calcipotriene and Leg-Dermatoses

Topics: Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents; Betamethasone; Calcitriol; Child; Dermatologic Agents; Double-Blind Method; Female; Glucocorticoids; Humans; Leg Dermatoses; Male; Middle Aged; Ointments; Prurigo

Topics: Adult; Aged; Amyloidosis; Anti-Inflammatory Agents; Betamethasone Valerate; Calcitriol; Dermatologic Agents; Double-Blind Method; Female; Humans; Leg Dermatoses; Lichenoid Eruptions; Male; Middle Aged; Ointments; Pilot Projects; Pruritus; Skin; Time Factors; Treatment Outcome

Porokeratosis is defined as a disorder of keratinization characterized by one or more atrophic patches surrounded by a clinically and histologically distinctive hyperkeratotic ridgelike border called the cornoid lamella. Lesions are most commonly located on the sun-exposed sides of trunk and extremities, while exclusive facial involvement has been also reported. Despite that the exact risk of cutaneous malignancy developing in porokeratosis is unknown, it is confirmed by series of case reports, including squamous cell carcinoma, basal cell carcinoma and even melanoma. Although no definite cure exists, a number of treatment modalities, from topical medications to laser and light devices, have been reported with variable success. Although promising, reports of disseminated superficial actinic porokeratosis treated with vitamin D3 analogs are rare. No satisfactory enough effect is obtained also with calcipotriol monotherapy.We report a case of disseminated superficial actinic porokeratosis in a 80-year-old female patient, successfully treated with combination of topical calcipotriol/betamethasone gel. A significant improvement was noticed after 3 weeks; almost full resolution of the clinical symptoms without appearance of fresh lesions was achieved in the second month. To the best of our knowledge, this is the first report of successful treatment with full resolution in a short interval, by simultaneous application of vitamin D3 analog (calcipotriol) and corticosteroid (betamethasone), combined in a one commercial product as a gel for treatment of keratinocyte proliferation's disorder such as psoriasis vulgaris. This promising new entity seems to be more effective, because of the simultaneous synergetic effects of the substations, namely the normalization of the proliferation of the keratinocytes by calcipotriol on one hand, and the reducing of the inflammation by the corticosteroid on another. Sun protection stays always mandatory, as well as the regular clinical observation, regarding the risk of malignant transformation.

Topics: Administration, Topical; Aged, 80 and over; Betamethasone; Calcitriol; Drug Administration Schedule; Drug Therapy, Combination; Female; Gels; Humans; Keratosis, Actinic; Leg Dermatoses; Porokeratosis; Treatment Outcome

Hyperkeratosis lenticularis perstans (HLP) or Flegel's disease is a rare dermatosis characterized by asymptomatic hyperkeratotic papules predominantly located on the lower extremities. Lesional and non-lesional epidermis samples were studied by light- and electron-microscopic examination. The main ultrastructural finding was the presence of structurally altered Odland bodies/membrane-coating granules. Different therapeutic options for HLP have been reported, but none of the treatments was shown to be consistently effective. Here, we report on a patient with Flegel's disease who did respond to topical 5-fluorouracil, whereas topical vitamin D(3) synthetics were ineffective.

Topics: Calcitriol; Dermatologic Agents; Dihydroxycholecalciferols; Female; Humans; Keratosis; Leg Dermatoses; Microscopy, Electron; Middle Aged; Skin; Treatment Outcome

Topics: Administration, Cutaneous; Calcitriol; Child; Dermatitis; Dermatologic Agents; Female; Foot Dermatoses; Hamartoma; Humans; Infant; Leg Dermatoses; Male; Skin Diseases

Topics: Adult; Calcitriol; Dermatitis, Allergic Contact; Dermatologic Agents; Drug Eruptions; Female; Humans; Leg Dermatoses; Patch Tests; Psoriasis

Topics: Aged; Aged, 80 and over; Arm; Calcitriol; Dermatologic Agents; Female; Humans; Leg Dermatoses; Male; Photosensitivity Disorders; Porokeratosis