatic Neoplasms; Red Fluorescent Protein

2005
[Follicular drug reaction from cetuximab: a common side effect in the treatment of metastatic colon carcinoma].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2006, Volume: 57, Issue:8

    Topics: Anaphylaxis; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Eruptions; Folliculitis; Humans; Infusions, Intravenous; Irinotecan; Liver Neoplasms; Male; Middle Aged; Skin

2006
Relationship between plasma exposure of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite and antitumor response in mice bearing human colon carcinoma xenografts.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jul-01, Volume: 11, Issue:13

    Topics: Animals; Antineoplastic Agents; Area Under Curve; Camptothecin; Cell Line, Tumor; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; HT29 Cells; Humans; Mice; Mice, SCID; Treatment Outcome; Xenograft Model Antitumor Assays

2005
[Second-line chemotherapy with bi-weekly CPT-11 and cisplatin for recurrent colorectal cancer resistant to 5-FU based chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:7

    Topics: Adult; Aged; Alopecia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colonic Neoplasms; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Nausea; Neoplasm Recurrence, Local; Rectal Neoplasms

2005
[Combination chemotherapy with oral TS-1 and low-dose CPT-11 by hepatic arterial infusion for multiple hepatic metastases from colon cancer--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:7

    Topics: Adenocarcinoma; Administration, Oral; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Irinotecan; Liver Neoplasms; Male; Middle Aged; Oxonic Acid; Pyridines; Tegafur

2005
Capecitabine as third line therapy in patients with advanced colorectal cancer.
    Acta oncologica (Stockholm, Sweden), 2005, Volume: 44, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Capecitabine; Carcinoembryonic Antigen; Colonic Neoplasms; Deoxycytidine; Disease Progression; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Prodrugs; Rectal Neoplasms; Retrospective Studies; Survival Rate

2005
Comparison between triple therapy with octreotide, galanin and serotonin vs. irinotecan or oxaliplatin in combination with 5-fluorouracil/leukovorin in human colon cancer.
    International journal of oncology, 2005, Volume: 27, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Body Weight; Camptothecin; Cell Proliferation; Colonic Neoplasms; Epidermal Growth Factor; Female; Fluorouracil; Galanin; Immunohistochemistry; In Situ Nick-End Labeling; Irinotecan; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Octreotide; Organoplatinum Compounds; Oxaliplatin; Platelet Endothelial Cell Adhesion Molecule-1; Poly(ADP-ribose) Polymerases; Serotonin; Time Factors; Treatment Outcome; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2005
Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate.
    Bioorganic & medicinal chemistry, 2005, Oct-01, Volume: 13, Issue:19

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Docosahexaenoic Acids; Drug Design; Drug Screening Assays, Antitumor; Humans; Leukemia L1210; Mice; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship

2005
The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-kappaB.
    Cancer letters, 2005, Nov-18, Volume: 229, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antipyrine; Apoptosis; Blotting, Western; Camptothecin; Caspase 3; Caspases; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Edaravone; Electrophoretic Mobility Shift Assay; Free Radical Scavengers; In Situ Nick-End Labeling; Irinotecan; Lung Neoplasms; Male; Mice; NF-kappa B; Reactive Oxygen Species

2005
Signaling through IFN regulatory factor-5 sensitizes p53-deficient tumors to DNA damage-induced apoptosis and cell death.
    Cancer research, 2005, Aug-15, Volume: 65, Issue:16

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Colonic Neoplasms; DNA Damage; DNA-Binding Proteins; Drug Synergism; HCT116 Cells; Humans; Interferon Regulatory Factors; Interferon-beta; Irinotecan; Phosphorylation; Signal Transduction; Transcription Factors; Transfection; Tumor Suppressor Protein p53

2005
[Assessment of immunotoxicity of irinotecan determined by the novel method, by which productivity of TNF-alpha from whole blood is stimulated by lipopolysaccharide].
    Rinsho byori. The Japanese journal of clinical pathology, 2005, Volume: 53, Issue:7

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Biomarkers; Blood; Camptothecin; Colonic Neoplasms; Female; Humans; Immunologic Tests; Infusions, Intravenous; Irinotecan; Lipopolysaccharides; Male; Middle Aged; Monocytes; Stomach Neoplasms; Tumor Necrosis Factor-alpha

2005
Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor-bearing mice.
    Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:5

    Topics: Animals; Area Under Curve; beta-Cyclodextrins; Camptothecin; Chromatography, High Pressure Liquid; Colonic Neoplasms; Disease Models, Animal; Female; Half-Life; Humans; Injections, Intraperitoneal; Injections, Intravenous; Mice; Mice, Nude; Polymers; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2006
Regression of colorectal adenomas with intravenous cytotoxic chemotherapy in a patient with familial adenomatous polyposis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Sep-01, Volume: 23, Issue:25

    Topics: Adenoma; Adenomatous Polyposis Coli; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Middle Aged; Treatment Outcome

2005
Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth.
    Oncogene, 2006, Jan-12, Volume: 25, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Cell Cycle; Cell Proliferation; Colonic Neoplasms; DNA Damage; Female; Flow Cytometry; Humans; Irinotecan; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Necrosis; Ploidies; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2006
The epidermal growth factor receptor tyrosine kinase inhibitor gefitinib sensitizes colon cancer cells to irinotecan.
    Anti-cancer drugs, 2005, Volume: 16, Issue:10

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Camptothecin; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Cyclin E; DNA Topoisomerases, Type II; DNA-Binding Proteins; Down-Regulation; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Irinotecan; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Signal Transduction

2005
[A case of colon cancer with multiple liver, lung and bone metastases successfully treated with combined weekly high-dose 5-FU (WHF) chemotherapy with UFT and CPT-11].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:10

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Irinotecan; Liver Neoplasms; Lung Neoplasms; Middle Aged; Tegafur; Uracil

2005
Novel fluoro-substituted camptothecins: in vivo antitumor activity, reduced gastrointestinal toxicity and pharmacokinetic characterization.
    Cancer chemotherapy and pharmacology, 2006, Volume: 58, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Female; Gastrointestinal Tract; Humans; Irinotecan; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Mice, Nude; Ovarian Neoplasms; Prodrugs; Rats; Rats, Sprague-Dawley; Tumor Burden; Xenograft Model Antitumor Assays

2006
Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: the inhibition of tumor growth in vivo.
    Journal of controlled release : official journal of the Controlled Release Society, 2005, Dec-10, Volume: 110, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Biological Availability; Camptothecin; Caspase 9; Cell Line, Tumor; Colonic Neoplasms; Female; Green Fluorescent Proteins; Half-Life; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Polyethylene Glycols; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger

2005
Secondary acute promyelocytic leukemia following irinotecan and oxaliplatin for advanced colon cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2006, Volume: 17, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Female; Humans; Irinotecan; Leukemia, Promyelocytic, Acute; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin

2006
[A case of peritoneal dissemination disappeared by CPT-11 + TS-1 combination chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:11

    Topics: Administration, Oral; Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Combinations; Humans; Infusions, Intravenous; Irinotecan; Male; Neoplasm Seeding; Oxonic Acid; Peritoneal Neoplasms; Pyridines; Tegafur

2005
[A case of metastatic colon cancer treated with oxaliplatin combination chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:11

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Floxuridine; Humans; Irinotecan; Liver Neoplasms; Male; Organoplatinum Compounds; Oxaliplatin; Quality of Life

2005
Novel two-step resection for lesions between the middle hepatic vein and vena cava which allows the middle hepatic vein to be preserved.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2006, Volume: 10, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Follow-Up Studies; Hepatectomy; Hepatic Veins; Humans; Irinotecan; Leucovorin; Liver; Liver Neoplasms; Liver Regeneration; Male; Rectal Neoplasms; Vena Cava, Inferior

2006
Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer.
    International journal of cancer, 2006, Jun-01, Volume: 118, Issue:11

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; CpG Islands; Dendritic Cells; Disease Models, Animal; Female; Fluorouracil; Humans; Immunotherapy; Irinotecan; Mice; Mice, Inbred BALB C; Oligonucleotides

2006
DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis.
    The Journal of biological chemistry, 2006, Mar-31, Volume: 281, Issue:13

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Carcinoma; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; Flow Cytometry; Gene Expression Regulation, Neoplastic; HCT116 Cells; HeLa Cells; HT29 Cells; Humans; Irinotecan; Models, Biological; Neoplasm Proteins; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Suppressor Protein p53

2006
Transarterial chemoembolization with degradable starch microspheres, irinotecan, and mitomycin-C in patients with liver metastases.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2006, Volume: 10, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemoembolization, Therapeutic; Colonic Neoplasms; Disease Progression; Hepatic Artery; Humans; Injections, Intra-Arterial; Irinotecan; Liver Neoplasms; Male; Microspheres; Middle Aged; Mitomycin; Rectal Neoplasms; Remission Induction; Starch; Stomach Neoplasms; Topoisomerase I Inhibitors

2006
Irinotecan/5-fluorouracil combination induces alterations in mitochondrial membrane potential and caspases on colon cancer cell lines.
    Oncology research, 2005, Volume: 15, Issue:7-8

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Line, Tumor; Colonic Neoplasms; Fluorouracil; HT29 Cells; Humans; Irinotecan; Membrane Potentials; Mitochondrial Membranes

2005
Expression of drug pathway proteins is independent of tumour type.
    The Journal of pathology, 2006, Volume: 209, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Breast Neoplasms; Camptothecin; Colonic Neoplasms; Cytochrome P-450 Enzyme System; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Irinotecan; Lung Neoplasms; Lymphoma; Male; Melanoma; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Tissue Array Analysis

2006
The antitumor effect of a novel differentiation inducer, 2, 2-Bis (4-(4-amino-3-hydroxyphenoxy) phenyl) adamantane (DPA), in combinatory therapy on human colon cancer.
    International journal of oncology, 2006, Volume: 28, Issue:4

    Topics: Adamantane; Animals; Antineoplastic Combined Chemotherapy Protocols; beta Catenin; Blotting, Western; Cadherins; Camptothecin; Carcinoembryonic Antigen; Catenins; Cell Adhesion Molecules; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Delta Catenin; Dose-Response Relationship, Drug; Drug Synergism; Fibronectins; G1 Phase; HT29 Cells; Humans; Intracellular Signaling Peptides and Proteins; Irinotecan; Male; Mice; Mice, Inbred ICR; Mice, Nude; Phosphoproteins; Resting Phase, Cell Cycle; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2006
Development of a highly active nanoliposomal irinotecan using a novel intraliposomal stabilization strategy.
    Cancer research, 2006, Mar-15, Volume: 66, Issue:6

    Topics: Animals; Breast Neoplasms; Camptothecin; Colonic Neoplasms; Drug Delivery Systems; Drug Stability; Female; HT29 Cells; Humans; Irinotecan; Liposomes; Mice; Mice, Nude; Nanostructures; Rats; Rats, Sprague-Dawley; Xenograft Model Antitumor Assays

2006
Novel missense mutation of the DNA topoisomerase I gene in SN-38-resistant DLD-1 cells.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:3

    Topics: Amino Acid Substitution; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Glycine; Humans; Irinotecan; Mutation, Missense; Protein Conformation; Serine

2006
Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines.
    Journal of gastroenterology, 2006, Volume: 41, Issue:2

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Caco-2 Cells; Camptothecin; Cell Line, Tumor; Cisplatin; Colonic Neoplasms; Cytokines; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; HT29 Cells; Humans; Interferons; Ligands; Mitomycin; Orotate Phosphoribosyltransferase; Paclitaxel; RNA, Messenger; Thymidine Phosphorylase; Thymidylate Synthase

2006
Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer.
    Oncology reports, 2006, Volume: 15, Issue:5

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Camptothecin; Caspase 3; Caspases; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Flow Cytometry; G2 Phase; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2006
Postchemotherapy characteristics of hepatic colorectal metastases: remnants of uncertain malignant potential.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2006, Volume: 10, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; DNA Repair; Follow-Up Studies; Gene Silencing; Hepatectomy; Humans; Irinotecan; Liver; Liver Neoplasms; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; O(6)-Methylguanine-DNA Methyltransferase; Organoplatinum Compounds; Oxaliplatin; Preoperative Care; Rectal Neoplasms; Remission Induction; Retrospective Studies; Topoisomerase I Inhibitors

2006
Enhanced antitumor effect of camptothecin loaded in long-circulating polymeric micelles.
    Journal of controlled release : official journal of the Controlled Release Society, 2006, May-30, Volume: 112, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Blood Circulation Time; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Female; Mice; Micelles; Polymers; Xenograft Model Antitumor Assays

2006
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Jun-06, Volume: 103, Issue:23

    Topics: Aging, Premature; Animals; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; CpG Islands; DNA Helicases; DNA Methylation; Epigenesis, Genetic; Exodeoxyribonucleases; Female; Genes, Tumor Suppressor; Humans; Irinotecan; Mice; Mice, Nude; Promoter Regions, Genetic; RecQ Helicases; RNA, Messenger; Topoisomerase I Inhibitors; Werner Syndrome; Werner Syndrome Helicase

2006
Enrichment of non-synchronized cells in the G1, S and G2 phases of the cell cycle for the study of apoptosis.
    Biochemical pharmacology, 2006, Nov-30, Volume: 72, Issue:11

    Topics: Apoptosis; Bromodeoxyuridine; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; Humans; Interphase; Nitriles; Ploidies; Staurosporine; Sulfones

2006
[Complete response to CPT-11 and UFT/LV combination therapy in a case with simultaneous multiple lung metastases from colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:6

    Topics: Adenocarcinoma; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Humans; Irinotecan; Leucovorin; Leukopenia; Lung Neoplasms; Middle Aged; Neoplasms, Multiple Primary; Neutropenia; Remission Induction; Tegafur; Uracil; Vomiting, Anticipatory

2006
[A patient with hepatic, pulmonary, and nodal metastases of colon cancer responding to CPT-11/TS-1 therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Humans; Irinotecan; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Male; Oxonic Acid; Pyridines; Quality of Life; Tegafur

2006
Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Proliferation; Colonic Neoplasms; Colony-Forming Units Assay; Dacarbazine; Diarrhea; Drug Synergism; Enzyme Inhibitors; Intestinal Diseases; Irinotecan; Organic Chemicals; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide; Topoisomerase I Inhibitors; Tumor Burden

2006
The effects of the oral, pan-VEGF-R kinase inhibitor CEP-7055 and chemotherapy in orthotopic models of glioblastoma and colon carcinoma in mice.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:7

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carbazoles; Carcinoma; Colonic Neoplasms; Dacarbazine; Glioblastoma; Humans; Irinotecan; Mice; Mice, Nude; Neoplasm Metastasis; Receptors, Vascular Endothelial Growth Factor; Temozolomide; Xenograft Model Antitumor Assays

2006
[Multiple hepatic metastases of colon cancer responding to combined therapy with TS-1 and CPT-11--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:8

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Humans; Irinotecan; Liver Neoplasms; Oxonic Acid; Remission Induction; Tegafur

2006
Novel colon-specific microspheres with highly dispersed hydroxycamptothecin cores: their preparation, release behavior, and therapeutic efficiency against colonic cancer.
    Journal of pharmaceutical sciences, 2006, Volume: 95, Issue:12

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Colon; Colonic Neoplasms; Drug Compounding; Drug Delivery Systems; Female; Gastric Juice; Gastric Mucosa; Humans; Intestinal Secretions; Intestine, Small; Kidney; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microspheres; Treatment Outcome; Xenograft Model Antitumor Assays

2006
Molecular characterization of established human colon carcinoma cell lines (HCT-8) made resistant to 5-fluorouracil by different selection schedules.
    Oncology research, 2005, Volume: 16, Issue:3

    Topics: Antineoplastic Agents; Camptothecin; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Oligonucleotide Array Sequence Analysis; Poly A; RNA, Messenger

2005
Highlights from the 42nd Annual Meeting of the American Society of Clinical Oncology, Atlanta, GA, June 2006.
    Clinical colorectal cancer, 2006, Volume: 6, Issue:2

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Clinical Trials, Phase III as Topic; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Gene Expression Profiling; Humans; Leucovorin; Neoplasm Metastasis; Organoplatinum Compounds

2006
[Evaluation of weekly low-dose CPT-11 combined with 5-FU/l-LV therapy for advanced and recurrent colorectal cancer--preliminary study].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:9

    Topics: Aged; Aged, 80 and over; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Leukopenia; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Quality of Life; Rectal Neoplasms

2006
[A case of non-curatively resected colon cancer with liver and lymph node metastases treated by TS-1/CPT-11 combination therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:9

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoembryonic Antigen; Colectomy; Colonic Neoplasms; Drug Administration Schedule; Drug Combinations; Humans; Irinotecan; Liver Neoplasms; Lymph Nodes; Lymphatic Metastasis; Male; Oxonic Acid; Tegafur

2006
Irinotecan cytotoxicity does not necessarily depend on the UGT1A1 polymorphism but on fluoropyrimidine: a molecular case report.
    Oncology reports, 2006, Volume: 16, Issue:5

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Glucuronosyltransferase; Humans; Irinotecan; Polymorphism, Genetic

2006
Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy.
    Cancer research, 2006, Oct-01, Volume: 66, Issue:19

    Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Combined Modality Therapy; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoglobulin G; Immunoglobulin M; Irinotecan; Lymphocytes, Tumor-Infiltrating; Lymphotoxin beta Receptor; Mice; Mice, Inbred BALB C; Mice, Nude; Random Allocation; Recombinant Fusion Proteins; Single-Blind Method; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

2006
Reversible posterior leukoencephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer.
    Archives of neurology, 2006, Volume: 63, Issue:10

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Aphasia; Bevacizumab; Blindness, Cortical; Blood Vessels; Camptothecin; Carcinoma; Cognition Disorders; Colonic Neoplasms; Dementia, Vascular; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Magnetic Resonance Imaging; Male; Middle Aged; Neovascularization, Pathologic; Occipital Lobe; Parietal Lobe; Vascular Endothelial Growth Factor A

2006
Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors.
    Cancer research, 2006, Oct-15, Volume: 66, Issue:20

    Topics: Animals; Camptothecin; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Female; Irinotecan; Lung Neoplasms; Mice; Mice, Inbred BALB C; Micelles; Nanoparticles; Polyethylene Glycols; Polyglutamic Acid; Random Allocation; Tissue Distribution; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2006
Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation with trifluorothymidine.
    European journal of cancer (Oxford, England : 1990), 2007, Volume: 43, Issue:1

    Topics: Antimetabolites; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Camptothecin; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; Drug Synergism; Flow Cytometry; Humans; Irinotecan; Trifluridine

2007
Searching for the Holy Grail of oncology.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2006, Nov-15, Volume: 63, Issue:22

    Topics: Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Diarrhea; Genetic Predisposition to Disease; Glucuronosyltransferase; Humans; Irinotecan; Neutropenia; Pharmacogenetics; Polymorphism, Single Nucleotide; Risk Assessment

2006
Complete response of highly advanced colon cancer with multiple lymph node metastases to irinotecan combined with UFT: report of a case.
    Surgery today, 2006, Volume: 36, Issue:12

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Colonoscopy; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Irinotecan; Lymphatic Metastasis; Middle Aged; Prodrugs; Tegafur; Tomography, X-Ray Computed; Uracil

2006
Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma.
    The American journal of pathology, 2006, Volume: 169, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Camptothecin; Carcinoma; Cecum; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Humans; Imatinib Mesylate; Irinotecan; Liver; Male; Mice; Mice, Nude; Pericytes; Piperazines; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Stromal Cells; Transplantation, Heterologous

2006
Effect of combined therapy with low-dose 5-aza-2'-deoxycytidine and irinotecan on colon cancer cell line HCT-15.
    Annals of surgical oncology, 2007, Volume: 14, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Camptothecin; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Drug Therapy, Combination; Gene Expression Regulation, Neoplastic; Humans; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Irinotecan; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Tumor Suppressor Protein p14ARF

2007
[Experimental study of effect of epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in combination with irinotecan].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2006, Volume: 28, Issue:8

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA Topoisomerases, Type I; Drug Synergism; ErbB Receptors; Gefitinib; HT29 Cells; Humans; Inhibitory Concentration 50; Irinotecan; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction

2006
Short hairpin RNAs targeting Bcl-xL modulate senescence and apoptosis following SN-38 and irinotecan exposure in a colon cancer model.
    Cancer chemotherapy and pharmacology, 2007, Volume: 60, Issue:5

    Topics: Animals; Antimycin A; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-X Protein; Camptothecin; Cell Death; Colonic Neoplasms; Down-Regulation; Doxorubicin; HCT116 Cells; Humans; Irinotecan; Mice; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Transfection; Xenograft Model Antitumor Assays

2007
Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in a colon cancer cell line.
    Journal of gastroenterology, 2006, Volume: 41, Issue:12

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Flow Cytometry; Fluorouracil; Humans; Irinotecan; Tumor Cells, Cultured

2006
[Feasibility of modified FOLFIRI regimen for patients with refractory advanced or recurrent colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:2

    Topics: Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Feasibility Studies; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Infusions, Intravenous; Irinotecan; Leucovorin; Leukopenia; Male; Middle Aged; Neutropenia; Quality of Life; Rectal Neoplasms

2007
[A retrospective study of irinotecan plus fluorouracil and l-leucovorin chemotherapy for advanced and metastatic colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:3

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Rectal Neoplasms; Retrospective Studies

2007
Adjuvant therapy for stage II and III colorectal cancer.
    Seminars in oncology, 2007, Volume: 34, Issue:2 Suppl 1

    Topics: Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Disease-Free Survival; Fluorouracil; Humans; Irinotecan; Leucovorin; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Prodrugs; Rectal Neoplasms; Vitamin B Complex

2007
Developing strategies for liver metastases from colorectal cancer.
    Seminars in oncology, 2007, Volume: 34, Issue:2 Suppl 1

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Catheter Ablation; Chemotherapy, Adjuvant; Colonic Neoplasms; Cryosurgery; Embolization, Therapeutic; Hepatectomy; Humans; Irinotecan; Liver Neoplasms; Neoadjuvant Therapy; Organoplatinum Compounds; Oxaliplatin; Portal Vein; Rectal Neoplasms; Remission Induction; Survival Rate; Time Factors; Topoisomerase I Inhibitors

2007
[Ischemic anastomotic bowel perforation during treatment with bevacizumab 10 months after surgery].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2008, Volume: 79, Issue:4

    Topics: Anastomosis, Surgical; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colectomy; Colitis, Ischemic; Colonic Neoplasms; Female; Fluorouracil; Humans; Ileostomy; Ileum; Intestinal Perforation; Ischemia; Leucovorin; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; Reoperation; Surgical Wound Dehiscence; Tomography, X-Ray Computed

2008
Bevacizumab in the treatment of colorectal cancer.
    Clinical advances in hematology & oncology : H&O, 2007, Volume: 5, Issue:1 Suppl 1

    Topics: Adenocarcinoma; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Lung Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Receptors, Cell Surface; Treatment Outcome

2007
Panitumumab in metastatic colorectal cancer.
    Clinical advances in hematology & oncology : H&O, 2007, Volume: 5, Issue:1 Suppl 1

    Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Epidermal Growth Factor; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Panitumumab

2007
[A case of ascending colon cancer with enlarged metastatic lymph nodes around superior mesenteric arterial root that responded dramatically to S-1 and CPT-11 combination chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colectomy; Colon, Ascending; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Humans; Irinotecan; Lymph Nodes; Lymphatic Metastasis; Male; Mesenteric Artery, Superior; Middle Aged; Oxonic Acid; Remission Induction; Tegafur

2007
Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer.
    Cancer research, 2007, May-15, Volume: 67, Issue:10

    Topics: Adenocarcinoma; Adenosine Triphosphatases; Animals; Antineoplastic Agents, Phytogenic; Brefeldin A; Camptothecin; Cation Transport Proteins; Cell Membrane; CHO Cells; Cisplatin; Colonic Neoplasms; Copper; Copper-Transporting ATPases; Cricetinae; Cricetulus; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Golgi Apparatus; Humans; Irinotecan; Monensin; Transfection

2007
Local and distant immune-mediated control of colon cancer growth with fusogenic membrane glycoproteins in combination with viral oncolysis.
    Human gene therapy, 2007, Volume: 18, Issue:5

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cancer Vaccines; Cell Fusion; Cell Line, Tumor; Colonic Neoplasms; Combined Modality Therapy; Genetic Therapy; Humans; Irinotecan; Measles virus; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oncolytic Virotherapy; T-Lymphocytes, Cytotoxic; Viral Fusion Proteins

2007
Reversible grade 4 hyperbilirubinemia in a patient with UGT1A1 7/7 genotype treated with irinotecan and cetuximab.
    Clinical colorectal cancer, 2007, Volume: 6, Issue:6

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Fluorouracil; Genotype; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Irinotecan; Leucovorin; Liver Neoplasms; Male; Organoplatinum Compounds; Polymorphism, Genetic

2007
Expression and characterization of a human carboxylesterase 2 splice variant.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:1

    Topics: Alternative Splicing; Antineoplastic Agents, Phytogenic; Base Sequence; Camptothecin; Carboxylesterase; Cloning, Molecular; Colon; Colonic Neoplasms; Humans; Irinotecan; Isoenzymes; Molecular Sequence Data; Prodrugs; Reverse Transcriptase Polymerase Chain Reaction; Topoisomerase I Inhibitors

2007
A renewed call for equipoise.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Aug-10, Volume: 25, Issue:23

    Topics: Adenocarcinoma; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Ethics, Medical; Fluorouracil; Humans; Irinotecan; Leucovorin; Leukemia; Randomized Controlled Trials as Topic; Recurrence; Treatment Outcome; Uncertainty

2007
[Efficacy of CPT-11 combined 5-FU/CF (FOLFIRI) regimen on advanced colorectal cancer].
    Ai zheng = Aizheng = Chinese journal of cancer, 2007, Volume: 26, Issue:8

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Diarrhea; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Nausea; Neoplasm Staging; Neutropenia; Rectal Neoplasms; Remission Induction; Retrospective Studies; Survival Rate; Young Adult

2007
Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in p53 mutant human colon cancer.
    Journal of experimental & clinical cancer research : CR, 2007, Volume: 26, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Gene Expression; Gene Expression Profiling; Humans; Irinotecan; Leucovorin; Mutation; Oligonucleotide Array Sequence Analysis; Tumor Cells, Cultured; Up-Regulation

2007
Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:9

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Adhesion; Cell Line, Tumor; Collagen Type II; Colonic Neoplasms; Female; Fibronectins; Floxuridine; Fluorouracil; Humans; Irinotecan; Laminin; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Nude; Models, Biological; Neoplasm Metastasis; Paclitaxel

2007
Report of an autopsy case of colon cancer with amyotrophic lateral sclerosis.
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2007, Volume: 104, Issue:9

    Topics: Adenocarcinoma; Amyotrophic Lateral Sclerosis; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged

2007
Effect of betulinic acid on anticancer drug-resistant colon cancer cells.
    Basic & clinical pharmacology & toxicology, 2007, Volume: 101, Issue:4

    Topics: Adenocarcinoma; Antineoplastic Agents; bcl-2-Associated X Protein; bcl-Associated Death Protein; Betulinic Acid; Camptothecin; Caspases; Cell Death; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Humans; Irinotecan; Mitochondria; Multidrug Resistance-Associated Proteins; Organoplatinum Compounds; Oxaliplatin; Pentacyclic Triterpenes; Triterpenes

2007
Therapy of colon carcinoma: an oncology perspective. Interview with Piotr M. Czaykowski by Paul C. Adams.
    Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2007, Volume: 21, Issue:8

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Carcinoembryonic Antigen; Carcinoma; Colonic Neoplasms; Combined Modality Therapy; Fluorouracil; Humans; Irinotecan; Quinazolines; Rectal Neoplasms; Thiophenes

2007
Survival after radiofrequency ablation of colorectal liver metastases: 10-year experience.
    Annals of surgery, 2007, Volume: 246, Issue:4

    Topics: Adenocarcinoma; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Carcinoembryonic Antigen; Catheter Ablation; Chemotherapy, Adjuvant; Cohort Studies; Colonic Neoplasms; Female; Fluorouracil; Follow-Up Studies; Humans; Laparoscopy; Leucovorin; Liver Neoplasms; Longitudinal Studies; Male; Middle Aged; Organoplatinum Compounds; Prospective Studies; Rectal Neoplasms; Risk Factors; Survival Rate; Treatment Outcome; Vitamin B Complex

2007
Investigation of two dosing schedules of vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, in combination with irinotecan in a human colon cancer xenograft model.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Nov-01, Volume: 13, Issue:21

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Administration Schedule; ErbB Receptors; Female; Humans; Irinotecan; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Piperidines; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Treatment Outcome

2007
[Systemic treatment of peritoneal metastases].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2007, Volume: 78, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Combined Modality Therapy; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, Intravenous; Irinotecan; Leucovorin; Neoplasm Staging; Peritoneal Neoplasms; Prognosis; Quality of Life

2007
Nutritional modulation of antitumor efficacy and diarrhea toxicity related to irinotecan chemotherapy in rats bearing the ward colon tumor.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Dec-01, Volume: 13, Issue:23

    Topics: Animals; Camptothecin; Colonic Neoplasms; Diarrhea; Diet; Fatty Acids, Omega-3; Female; Food-Drug Interactions; Glutamine; Irinotecan; Oligosaccharides; Probiotics; Rats

2007
Comparative cytotoxicity of C-1311 in colon cancer in vitro and in vivo using the hollow fiber assay.
    Journal of chemotherapy (Florence, Italy), 2007, Volume: 19, Issue:5

    Topics: Aminoacridines; Animals; Antineoplastic Agents; Camptothecin; Capecitabine; Cell Line, Tumor; Cell Proliferation; Clinical Trials, Phase II as Topic; Colonic Neoplasms; Deoxycytidine; Drug Screening Assays, Antitumor; Fluorouracil; HT29 Cells; Humans; In Vitro Techniques; Irinotecan; Mice; Mice, Nude; Organoplatinum Compounds; Oxaliplatin; Paclitaxel

2007
Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice.
    Neoplasia (New York, N.Y.), 2007, Volume: 9, Issue:12

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cecal Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Endothelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Irinotecan; Male; Mice; Mice, Nude; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Purines; Signal Transduction; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2007
Semi-mechanistic description of the in-vitro antiproliferative effect of different antitumour agents.
    The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:1

    Topics: Algorithms; Animals; Antineoplastic Agents; Camptothecin; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Inhibitory Concentration 50; Rats; Signal Transduction; Time Factors; Topotecan

2008
Pharmacological targeting of NF-kappaB potentiates the effect of the topoisomerase inhibitor CPT-11 on colon cancer cells.
    British journal of cancer, 2008, Jan-29, Volume: 98, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Synergism; Female; HT29 Cells; Humans; I-kappa B Kinase; Irinotecan; Mice; Mice, Nude; NF-kappa B; Protein Kinase Inhibitors; Pyrimidines; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2008
[An elderly case of recurrent colon cancer responding to weekly S-1 chemotherapy leading to partial response].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2008, Volume: 35, Issue:1

    Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Combinations; Female; Humans; Irinotecan; Lung Neoplasms; Neoplasm Recurrence, Local; Oxonic Acid; Tegafur; Tomography, X-Ray Computed; Treatment Failure

2008
A case of late-onset severe cardiotoxicity from 5-fluorouracil therapy resulting in death.
    The New Zealand medical journal, 2007, Nov-30, Volume: 120, Issue:1266

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fatal Outcome; Fluorouracil; Heart Arrest; Humans; Leucovorin; Male

2007
Altered expression of cell proliferation-related and interferon-stimulated genes in colon cancer cells resistant to SN38.
    Cancer biology & therapy, 2008, Volume: 7, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; Interferons; Irinotecan; Oligonucleotide Array Sequence Analysis; Time Factors

2008
[A long survival case of advanced colon cancer with lung metastasis and cancerous pleuritis responding to CPT-11 and S-1 combination therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2008, Volume: 35, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Combinations; Humans; Irinotecan; Lung Neoplasms; Male; Neoplasm Staging; Oxonic Acid; Pleurisy; Positron-Emission Tomography; Tegafur; Time Factors; Tomography, X-Ray Computed

2008
Bolus oral glutamine protects rats against CPT-11-induced diarrhea and differentially activates cytoprotective mechanisms in host intestine but not tumor.
    The Journal of nutrition, 2008, Volume: 138, Issue:4

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Camptothecin; Colon; Colonic Neoplasms; Cytoprotection; Diarrhea; Female; Glutamine; Irinotecan; Neoplasms, Experimental; Rats

2008
The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner.
    Cancer research, 2008, Apr-01, Volume: 68, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Colonic Neoplasms; Cyclin-Dependent Kinase 9; Down-Regulation; Drug Synergism; Flavonoids; HCT116 Cells; Humans; Irinotecan; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Rad51 Recombinase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Topoisomerase I Inhibitors; Tumor Suppressor Protein p53

2008
Treatment of human colon cancer xenografts with TRA-8 anti-death receptor 5 antibody alone or in combination with CPT-11.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Apr-01, Volume: 14, Issue:7

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Antibody Technique; Humans; Irinotecan; Mice; Mice, Nude; Receptors, TNF-Related Apoptosis-Inducing Ligand; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Xenograft Model Antitumor Assays

2008
[Multiple hepatic metastases and ovarian metastases of colon cancer responding to combined therapy with S-1 and CPT-11--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2008, Volume: 35, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Combinations; Female; Humans; Irinotecan; Liver Neoplasms; Middle Aged; Ovarian Neoplasms; Oxonic Acid; Tegafur; Tomography, X-Ray Computed

2008
Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect.
    BMC biotechnology, 2008, May-04, Volume: 8

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Diffusion; Drug Carriers; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Particle Size; Rabbits; Treatment Outcome

2008
Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors.
    Neoplasia (New York, N.Y.), 2008, Volume: 10, Issue:5

    Topics: Animals; Apoptosis; Blotting, Western; Camptothecin; Cecum; Cell Proliferation; Colonic Neoplasms; Drug Therapy, Combination; Endothelial Cells; Enzyme Inhibitors; ErbB Receptors; Humans; Immunoenzyme Techniques; In Situ Nick-End Labeling; Irinotecan; Lymphatic Metastasis; Male; Mice; Mice, Nude; Necrosis; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, ErbB-2; RNA, Small Interfering; Topoisomerase I Inhibitors; Transforming Growth Factor alpha

2008
Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential.
    Oncology reports, 2008, Volume: 19, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Camptothecin; Cell Proliferation; Colonic Neoplasms; DNA Topoisomerases, Type I; Flow Cytometry; G2 Phase; Humans; Immunoenzyme Techniques; Inhibitor of Apoptosis Proteins; Irinotecan; Microtubule-Associated Proteins; Neoplasm Proteins; S Phase; Survivin; Topoisomerase I Inhibitors; Tumor Cells, Cultured

2008
Recombinant human insulin-like growth factor-binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2008, Volume: 18, Issue:6

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carboplatin; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Down-Regulation; Drug Synergism; Female; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Proteins; Irinotecan; Lung Neoplasms; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Signal Transduction; Transplantation, Heterologous

2008
Clinical trials referral resource. Clinical trials with 9-aminocamptothecin.
    Oncology (Williston Park, N.Y.), 1995, Volume: 9, Issue:8

    Topics: Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Colonic Neoplasms; Humans; Lung Neoplasms; Lymphoma; Neutropenia

1995
Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors.
    Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:5

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Colonic Neoplasms; Female; Humans; Irinotecan; Mice; Mice, Inbred CBA; Neoplasms, Experimental; Random Allocation; Rhabdomyosarcoma; Topoisomerase I Inhibitors; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured

1995
Chemotherapy-induced nuclear alterations of morphologic and genomic characteristics in a human colon cancer grafted onto nude mice.
    Diseases of the colon and rectum, 1995, Volume: 38, Issue:8

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Camptothecin; Cell Nucleus; Chromatin; Colonic Neoplasms; DNA, Neoplasm; Doxorubicin; Female; Fluorouracil; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, APC; Genes, p53; Genes, ras; Genome, Human; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Ploidies; Transplantation, Heterologous

1995
[A model for sensitivity determination of anticancer agents against chemical-induced colon cancer in rats].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:10

    Topics: Animals; Camptothecin; Cell Division; Cisplatin; Colonic Neoplasms; Dimethylhydrazines; Drug Screening Assays, Antitumor; Irinotecan; Male; Rats; Rats, Sprague-Dawley

1995
Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen.
    Cancer research, 1995, May-15, Volume: 55, Issue:10

    Topics: Camptothecin; Cell Cycle; Cell Division; Colonic Neoplasms; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; RNA, Messenger; Time Factors; Tumor Cells, Cultured

1995
Identification and kinetics of a beta-glucuronide metabolite of SN-38 in human plasma after administration of the camptothecin derivative irinotecan.
    Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Biotransformation; Camptothecin; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Glucuronates; Glucuronidase; Humans; Irinotecan; Middle Aged; Time Factors

1995
Establishment and characterization of human gastric and colonic xenograft lines resistant to CPT-11 (a new derivative of camptothecin).
    Journal of surgical oncology, 1995, Volume: 59, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; Colonic Neoplasms; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance; Humans; Irinotecan; Male; Mice; Mice, Nude; Stomach Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured

1995
In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues.
    Cancer research, 1995, Feb-01, Volume: 55, Issue:3

    Topics: Animals; Antineoplastic Agents; Body Weight; Camptothecin; Cattle; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Drug Screening Assays, Antitumor; Female; Humans; Mice; Mice, Nude; Thymus Gland; Topoisomerase I Inhibitors; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured

1995
Different modes of cell-killing action between DNA topoisomerase I and II inhibitors revealed by kinetic analysis.
    Japanese journal of cancer research : Gann, 1994, Volume: 85, Issue:2

    Topics: Amsacrine; Antineoplastic Agents; Camptothecin; Carbazoles; Cell Cycle; Colonic Neoplasms; Diterpenes; DNA Replication; Dose-Response Relationship, Drug; Etoposide; Flow Cytometry; G2 Phase; Humans; Indoles; Mitosis; Quinones; S Phase; Teniposide; Time Factors; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Stem Cell Assay

1994
[Antitumor effect of camptothecin analog on liver metastatic model of human colon cancer in nude mice].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; Colonic Neoplasms; Female; Humans; Irinotecan; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Tumor Cells, Cultured

1994
Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials.
    Journal of the National Cancer Institute, 1994, Jun-01, Volume: 86, Issue:11

    Topics: Camptothecin; Carcinoma; Clinical Trials as Topic; Colonic Neoplasms; DNA, Neoplasm; Humans; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1994
New perspectives in colon cancer chemotherapy.
    Diseases of the colon and rectum, 1994, Volume: 37, Issue:2 Suppl

    Topics: Animals; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation

1994
Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor
    Cancer research, 1993, Jun-15, Volume: 53, Issue:12

    Topics: Adolescent; Adult; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Child; Colonic Neoplasms; Drug Administration Schedule; Drug Resistance; Drug Screening Assays, Antitumor; Female; Humans; Irinotecan; Male; Melphalan; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Rhabdomyosarcoma; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured; Vincristine

1993
Water soluble inhibitors of topoisomerase I: quaternary salt derivatives of camptothecin.
    Journal of medicinal chemistry, 1996, Feb-02, Volume: 39, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Female; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Nude; Ovarian Neoplasms; Solubility; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Water

1996
Irinotecan is an active agent in untreated patients with metastatic colorectal cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Diarrhea; Drug Administration Schedule; Female; Humans; Irinotecan; Liver; Lung; Male; Middle Aged; Neutropenia; Rectal Neoplasms; Remission Induction; Survival Analysis

1996
Rapid tumour lysis syndrome in a metastatic colorectal cancer increased by treatment (CPT-11)
    European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A, Issue:4

    Topics: Adenocarcinoma; Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Fatal Outcome; Female; Humans; Irinotecan; Tumor Lysis Syndrome

1996
Variation in topoisomerase I gene copy number as a mechanism for intrinsic drug sensitivity.
    British journal of cancer, 1996, Volume: 74, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Line; Cell Survival; Colonic Neoplasms; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Female; Gene Amplification; Gene Expression; Genetic Variation; Humans; In Situ Hybridization, Fluorescence; Irinotecan; Karyotyping; Kinetics; Nuclear Proteins; Tumor Cells, Cultured

1996
Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells.
    Cancer research, 1996, Oct-01, Volume: 56, Issue:19

    Topics: Antineoplastic Agents, Phytogenic; Aphidicolin; Camptothecin; Carcinoma; CDC2 Protein Kinase; Colonic Neoplasms; Cyclins; DNA Damage; DNA Repair; DNA Replication; Enzyme Inhibitors; G2 Phase; Humans; S Phase; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1996
Local delivery of chemotherapy and concurrent external beam radiotherapy prolongs survival in metastatic brain tumor models.
    Cancer research, 1996, Nov-15, Volume: 56, Issue:22

    Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Camptothecin; Carboplatin; Carcinoma; Carcinoma, Lewis Lung; Carmustine; Colonic Neoplasms; Combined Modality Therapy; Female; Humans; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Polymers; Radiotherapy Dosage; Tumor Cells, Cultured

1996
Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines.
    Oncology research, 1996, Volume: 8, Issue:7-8

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Camptothecin; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; DNA Fragmentation; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Resistance, Neoplasm; Enzyme Induction; Enzyme Inhibitors; GADD45 Proteins; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Intracellular Signaling Peptides and Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Protein Biosynthesis; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Topoisomerase I Inhibitors; Transcriptional Activation; Tumor Cells, Cultured

1996
Influence of route of administration on [3H]-camptothecin distribution and tumor uptake in CASE-bearing nude mice: whole-body autoradiographic studies.
    Cancer chemotherapy and pharmacology, 1996, Volume: 39, Issue:1-2

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Autoradiography; Camptothecin; Colonic Neoplasms; Humans; Injections, Intramuscular; Injections, Intravenous; Mice; Mice, Nude; Tissue Distribution

1996
[Caring for patients treated with Campto (CPT-11)].
    Soins; la revue de reference infirmiere, 1996, Issue:610

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials, Phase II as Topic; Colonic Neoplasms; Drug Monitoring; Humans; Irinotecan; Nursing Records

1996
Interferon potentiates antiproliferative activity of CPT-11 against human colon cancer xenografts.
    Cancer letters, 1996, Dec-20, Volume: 110, Issue:1-2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; Colonic Neoplasms; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Interferon-alpha; Interferon-beta; Interferon-gamma; Irinotecan; Mice; Mice, Inbred BALB C; Mice, Nude; Recombinant Proteins; Transplantation, Heterologous; Tumor Cells, Cultured

1996
CPT-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants.
    International journal of cancer, 1997, Jan-27, Volume: 70, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Colonic Neoplasms; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Female; Humans; Irinotecan; Mice; Mice, Nude; Transplantation, Heterologous; Tumor Cells, Cultured

1997
The multidrug resistance-associated protein gene confers drug resistance in human gastric and colon cancers.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:12

    Topics: Antineoplastic Agents; Camptothecin; Cisplatin; Colonic Neoplasms; Doxorubicin; Etoposide; Genes, MDR; Humans; Irinotecan; Mitomycin; Polymerase Chain Reaction; RNA, Messenger; Stomach Neoplasms; Tumor Cells, Cultured; Verapamil; Vincristine

1996
Topotecan increases topoisomerase IIalpha levels and sensitivity to treatment with etoposide in schedule-dependent process.
    Cancer research, 1997, Apr-15, Volume: 57, Issue:8

    Topics: Animals; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Enzyme Induction; Etoposide; Female; Humans; Isoenzymes; Mice; Mice, Nude; Neoplasm Proteins; Topoisomerase II Inhibitors; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured; Up-Regulation

1997
SN-38, a metabolite of the camptothecin derivative CPT-11, potentiates the cytotoxic effect of radiation in human colon adenocarcinoma cells grown as spheroids.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1997, Volume: 43, Issue:2

    Topics: Adenocarcinoma; Camptothecin; Cell Survival; Colonic Neoplasms; Humans; Irinotecan; Radiation Dosage; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Cells, Cultured

1997
Novel 7-alkyl methylenedioxy-camptothecin derivatives exhibit increased cytotoxicity and induce persistent cleavable complexes both with purified mammalian topoisomerase I and in human colon carcinoma SW620 cells.
    Molecular pharmacology, 1997, Volume: 52, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Aphidicolin; Base Sequence; Camptothecin; Colonic Neoplasms; DNA Damage; DNA Topoisomerases, Type I; Humans; Molecular Sequence Data; Structure-Activity Relationship; Tumor Cells, Cultured

1997
[A case of recurrent advanced colon cancer treated with CPT-11 for second-line chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:10

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoembryonic Antigen; Cisplatin; Colonic Neoplasms; Drug Resistance, Neoplasm; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local; Remission Induction

1997
In vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells.
    Nucleic acids research, 1997, Oct-15, Volume: 25, Issue:20

    Topics: Antineoplastic Agents, Phytogenic; Base Sequence; Binding Sites; Camptothecin; Colonic Neoplasms; DNA Damage; DNA Topoisomerases, Type I; DNA, Neoplasm; DNA, Ribosomal; Enzyme Inhibitors; Humans; Molecular Sequence Data; Polymerase Chain Reaction; RNA, Ribosomal, 18S; Sequence Analysis, DNA; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1997
Irinotecan hydrochloride (CPT-11) resistance identified by K-ras mutation in patients with progressive colon cancer after treatment with 5-fluorouracil (5-FU).
    American journal of clinical oncology, 1997, Volume: 20, Issue:5

    Topics: Adenine; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Codon; Colonic Neoplasms; Disease Progression; DNA, Neoplasm; Drug Resistance, Neoplasm; Exons; Female; Fluorouracil; Forecasting; Genes, ras; Guanine; Humans; Irinotecan; Male; Middle Aged; Mutation; Prognosis; Retreatment; Sequence Analysis, DNA; Survival Rate; Thymine; Treatment Failure

1997
Antitumor activity of a novel quinoline derivative, TAS-103, with inhibitory effects on topoisomerases I and II.
    Japanese journal of cancer research : Gann, 1997, Volume: 88, Issue:10

    Topics: Adenocarcinoma; Aminoquinolines; Animals; Antineoplastic Agents; Camptothecin; Cisplatin; Colonic Neoplasms; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Etoposide; Humans; Indenes; Indoles; Irinotecan; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Pyridines; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1997
Studies of the efficacy and pharmacology of irinotecan against human colon tumor xenograft models.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:3

    Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; Colonic Neoplasms; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Humans; Injections, Intravenous; Irinotecan; Metabolic Clearance Rate; Mice; Mice, Inbred CBA; Models, Biological; Neoplasm Transplantation; Thymectomy; Transplantation, Heterologous

1998
Schedule-dependent synergism between raltitrexed and irinotecan in human colon cancer cells in vitro.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Humans; Irinotecan; Quinazolines; Thiophenes; Tumor Cells, Cultured

1998
Irinotecan-induced immune thrombocytopenia.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1998, Volume: 9, Issue:4

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Immunoglobulin G; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Thrombocytopenia

1998
Comparison of the pharmacokinetics and efficacy of irinotecan after administration by the intravenous versus intraperitoneal route in mice.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Female; Injections, Intraperitoneal; Injections, Intravenous; Irinotecan; Mice; Mice, Inbred BALB C

1998
Colon cancer: new drug options improve on 5-FU.
    Journal of the National Cancer Institute, 1998, Jul-01, Volume: 90, Issue:13

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Survival Analysis; Tegafur; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome

1998
Potent and broad antitumor effects of DX-8951f, a water-soluble camptothecin derivative, against various human tumors xenografted in nude mice.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Colonic Neoplasms; Humans; Irinotecan; Kidney Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Stomach Neoplasms; Subrenal Capsule Assay; Tumor Cells, Cultured

1998
Prevention of intestinal toxic effects and intensification of irinotecan's therapeutic efficacy against murine colon cancer liver metastases by oral administration of the lipopeptide JBT 3002.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:9

    Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Drug Synergism; Intestinal Diseases; Irinotecan; Lipopeptides; Lipoproteins; Liver Neoplasms, Experimental; Macrophage Activation; Macrophages; Mice; Mice, Inbred BALB C

1998
Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:9

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Colonic Neoplasms; DNA Damage; DNA Fragmentation; DNA, Neoplasm; Enzyme Inhibitors; Estrogens; Female; Flow Cytometry; G1 Phase; Genes, p53; Humans; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nocodazole; Oncogene Proteins, Viral; Recombinant Fusion Proteins; Repressor Proteins; Topoisomerase I Inhibitors; Transfection; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tumor Suppressor Protein p53

1997
Evaluation of irinotecan in combination with 5-fluorouracil or etoposide in xenograft models of colon adenocarcinoma and rhabdomyosarcoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:1

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Etoposide; Female; Fluorouracil; Humans; Irinotecan; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Rhabdomyosarcoma; Transplantation, Heterologous

1996
Irinotecan (CPT-11) metabolites in human bile and urine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:12

    Topics: Antineoplastic Agents, Phytogenic; Bile; Camptothecin; Colonic Neoplasms; Female; Humans; Irinotecan; Liver Neoplasms; Mass Spectrometry; Middle Aged; Neoplasm Metastasis

1996
Combination of irinotecan (CPT11) and 5-fluorouracil with an analysis of cellular determinants of drug activity.
    Biochemical pharmacology, 1998, Nov-15, Volume: 56, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Screening Assays, Antitumor; Flow Cytometry; Fluorouracil; Humans; Irinotecan; Tumor Cells, Cultured

1998
Bradycardia induced by irinotecan: a case report.
    Japanese journal of clinical oncology, 1998, Volume: 28, Issue:11

    Topics: Aged; Antineoplastic Agents, Phytogenic; Bradycardia; Camptothecin; Cholinergic Agents; Colonic Neoplasms; Diarrhea; Electrocardiography; Humans; Irinotecan; Male

1998
Encapsulation of the topoisomerase I inhibitor GL147211C in pegylated (STEALTH) liposomes: pharmacokinetics and antitumor activity in HT29 colon tumor xenografts.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:12

    Topics: Animals; Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Drug Carriers; Drug Screening Assays, Antitumor; Enzyme Inhibitors; HT29 Cells; Humans; Liposomes; Male; Mice; Mice, Nude; Neoplasm Transplantation; Rats; Rats, Sprague-Dawley; Topoisomerase I Inhibitors; Transplantation, Heterologous; Treatment Outcome

1998
Diffuse mucosal damage in the large intestine associated with Irinotecan (CPT-11).
    Digestive diseases and sciences, 1998, Volume: 43, Issue:12

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Camptothecin; Colon; Colonic Neoplasms; Fatal Outcome; Humans; Intestinal Mucosa; Irinotecan; Liver Neoplasms; Male; Middle Aged

1998
Enhanced antitumor activity of 6-hydroxymethylacylfulvene in combination with irinotecan and 5-fluorouracil in the HT29 human colon tumor xenograft model.
    Cancer research, 1999, Mar-01, Volume: 59, Issue:5

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; HT29 Cells; Humans; Irinotecan; Mice; Mice, Nude; Neoplasm Transplantation; Sesquiterpenes; Transplantation, Heterologous

1999
Detection of poly(ADP-ribose) polymerase cleavage in response to treatment with topoisomerase I inhibitors: a potential surrogate end point to assess treatment effectiveness.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Biopsy; Camptothecin; Caspases; Cell Division; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Irinotecan; Mice; Mice, Nude; Neoplasm Transplantation; Poly(ADP-ribose) Polymerases; Time Factors; Topoisomerase I Inhibitors; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured

1999
Cellular pharmacology of the combination of the DNA topoisomerase I inhibitor SN-38 and the diaminocyclohexane platinum derivative oxaliplatin.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:5

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Cell Cycle; Colonic Neoplasms; Cross-Linking Reagents; DNA Adducts; DNA Damage; DNA, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Mammary Neoplasms, Experimental; Nucleic Acid Synthesis Inhibitors; Organoplatinum Compounds; Oxaliplatin; RNA, Neoplasm; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1999
Synergistic cytotoxicity, apoptosis and protein-linked DNA breakage by etoposide and camptothecin in human U87 glioma cells: dependence on tyrosine phosphorylation.
    Journal of neuro-oncology, 1999, Volume: 41, Issue:3

    Topics: Brain Neoplasms; Camptothecin; Cell Survival; Colonic Neoplasms; DNA Damage; Drug Synergism; Etoposide; Glioblastoma; Glioma; Humans; Mitotic Index; Phosphotyrosine; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1999
CPT-11 converting carboxylesterase and topoisomerase activities in tumour and normal colon and liver tissues.
    British journal of cancer, 1999, Volume: 80, Issue:3-4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylic Ester Hydrolases; Colon; Colonic Neoplasms; DNA Topoisomerases, Type I; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Irinotecan; Liver; Liver Neoplasms; Male; Middle Aged; Rectal Neoplasms; Topoisomerase I Inhibitors

1999
FDG PET evaluation of residual masses and regrowth of abdominal lymph node metastases from colon cancer compared with CT during chemotherapy.
    Clinical nuclear medicine, 1999, Volume: 24, Issue:4

    Topics: Abdominal Neoplasms; Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colectomy; Colonic Neoplasms; Fluorodeoxyglucose F18; Fluorouracil; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Radionuclide Imaging; Radiopharmaceuticals; Remission Induction; Tomography, X-Ray Computed

1999
Characterisation of a synergistic interaction between a thymidylate synthase inhibitor, ZD1694, and a novel lipophilic topoisomerase I inhibitor karenitecin, BNP1100: mechanisms and clinical implications.
    European journal of cancer (Oxford, England : 1990), 1999, Volume: 35, Issue:6

    Topics: Antimetabolites, Antineoplastic; Camptothecin; Cell Division; Cell Survival; Colonic Neoplasms; DNA Damage; Drug Synergism; Enzyme Inhibitors; Humans; Quinazolines; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1999
[Experimental study on intraperitoneal and intravenous administration of anti-tumor agents for liver metastasis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:12

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cisplatin; Colonic Neoplasms; Fluorouracil; Infusions, Intravenous; Infusions, Parenteral; Irinotecan; Liver Neoplasms; Mice; Mice, Inbred BALB C; Tumor Cells, Cultured

1999
Irinotecan combined with bolus fluorouracil, continuous infusion fluorouracil, and high-dose leucovorin every two weeks (LV5FU2 regimen): a clinical dose-finding and pharmacokinetic study in patients with pretreated metastatic colorectal cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:9

    Topics: Adult; Aged; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Diarrhea; Drug Administration Schedule; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neutropenia; Rectal Neoplasms

1999
Schedule-dependent cytotoxicity of SN-38 in p53 wild-type and mutant colon adenocarcinoma cell lines.
    British journal of cancer, 1999, Volume: 81, Issue:8

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Cycle; Colonic Neoplasms; DNA Topoisomerases, Type I; Flow Cytometry; Humans; Irinotecan; Mutation; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1999
Tumor necrosis factor-related apoptosis-inducing ligand's antitumor activity in vivo is enhanced by the chemotherapeutic agent CPT-11.
    Cancer research, 1999, Dec-15, Volume: 59, Issue:24

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Colonic Neoplasms; Disease Models, Animal; Drug Screening Assays, Antitumor; Drug Synergism; Female; HT29 Cells; Humans; Irinotecan; Membrane Glycoproteins; Mice; Mice, SCID; Neoplasm Transplantation; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha

1999
Glutamine for irinotecan diarrhea.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:2

    Topics: Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Diarrhea; Female; Glutamine; Humans; Irinotecan; Male; Middle Aged; Rectal Neoplasms

2000
In vitro augmentation of antitumor effect in combination with CPT-11 and CDDP for human colorectal cancer.
    Journal of surgical oncology, 2000, Volume: 73, Issue:1

    Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colonic Neoplasms; Coloring Agents; Drug Synergism; Female; Humans; Irinotecan; Male; Middle Aged; Mitomycin; Rectal Neoplasms; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured

2000
Sequence-dependent growth inhibition and DNA damage formation by the irinotecan-5-fluorouracil combination in human colon carcinoma cell lines.
    European journal of cancer (Oxford, England : 1990), 1999, Volume: 35, Issue:13

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Division; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Fluorouracil; Humans; Irinotecan; Tumor Cells, Cultured

1999
Altered pharmacokinetics and metabolism of CPT-11 in liver dysfunction: a need for guidelines.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; Colonic Neoplasms; Female; Fever; Humans; Infusions, Intravenous; Irinotecan; Liver Diseases; Metabolic Clearance Rate; Middle Aged; Practice Guidelines as Topic; Sleep

2000
Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:4

    Topics: Antineoplastic Agents; Biopsy; Camptothecin; Cell Division; Colon; Colonic Neoplasms; Culture Techniques; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Etoposide; Humans; Irinotecan; Thymidine; Topoisomerase I Inhibitors; Topotecan; Tritium; Tumor Cells, Cultured

2000
Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase.
    Cancer gene therapy, 2000, Volume: 7, Issue:4

    Topics: Alkaloids; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-X Protein; Butyrates; Camptothecin; Caspase 3; Caspases; Cell Survival; Colonic Neoplasms; Drug Interactions; Ganciclovir; Humans; Membrane Proteins; Paclitaxel; Peptide Hydrolases; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Simplexvirus; Staurosporine; Thymidine Kinase; Transfection; Tumor Cells, Cultured

2000
Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells.
    Cancer research, 2000, Jul-15, Volume: 60, Issue:14

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-X Protein; Camptothecin; Cell Cycle; Cell Differentiation; Cell Division; Cells, Cultured; Colon; Colonic Neoplasms; Cyclin B; Cyclin E; Cyclooxygenase 2; Diet; Dose-Response Relationship, Drug; Flavonoids; HT29 Cells; Humans; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred C57BL; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Cells, Cultured

2000
[A case of metastatic colon carcinoma in which a continuous intrahepatic artery-infusion of 5-FU leucovorin and cisplatin, and systemic chemotherapy with CPT-11 was very effective].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:9

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged

2000
Characterization of CPT-11 converting carboxylesterase activity in colon tumor and normal tissues: comparison with p-nitro-phenylacetate converting carboxylesterase activity.
    Anti-cancer drugs, 2000, Volume: 11, Issue:6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylic Ester Hydrolases; Colon; Colonic Neoplasms; DNA Topoisomerases, Type I; Enzyme Activation; Enzyme Inhibitors; Humans; Irinotecan; Kinetics; Liver; Nitrophenols; Rats; Substrate Specificity; Topoisomerase I Inhibitors

2000
New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer.
    International journal of cancer, 2000, Oct-15, Volume: 88, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Colonic Neoplasms; Doxorubicin; Drug Resistance, Multiple; Enzyme Inhibitors; Female; Humans; Irinotecan; Lung Neoplasms; Melanoma; Mice; Mice, Nude; Neoplasms; Ovarian Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2000
[Response of metastatic colorectal cancers to treatment with CPT11 (irinotecan): implications of the mismatched base repair system].
    Gastroenterologie clinique et biologique, 2000, Volume: 24, Issue:10

    Topics: Adaptor Proteins, Signal Transducing; Adult; Antineoplastic Agents, Phytogenic; Base Pair Mismatch; Camptothecin; Carrier Proteins; Colonic Neoplasms; DNA Repair; DNA-Binding Proteins; Humans; Irinotecan; Microsatellite Repeats; Middle Aged; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; Proto-Oncogene Proteins; Rectal Neoplasms; Retrospective Studies

2000
Double cancer (lung and colon cancer) that showed complete remission with irinotecan and cisplatin combined chemotherapy.
    Journal of gastroenterology, 2000, Volume: 35, Issue:11

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colonic Neoplasms; Humans; Irinotecan; Lung Neoplasms; Male; Neoplasms, Multiple Primary; Radiography

2000
[Experimental study on intraperitoneal versus intravenous CPT-11 for peritoneal seeding and liver metastasis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:12

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Female; Infusions, Intravenous; Infusions, Parenteral; Irinotecan; Liver Neoplasms; Mice; Mice, Inbred BALB C; Peritoneal Neoplasms

2000
[Three cases of liver metastasis of colon cancer responding to systemic combination chemotherapy utilizing CPT-11].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:14

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colonic Neoplasms; Doxorubicin; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Irinotecan; Liver Neoplasms; Male; Tegafur; Uracil

2000
Structure-activity relationship of alkyl camptothecin esters.
    Annals of the New York Academy of Sciences, 2000, Volume: 922

    Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Division; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esters; Female; HL-60 Cells; Humans; Mice; Structure-Activity Relationship; U937 Cells; Xenograft Model Antitumor Assays

2000
9-Nitrocamptothecin liposome aerosol treatment of human cancer subcutaneous xenografts and pulmonary cancer metastases in mice.
    Annals of the New York Academy of Sciences, 2000, Volume: 922

    Topics: Aerosols; Animals; Antineoplastic Agents; Bone Neoplasms; Camptothecin; Colonic Neoplasms; Drug Carriers; Female; Humans; Liposomes; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Nude; Microscopy, Electron; Osteosarcoma; Particle Size; Phosphatidylcholines; Xenograft Model Antitumor Assays

2000
Modified lactone/carboxylate salt equilibria in vivo by liposomal delivery of 9-nitro-camptothecin.
    Annals of the New York Academy of Sciences, 2000, Volume: 922

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carboxylic Acids; Chemistry, Pharmaceutical; Colonic Neoplasms; Delayed-Action Preparations; Drug Stability; Humans; Lactones; Liposomes; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Rats; Rats, Sprague-Dawley; Solubility; Tissue Distribution; Xenograft Model Antitumor Assays

2000
New analogues of camptothecins. Activity and resistance.
    Annals of the New York Academy of Sciences, 2000, Volume: 922

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; Colonic Neoplasms; Drug Administration Schedule; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Mice; Mice, Nude; Ovarian Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2000
Pharmacokinetics of orally administered camptothecins.
    Annals of the New York Academy of Sciences, 2000, Volume: 922

    Topics: Administration, Oral; Anion Transport Proteins; Antineoplastic Agents, Phytogenic; Biological Transport, Active; Biotransformation; Caco-2 Cells; Camptothecin; Carrier Proteins; Cell Membrane Permeability; Colonic Neoplasms; Enzyme Inhibitors; Humans; Hydrolysis; Intestinal Absorption; Intestinal Mucosa; Irinotecan; Liver; Liver Neoplasms; Probenecid; Prodrugs; Rectal Neoplasms

2000
Pharmacological determinants of 9-aminocamptothecin cytotoxicity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:1

    Topics: Antineoplastic Agents; Breast Neoplasms; Camptothecin; Cell Division; Colonic Neoplasms; Dose-Response Relationship, Drug; Humans; Tumor Cells, Cultured; Urinary Bladder Neoplasms

2001
Ternary combination of irinotecan, fluorouracil-folinic acid and oxaliplatin: results on human colon cancer cell lines.
    British journal of cancer, 2001, Volume: 84, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Clinical Trials as Topic; Colonic Neoplasms; Drug Interactions; Drug Therapy, Combination; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Tumor Cells, Cultured

2001
[Weekly low dose CPT-11 for multiple lung metastases of colon cancer on an out-patient treatment: a case report].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2001, Volume: 98, Issue:2

    Topics: Adult; Ambulatory Care; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Irinotecan; Lung Neoplasms

2001
North Central Cancer Treatment Group--Mayo Clinic trials in colon cancer.
    Seminars in oncology, 2001, Volume: 28, Issue:1 Suppl 1

    Topics: Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Chemotherapy, Adjuvant; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Irinotecan; Leucovorin; Levamisole

2001
Unusual potency of BN 80915, a novel fluorinated E-ring modified camptothecin, toward human colon carcinoma cells.
    Cancer research, 2001, Apr-01, Volume: 61, Issue:7

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Caco-2 Cells; Camptothecin; Cell Division; Colonic Neoplasms; DNA Topoisomerases, Type I; DNA, Superhelical; Growth Inhibitors; HT29 Cells; Humans; Kinetics; Multidrug Resistance-Associated Proteins; Spheroids, Cellular; Tumor Cells, Cultured

2001
Use of a modified ornithine decarboxylase promoter to achieve efficient c-MYC- or N-MYC-regulated protein expression.
    Cancer research, 2001, Apr-01, Volume: 61, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biotransformation; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Chloramphenicol O-Acetyltransferase; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Genes, myc; Genes, Reporter; Glioblastoma; Humans; Immunoblotting; Irinotecan; MyoD Protein; Neuroblastoma; Ornithine Decarboxylase; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myc; Rabbits; Rhabdomyosarcoma; Transfection; Transgenes; Tumor Cells, Cultured

2001
Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells.
    Oncogene, 2001, Apr-05, Volume: 20, Issue:15

    Topics: Adaptor Proteins, Signal Transducing; Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carrier Proteins; Colonic Neoplasms; Cycloheximide; DNA Fragmentation; Fas Ligand Protein; fas Receptor; Fas-Associated Death Domain Protein; Genes, p53; HT29 Cells; Humans; Membrane Glycoproteins; Mutation

2001
Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells.
    Cancer research, 2001, Aug-01, Volume: 61, Issue:15

    Topics: Animals; Breast Neoplasms; Camptothecin; Cell Line; CHO Cells; Colonic Neoplasms; Cricetinae; DNA Topoisomerases, Type I; Down-Regulation; Drug Resistance, Neoplasm; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; KB Cells; Peptide Hydrolases; Proteasome Endopeptidase Complex; Ubiquitins

2001
Two unusual sites of colon cancer metastases and a rare thyroid lymphoma. Case 2. Chemotherapy-responsive right artial metastasis from colon carcinoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Aug-01, Volume: 19, Issue:15

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Heart Atria; Heart Neoplasms; Humans; Irinotecan; Male; Middle Aged; Ultrasonography

2001
High-performance liquid chromatographic technique for the simultaneous determination of lactone and hydroxy acid forms of camptothecin and SN-38 in tissue culture media and cancer cells.
    Analytical biochemistry, 2001, Oct-01, Volume: 297, Issue:1

    Topics: Camptothecin; Cell Extracts; Chromatography, High Pressure Liquid; Colonic Neoplasms; Culture Media; Drug Stability; HT29 Cells; Humans; Irinotecan; Lactones; Reproducibility of Results; Sensitivity and Specificity; Sonication; Time Factors

2001
Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo.
    Anti-cancer drugs, 2001, Volume: 12, Issue:9

    Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Colonic Neoplasms; DNA Adducts; DNA Repair; DNA-Binding Proteins; Drug Interactions; Drug Screening Assays, Antitumor; Drug Synergism; Endonucleases; Enzyme Inhibitors; Female; Humans; Irinotecan; Mice; Organoplatinum Compounds; Oxaliplatin; Poly(ADP-ribose) Polymerases; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; Xeroderma Pigmentosum Group A Protein

2001
The differentiation inducers phenylacetate and phenylbutyrate modulate camptothecin sensitivity in colon carcinoma cells in vitro by intracellular acidification.
    International journal of oncology, 2001, Volume: 19, Issue:5

    Topics: Annexin A5; Antineoplastic Agents, Phytogenic; Apoptosis; Bicarbonates; Camptothecin; Cell Cycle; Cell Differentiation; Cell Survival; Colonic Neoplasms; Drug Resistance, Neoplasm; Glutamine; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Phenylacetates; Phenylbutyrates; Tumor Cells, Cultured

2001
[Pharmacokinetic study of the intraperitoneal administration of CPT-11 for patients with peritoneal seedings of gastric and colonic cancers].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2001, Volume: 28, Issue:11

    Topics: Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Female; Humans; Injections, Intraperitoneal; Irinotecan; Male; Middle Aged; Neoplasm Seeding; Peritoneal Neoplasms; Stomach Neoplasms

2001
[Two cases of multiple liver metastases of colon cancer with systemic irinotecan and hepatic arterial injection of 5-FU].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2001, Volume: 28, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Male

2001
[A case of lung metastasis from colon cancer treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2001, Volume: 28, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Irinotecan; Liver Neoplasms; Lung Neoplasms; Middle Aged

2001
Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:12

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Colonic Neoplasms; Flavonoids; Humans; Irinotecan; Male; Mice; Mice, Nude; Piperidines; Transplantation, Heterologous; Tumor Cells, Cultured

2001
Treatment of human colon carcinoma cell lines with anti-neoplastic agents enhances their lytic sensitivity to antigen-specific CD8+ cytotoxic T lymphocytes.
    Cancer immunology, immunotherapy : CII, 2001, Volume: 50, Issue:9

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 3; Caspases; CD8-Positive T-Lymphocytes; Cell Survival; Chromium; Cisplatin; Colonic Neoplasms; Cytotoxicity, Immunologic; fas Receptor; Flow Cytometry; Fluorouracil; Humans; In Situ Nick-End Labeling; Intercellular Adhesion Molecule-1; Interferon-gamma; Irinotecan; Recombinant Proteins; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured

2001
Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts.
    International journal of oncology, 2002, Volume: 20, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Cisplatin; Colonic Neoplasms; Disease Models, Animal; Drug Synergism; Female; Fluorouracil; Humans; Irinotecan; Mice; Mice, Nude; Neoplasm Transplantation; Signal Transduction; Sphingomyelins; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured

2002
[Irinotecan and tomudex in the treatment of patients with advanced cancer of the large intestine].
    Voprosy onkologii, 2001, Volume: 47, Issue:6

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Female; Humans; Irinotecan; Male; Middle Aged; Quinazolines; Rectal Neoplasms; Thiophenes; Time Factors

2001
Promising drug is victim of bad business.
    Nature medicine, 2002, Volume: 8, Issue:3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Camptothecin; Cetuximab; Clinical Trials as Topic; Colonic Neoplasms; Drug Approval; Drug Industry; ErbB Receptors; Humans; Irinotecan; Patents as Topic; Recombinant Fusion Proteins; United States; United States Food and Drug Administration

2002
Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.
    Nature medicine, 2002, Volume: 8, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Camptothecin; Carrier Proteins; Caspase 8; Caspase 9; Caspases; Colonic Neoplasms; Enzyme Activation; Etoposide; Fas-Associated Death Domain Protein; Female; Flow Cytometry; Humans; Membrane Glycoproteins; Mice; Mice, Nude; Mitochondria; Mutation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Receptors, Tumor Necrosis Factor; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2002
Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin.
    The Journal of biological chemistry, 2002, May-10, Volume: 277, Issue:19

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; beta-Galactosidase; Blotting, Western; Bromodeoxyuridine; Camptothecin; Cell Cycle; Cellular Senescence; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; Dose-Response Relationship, Drug; Down-Regulation; Humans; Microscopy, Fluorescence; Models, Biological; Protein Binding; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2002
Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms.
    International journal of oncology, 2002, Volume: 20, Issue:4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Female; Humans; Irinotecan; Mice; Mice, Nude; Mutation; Neoplasm Transplantation; Nuclear Proteins; Oligonucleotides, Antisense; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2002
Ceramide involvement in homocamptothecin- and camptothecin-induced cytotoxicity and apoptosis in colon HT29 cells.
    International journal of oncology, 2002, Volume: 20, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspases; Cell Survival; Ceramides; Colonic Neoplasms; Enzyme Inhibitors; Genes, p53; HT29 Cells; Humans; Lipids; Mutation; Sphingomyelin Phosphodiesterase; Sphingomyelins; trans-Golgi Network

2002
Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: microarray analysis of dose- and time-dependent effects.
    Cancer research, 2002, Mar-15, Volume: 62, Issue:6

    Topics: Aphidicolin; Camptothecin; Cell Cycle; Colonic Neoplasms; DNA Damage; Dose-Response Relationship, Drug; Enzyme Inhibitors; G2 Phase; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, cdc; Humans; Mitosis; Oligonucleotide Array Sequence Analysis; Topoisomerase I Inhibitors; Transcription, Genetic

2002
Efficient induction of apoptosis by ONYX-015 adenovirus in human colon cancer cell lines regardless of p53 status.
    Anti-cancer drugs, 2002, Volume: 13, Issue:1

    Topics: Adenoviridae; Antineoplastic Agents; Apoptosis; Camptothecin; Colonic Neoplasms; Combined Modality Therapy; Fluorouracil; Humans; Irinotecan; Mutation; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2002
Stromal extracellular matrix reduces chemotherapy-induced apoptosis in colon cancer cell lines.
    Clinical & experimental metastasis, 2002, Volume: 19, Issue:1

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; bcl-X Protein; Camptothecin; Collagen; Colonic Neoplasms; Enzyme Inhibitors; Etoposide; Extracellular Matrix; Extracellular Matrix Proteins; Fibroblasts; Fibronectins; Fluorouracil; Genes, bcl-2; Hepatocytes; Humans; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Rats, Wistar; Stromal Cells; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

2002
Factors influencing the cellular accumulation of SN-38 and camptothecin.
    Cancer chemotherapy and pharmacology, 2002, Volume: 49, Issue:3

    Topics: Adenocarcinoma; Biological Transport; Camptothecin; Colonic Neoplasms; Drug Resistance, Multiple; Enzyme Inhibitors; Female; Genes, MDR; Humans; Irinotecan; Kinetics; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Topoisomerase I Inhibitors; Tumor Cells, Cultured

2002
Enhanced clearance of topoisomerase I inhibitors from human colon cancer cells by glucuronidation.
    Biochemical pharmacology, 2002, Feb-15, Volume: 63, Issue:4

    Topics: Anthraquinones; Camptothecin; Colonic Neoplasms; Enzyme Inhibitors; Glucuronates; Glucuronides; HT29 Cells; Humans; Irinotecan; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metabolic Clearance Rate; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tyrosine

2002
Anaphylactic shock secondary to intravenous administration of folinic acid: a first report.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2002, Volume: 13, Issue:3

    Topics: Aged; Aged, 80 and over; Anaphylaxis; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Injections, Intravenous; Irinotecan; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Treatment Outcome

2002
Enhanced tumor killing by Apo2L/TRAIL and CPT-11 co-treatment is associated with p21 cleavage and differential regulation of Apo2L/TRAIL ligand and its receptors.
    Oncogene, 2002, May-16, Volume: 21, Issue:22

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Carcinoma; Caspases; Cell Cycle; Cells, Cultured; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Synergism; Humans; Irinotecan; Kinetics; Membrane Glycoproteins; Neoplasms; Receptors, Tumor Necrosis Factor; RNA, Neoplasm; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2002
GEM 231, a second-generation antisense agent complementary to protein kinase A RIalpha subunit, potentiates antitumor activity of irinotecan in human colon, pancreas, prostate and lung cancer xenografts.
    International journal of oncology, 2002, Volume: 21, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Camptothecin; Colonic Neoplasms; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Female; Humans; Irinotecan; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Oligonucleotides; Oligonucleotides, Antisense; Pancreatic Neoplasms; Prostatic Neoplasms; Survival Rate; Treatment Outcome

2002
Antisense oligonucleotide targeted to RIalpha subunit of cAMP-dependent protein kinase (GEM231) enhances therapeutic effectiveness of cancer chemotherapeutic agent irinotecan in nude mice bearing human cancer xenografts: in vivo synergistic activity, phar
    International journal of oncology, 2002, Volume: 21, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Breast Neoplasms; Camptothecin; Colonic Neoplasms; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Irinotecan; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Oligonucleotides; Oligonucleotides, Antisense; Prostatic Neoplasms; Survival Rate; Tissue Distribution; Treatment Outcome

2002
Homocamptothecin-daunorubicin association overcomes multidrug-resistance in breast cancer MCF7 cells.
    Breast cancer research and treatment, 2002, Volume: 73, Issue:2

    Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Carcinoma; Colonic Neoplasms; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Leukemia, Myeloid; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Polymerase Chain Reaction; RNA, Neoplasm; Treatment Outcome; Tumor Cells, Cultured

2002
[A case of advanced colon cancer with para-aortic lymph node metastasis responding greatly to treatment by adjuvant chemotherapy of low-dose CPT-11 on an outpatient basis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:6

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Fluorouracil; Humans; Irinotecan; Lymph Nodes; Lymphatic Metastasis

2002
Irinotecan pharmacokinetics-pharmacodynamics: the clinical relevance of prolonged exposure to SN-38.
    British journal of cancer, 2002, Jul-15, Volume: 87, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; Colonic Neoplasms; Colorectal Neoplasms; Drug Administration Schedule; Female; Humans; Irinotecan; Lung Neoplasms; Male; Middle Aged; Neutropenia; Ovarian Neoplasms; Prodrugs; Random Allocation; Tumor Cells, Cultured; Uterine Cervical Neoplasms

2002
[The effect of CPT-11 in combination with interferon-alpha against human colon carcinoma heterotransplanted in nude mice: preliminary report].
    Nihon Geka Gakkai zasshi, 1992, Volume: 93, Issue:12

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Cycle; Colonic Neoplasms; DNA, Neoplasm; Humans; Interferon-alpha; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation

1992
Sequential administration of camptothecin and etoposide circumvents the antagonistic cytotoxicity of simultaneous drug administration in slowly growing human colon carcinoma HT-29 cells.
    European journal of cancer (Oxford, England : 1990), 1992, Volume: 28A, Issue:4-5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Division; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; DNA, Single-Stranded; Drug Administration Schedule; Drug Interactions; Etoposide; Humans; Kinetics; RNA, Neoplasm; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1992
Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors.
    Cancer chemotherapy and pharmacology, 1992, Volume: 31, Issue:3

    Topics: Adenocarcinoma; Adult; Animals; Antineoplastic Agents; Camptothecin; Child; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Osteosarcoma; Remission Induction; Rhabdomyosarcoma; Time Factors; Topotecan; Tumor Cells, Cultured

1992
S-phase population analysis does not correlate with the cytotoxicity of camptothecin and 10,11-methylenedioxycamptothecin in human colon carcinoma HT-29 cells.
    Cancer communications, 1991, Volume: 3, Issue:8

    Topics: Animals; Aphidicolin; Camptothecin; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Diterpenes; DNA Polymerase II; DNA Replication; DNA, Neoplasm; Humans; Molecular Structure; S Phase; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1991
Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines.
    Cancer research, 1990, Dec-15, Volume: 50, Issue:24

    Topics: Antineoplastic Agents; Camptothecin; Cell Line; Cell Nucleus; Colonic Neoplasms; DNA Topoisomerases, Type II; Drug Resistance; Humans; Kinetics; Lung Neoplasms; Molecular Weight; RNA, Messenger

1990
10,11-Methylenedioxycamptothecin, a topoisomerase I inhibitor of increased potency: DNA damage and correlation to cytotoxicity in human colon carcinoma (HT-29) cells.
    Cancer communications, 1990, Volume: 2, Issue:12

    Topics: Camptothecin; Colonic Neoplasms; Colony-Forming Units Assay; DNA Damage; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Topoisomerase I Inhibitors

1990
DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts.
    Science (New York, N.Y.), 1989, Nov-24, Volume: 246, Issue:4933

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Biomarkers, Tumor; Camptothecin; Colonic Neoplasms; DNA Topoisomerases, Type I; DNA, Neoplasm; Drug Design; Humans; Intestinal Mucosa; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Topoisomerase I Inhibitors; Transplantation, Heterologous

1989