calix(4)arene and Colorectal-Neoplasms

calix(4)arene has been researched along with Colorectal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for calix(4)arene and Colorectal-Neoplasms

Article	Year
Targeting Colorectal Cancer Cells with a Functionalised Calix[4]arene Receptor: Biophysical Studies. Molecules (Basel, Switzerland), 2022, Jan-14, Volume: 27, Issue:2 Colorectal cancer (CRC) is a disease which is causing a high degree of mortality around the world. The present study reports the antiproliferative impact of the thioacetamide calix[4]arene, CAII receptor on a highly differentiated Caco-2 cell line. This statement is corroborated by the MTT assay results which revealed a reduction in the cell viability with an IC50 value of 19.02 ± 0.04 µM. Microscopic results indicated that at the starting amount of 10 µM of CAII, a decrease in cells confluency can already be observed in addition to changes in cells morphology. Cell metabolic pathway changes were also investigated. Topics: Antineoplastic Agents; Caco-2 Cells; Calixarenes; Carbonic Anhydrase II; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Humans; Phenols	2022

Article

Year

Targeting Colorectal Cancer Cells with a Functionalised Calix[4]arene Receptor: Biophysical Studies.

Molecules (Basel, Switzerland), 2022, Jan-14, Volume: 27, Issue:2

Colorectal cancer (CRC) is a disease which is causing a high degree of mortality around the world. The present study reports the antiproliferative impact of the thioacetamide calix[4]arene, CAII receptor on a highly differentiated Caco-2 cell line. This statement is corroborated by the MTT assay results which revealed a reduction in the cell viability with an IC50 value of 19.02 ± 0.04 µM. Microscopic results indicated that at the starting amount of 10 µM of CAII, a decrease in cells confluency can already be observed in addition to changes in cells morphology. Cell metabolic pathway changes were also investigated.

Topics: Antineoplastic Agents; Caco-2 Cells; Calixarenes; Carbonic Anhydrase II; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Humans; Phenols

2022