calycosin-7-o-beta-d-glucopyranoside and Arthritis--Rheumatoid

calycosin-7-o-beta-d-glucopyranoside has been researched along with Arthritis--Rheumatoid* in 1 studies

Other Studies

1 other study(ies) available for calycosin-7-o-beta-d-glucopyranoside and Arthritis--Rheumatoid

ArticleYear
Ononin induces cell apoptosis and reduces inflammation in rheumatoid arthritis fibroblast-like synoviocytes by alleviating MAPK and NF-κB signaling pathways.
    Acta biochimica Polonica, 2021, Jun-02, Volume: 68, Issue:2

    As a kind of chronic inflammatory diseases, Rheumatoid arthritis (RA) has a low cure rate and easy recurrence. It has widely reported that abnormal activation of mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B (NF-κB) signaling pathways are associated with the development of RA inflammation. Blocking the inflammatory signaling pathways of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) can delay the development of RA. Ononin is a natural isoflavone glycoside and plays a key role in modulating inflammation related signaling pathways. However, whether Ononin exerts anti-inflammatory effects on RA inflammation remains unknown. In this study, we evaluated the therapeutic effect of Ononin on RA by establishing a tumor necrosis factor α (TNF-α)-induced RA-FLS cell model. Our data confirmed that Ononin could alleviate TNF-α-induced RA-FLS and MH7A cells viability, increase cell apoptosis, decrease the production of pro-inflammatory cytokines like interleukin-1β (IL-1β) and interleukin 6 (IL-6), and further inhibit the abnormal activation of NF-κB and MAPK pathways. Our results suggested that Ononin could be a potential therapeutic agent for RA.

    Topics: Apoptosis; Arthritis, Rheumatoid; Cell Line; Cell Survival; Cytokines; Fibroblasts; Glucosides; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Isoflavones; Mitogen-Activated Protein Kinases; NF-kappa B; Signal Transduction; Synoviocytes; Tumor Necrosis Factor-alpha

2021