calca-protein--human and Enterobacteriaceae-Infections

To limit the regulation of antibiotherapy in neonatal early infections by improving the tracking and the diagnosis of infected newborns.. First part: analysis of procalcitonin (PCT) in the cord. Method of tracking: 87 cases. Cut-off PCT=0.5 ng/mL. Measurement of CRP at 24 h if PCT>0.5 ng/mL. Second part: analysis of the PCT between 4 h and 6 h in the event of infectious risk; 47 cases over 6 months. Cut-off PCT=2 ng/mL. Measurement of CRP at 12 h and/or 24 h.. In 2012, there were 10 antibiotherapies prescribed per 1000 births versus 30/1000 in 2011. A reduction in two thirds of the indications was seen.. Markers of inflammation, i.e., the PCT (good specificity and good negative predictive value from 0 to 6 h of life) and CRP (good sensitivity and good positive predictive value from 12 to 24 of life) should be combined in time.

Topics: Anti-Bacterial Agents; Bacterial Infections; C-Reactive Protein; Calcitonin; Calcitonin Gene-Related Peptide; Drug Utilization; Enterobacteriaceae Infections; Female; Fetal Blood; Humans; Infant, Newborn; Infant, Premature, Diseases; Infectious Disease Transmission, Vertical; Male; Pregnancy; Pregnancy Complications, Infectious; Protein Precursors; Streptococcal Infections; Streptococcus agalactiae

Topics: Aged; Biomarkers; Calcitonin; Calcitonin Gene-Related Peptide; Enterobacter cloacae; Enterobacteriaceae Infections; Humans; Male; Postoperative Complications; Protein Precursors

A fatal case of Waterhouse-Friderichsen syndrome resulting from infection in a previously healthy 74-year-old woman is reported. The patient died suddenly within 14 hours after presentation. The diagnosis of Waterhouse-Friderichsen syndrome as the cause of death was established post mortem based on autopsy findings, microscopic examination, measurement of serum procalcitonin concentration (113 ng/ml), and outcome of postmortem bacteriologic cultures that grew in heart and spleen blood samples. Since the introduction of as a new group in the family in 1983, more recent case studies have established its clinical significance and pathogenic potential to cause severe, life-threatening bacteremia and sepsis. is a rare pathogen that should be added to the list of unusual bacteria causing Waterhouse-Friderichsen syndrome.

Topics: Aged; Calcitonin; Calcitonin Gene-Related Peptide; Enterobacteriaceae; Enterobacteriaceae Infections; Fatal Outcome; Female; Heart; Humans; Protein Precursors; Spleen; Waterhouse-Friderichsen Syndrome