calcipotriene and Keratosis--Seborrheic

Patients with seborrheic keratoses frequently desire an effective topical therapy for seborrheic keratoses.. To compare topical calcipotriene, topical tazarotene, and topical imiquimod with standard cryosurgery in the treatment of seborrheic keratoses.. Fifteen patients with numerous seborrheic keratoses were enrolled in an open-label study comparing cryosurgery with topical agents. Eight separate seborrheic keratoses were selected to be treated with topical medications. One lesion was treated with cryosurgery.. One treatment with cryosurgery led to clinical and histological improvement of all lesions treated. Neither scarring nor recurrence resulted in cryosurgery. In seven of 15 patients, tazarotene 0.1% cream applied BID caused clinical improvement in lesions within 16 weeks.. Cryosurgery produces clinical and histological improvement of seborrheic keratoses. The result with cryosurgery was cosmetically acceptable to all patients. Responders to tazarotene cream 0.1% found it cosmetically acceptable.

Topics: Adjuvants, Immunologic; Administration, Topical; Aged; Aminoquinolines; Calcitriol; Cryosurgery; Dermatologic Agents; Drug Administration Schedule; Female; Humans; Imiquimod; Keratosis, Seborrheic; Male; Middle Aged; Nicotinic Acids; Pilot Projects; Retinoids; Treatment Outcome

Seborrheic keratosis is the most common slow-growing, benign epithelial tumour, usually appearing on sun-exposed areas. Treatment modalities for seborrheic keratosis may be uncomfortable and/or time-consuming. We present a case series of 12 patients with solitary seborrheic keratosis localized on the face treated with 0.005% calcipotriol ointment. The treatment lasted 3-8 months and resulted in complete regression of the lesions. Remission (follow-up period) lasted from 6 to 10 years. We conclude that topical calcipotriol may be a useful treatment option for seborrheic keratosis.

Topics: Calcitriol; Humans; Keratosis, Seborrheic

Topics: Adult; Aminolevulinic Acid; Calcitriol; Dermatologic Agents; Diagnosis, Differential; Female; Humans; Keratosis, Seborrheic; Photochemotherapy; Photosensitizing Agents