calca-protein--human and Headache-Disorders

A bidirectional causal relationship has been established between temporomandibular disorders (TMDs) and chronic headaches. Recent advances in the neurobiology of chronic pain offer a framework for understanding the comorbidity between these two conditions that might reside in the shared biomolecular mechanisms of peripheral and central sensitization. The initiation of these processes is inflammatory in nature and is most likely mediated by key molecules, including calcitonin gene-related peptide (CGRP). This scoping review proposes that CGRP-mediated neuroinflammation in the trigeminal ganglion may partly explain the biomolecular bidirectional link between TMDs and chronic headaches. Finally, clinical implications of this neuropathologic process are briefly discussed.

Topics: Calcitonin Gene-Related Peptide; Headache Disorders; Humans; Migraine Disorders; Receptors, Calcitonin Gene-Related Peptide; Temporomandibular Joint Disorders

Headache disorders are common worldwide and often disabling. Until recently, treatments were borrowed from other branches of neurology and medicine. Monoclonal antibodies targeting calcitonin gene-related peptide (CGRP) ligand and receptor, small molecule CGRP receptor antagonist gepants, serotonin

Topics: Antibodies, Monoclonal; Calcitonin Gene-Related Peptide; Headache Disorders; Humans; Neurotransmitter Agents; Piperidines; Pyridines; Serotonin Receptor Agonists; Treatment Outcome