calixarenes and Cholera

calixarenes has been researched along with Cholera* in 1 studies

Other Studies

1 other study(ies) available for calixarenes and Cholera

Article	Year
Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix[5]arene. Organic & biomolecular chemistry, 2013, Jul-14, Volume: 11, Issue:26 Cholera toxin (CT), the causative agent of cholera, displays a pentavalent binding domain that targets the oligosaccharide of ganglioside GM1 (GM1os) on the periphery of human abdominal epithelial cells. Here, we report the first GM1os-based CT inhibitor that matches the valency of the CT binding domain (CTB). This pentavalent inhibitor contains five GM1os moieties linked to a calix[5]arene scaffold. When evaluated by an inhibition assay, it achieved a picomolar inhibition potency (IC50 = 450 pM) for CTB. This represents a significant multivalency effect, with a relative inhibitory potency of 100,000 compared to a monovalent GM1os derivative, making GM1os-calix[5]arene one of the most potent known CTB inhibitors. Topics: Antitoxins; Calixarenes; Cholera; Cholera Toxin; G(M1) Ganglioside; Humans; Models, Molecular; Vibrio cholerae	2013

Article

Year

Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix[5]arene.

Organic & biomolecular chemistry, 2013, Jul-14, Volume: 11, Issue:26

Cholera toxin (CT), the causative agent of cholera, displays a pentavalent binding domain that targets the oligosaccharide of ganglioside GM1 (GM1os) on the periphery of human abdominal epithelial cells. Here, we report the first GM1os-based CT inhibitor that matches the valency of the CT binding domain (CTB). This pentavalent inhibitor contains five GM1os moieties linked to a calix[5]arene scaffold. When evaluated by an inhibition assay, it achieved a picomolar inhibition potency (IC50 = 450 pM) for CTB. This represents a significant multivalency effect, with a relative inhibitory potency of 100,000 compared to a monovalent GM1os derivative, making GM1os-calix[5]arene one of the most potent known CTB inhibitors.

Topics: Antitoxins; Calixarenes; Cholera; Cholera Toxin; G(M1) Ganglioside; Humans; Models, Molecular; Vibrio cholerae

2013