calcipotriene and Hyperpigmentation

Topics: Administration, Cutaneous; Antineoplastic Combined Chemotherapy Protocols; Calcitriol; Dermatologic Agents; Docetaxel; Edema; Female; Humans; Hyperpigmentation; Intestinal Neoplasms; Lower Extremity; Middle Aged; Ointments; Sclerosis; Skin Pigmentation; Treatment Outcome

Topics: Adult; Breast Diseases; Breast Neoplasms; Calcitriol; Dermatologic Agents; Diagnosis, Differential; Eczema; Female; Humans; Hyperpigmentation; Keratosis; Nipples; Paget's Disease, Mammary

Topics: Calcitriol; Dermatologic Agents; Humans; Hyperpigmentation; Male; Melanoma; Middle Aged; Psoriasis; Skin Neoplasms

Topics: Administration, Topical; Calcitriol; Child; Combined Modality Therapy; Emollients; Facial Hemiatrophy; Female; Follow-Up Studies; Humans; Hyperpigmentation; Male; PUVA Therapy; Scleroderma, Localized; Treatment Outcome; Ultrasonography

Topics: Adult; Calcitriol; Diagnostic Errors; Follow-Up Studies; Hand Dermatoses; Humans; Hyperpigmentation; Male; Minocycline; Papilloma; Regional Blood Flow; Skin; Skin Diseases, Vascular; Skin Neoplasms; Treatment Failure

The combination of UVB phototherapy with topical application of vitamin D analogs is frequently used for treating psoriasis. This regimen is not only very effective but also has only minimal side effects. Pronounced, persistent hyperpigmentation developed in the psoriatic plaques in a patient who was treated with combined UVB (311 nm) radiation and topical calcipotriol.

Topics: Aged; Aged, 80 and over; Calcitriol; Combined Modality Therapy; Dermatologic Agents; Female; Humans; Hyperpigmentation; Psoriasis; Ultraviolet Therapy

The vitamin D3 analogue calcipotriol (calcipotriene) is an effective topical treatment for psoriasis. In combination with other antipsoriatic agents, such as ultraviolet radiation, calcipotriol is reported to improve the overall efficacy of the treatment. Here we describe two patients treated with a combination treatment of calcipotriol and bath psoralens and ultraviolet A who developed hyperpigmentation at the lesional sites where calcipotriol ointment was applied.

Topics: Adult; Calcitriol; Dermatologic Agents; Drug Eruptions; Female; Humans; Hyperpigmentation; Male; Middle Aged; Photochemotherapy; Psoriasis

Calcipotriol is a synthetic analogue of vitamin D, used in the treatment of psoriasis. Until now no specific sid-effects have been described after combined therapy with calcipotriol and UV. We describe 3 patients, who in the summer of 1993, after a combined treatment of calcipotriol and heliotherapy, developed hyperpigmentation in the site where the ointment had been applied. Hyperpigmentation healed spontaneously in less than 7 months. To the best of our knowledge there are no other reports of this side-effect due to calcipotriol. In our opinion the fact that the 3 patients presented the hyperpigmentation only on the treated lesions and that, in the past, they had not presented similar lesions after exposure to sunlight confirms the relationship between the hyperpigmentation and the combined treatment used.

Topics: Adult; Aged; Calcitriol; Combined Modality Therapy; Dermatologic Agents; Female; Heliotherapy; Humans; Hyperpigmentation; Male; Middle Aged; Psoriasis