calcimycin and Alcoholic-Intoxication

Calcium, other divalent cations, and calcium antagonists were tested for their ability to alter ethanol-induced sleeping time, hypothermia, and behavioral intoxication in mice and rats. Calcium given intraventricularly significantly enhanced sleeping time and behavioral intoxication in a dose-related manner. The ionophores X537A and A23187 accentuated the effect of a low dose of calcium, whereas the calcium chelators EDTA and EGTA decreased sleeping time. Calcium also enhanced tertiary butanol- and chloral hydrate-induced sleeping time. The effects of cations on ethanol-induced hypothermia were less significant. The results suggest the existence of a central calcium pool that is involved in ethanol intoxication in rodents.

Topics: Alcoholic Intoxication; Animals; Body Temperature Regulation; Calcimycin; Calcium; Cations, Divalent; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Lasalocid; Male; Mice; Movement; Rats