calixarenes has been researched along with Acute-Kidney-Injury* in 1 studies
1 other study(ies) available for calixarenes and Acute-Kidney-Injury
| Article | Year |
|---|---|
Coassembly of hypoxia-sensitive macrocyclic amphiphiles and extracellular vesicles for targeted kidney injury imaging and therapy.
Hypoxia is a major contributor to global kidney diseases. Targeting hypoxia is a promising therapeutic option against both acute kidney injury and chronic kidney disease; however, an effective strategy that can achieve simultaneous targeted kidney hypoxia imaging and therapy has yet to be established. Herein, we fabricated a unique nano-sized hypoxia-sensitive coassembly (Pc/C5A@EVs) via molecular recognition and self-assembly, which is composed of the macrocyclic amphiphile C5A, the commercial dye sulfonated aluminum phthalocyanine (Pc) and mesenchymal stem cell-excreted extracellular vesicles (MSC-EVs).. This synergetic nanoscale coassembly with great translational potential provides a novel strategy for precise kidney hypoxia diagnosis and efficient kidney injury treatment. Furthermore, our strategy of coassembling exogenous macrocyclic receptors with endogenous cell-derived membranous structures may offer a functional platform to address multiple clinical needs. Topics: Acute Kidney Injury; Animals; Calixarenes; Cell Hypoxia; Cell Line; Epithelial Cells; Extracellular Vesicles; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Inflammation; Integrins; Macrocyclic Compounds; Macrophages; Mice; NF-kappa B; Organometallic Compounds; Signal Transduction; Surface-Active Agents | 2021 |