calcitonin and Weight-Loss

calcitonin has been researched along with Weight-Loss* in 1 studies

Other Studies

1 other study(ies) available for calcitonin and Weight-Loss

ArticleYear
Combined Amylin/GLP-1 pharmacotherapy to promote and sustain long-lasting weight loss.
    Scientific reports, 2019, 06-11, Volume: 9, Issue:1

    A growing appreciation of the overlapping neuroendocrine mechanisms controlling energy balance has highlighted combination therapies as a promising strategy to enhance sustained weight loss. Here, we investigated whether amylin- and glucagon-like-peptide-1 (GLP-1)-based combination therapies produce greater food intake- and body weight-suppressive effects compared to monotherapies in both lean and diet-induced obese (DIO) rats. In chow-maintained rats, systemic amylin and GLP-1 combine to reduce meal size. Furthermore, the amylin and GLP-1 analogs salmon calcitonin (sCT) and liraglutide produce synergistic-like reductions in 24 hours energy intake and body weight. The administration of sCT with liraglutide also led to a significant enhancement in cFos-activation in the dorsal-vagal-complex (DVC) compared to mono-therapy, suggesting an activation of distinct, yet overlapping neural substrates in this critical energy balance hub. In DIO animals, long-term daily administration of this combination therapy, specifically in a stepwise manner, results in reduced energy intake and greater body weight loss over time when compared to chronic mono- and combined-treated groups, without affecting GLP-1 receptor, preproglucagon or amylin-receptor gene expression in the DVC.

    Topics: Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; Calcitonin; Diet, High-Fat; Eating; Energy Intake; Energy Metabolism; Glucagon-Like Peptide 1; Islet Amyloid Polypeptide; Male; Obesity; Rats; Receptors, Glucagon; Weight Loss

2019