cambinol and Alzheimer-Disease

Neutral sphingomyelinase 2 (nSMase2) catalyzes the cleavage of sphingomyelin to phosphorylcholine and ceramide, an essential step in the formation and release of exosomes from cells that is critical for intracellular communication. Chronic increase of brain nSMase2 activity and related exosome release have been implicated in various pathological processes, including the progression of Alzheimer's disease (AD), making nSMase2 a viable therapeutic target. Recently, we identified phenyl (

Topics: Alzheimer Disease; Animals; Body Weight; Brain; Disease Models, Animal; Enzyme Inhibitors; Exosomes; Female; Humans; Male; Mice; Mice, Transgenic; Pyridazines; Sphingomyelin Phosphodiesterase; Structure-Activity Relationship

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies; Disease Models, Animal; Disease Progression; Entorhinal Cortex; Humans; Mice; Models, Biological; Naphthalenes; Pyrimidinones; tau Proteins; Treatment Failure