calixarenes and Staphylococcal-Infections

calixarenes has been researched along with Staphylococcal-Infections* in 1 studies

Other Studies

1 other study(ies) available for calixarenes and Staphylococcal-Infections

Article	Year
Phosphonium pillar[5]arenes as a new class of efficient biofilm inhibitors: importance of charge cooperativity and the pillar platform. Chemical communications (Cambridge, England), 2016, Aug-23, Volume: 52, Issue:70 Biofilm formation, which frequently occurs in microbial infections and often reduces the efficacy of antibiotics, also perturbs many industrial and domestic processes. We found that a new class of water soluble pillar[5]arenes bearing phosphonium moieties (1, 2) and their respective ammonium analogues (3, 4) inhibit biofilm formation with IC50 values in the range of 0.67-1.66 μM. These compounds have no antimicrobial activity, do not damage red blood cell membranes, and do not affect mammalian cell viability in culture. Comparison of the antibiofilm activities of the phosphonium-decorated pillar[5]arene derivatives 1 and 2 with their respective ammonium counterparts 3 and 4 and their monomers 5 and 6, demonstrate that while positive charges, charge cooperativity and the pillararene platform are essential for the observed antibiofilm activity the nature of the charges is not. Topics: Anti-Bacterial Agents; Biofilms; Calixarenes; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Organophosphorus Compounds; Quaternary Ammonium Compounds; Staphylococcal Infections; Staphylococcus aureus	2016

Article

Year

Phosphonium pillar[5]arenes as a new class of efficient biofilm inhibitors: importance of charge cooperativity and the pillar platform.

Chemical communications (Cambridge, England), 2016, Aug-23, Volume: 52, Issue:70

Biofilm formation, which frequently occurs in microbial infections and often reduces the efficacy of antibiotics, also perturbs many industrial and domestic processes. We found that a new class of water soluble pillar[5]arenes bearing phosphonium moieties (1, 2) and their respective ammonium analogues (3, 4) inhibit biofilm formation with IC50 values in the range of 0.67-1.66 μM. These compounds have no antimicrobial activity, do not damage red blood cell membranes, and do not affect mammalian cell viability in culture. Comparison of the antibiofilm activities of the phosphonium-decorated pillar[5]arene derivatives 1 and 2 with their respective ammonium counterparts 3 and 4 and their monomers 5 and 6, demonstrate that while positive charges, charge cooperativity and the pillararene platform are essential for the observed antibiofilm activity the nature of the charges is not.

Topics: Anti-Bacterial Agents; Biofilms; Calixarenes; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Organophosphorus Compounds; Quaternary Ammonium Compounds; Staphylococcal Infections; Staphylococcus aureus

2016