calpain-inhibitor-iii and Muscular-Dystrophy--Animal

calpain-inhibitor-iii has been researched along with Muscular-Dystrophy--Animal* in 1 studies

Other Studies

1 other study(ies) available for calpain-inhibitor-iii and Muscular-Dystrophy--Animal

Article	Year
Novel cell-penetrating alpha-keto-amide calpain inhibitors as potential treatment for muscular dystrophy. Bioorganic & medicinal chemistry letters, 2005, Dec-01, Volume: 15, Issue:23 Dipeptide-derived alpha-keto-amide compounds with potent calpain inhibitory activity have been identified. These reversible covalent inhibitors have IC(50) values down to 25nM and exhibit greatly improved activity in muscle cells compared to the reference compound MDL28170. Several novel calpain inhibitors have shown positive effects on histological parameters in an animal model of Duchenne muscular dystrophy demonstrating their potential as a treatment option for this fatal disease. Topics: Amides; Animals; Calpain; Cysteine Proteinase Inhibitors; Diaphragm; Dipeptides; Mice; Mice, Inbred mdx; Molecular Structure; Muscular Dystrophy, Animal	2005

Article

Year

Novel cell-penetrating alpha-keto-amide calpain inhibitors as potential treatment for muscular dystrophy.

Bioorganic & medicinal chemistry letters, 2005, Dec-01, Volume: 15, Issue:23

Dipeptide-derived alpha-keto-amide compounds with potent calpain inhibitory activity have been identified. These reversible covalent inhibitors have IC(50) values down to 25nM and exhibit greatly improved activity in muscle cells compared to the reference compound MDL28170. Several novel calpain inhibitors have shown positive effects on histological parameters in an animal model of Duchenne muscular dystrophy demonstrating their potential as a treatment option for this fatal disease.

Topics: Amides; Animals; Calpain; Cysteine Proteinase Inhibitors; Diaphragm; Dipeptides; Mice; Mice, Inbred mdx; Molecular Structure; Muscular Dystrophy, Animal

2005