calix(4)arene has been researched along with Alzheimer-Disease* in 1 studies
1 other study(ies) available for calix(4)arene and Alzheimer-Disease
Article | Year |
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Novel Peptide-Calix[4]arene Conjugate Inhibits Aβ Aggregation and Rescues Neurons from Aβ's Oligomers Cytotoxicity
Alzheimer's disease (AD) is a progressive neurodegenerative condition affecting people in the elderly. Targeting aggregation of β-amyloid peptides (Aβ) is considered a promising approach for the therapeutic treatment of the disease. Peptide based inhibitors of β-amyloid fibrillation are emerging as safe drug candidates as well as interesting compounds for early diagnosis of AD. Peptide conjugation via covalent bond with functional moieties enables the resultant hybrid system to acquire desired functions. Here we report the synthesis, the structural characterization, and the Aβ Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Calixarenes; Humans; Neurons; Peptide Fragments; Phenols | 2021 |