calix(4)arene and Disease-Models--Animal

calix(4)arene has been researched along with Disease-Models--Animal* in 2 studies

Other Studies

2 other study(ies) available for calix(4)arene and Disease-Models--Animal

Article	Year
Metal ion-responsive nanocarrier derived from phosphonated calix[4]arenes for delivering dauricine specifically to sites of brain injury in a mouse model of intracerebral hemorrhage. Journal of nanobiotechnology, 2020, Apr-19, Volume: 18, Issue:1 Primary intracerebral hemorrhage (ICH) is a leading cause of long-term disability and death worldwide. Drug delivery vehicles to treat ICH are less than satisfactory because of their short circulation lives, lack of specific targeting to the hemorrhagic site, and poor control of drug release. To exploit the fact that metal ions such as Fe Topics: Animals; Benzylisoquinolines; Blood-Brain Barrier; Calixarenes; Cerebral Hemorrhage; Disease Models, Animal; Drug Carriers; Humans; Interleukin-1beta; Ions; Male; Matrix Metalloproteinase 9; Metals; Mice; Mice, Inbred C57BL; Nanostructures; Neurons; Neuroprotective Agents; Organophosphonates; Phenols; Reactive Oxygen Species; Tetrahydroisoquinolines	2020
Topical Delivery of Curcumin by Choline-Calix[4]arene-Based Nanohydrogel Improves Its Therapeutic Effect on a Psoriasis Mouse Model. International journal of molecular sciences, 2020, Jul-17, Volume: 21, Issue:14 Curcumin (CUR) has shown remarkable efficacy in the treatment of skin diseases, but its effective transdermal delivery is still a major challenge and stimulates interest in the design of novel systems for CUR dispersion, preservation, and delivery facilitation to the deeper layers of the skin. The present work aimed to investigate the potential of a nanohydrogel, formed by a micellar choline-calix[4]arene amphiphile (CALIX) and CUR, in the treatment of skin diseases through an imiquimod (IMQ)-induced psoriasis model. Psoriasis plaques are associated with aberrant keratinization, abnormal distribution of tight junctions (TJs) proteins, and enhanced expression of inflammatory markers. The nanohydrogel restored the normal distribution of TJs proteins ZO1 and occludin and reduced the expression of TNF-α and inducible nitric oxide synthetase (iNOS) compared to the untreated IMQ group. The novelty lies in the calix[4]arene-based nanohydrogel as a potential new soft material for the topical skin delivery of CUR. The nanohydrogel, due to its physicochemical and mechanical properties, enhances the drug water-solubility, preserves CUR from rapid degradation, and eases the local skin administration and penetration. Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calixarenes; Choline; Curcumin; Disease Models, Animal; Drug Carriers; Hydrogels; Male; Mice; Mice, Inbred BALB C; Phenols; Psoriasis	2020

Article

Year

Metal ion-responsive nanocarrier derived from phosphonated calix[4]arenes for delivering dauricine specifically to sites of brain injury in a mouse model of intracerebral hemorrhage.

Journal of nanobiotechnology, 2020, Apr-19, Volume: 18, Issue:1

Primary intracerebral hemorrhage (ICH) is a leading cause of long-term disability and death worldwide. Drug delivery vehicles to treat ICH are less than satisfactory because of their short circulation lives, lack of specific targeting to the hemorrhagic site, and poor control of drug release. To exploit the fact that metal ions such as Fe

Topics: Animals; Benzylisoquinolines; Blood-Brain Barrier; Calixarenes; Cerebral Hemorrhage; Disease Models, Animal; Drug Carriers; Humans; Interleukin-1beta; Ions; Male; Matrix Metalloproteinase 9; Metals; Mice; Mice, Inbred C57BL; Nanostructures; Neurons; Neuroprotective Agents; Organophosphonates; Phenols; Reactive Oxygen Species; Tetrahydroisoquinolines

2020

Topical Delivery of Curcumin by Choline-Calix[4]arene-Based Nanohydrogel Improves Its Therapeutic Effect on a Psoriasis Mouse Model.

International journal of molecular sciences, 2020, Jul-17, Volume: 21, Issue:14

Curcumin (CUR) has shown remarkable efficacy in the treatment of skin diseases, but its effective transdermal delivery is still a major challenge and stimulates interest in the design of novel systems for CUR dispersion, preservation, and delivery facilitation to the deeper layers of the skin. The present work aimed to investigate the potential of a nanohydrogel, formed by a micellar choline-calix[4]arene amphiphile (CALIX) and CUR, in the treatment of skin diseases through an imiquimod (IMQ)-induced psoriasis model. Psoriasis plaques are associated with aberrant keratinization, abnormal distribution of tight junctions (TJs) proteins, and enhanced expression of inflammatory markers. The nanohydrogel restored the normal distribution of TJs proteins ZO1 and occludin and reduced the expression of TNF-α and inducible nitric oxide synthetase (iNOS) compared to the untreated IMQ group. The novelty lies in the calix[4]arene-based nanohydrogel as a potential new soft material for the topical skin delivery of CUR. The nanohydrogel, due to its physicochemical and mechanical properties, enhances the drug water-solubility, preserves CUR from rapid degradation, and eases the local skin administration and penetration.

Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calixarenes; Choline; Curcumin; Disease Models, Animal; Drug Carriers; Hydrogels; Male; Mice; Mice, Inbred BALB C; Phenols; Psoriasis

2020