Compounds > camptothecin
Page last updated: 2024-08-22

camptothecin and Adult Premature Aging Syndrome

camptothecin has been researched along with Adult Premature Aging Syndrome in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (15.00)18.2507
2000's15 (75.00)29.6817
2010's2 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aiello, FA; Campbell, JL; Franchitto, A; Malacaria, E; Palma, A; Pichierri, P; Shen, B; Zheng, L1
Bleibel, WK; Cook, E; Eileen Dolan, M; Hennessy, K; Innocenti, F; Liu, W; Mirkov, S; Nagasubramanian, R; Ramírez, J; Ratain, MJ; Rosner, GL; Shukla, SJ1
Bachler, MA; Bird, JL; Campisi, J; Cox, LS; Faragher, RG; Heo, SJ; Jennert-Burston, KC; Lowe, JE; Mason, PA1
Poot, M; Rabinovitch, PS; Silber, JR1
Furuichi, Y; Goto, M; Hayashi, M; Honma, M; Sakamoto, H; Satoh, T; Sofuni, T; Sugimoto, M; Tadokoro, S; Tanabe, H1
Franchitto, A; Pichierri, P; Rosselli, F1
Indig, FE; Latterich, M; Lopreiato, JO; Partridge, JJ1
Bohr, VA; Harrigan, JA; Indig, FE; Laine, JP; Opresko, PL; von Kobbe, C1
Blank, A; Bobola, MS; D Kolstoe, D; Gold, B; Loeb, LA; Meade, EH; Rabinovitch, PS; Silber, JR; Varadarajan, S1
Bird, J; Burton, D; Faragher, RG; Green, MH; Jennert-Burston, K; Lowe, J; Ostler, EL; Sheerin, A1
Agrelo, R; Artiga, MJ; Bohr, VA; Castells, A; Cheng, WH; Espada, J; Esteller, M; Fraga, MF; Guerrero, D; Herranz, M; Paz, MF; Ropero, S; Sanchez-Cespedes, M; Setien, F; von Kobbe, C1
Boubriak, I; Clancy, DJ; Cox, LS; Saunders, RD1
Lebel, M; Leder, P1
Gollahon, KA; Poot, M; Rabinovitch, PS1
Cogoni, C; Macino, G1
Franchitto, A; Mosesso, P; Palitti, F; Pichierri, P2
Furuichi, Y; Goto, M; Heo, SJ; Nishikawa, K; Sakamoto, S; Shimamoto, A1
Lebel, M1
Fujita, K; Furuichi, Y; Imamura, O; Itoh, C; Matsumoto, T; Takeda, S1

Reviews

1 review(s) available for camptothecin and Adult Premature Aging Syndrome

ArticleYear
Camptothecin sensitivity in Werner syndrome fibroblasts as assessed by the COMET technique.
    Annals of the New York Academy of Sciences, 2004, Volume: 1019

    Topics: Adenosine Triphosphatases; Camptothecin; Cellular Senescence; Comet Assay; DNA; DNA Damage; DNA Helicases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Humans; Mutation; Phenotype; Protein Structure, Tertiary; RecQ Helicases; Werner Syndrome

2004

Other Studies

19 other study(ies) available for camptothecin and Adult Premature Aging Syndrome

ArticleYear
RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease.
    Nucleic acids research, 2019, 07-26, Volume: 47, Issue:13

    Topics: BRCA2 Protein; Camptothecin; Cell Line, Transformed; Checkpoint Kinase 1; DNA Breaks, Double-Stranded; DNA Replication; DNA-Binding Proteins; DNA, Single-Stranded; Endonucleases; Enzyme Activation; Fibroblasts; Humans; Mitochondria; Mitosis; Multiprotein Complexes; Nucleic Acid Conformation; Phosphorylation; Protein Processing, Post-Translational; Rad51 Recombinase; RNA Interference; Topoisomerase I Inhibitors; Werner Syndrome; Werner Syndrome Helicase

2019
The Werner's syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds.
    Cancer chemotherapy and pharmacology, 2009, Volume: 63, Issue:5

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; B-Lymphocytes; Camptothecin; Carboplatin; Cell Proliferation; Cell Survival; Cells, Cultured; Cisplatin; Daunorubicin; Enzyme Inhibitors; Etoposide; Exodeoxyribonucleases; Genotype; Humans; Platinum Compounds; Polymorphism, Single Nucleotide; RecQ Helicases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Topoisomerase Inhibitors; Werner Syndrome; Werner Syndrome Helicase

2009
Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease.
    Biogerontology, 2012, Volume: 13, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Base Sequence; Camptothecin; Cell Line; Comet Assay; Electrophoresis, Polyacrylamide Gel; Exodeoxyribonucleases; Flow Cytometry; Gene Knockdown Techniques; Humans; Molecular Sequence Data; RecQ Helicases; Reverse Transcriptase Polymerase Chain Reaction; Werner Syndrome; Werner Syndrome Helicase

2012
A novel flow cytometric technique for drug cytotoxicity gives results comparable to colony-forming assays.
    Cytometry, 2002, May-01, Volume: 48, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Antimetabolites; Antineoplastic Agents, Phytogenic; Benzimidazoles; Bromodeoxyuridine; Camptothecin; Carcinogens; Cell Division; Cell Line; Cell Survival; Fibroblasts; Flow Cytometry; Fluorescent Dyes; Humans; Lymphocytes; Stem Cells; Werner Syndrome

2002
Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients.
    Mutation research, 2002, Sep-26, Volume: 520, Issue:1-2

    Topics: 4-Nitroquinoline-1-oxide; B-Lymphocytes; Bloom Syndrome; Camptothecin; Carcinogens; Case-Control Studies; Cell Division; Cell Line; Chromosome Aberrations; Etoposide; Herpesvirus 4, Human; Humans; Karyotyping; Metaphase; Micronuclei, Chromosome-Defective; Mitomycin; Sister Chromatid Exchange; Werner Syndrome

2002
Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle.
    Oncogene, 2003, Mar-13, Volume: 22, Issue:10

    Topics: Ataxia Telangiectasia Mutated Proteins; Camptothecin; Cell Cycle Proteins; Cell Nucleus Structures; Cells, Cultured; DNA Damage; DNA Helicases; DNA Replication; DNA-Binding Proteins; Enzyme Inhibitors; Exodeoxyribonucleases; Fibroblasts; Humans; Hydroxyurea; Lymphocytes; Phosphorylation; Protein Serine-Threonine Kinases; RecQ Helicases; S Phase; Tumor Suppressor Proteins; Werner Syndrome; Werner Syndrome Helicase

2003
DNA damage modulates nucleolar interaction of the Werner protein with the AAA ATPase p97/VCP.
    Molecular biology of the cell, 2003, Volume: 14, Issue:10

    Topics: Adenosine Triphosphatases; Animals; Antigens, Nuclear; Camptothecin; Cell Cycle Proteins; Cell Nucleolus; Cells, Cultured; Cloning, Molecular; DNA Damage; DNA Helicases; DNA Topoisomerases, Type I; DNA-Binding Proteins; Endoplasmic Reticulum; Exodeoxyribonucleases; Fluorescent Antibody Technique; Golgi Apparatus; Humans; K562 Cells; Ku Autoantigen; Membrane Fusion; Mice; Mutation; Protein Binding; Protein Structure, Tertiary; RecQ Helicases; Valosin Containing Protein; Werner Syndrome; Werner Syndrome Helicase

2003
Werner protein stimulates topoisomerase I DNA relaxation activity.
    Cancer research, 2003, Nov-01, Volume: 63, Issue:21

    Topics: Adenosine Triphosphatases; Camptothecin; Cells, Cultured; DNA Helicases; DNA Topoisomerases, Type I; DNA, Superhelical; Exodeoxyribonucleases; Fibroblasts; Fluorescent Antibody Technique, Indirect; Humans; Peptide Mapping; Protein Structure, Tertiary; RecQ Helicases; Werner Syndrome; Werner Syndrome Helicase

2003
The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function.
    DNA repair, 2004, Jun-03, Volume: 3, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Adenine; Alkylating Agents; Antineoplastic Agents; Apoptosis; Camptothecin; Carcinogens; Cells, Cultured; DNA Damage; DNA Helicases; DNA Replication; Drug Resistance; Exodeoxyribonucleases; Fibroblasts; Glioma; Guanine; Humans; Hydroxyurea; Netropsin; O(6)-Methylguanine-DNA Methyltransferase; Oligonucleotides, Antisense; RecQ Helicases; Werner Syndrome; Werner Syndrome Helicase

2004
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Jun-06, Volume: 103, Issue:23

    Topics: Aging, Premature; Animals; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; CpG Islands; DNA Helicases; DNA Methylation; Epigenesis, Genetic; Exodeoxyribonucleases; Female; Genes, Tumor Suppressor; Humans; Irinotecan; Mice; Mice, Nude; Promoter Regions, Genetic; RecQ Helicases; RNA, Messenger; Topoisomerase I Inhibitors; Werner Syndrome; Werner Syndrome Helicase

2006
Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.
    Aging cell, 2008, Volume: 7, Issue:3

    Topics: Alleles; Amino Acid Sequence; Animals; Camptothecin; Drosophila melanogaster; Exodeoxyribonucleases; Genomic Instability; Humans; Molecular Sequence Data; Mutation; Protein Conformation; Protein Structure, Tertiary; Recombination, Genetic; RecQ Helicases; Sequence Alignment; Sequence Homology, Amino Acid; Werner Syndrome; Werner Syndrome Helicase

2008
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Oct-27, Volume: 95, Issue:22

    Topics: Animals; Base Sequence; Camptothecin; Cell Division; Cells, Cultured; Chimera; Chromosome Mapping; Cloning, Molecular; Crosses, Genetic; DNA Helicases; DNA Primers; Female; Fetal Death; Homozygote; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Molecular Sequence Data; Muridae; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Recombination, Genetic; Sequence Deletion; Stem Cells; Transfection; Werner Syndrome

1998
Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase.
    Human genetics, 1999, Volume: 104, Issue:1

    Topics: Apoptosis; B-Lymphocytes; Camptothecin; Cell Line, Transformed; Flow Cytometry; Humans; Lymphocyte Activation; Lymphocytes; S Phase; Werner Syndrome

1999
Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase.
    Science (New York, N.Y.), 1999, Dec-17, Volume: 286, Issue:5448

    Topics: Adenosine Triphosphatases; Amino Acid Sequence; Bloom Syndrome; Camptothecin; DNA Helicases; DNA, Fungal; Enzyme Inhibitors; Etoposide; Fungal Proteins; Gene Silencing; Genes, Fungal; Genetic Complementation Test; Humans; Molecular Sequence Data; Molecular Weight; Mutagenesis, Insertional; Neurospora crassa; RecQ Helicases; Sequence Alignment; Transcription, Genetic; Transgenes; Werner Syndrome

1999
Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage.
    Mutation research, 2000, Nov-30, Volume: 456, Issue:1-2

    Topics: Camptothecin; Cell Cycle; Cell Line, Transformed; Chromosome Aberrations; DNA Replication; Enzyme Inhibitors; G2 Phase; Humans; RNA Polymerase II; S Phase; Topoisomerase I Inhibitors; Werner Syndrome

2000
Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.
    Genes to cells : devoted to molecular & cellular mechanisms, 2001, Volume: 6, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Aphidicolin; Bleomycin; Camptothecin; Cell Line; Cell Nucleus; DNA Damage; DNA Helicases; DNA Replication; DNA-Binding Proteins; Dose-Response Relationship, Drug; Etoposide; Humans; Immunoblotting; Immunohistochemistry; In Situ Hybridization, Fluorescence; Mutagens; Proteins; Rad51 Recombinase; Trans-Activators; Werner Syndrome

2001
Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle.
    Molecular biology of the cell, 2001, Volume: 12, Issue:8

    Topics: Apoptosis; Camptothecin; Cells, Cultured; Comet Assay; DNA Damage; DNA Helicases; DNA Nucleotidyltransferases; DNA Repair; DNA Replication; DNA-Binding Proteins; Enzyme Inhibitors; Exodeoxyribonucleases; Fibroblasts; Flow Cytometry; Humans; Hydroxyurea; Immunohistochemistry; Nucleic Acid Synthesis Inhibitors; Rad51 Recombinase; RecQ Helicases; S Phase; Werner Syndrome; Werner Syndrome Helicase

2001
Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.
    Carcinogenesis, 2002, Volume: 23, Issue:1

    Topics: Animals; Benzamides; Camptothecin; Carrier Proteins; DNA Helicases; DNA Topoisomerases, Type I; Exodeoxyribonucleases; Eye Color; Gene Frequency; Genes, Duplicate; Genotype; Hair Color; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Mutant Strains; Mutagenesis; Phenotype; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; RecQ Helicases; Sequence Deletion; Sequence Homology; Topoisomerase I Inhibitors; Werner Syndrome; Werner Syndrome Helicase

2002
Werner and Bloom helicases are involved in DNA repair in a complementary fashion.
    Oncogene, 2002, Jan-31, Volume: 21, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Adenosine Triphosphatases; Amino Acid Sequence; Animals; B-Lymphocytes; Bloom Syndrome; Camptothecin; Cell Cycle; Cell Line; Chickens; Chromosome Aberrations; Clone Cells; Coculture Techniques; DNA; DNA Damage; DNA Helicases; DNA Repair; Drug Resistance; Etoposide; Gene Targeting; Humans; Methyl Methanesulfonate; Molecular Sequence Data; Mutagenicity Tests; Radiation Tolerance; RecQ Helicases; Sequence Alignment; Sequence Homology, Amino Acid; Sister Chromatid Exchange; Species Specificity; Ultraviolet Rays; Werner Syndrome

2002