calcimycin and Fatty-Liver

calcimycin has been researched along with Fatty-Liver* in 1 studies

Other Studies

1 other study(ies) available for calcimycin and Fatty-Liver

Article	Year
Evidence against a role for disturbed hepatocellular calcium homeostasis in the fatty liver of carbon tetrachloride hepatotoxicity. Toxicologic pathology, 1984, Volume: 12, Issue:1 A consensus does not exist regarding the nature of mechanisms linking the initial events of CCl4 metabolism to emergence of the classical indices of CCl4 liver cell injury. The possibility that a CCl4-dependent disturbance of intrahepatocellular calcium homeostasis might be a linking mechanism was investigated with isolated hepatocytes in suspension. CCl4-dependent inhibition of very low density lipoprotein secretion was studied. On the basis of kinetic data, dose-response data, and failure of elevated cytosolic calcium levels to inhibit lipid secretion, it was concluded that disturbed intracellular calcium homeostasis probably is not important in CCl4-dependent inhibition of secretion of very low density lipoproteins. Topics: Animals; Aspartate Aminotransferases; Calcimycin; Calcium; Carbon Radioisotopes; Carbon Tetrachloride; Digitonin; Fatty Liver; Homeostasis; In Vitro Techniques; Lipoproteins, VLDL; Male; Microsomes, Liver; Rats; Rats, Inbred Strains	1984

Article

Year

Evidence against a role for disturbed hepatocellular calcium homeostasis in the fatty liver of carbon tetrachloride hepatotoxicity.

Toxicologic pathology, 1984, Volume: 12, Issue:1

A consensus does not exist regarding the nature of mechanisms linking the initial events of CCl4 metabolism to emergence of the classical indices of CCl4 liver cell injury. The possibility that a CCl4-dependent disturbance of intrahepatocellular calcium homeostasis might be a linking mechanism was investigated with isolated hepatocytes in suspension. CCl4-dependent inhibition of very low density lipoprotein secretion was studied. On the basis of kinetic data, dose-response data, and failure of elevated cytosolic calcium levels to inhibit lipid secretion, it was concluded that disturbed intracellular calcium homeostasis probably is not important in CCl4-dependent inhibition of secretion of very low density lipoproteins.

Topics: Animals; Aspartate Aminotransferases; Calcimycin; Calcium; Carbon Radioisotopes; Carbon Tetrachloride; Digitonin; Fatty Liver; Homeostasis; In Vitro Techniques; Lipoproteins, VLDL; Male; Microsomes, Liver; Rats; Rats, Inbred Strains

1984