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camptothecin and Abnormalities, Autosome

camptothecin has been researched along with Abnormalities, Autosome in 41 studies

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19903 (7.32)18.7374
1990's18 (43.90)18.2507
2000's13 (31.71)29.6817
2010's7 (17.07)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cristini, A; Favre, G; Faye, JC; Guirouilh-Barbat, J; Lemarié, A; Lopez, BS; Mamouni, K; Monferran, S; Sordet, O1
Ikura, M; Ikura, T; Matsuda, S; Matsuda, T; Matsuda, Y; Yanagisawa, SY1
Darroudi, F; de Groot, J; de Winter, JP; Godthelp, BC; Joenje, H; Oostra, AB; Scheper, RJ; Steltenpool, J; van der Lelij, P; van Gosliga, D; van Zon, W; Waisfisz, Q; Wolthuis, RM1
Gamulin, M; Kasuba, V; Rozgaj, R; Trosić, I1
Chessa, L; De Amicis, A; Delia, D; Fanciulli, M; Ferrari, F; Piane, M1
Bishop, DK; Dejsuphong, D; Hirota, K; Qing, Y; Sakai, W; Takeda, S; Wu, X; Yamamoto, KN; Yamazoe, M1
Attia, S1
Bishop, AJ; Hasty, P; Hu, L; Kim, SA; Kim, TM; Ko, JH; Montagna, C; Vijg, J1
Furuichi, Y; Goto, M; Hayashi, M; Honma, M; Sakamoto, H; Satoh, T; Sofuni, T; Sugimoto, M; Tadokoro, S; Tanabe, H1
Ahnn, J; Han, JW; Han, SM; Kim, YM; Koo, HS; Lee, MH1
Chessa, L; Mosesso, P; Palitti, F; Penna, S; Pepe, G; Piane, M1
Dendouga, N; Gao, H; Janicot, M; McGowan, CH; Moechars, D; Vialard, J1
Imai, T; Inoue, H; Mori, M; Shiomi, N; Shiomi, T; Tateishi, S; Tsuji, H; Yamaizumi, M1
Berend, S; Fuchs, N; Kopjar, N; Radić, B; Vrdoljak, AL; Zeljezić, D1
Bernal, JA; Espina, A; Méndez-Vidal, C; Pintor-Toro, JA; Roche, M; Tortolero, M1
Averbeck, D; Duchaud, E; Moustacchi, E; Rosselli, F1
Bassi, L; Cortés, F; Di Chiara, D; Fiore, M; Palitti, F; Pinero, J1
Johnson, RT; Ryan, AJ; Squires, S; Strutt, HL1
Cortés, F; Palitti, F; Piñero, J1
Ikeda, T; Nakaike, S; Nakane, S; Ohsawa, M; Suzuki, H; Yamagishi, T1
Cortés, F; Piñero, J1
Evans, A; Johnson, RT; Ryan, AJ; Squires, S; Strutt, HL1
Nakane, S; Suzuki, H1
Kojima, A; Saijo, N; Shinkai, T1
Andoh, T; Aratani, Y; Koyama, H1
De Salvia, R; Degrassi, F; Fiore, M; Zanier, R1
Cortés, F; López-Baena, M; Mateos, S; Piñero, J1
Enomoto, T; Katada, T; Masuko, T; Narita, Y; Seki, M; Sonoda, E; Takeda, S; Wang, W; Yamada, K1
Franchitto, A; Mosesso, P; Palitti, F; Pichierri, P2
Colussi, C; Franchitto, A; Palitti, F; Pichierri, P; Piergentili, R1
Fujita, K; Furuichi, Y; Imamura, O; Itoh, C; Matsumoto, T; Takeda, S1
AbuBakar, S; Albrecht, T; Boldogh, I; Deng, CZ; Fons, MP1
Sumner, AT1
Andersson, HC; Kihlman, BA2
Qi, XD; Tang, WD; Tu, ZH; Wang, MY; Xiao, WQ1
Allen, JW; Backer, LC; Campbell, JA; DeMarini, DM; Doerr, CL; Harrington-Brock, K; Howard, DR; Kligerman, AD; Moore, MM1
Chen, AY; Hwang, JL; Juan, CC; Shyy, SH; Whang-Peng, J1
De Salvia, R; Degrassi, F; Palitti, F; Tanzarella, C1
Covey, JM; Kao-Shan, CS; Kerrigan, D; Pommier, Y; Whang-Peng, J1

Other Studies

41 other study(ies) available for camptothecin and Abnormalities, Autosome

ArticleYear
RhoB promotes γH2AX dephosphorylation and DNA double-strand break repair.
    Molecular and cellular biology, 2014, Volume: 34, Issue:16

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Checkpoint Kinase 2; Chromosome Aberrations; DNA Breaks, Double-Stranded; DNA Repair; ELAV Proteins; Genomic Instability; HCT116 Cells; Histones; Humans; Mice; Mice, Knockout; Phosphorylation; Protein Binding; Protein Phosphatase 2; rhoB GTP-Binding Protein; RNA Interference; RNA-Binding Proteins; RNA, Small Interfering; Topoisomerase I Inhibitors

2014
Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine.
    Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 151, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Aminacrine; Camptothecin; Cell Cycle Proteins; Chromosome Aberrations; Comet Assay; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; G2 Phase Cell Cycle Checkpoints; Green Fluorescent Proteins; HeLa Cells; Histones; Humans; MCF-7 Cells; Micronuclei, Chromosome-Defective; Micronucleus Tests; Nuclear Proteins; Phosphorylation; Propyl Gallate; Recombinant Fusion Proteins; Serine; Trans-Activators; Transfection

2016
The cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2.
    PloS one, 2009, Sep-07, Volume: 4, Issue:9

    Topics: Acetyltransferases; Camptothecin; Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; Chromosome Aberrations; Chromosome Segregation; Cohesins; Congenital Abnormalities; DNA Damage; Etoposide; Fibroblasts; Growth Disorders; Humans; Infant; Male; Mitomycin; Nucleic Acid Synthesis Inhibitors; Sister Chromatid Exchange; Syndrome

2009
Assessment of cyto/genotoxicity of irinotecan in v79 cells using the comet, micronucleus, and chromosome aberration assay.
    Arhiv za higijenu rada i toksikologiju, 2010, Volume: 61, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line; Cells, Cultured; Chromosome Aberrations; Comet Assay; Cricetinae; Cricetulus; Irinotecan; Micronucleus Tests; Mutagenicity Tests

2010
Role of senataxin in DNA damage and telomeric stability.
    DNA repair, 2011, Feb-07, Volume: 10, Issue:2

    Topics: Camptothecin; Cell Line, Tumor; Chromosome Aberrations; DNA Damage; DNA Helicases; DNA Repair; Humans; Hydrogen Peroxide; In Situ Hybridization, Fluorescence; Lymphocytes; Mitomycin; Multifunctional Enzymes; RNA Helicases; Spinocerebellar Ataxias; Spinocerebellar Degenerations; Telomere; X-Rays

2011
The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination.
    PLoS genetics, 2011, Volume: 7, Issue:7

    Topics: Animals; BRCA2 Protein; Camptothecin; Cell Line; Cell Proliferation; Chickens; Chromosome Aberrations; Cisplatin; Clone Cells; DNA Damage; Epistasis, Genetic; Gamma Rays; Gene Conversion; Gene Deletion; Genetic Loci; Genome; Homologous Recombination; Models, Biological; Phenotype; Phthalazines; Piperazines; Rad51 Recombinase

2011
Modulation of irinotecan-induced genomic DNA damage by theanine.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chromosome Aberrations; DNA Damage; Dose-Response Relationship, Drug; Glutamates; Irinotecan; Male; Mice; Micronucleus Tests; Oxidative Stress

2012
RAD51 mutants cause replication defects and chromosomal instability.
    Molecular and cellular biology, 2012, Volume: 32, Issue:18

    Topics: Adenosine Triphosphate; Animals; Camptothecin; Cell Line; Chromosomal Instability; Chromosome Aberrations; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; DNA Replication; Embryonic Stem Cells; Green Fluorescent Proteins; Humans; Mice; Promoter Regions, Genetic; Rad51 Recombinase; RNA Interference; RNA, Small Interfering

2012
Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients.
    Mutation research, 2002, Sep-26, Volume: 520, Issue:1-2

    Topics: 4-Nitroquinoline-1-oxide; B-Lymphocytes; Bloom Syndrome; Camptothecin; Carcinogens; Case-Control Studies; Cell Division; Cell Line; Chromosome Aberrations; Etoposide; Herpesvirus 4, Human; Humans; Karyotyping; Metaphase; Micronuclei, Chromosome-Defective; Mitomycin; Sister Chromatid Exchange; Werner Syndrome

2002
Caenorhabditis elegans dna-2 is involved in DNA repair and is essential for germ-line development.
    FEBS letters, 2003, Dec-04, Volume: 555, Issue:2

    Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Camptothecin; Chromosome Aberrations; DNA Damage; DNA Repair; DNA, Helminth; Gamma Rays; Genes, Lethal; Germ Cells; Heterozygote; Homozygote; Oocytes; Ovum; Phenotype; RNA Interference; Temperature

2003
The novel human gene aprataxin is directly involved in DNA single-strand-break repair.
    Cellular and molecular life sciences : CMLS, 2005, Volume: 62, Issue:4

    Topics: Apraxia, Ideomotor; Camptothecin; Cerebellar Ataxia; Chromosome Aberrations; Comet Assay; Diagnosis, Differential; DNA Damage; DNA Repair; DNA Topoisomerases, Type I; DNA-Binding Proteins; DNA, Single-Stranded; Humans; Male; Nuclear Proteins; Pedigree; Point Mutation; Radiation Tolerance; X-Rays

2005
Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis.
    Molecular and cellular biology, 2005, Volume: 25, Issue:17

    Topics: Animals; Camptothecin; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; DNA Damage; DNA-Binding Proteins; Endonucleases; Fibroblasts; Genomic Instability; Mice; Rad51 Recombinase; Saccharomyces cerevisiae Proteins

2005
Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination.
    Nucleic acids research, 2007, Volume: 35, Issue:2

    Topics: Camptothecin; Cell Line, Tumor; Chromosome Aberrations; Comet Assay; DNA Breaks, Single-Stranded; DNA Damage; DNA Repair; DNA-Binding Proteins; Enzyme Inhibitors; Gene Deletion; Gene Targeting; Genes, Lethal; Humans; Proliferating Cell Nuclear Antigen; S Phase; Topoisomerase I Inhibitors; Ubiquitin; Ubiquitin-Protein Ligases; X-Rays

2007
Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro.
    Acta biochimica Polonica, 2007, Volume: 54, Issue:3

    Topics: Acetylcholinesterase; Adult; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cells, Cultured; Cholinesterase Inhibitors; Chromosome Aberrations; Female; Humans; Irinotecan; Lymphocytes; Molecular Structure; Oximes; Pyridinium Compounds

2007
Proliferative potential after DNA damage and non-homologous end joining are affected by loss of securin.
    Cell death and differentiation, 2008, Volume: 15, Issue:1

    Topics: Base Sequence; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromosome Aberrations; DNA; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Doxorubicin; Genomic Instability; Humans; Molecular Sequence Data; Neoplasm Proteins; RNA, Small Interfering; Securin

2008
Comparison of the effects of DNA topoisomerase inhibitors on lymphoblasts from normal and Fanconi anemia donors.
    Mutation research, 1994, Volume: 325, Issue:4

    Topics: Camptothecin; Cell Division; Cells, Cultured; Chromosome Aberrations; DNA; DNA Damage; DNA Repair; Fanconi Anemia; Hematopoietic Stem Cells; Humans; Indoles; Isoquinolines; Lymphocytes; Methoxsalen; Nalidixic Acid; Novobiocin; Skin; Topoisomerase I Inhibitors

1994
Higher G2 sensitivity to the induction of chromosomal damage in the CHO mutant EM9 than in its parental line AA8 by camptothecin, an inhibitor of DNA topoisomerase I.
    Mutation research, 1993, Volume: 285, Issue:2

    Topics: Animals; Camptothecin; CHO Cells; Chromosome Aberrations; Chromosomes; Cricetinae; G2 Phase; Mutagens; Mutation; Topoisomerase I Inhibitors

1993
Hypersensitivity of Cockayne's syndrome cells to camptothecin is associated with the generation of abnormally high levels of double strand breaks in nascent DNA.
    Cancer research, 1993, May-01, Volume: 53, Issue:9

    Topics: Aphidicolin; Camptothecin; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cockayne Syndrome; DNA; DNA Damage; DNA Repair; Humans; In Vitro Techniques; RNA; Time Factors; Topoisomerase I Inhibitors; Ultraviolet Rays

1993
Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8.
    Mutation research, 1993, Volume: 288, Issue:2

    Topics: Amsacrine; Animals; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Mutation; Sister Chromatid Exchange; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1993
Efficient induction of chromosome-type aberrations by topoisomerase II inhibitors closely associated with stabilization of the cleavable complex in cultured fibroblastic cells.
    Mutation research, 1995, Volume: 328, Issue:2

    Topics: 2,4-Dinitrophenol; Aclarubicin; Adenosine Triphosphate; Animals; Camptothecin; Cells, Cultured; Chromosome Aberrations; Cricetinae; Dinitrophenols; DNA; DNA Damage; DNA Topoisomerases, Type II; Doxorubicin; Etoposide; Fibroblasts; Topoisomerase II Inhibitors

1995
Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured Chinese hamster ovary cells.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:5

    Topics: Amsacrine; Animals; Camptothecin; Cell Death; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Damage; Drug Synergism; Electrophoresis, Agar Gel; Metaphase; Sister Chromatid Exchange; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1994
Different fates of camptothecin-induced replication fork-associated double-strand DNA breaks in mammalian cells.
    Carcinogenesis, 1994, Volume: 15, Issue:5

    Topics: Animals; Caffeine; Camptothecin; Cell Line; CHO Cells; Chromosome Aberrations; Cricetinae; DNA; DNA Damage; DNA Replication; DNA, Neoplasm; Humans; Mitosis; Sensitivity and Specificity; Skin; Skin Physiological Phenomena; Urinary Bladder Neoplasms

1994
Differential induction of chromosomal aberrations by topoisomerase inhibitors in cultured Chinese hamster cells.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:2

    Topics: Aclarubicin; Animals; Camptothecin; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Doxorubicin; Etoposide; Fibroblasts; Lung; Mitoxantrone; Sister Chromatid Exchange; Topoisomerase I Inhibitors

1994
Cytogenetic effects of CPT-11 and its active metabolite, SN-38 on human lymphocytes.
    Japanese journal of clinical oncology, 1993, Volume: 23, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Chromosome Aberrations; Dose-Response Relationship, Drug; Humans; Irinotecan; Lymphocytes; Mutagens; Neoplasms; Sister Chromatid Exchange; Time Factors

1993
Effects of DNA topoisomerase inhibitors on nonhomologous and homologous recombination in mammalian cells.
    Mutation research, 1996, Feb-15, Volume: 362, Issue:2

    Topics: Adenine Phosphoribosyltransferase; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; Diketopiperazines; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Mutagenesis; Mutagenicity Tests; Nucleic Acid Heteroduplexes; Piperazines; Recombination, Genetic; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transfection

1996
Topoisomerase I activity and cellular response to radiation in Chinese hamster cells.
    International journal of radiation biology, 1996, Volume: 70, Issue:3

    Topics: Animals; Camptothecin; Cell Cycle; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Topoisomerases, Type I; Enzyme Inhibitors; Flow Cytometry; Topoisomerase I Inhibitors

1996
Enhanced sensitivity to topoisomerase inhibitors in synchronous CHO cells pre-treated with 5-azacytidine.
    Mutation research, 1998, Oct-12, Volume: 421, Issue:1

    Topics: Amsacrine; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Azacitidine; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Methylation; Drug Interactions; Enzyme Inhibitors; S Phase; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1998
Possible association of BLM in decreasing DNA double strand breaks during DNA replication.
    The EMBO journal, 2000, Jul-03, Volume: 19, Issue:13

    Topics: Adenosine Triphosphatases; Amino Acid Sequence; Animals; Base Sequence; Bloom Syndrome; Camptothecin; Cell Cycle; Cells, Cultured; Chickens; Chromosome Aberrations; DNA Damage; DNA Helicases; DNA Primers; DNA Repair Enzymes; DNA Replication; Etoposide; Fungal Proteins; Methyl Methanesulfonate; Molecular Sequence Data; RecQ Helicases; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid

2000
Evidence that camptothecin-induced aberrations in the G(2) phase of cell cycle of Chinese hamster ovary (CHO) cell lines is associated with transcription.
    Mutation research, 2000, Sep-18, Volume: 452, Issue:2

    Topics: Amanitins; Animals; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; Cricetulus; G2 Phase; RNA, Messenger; Transcription, Genetic

2000
Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage.
    Mutation research, 2000, Nov-30, Volume: 456, Issue:1-2

    Topics: Camptothecin; Cell Cycle; Cell Line, Transformed; Chromosome Aberrations; DNA Replication; Enzyme Inhibitors; G2 Phase; Humans; RNA Polymerase II; S Phase; Topoisomerase I Inhibitors; Werner Syndrome

2000
Hypersensitivity to camptothecin in MSH2 deficient cells is correlated with a role for MSH2 protein in recombinational repair.
    Carcinogenesis, 2001, Volume: 22, Issue:11

    Topics: Animals; Antineoplastic Agents, Phytogenic; Base Pair Mismatch; Camptothecin; Cell Cycle; Cell Survival; Chromosome Aberrations; Colorectal Neoplasms; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; Drug Hypersensitivity; Flow Cytometry; Mice; Mice, Knockout; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Rad51 Recombinase; Sister Chromatid Exchange; Tumor Cells, Cultured

2001
Werner and Bloom helicases are involved in DNA repair in a complementary fashion.
    Oncogene, 2002, Jan-31, Volume: 21, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Adenosine Triphosphatases; Amino Acid Sequence; Animals; B-Lymphocytes; Bloom Syndrome; Camptothecin; Cell Cycle; Cell Line; Chickens; Chromosome Aberrations; Clone Cells; Coculture Techniques; DNA; DNA Damage; DNA Helicases; DNA Repair; Drug Resistance; Etoposide; Gene Targeting; Humans; Methyl Methanesulfonate; Molecular Sequence Data; Mutagenicity Tests; Radiation Tolerance; RecQ Helicases; Sequence Alignment; Sequence Homology, Amino Acid; Sister Chromatid Exchange; Species Specificity; Ultraviolet Rays; Werner Syndrome

2002
Modulation of the frequency of human cytomegalovirus-induced chromosome aberrations by camptothecin.
    Virology, 1992, Volume: 189, Issue:1

    Topics: Benzamides; Camptothecin; Cells, Cultured; Chromosome Aberrations; Cytomegalovirus Infections; DNA Repair; Dose-Response Relationship, Drug; Humans; Lymphocytes; Novobiocin; Poly(ADP-ribose) Polymerase Inhibitors

1992
Inhibitors of topoisomerases do not block the passage of human lymphocyte chromosomes through mitosis.
    Journal of cell science, 1992, Volume: 103 ( Pt 1)

    Topics: Amsacrine; Camptothecin; Chromosome Aberrations; Chromosomes, Human; Daunorubicin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Ellipticines; Ethidium; Etoposide; Humans; In Vitro Techniques; Lymphocytes; Mitosis; Mitoxantrone; Nalidixic Acid; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1992
Induction of chromosomal aberrations by camptothecin in root-tip cells of Vicia faba.
    Mutation research, 1992, Volume: 268, Issue:2

    Topics: Autoradiography; Camptothecin; Chromatids; Chromosome Aberrations; DNA Damage; DNA Replication; Fabaceae; Interphase; Mutagenesis; Plants, Medicinal

1992
Enhancement and reduction by methylated oxypurines of the frequencies of chromatid aberrations induced by camptothecin in root-tip cells of Vicia faba.
    Mutation research, 1992, Volume: 269, Issue:2

    Topics: Caffeine; Camptothecin; Chromatids; Chromosome Aberrations; Dose-Response Relationship, Drug; Methylnitrosourea; Mutagenicity Tests; Mutagens; Plants; Purines; Theophylline; Uric Acid

1992
[Effects of 10-hydroxycamptothecin on induced chromosome aberrations in Chinese hamster ovary cells and micronuclei in mouse bone marrow and fetal liver].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:4

    Topics: Animals; Bone Marrow; Camptothecin; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Female; Liver; Mice; Micronucleus Tests; Mutagenicity Tests; Ovary

1990
Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro.
    Mutagenesis, 1990, Volume: 5, Issue:6

    Topics: Amsacrine; Animals; Bone Marrow; Bone Marrow Cells; Camptothecin; Cell Line; Chromatids; Chromosome Aberrations; Dose-Response Relationship, Drug; Gene Rearrangement; In Vitro Techniques; Lymphocytes; Lymphoma; Male; Mice; Mice, Inbred C57BL; Mutagens; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1990
Studies of topoisomerase-specific antitumor drugs in human lymphocytes using rabbit antisera against recombinant human topoisomerase II polypeptide.
    Cancer research, 1989, Feb-15, Volume: 49, Issue:4

    Topics: Animals; Antibodies; Base Sequence; Camptothecin; Chromosome Aberrations; Cloning, Molecular; DNA Replication; DNA Topoisomerases, Type II; Escherichia coli; Genes; Genetic Vectors; Humans; Immune Sera; Lymphocyte Activation; Lymphocytes; Molecular Sequence Data; Podophyllotoxin; Rabbits; Recombinant Proteins; Teniposide; Topoisomerase II Inhibitors

1989
Induction of chromosomal aberrations and SCE by camptothecin, an inhibitor of mammalian topoisomerase I.
    Mutation research, 1989, Volume: 211, Issue:1

    Topics: Camptothecin; Cells, Cultured; Chromosome Aberrations; Culture Media; Humans; Interphase; Lymphocytes; Mitotic Index; Sister Chromatid Exchange; Topoisomerase I Inhibitors

1989
Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.
    Cancer research, 1988, Feb-01, Volume: 48, Issue:3

    Topics: Amsacrine; Animals; Camptothecin; Cell Line; Cell Survival; Chromosome Aberrations; Cricetinae; Drug Resistance; Ellipticines; Etoposide; Mitomycin; Mitomycins; Sister Chromatid Exchange; Topoisomerase II Inhibitors

1988