camptothecin has been researched along with Abnormalities, Autosome in 41 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (7.32) | 18.7374 |
1990's | 18 (43.90) | 18.2507 |
2000's | 13 (31.71) | 29.6817 |
2010's | 7 (17.07) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Cristini, A; Favre, G; Faye, JC; Guirouilh-Barbat, J; Lemarié, A; Lopez, BS; Mamouni, K; Monferran, S; Sordet, O | 1 |
Ikura, M; Ikura, T; Matsuda, S; Matsuda, T; Matsuda, Y; Yanagisawa, SY | 1 |
Darroudi, F; de Groot, J; de Winter, JP; Godthelp, BC; Joenje, H; Oostra, AB; Scheper, RJ; Steltenpool, J; van der Lelij, P; van Gosliga, D; van Zon, W; Waisfisz, Q; Wolthuis, RM | 1 |
Gamulin, M; Kasuba, V; Rozgaj, R; Trosić, I | 1 |
Chessa, L; De Amicis, A; Delia, D; Fanciulli, M; Ferrari, F; Piane, M | 1 |
Bishop, DK; Dejsuphong, D; Hirota, K; Qing, Y; Sakai, W; Takeda, S; Wu, X; Yamamoto, KN; Yamazoe, M | 1 |
Attia, S | 1 |
Bishop, AJ; Hasty, P; Hu, L; Kim, SA; Kim, TM; Ko, JH; Montagna, C; Vijg, J | 1 |
Furuichi, Y; Goto, M; Hayashi, M; Honma, M; Sakamoto, H; Satoh, T; Sofuni, T; Sugimoto, M; Tadokoro, S; Tanabe, H | 1 |
Ahnn, J; Han, JW; Han, SM; Kim, YM; Koo, HS; Lee, MH | 1 |
Chessa, L; Mosesso, P; Palitti, F; Penna, S; Pepe, G; Piane, M | 1 |
Dendouga, N; Gao, H; Janicot, M; McGowan, CH; Moechars, D; Vialard, J | 1 |
Imai, T; Inoue, H; Mori, M; Shiomi, N; Shiomi, T; Tateishi, S; Tsuji, H; Yamaizumi, M | 1 |
Berend, S; Fuchs, N; Kopjar, N; Radić, B; Vrdoljak, AL; Zeljezić, D | 1 |
Bernal, JA; Espina, A; Méndez-Vidal, C; Pintor-Toro, JA; Roche, M; Tortolero, M | 1 |
Averbeck, D; Duchaud, E; Moustacchi, E; Rosselli, F | 1 |
Bassi, L; Cortés, F; Di Chiara, D; Fiore, M; Palitti, F; Pinero, J | 1 |
Johnson, RT; Ryan, AJ; Squires, S; Strutt, HL | 1 |
Cortés, F; Palitti, F; Piñero, J | 1 |
Ikeda, T; Nakaike, S; Nakane, S; Ohsawa, M; Suzuki, H; Yamagishi, T | 1 |
Cortés, F; Piñero, J | 1 |
Evans, A; Johnson, RT; Ryan, AJ; Squires, S; Strutt, HL | 1 |
Nakane, S; Suzuki, H | 1 |
Kojima, A; Saijo, N; Shinkai, T | 1 |
Andoh, T; Aratani, Y; Koyama, H | 1 |
De Salvia, R; Degrassi, F; Fiore, M; Zanier, R | 1 |
Cortés, F; López-Baena, M; Mateos, S; Piñero, J | 1 |
Enomoto, T; Katada, T; Masuko, T; Narita, Y; Seki, M; Sonoda, E; Takeda, S; Wang, W; Yamada, K | 1 |
Franchitto, A; Mosesso, P; Palitti, F; Pichierri, P | 2 |
Colussi, C; Franchitto, A; Palitti, F; Pichierri, P; Piergentili, R | 1 |
Fujita, K; Furuichi, Y; Imamura, O; Itoh, C; Matsumoto, T; Takeda, S | 1 |
AbuBakar, S; Albrecht, T; Boldogh, I; Deng, CZ; Fons, MP | 1 |
Sumner, AT | 1 |
Andersson, HC; Kihlman, BA | 2 |
Qi, XD; Tang, WD; Tu, ZH; Wang, MY; Xiao, WQ | 1 |
Allen, JW; Backer, LC; Campbell, JA; DeMarini, DM; Doerr, CL; Harrington-Brock, K; Howard, DR; Kligerman, AD; Moore, MM | 1 |
Chen, AY; Hwang, JL; Juan, CC; Shyy, SH; Whang-Peng, J | 1 |
De Salvia, R; Degrassi, F; Palitti, F; Tanzarella, C | 1 |
Covey, JM; Kao-Shan, CS; Kerrigan, D; Pommier, Y; Whang-Peng, J | 1 |
41 other study(ies) available for camptothecin and Abnormalities, Autosome
Article | Year |
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RhoB promotes γH2AX dephosphorylation and DNA double-strand break repair.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Checkpoint Kinase 2; Chromosome Aberrations; DNA Breaks, Double-Stranded; DNA Repair; ELAV Proteins; Genomic Instability; HCT116 Cells; Histones; Humans; Mice; Mice, Knockout; Phosphorylation; Protein Binding; Protein Phosphatase 2; rhoB GTP-Binding Protein; RNA Interference; RNA-Binding Proteins; RNA, Small Interfering; Topoisomerase I Inhibitors | 2014 |
Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine.
Topics: Adaptor Proteins, Signal Transducing; Aminacrine; Camptothecin; Cell Cycle Proteins; Chromosome Aberrations; Comet Assay; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; G2 Phase Cell Cycle Checkpoints; Green Fluorescent Proteins; HeLa Cells; Histones; Humans; MCF-7 Cells; Micronuclei, Chromosome-Defective; Micronucleus Tests; Nuclear Proteins; Phosphorylation; Propyl Gallate; Recombinant Fusion Proteins; Serine; Trans-Activators; Transfection | 2016 |
The cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2.
Topics: Acetyltransferases; Camptothecin; Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; Chromosome Aberrations; Chromosome Segregation; Cohesins; Congenital Abnormalities; DNA Damage; Etoposide; Fibroblasts; Growth Disorders; Humans; Infant; Male; Mitomycin; Nucleic Acid Synthesis Inhibitors; Sister Chromatid Exchange; Syndrome | 2009 |
Assessment of cyto/genotoxicity of irinotecan in v79 cells using the comet, micronucleus, and chromosome aberration assay.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line; Cells, Cultured; Chromosome Aberrations; Comet Assay; Cricetinae; Cricetulus; Irinotecan; Micronucleus Tests; Mutagenicity Tests | 2010 |
Role of senataxin in DNA damage and telomeric stability.
Topics: Camptothecin; Cell Line, Tumor; Chromosome Aberrations; DNA Damage; DNA Helicases; DNA Repair; Humans; Hydrogen Peroxide; In Situ Hybridization, Fluorescence; Lymphocytes; Mitomycin; Multifunctional Enzymes; RNA Helicases; Spinocerebellar Ataxias; Spinocerebellar Degenerations; Telomere; X-Rays | 2011 |
The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination.
Topics: Animals; BRCA2 Protein; Camptothecin; Cell Line; Cell Proliferation; Chickens; Chromosome Aberrations; Cisplatin; Clone Cells; DNA Damage; Epistasis, Genetic; Gamma Rays; Gene Conversion; Gene Deletion; Genetic Loci; Genome; Homologous Recombination; Models, Biological; Phenotype; Phthalazines; Piperazines; Rad51 Recombinase | 2011 |
Modulation of irinotecan-induced genomic DNA damage by theanine.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chromosome Aberrations; DNA Damage; Dose-Response Relationship, Drug; Glutamates; Irinotecan; Male; Mice; Micronucleus Tests; Oxidative Stress | 2012 |
RAD51 mutants cause replication defects and chromosomal instability.
Topics: Adenosine Triphosphate; Animals; Camptothecin; Cell Line; Chromosomal Instability; Chromosome Aberrations; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; DNA Replication; Embryonic Stem Cells; Green Fluorescent Proteins; Humans; Mice; Promoter Regions, Genetic; Rad51 Recombinase; RNA Interference; RNA, Small Interfering | 2012 |
Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients.
Topics: 4-Nitroquinoline-1-oxide; B-Lymphocytes; Bloom Syndrome; Camptothecin; Carcinogens; Case-Control Studies; Cell Division; Cell Line; Chromosome Aberrations; Etoposide; Herpesvirus 4, Human; Humans; Karyotyping; Metaphase; Micronuclei, Chromosome-Defective; Mitomycin; Sister Chromatid Exchange; Werner Syndrome | 2002 |
Caenorhabditis elegans dna-2 is involved in DNA repair and is essential for germ-line development.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Camptothecin; Chromosome Aberrations; DNA Damage; DNA Repair; DNA, Helminth; Gamma Rays; Genes, Lethal; Germ Cells; Heterozygote; Homozygote; Oocytes; Ovum; Phenotype; RNA Interference; Temperature | 2003 |
The novel human gene aprataxin is directly involved in DNA single-strand-break repair.
Topics: Apraxia, Ideomotor; Camptothecin; Cerebellar Ataxia; Chromosome Aberrations; Comet Assay; Diagnosis, Differential; DNA Damage; DNA Repair; DNA Topoisomerases, Type I; DNA-Binding Proteins; DNA, Single-Stranded; Humans; Male; Nuclear Proteins; Pedigree; Point Mutation; Radiation Tolerance; X-Rays | 2005 |
Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis.
Topics: Animals; Camptothecin; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; DNA Damage; DNA-Binding Proteins; Endonucleases; Fibroblasts; Genomic Instability; Mice; Rad51 Recombinase; Saccharomyces cerevisiae Proteins | 2005 |
Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination.
Topics: Camptothecin; Cell Line, Tumor; Chromosome Aberrations; Comet Assay; DNA Breaks, Single-Stranded; DNA Damage; DNA Repair; DNA-Binding Proteins; Enzyme Inhibitors; Gene Deletion; Gene Targeting; Genes, Lethal; Humans; Proliferating Cell Nuclear Antigen; S Phase; Topoisomerase I Inhibitors; Ubiquitin; Ubiquitin-Protein Ligases; X-Rays | 2007 |
Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro.
Topics: Acetylcholinesterase; Adult; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cells, Cultured; Cholinesterase Inhibitors; Chromosome Aberrations; Female; Humans; Irinotecan; Lymphocytes; Molecular Structure; Oximes; Pyridinium Compounds | 2007 |
Proliferative potential after DNA damage and non-homologous end joining are affected by loss of securin.
Topics: Base Sequence; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromosome Aberrations; DNA; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Doxorubicin; Genomic Instability; Humans; Molecular Sequence Data; Neoplasm Proteins; RNA, Small Interfering; Securin | 2008 |
Comparison of the effects of DNA topoisomerase inhibitors on lymphoblasts from normal and Fanconi anemia donors.
Topics: Camptothecin; Cell Division; Cells, Cultured; Chromosome Aberrations; DNA; DNA Damage; DNA Repair; Fanconi Anemia; Hematopoietic Stem Cells; Humans; Indoles; Isoquinolines; Lymphocytes; Methoxsalen; Nalidixic Acid; Novobiocin; Skin; Topoisomerase I Inhibitors | 1994 |
Higher G2 sensitivity to the induction of chromosomal damage in the CHO mutant EM9 than in its parental line AA8 by camptothecin, an inhibitor of DNA topoisomerase I.
Topics: Animals; Camptothecin; CHO Cells; Chromosome Aberrations; Chromosomes; Cricetinae; G2 Phase; Mutagens; Mutation; Topoisomerase I Inhibitors | 1993 |
Hypersensitivity of Cockayne's syndrome cells to camptothecin is associated with the generation of abnormally high levels of double strand breaks in nascent DNA.
Topics: Aphidicolin; Camptothecin; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cockayne Syndrome; DNA; DNA Damage; DNA Repair; Humans; In Vitro Techniques; RNA; Time Factors; Topoisomerase I Inhibitors; Ultraviolet Rays | 1993 |
Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8.
Topics: Amsacrine; Animals; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Mutation; Sister Chromatid Exchange; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1993 |
Efficient induction of chromosome-type aberrations by topoisomerase II inhibitors closely associated with stabilization of the cleavable complex in cultured fibroblastic cells.
Topics: 2,4-Dinitrophenol; Aclarubicin; Adenosine Triphosphate; Animals; Camptothecin; Cells, Cultured; Chromosome Aberrations; Cricetinae; Dinitrophenols; DNA; DNA Damage; DNA Topoisomerases, Type II; Doxorubicin; Etoposide; Fibroblasts; Topoisomerase II Inhibitors | 1995 |
Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured Chinese hamster ovary cells.
Topics: Amsacrine; Animals; Camptothecin; Cell Death; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Damage; Drug Synergism; Electrophoresis, Agar Gel; Metaphase; Sister Chromatid Exchange; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1994 |
Different fates of camptothecin-induced replication fork-associated double-strand DNA breaks in mammalian cells.
Topics: Animals; Caffeine; Camptothecin; Cell Line; CHO Cells; Chromosome Aberrations; Cricetinae; DNA; DNA Damage; DNA Replication; DNA, Neoplasm; Humans; Mitosis; Sensitivity and Specificity; Skin; Skin Physiological Phenomena; Urinary Bladder Neoplasms | 1994 |
Differential induction of chromosomal aberrations by topoisomerase inhibitors in cultured Chinese hamster cells.
Topics: Aclarubicin; Animals; Camptothecin; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Doxorubicin; Etoposide; Fibroblasts; Lung; Mitoxantrone; Sister Chromatid Exchange; Topoisomerase I Inhibitors | 1994 |
Cytogenetic effects of CPT-11 and its active metabolite, SN-38 on human lymphocytes.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Chromosome Aberrations; Dose-Response Relationship, Drug; Humans; Irinotecan; Lymphocytes; Mutagens; Neoplasms; Sister Chromatid Exchange; Time Factors | 1993 |
Effects of DNA topoisomerase inhibitors on nonhomologous and homologous recombination in mammalian cells.
Topics: Adenine Phosphoribosyltransferase; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; Diketopiperazines; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Mutagenesis; Mutagenicity Tests; Nucleic Acid Heteroduplexes; Piperazines; Recombination, Genetic; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transfection | 1996 |
Topoisomerase I activity and cellular response to radiation in Chinese hamster cells.
Topics: Animals; Camptothecin; Cell Cycle; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Topoisomerases, Type I; Enzyme Inhibitors; Flow Cytometry; Topoisomerase I Inhibitors | 1996 |
Enhanced sensitivity to topoisomerase inhibitors in synchronous CHO cells pre-treated with 5-azacytidine.
Topics: Amsacrine; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Azacitidine; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Methylation; Drug Interactions; Enzyme Inhibitors; S Phase; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1998 |
Possible association of BLM in decreasing DNA double strand breaks during DNA replication.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Animals; Base Sequence; Bloom Syndrome; Camptothecin; Cell Cycle; Cells, Cultured; Chickens; Chromosome Aberrations; DNA Damage; DNA Helicases; DNA Primers; DNA Repair Enzymes; DNA Replication; Etoposide; Fungal Proteins; Methyl Methanesulfonate; Molecular Sequence Data; RecQ Helicases; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid | 2000 |
Evidence that camptothecin-induced aberrations in the G(2) phase of cell cycle of Chinese hamster ovary (CHO) cell lines is associated with transcription.
Topics: Amanitins; Animals; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; Cricetulus; G2 Phase; RNA, Messenger; Transcription, Genetic | 2000 |
Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage.
Topics: Camptothecin; Cell Cycle; Cell Line, Transformed; Chromosome Aberrations; DNA Replication; Enzyme Inhibitors; G2 Phase; Humans; RNA Polymerase II; S Phase; Topoisomerase I Inhibitors; Werner Syndrome | 2000 |
Hypersensitivity to camptothecin in MSH2 deficient cells is correlated with a role for MSH2 protein in recombinational repair.
Topics: Animals; Antineoplastic Agents, Phytogenic; Base Pair Mismatch; Camptothecin; Cell Cycle; Cell Survival; Chromosome Aberrations; Colorectal Neoplasms; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; Drug Hypersensitivity; Flow Cytometry; Mice; Mice, Knockout; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Rad51 Recombinase; Sister Chromatid Exchange; Tumor Cells, Cultured | 2001 |
Werner and Bloom helicases are involved in DNA repair in a complementary fashion.
Topics: 4-Nitroquinoline-1-oxide; Adenosine Triphosphatases; Amino Acid Sequence; Animals; B-Lymphocytes; Bloom Syndrome; Camptothecin; Cell Cycle; Cell Line; Chickens; Chromosome Aberrations; Clone Cells; Coculture Techniques; DNA; DNA Damage; DNA Helicases; DNA Repair; Drug Resistance; Etoposide; Gene Targeting; Humans; Methyl Methanesulfonate; Molecular Sequence Data; Mutagenicity Tests; Radiation Tolerance; RecQ Helicases; Sequence Alignment; Sequence Homology, Amino Acid; Sister Chromatid Exchange; Species Specificity; Ultraviolet Rays; Werner Syndrome | 2002 |
Modulation of the frequency of human cytomegalovirus-induced chromosome aberrations by camptothecin.
Topics: Benzamides; Camptothecin; Cells, Cultured; Chromosome Aberrations; Cytomegalovirus Infections; DNA Repair; Dose-Response Relationship, Drug; Humans; Lymphocytes; Novobiocin; Poly(ADP-ribose) Polymerase Inhibitors | 1992 |
Inhibitors of topoisomerases do not block the passage of human lymphocyte chromosomes through mitosis.
Topics: Amsacrine; Camptothecin; Chromosome Aberrations; Chromosomes, Human; Daunorubicin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Ellipticines; Ethidium; Etoposide; Humans; In Vitro Techniques; Lymphocytes; Mitosis; Mitoxantrone; Nalidixic Acid; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1992 |
Induction of chromosomal aberrations by camptothecin in root-tip cells of Vicia faba.
Topics: Autoradiography; Camptothecin; Chromatids; Chromosome Aberrations; DNA Damage; DNA Replication; Fabaceae; Interphase; Mutagenesis; Plants, Medicinal | 1992 |
Enhancement and reduction by methylated oxypurines of the frequencies of chromatid aberrations induced by camptothecin in root-tip cells of Vicia faba.
Topics: Caffeine; Camptothecin; Chromatids; Chromosome Aberrations; Dose-Response Relationship, Drug; Methylnitrosourea; Mutagenicity Tests; Mutagens; Plants; Purines; Theophylline; Uric Acid | 1992 |
[Effects of 10-hydroxycamptothecin on induced chromosome aberrations in Chinese hamster ovary cells and micronuclei in mouse bone marrow and fetal liver].
Topics: Animals; Bone Marrow; Camptothecin; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Female; Liver; Mice; Micronucleus Tests; Mutagenicity Tests; Ovary | 1990 |
Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro.
Topics: Amsacrine; Animals; Bone Marrow; Bone Marrow Cells; Camptothecin; Cell Line; Chromatids; Chromosome Aberrations; Dose-Response Relationship, Drug; Gene Rearrangement; In Vitro Techniques; Lymphocytes; Lymphoma; Male; Mice; Mice, Inbred C57BL; Mutagens; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1990 |
Studies of topoisomerase-specific antitumor drugs in human lymphocytes using rabbit antisera against recombinant human topoisomerase II polypeptide.
Topics: Animals; Antibodies; Base Sequence; Camptothecin; Chromosome Aberrations; Cloning, Molecular; DNA Replication; DNA Topoisomerases, Type II; Escherichia coli; Genes; Genetic Vectors; Humans; Immune Sera; Lymphocyte Activation; Lymphocytes; Molecular Sequence Data; Podophyllotoxin; Rabbits; Recombinant Proteins; Teniposide; Topoisomerase II Inhibitors | 1989 |
Induction of chromosomal aberrations and SCE by camptothecin, an inhibitor of mammalian topoisomerase I.
Topics: Camptothecin; Cells, Cultured; Chromosome Aberrations; Culture Media; Humans; Interphase; Lymphocytes; Mitotic Index; Sister Chromatid Exchange; Topoisomerase I Inhibitors | 1989 |
Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.
Topics: Amsacrine; Animals; Camptothecin; Cell Line; Cell Survival; Chromosome Aberrations; Cricetinae; Drug Resistance; Ellipticines; Etoposide; Mitomycin; Mitomycins; Sister Chromatid Exchange; Topoisomerase II Inhibitors | 1988 |