calca-protein--human and Multiple-Sclerosis

As known multiple sclerosis (MS) is a chronic neuroinflammatory progressive disease. The aim of this study was to assess some inflammatory markers in MS patients and their relationships with clinical subgroups and disability status.. The serum levels of procalcitonin (PCT), YKL-40, IFN-γ and TNF-α were measured by an ELISA microplate reader in 59 MS patients and in 29 healthy subjects.. Mean serum PCT and TNF-α levels were significantly higher in patients with MS than control group (P<0.001). Serum YKL-40 and IFN-γ concentrations were elevated in MS group compared the healthy subjects, but the difference was not significantly. CIS, RRMS and SPMS groups had higher levels of PCT and TNF-α than control group. YKL-40 levels were positively correlated with EDSS score (r=0.412, P=0.001). IFN-γ and TNF-α levels were found to be negatively correlated with EDSS score (r=-0.347, P=0.007 and r=-0.328, P=0.011, respectively).. Increased levels of these inflammatory markers might provide important contributions to the underlying inflammatory pathways in MS.

Topics: Adipokines; Adult; Biomarkers; Calcitonin; Calcitonin Gene-Related Peptide; Chitinase-3-Like Protein 1; Female; Humans; Interferon-gamma; Lectins; Male; Middle Aged; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Protein Precursors; Tumor Necrosis Factor-alpha