calpain has been researched along with Central-Nervous-System-Diseases* in 3 studies
3 review(s) available for calpain and Central-Nervous-System-Diseases
| Article | Year |
|---|---|
Melatonin, a calpain inhibitor in the central nervous system: Current status and future perspectives.
Dysregulation of neuronal Ca Topics: Animals; Calpain; Central Nervous System; Central Nervous System Diseases; Cysteine Proteinase Inhibitors; Humans; Melatonin; Signal Transduction | 2019 |
Development and therapeutic potential of calpain inhibitors.
Topics: Animals; Calcium; Calpain; Cataract; Central Nervous System Diseases; Humans; Muscular Dystrophies; Myocardial Ischemia; Proteins | 1997 |
Calpain inhibition: an overview of its therapeutic potential.
Increasing evidence now suggests that excessive activation of the Ca(2+)-dependent protease calpain could play a key or contributory role in the pathology of a variety of disorders, including cerebral ischaemia, cataract, myocardial ischaemia, muscular dystrophy and platelet aggregation. In this review, Kevin Wang and Po-Wai Yuen discuss the evidence linking these disorders to calpain overactivation. At present, it is difficult to confirm the exact role of calpain in these disorders because of the lack of potent, selective and cell-permeable calpain inhibitors. However, given the multiple therapeutic indications for calpain, it appears that achievement of selective calpain inhibition is an important pharmacological goal. Topics: Amino Acid Sequence; Brain Ischemia; Calpain; Central Nervous System Diseases; Humans; Molecular Sequence Data; Myocardial Ischemia | 1994 |