calicheamicin-gamma(1)i and Cell-Transformation--Viral

calicheamicin-gamma(1)i has been researched along with Cell-Transformation--Viral* in 1 studies

Other Studies

1 other study(ies) available for calicheamicin-gamma(1)i and Cell-Transformation--Viral

ArticleYear
Sensitivity of fibroblasts derived from ataxia-telangiectasia patients to calicheamicin gamma 1I.
    Mutation research, 1990, Volume: 245, Issue:3

    We report the hypersensitivity of SV40-transformed fibroblasts derived from ataxia telangiectasia (AT) patients to calicheamicin gamma 1I. In common with other free-radical generating agents such as bleomycin and ionizing radiation, treatment with calicheamicin gamma 1I reveals AT derived lines to be 6-fold more sensitive to this drug when compared to controls. Furthermore, in common with ionizing radiation, AT cells did not show dose-dependent inhibition of DNA synthesis after treatment with calicheamicin gamma 1I.

    Topics: Aminoglycosides; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Ataxia Telangiectasia; Bleomycin; Cell Line; Cell Survival; Cell Transformation, Viral; DNA; Dose-Response Relationship, Drug; Enediynes; Fibroblasts; Mesylates

1990