calixarenes and HIV-Infections

calixarenes has been researched along with HIV-Infections* in 2 studies

Other Studies

2 other study(ies) available for calixarenes and HIV-Infections

ArticleYear
Synthesis and anti-HIV evaluation of water-soluble calixarene-based bithiazolyl podands.
    Bioorganic & medicinal chemistry, 2010, Jan-01, Volume: 18, Issue:1

    Nine anionic water-soluble calix[4]arene species, incorporating sulfonate, carboxylate or phosphonate groups, six of them incorporating two 2,2'-bithiazole subunits in alternate position at the lower rim, have been synthesised and evaluated as anti-HIV agents on various HIV strains and cells of the lymphocytic lineage (HIV-1 III B/MT4, HIV-1 LAI/CEM-SS, HIV-1 Bal/PBMC), using AZT as reference compound. A toxicity was detected for a minority of compounds on PBMC whereas for the others no cellular toxicity was measured at concentrations up to 100 microM. Most of the compounds have an antiviral activity in a 10-50 microM range, and one of them, sulfonylated, displays its activity, whatever the tropism of the virus, at a micromolar concentration.

    Topics: Anti-HIV Agents; Calixarenes; Cell Line; Cell Survival; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Microbial Sensitivity Tests; Molecular Structure; Thiazoles; Water

2010
Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold.
    Bioorganic & medicinal chemistry letters, 2010, Apr-01, Volume: 20, Issue:7

    A potential anti-HIV and HCV drug candidate is highly desirable as coinfection has become a worldwide public health challenge. A potent compound based on a tetrabutoxy-calix[4]arene scaffold that possesses dual inhibition for both HIV and HCV is described. Structural activity relationship studies demonstrate the effects of lower-rim alkylation in maintaining cone conformation and upper-rim interacting head groups on the calix[4]arene play key roles for its potent dual antiviral activities.

    Topics: Antiviral Agents; Calixarenes; Cell Line; Cell Survival; Hepacivirus; Hepatitis C; HIV; HIV Infections; Inhibitory Concentration 50; Models, Molecular; Molecular Structure

2010