calcium-sulfide and Poisoning

Lime sulfur is a common bactericide with strong alkalinity, and is highly corrosive to humans and animals. It is rare for lime sulfur poisoning clinically. This article discusses the clinical manifestations of a patient who was poisoned by oral lime sulfur. After the poisoning, the mucosa of the lips and pharynx broke, fever, and pulmonary inflammation quickly appeared. The pulmonary CT showed slight interstitial changes in both lungs. Through high flow oxygen inhalation, fluid infusion, drainage, maintenance of water and electrolyte balance, protection of important organ functions, and other symptomatic support and treatment, as well as control of blood pressure, blood sugar, maintenance of circulatory function and other targeted measures, the patient's condition gradually improved.. 石硫合剂是一种较为常见的杀菌剂，呈强碱性，对人畜有强腐蚀性，石硫合剂中毒临床上较为罕见。本文对1例口服石硫合剂中毒患者的临床表现进行分析，中毒后快速出现口唇及咽部黏膜破溃、发热、肺部炎症，肺部CT见两肺轻度间质性改变；经高流量吸氧，补液促排，维持水电解质平衡、保护重要脏器功能等对症支持治疗，以及控制血压、血糖、维持循环功能等针对性措施，患者病情逐渐好转。.

Topics: Animals; Calcium Compounds; Humans; Poisoning; Sulfides

The Second Affiliated Hospital of Shandong First Medical University treated a patient with oral sulfur mixture poisoning on January 14, 2020. The patient presented with cyanosis and disturbance of consciousness as the first manifestations, accompanied by metabolic acidosis, shock, hypercalcemia and severe liver function and myocardial damage. The patient was given active treatment, including gastric lavage, blood purification, methylene blue application, correction of shock, organ support and other therapies. However the treatment was poor. Finally, the patient's family chose to give up and requested to be discharged from the hospital, and the patient died on the same day after follow-up.. 山东第一医科大学第二附属医院于2020年1月14日收治1例口服石硫合剂中毒患者，患者以紫绀、意识障碍为首发表现，伴有代谢性酸中毒、休克、高钙血症以及严重肝功能、心肌损害，予以洗胃、血液净化、亚甲蓝应用及纠正休克、脏器支持等治疗，效果欠佳。最终患者家属要求出院，随访患者当日死亡。.

Topics: Calcium Compounds; Humans; Poisoning; Sulfides

We carried out animal experiments to toxicologically verify polysulphide poisoning by analyzing tissue samples. A bathing agent containing calcium polysulphides was administered orally to rats, and then polysulphides and sulphide, the decomposed product of polysulphides, were analyzed by GC and GC/MS. The concentrations of polysulphides (mumol/ml or g) were found to be highest in blood (0.196), followed by the liver (0.051), the lungs (0.018) and kidneys (0.013), but were below the detection limit (0.005 mumol/g) in the other tissues tested. Sulphide was detected in all the tissue samples and was found to be highest in the blood (0.518 mumol/ml), this being 40 times higher than that required for fatal poisoning in the case of hydrogen sulphide. Polysulphide poisoning was considered to be confirmatively diagnosed by detecting and measuring polysuphides and supplementarily sulphide in body tissues, most pertinently in the blood. Two practical cases of suspected poisoning by polysulphides are briefly described.

Topics: Animals; Calcium Compounds; Cause of Death; Chromatography, Gas; Clinical Protocols; Disease Models, Animal; Evaluation Studies as Topic; Female; Forensic Medicine; Humans; Kidney; Liver; Male; Middle Aged; Poisoning; Rats; Rats, Wistar; Sulfides; Thiosulfates