caffeine and Vomiting studies

Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.

Research Excerpts

Excerpt	Relevance	Reference
"One hundred and fifty-seven evaluable patients with advanced metastatic malignant melanoma were randomly assigned to receive either methyl-CCNU (MeCCNU) (200 mg/m2 orally every 6 weeks) (82 patients) or a combination of MeCCNU, chlorpromazine (50 mg/m2 im), and caffeine (600 mg/m2 sc) in the periumbilical area (75 patients)."	9.05	Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma. ( Cohen, MH; Schoenfeld, D; Wolter, J, 1980)
"The aim of this study was to explore the relationships between nausea and vomiting in pregnancy and (a) fetal growth restriction; and (b) maternal caffeine metabolism and fetal growth restriction."	7.79	Does nausea and vomiting of pregnancy play a role in the association found between maternal caffeine intake and fetal growth restriction? ( Alwan, N; Boylan, SM; Cade, JE; Cooke, MS; Dolby, VA; Greenwood, DC; Hay, AW; Kirk, SF; Konje, JC; Potdar, N; Shires, S; Simpson, NA; Taub, N; Thomas, JD; Walker, JJ; White, KL; Wild, CP, 2013)
"This article provides an analysis of the use of artificial sweeteners, caffeine, and excess fluids in patients diagnosed with anorexia nervosa (AN)."	7.75	Caffeine, artificial sweetener, and fluid intake in anorexia nervosa. ( Crosby, RD; Crow, S; Doyle, P; Ertelt, TE; Fischer, S; Lancaster, K; Le Grange, D; Marino, JM; Mitchell, JE; Peterson, CB; Wonderlich, SA, 2009)
"Signals of early pregnancy included an aversion to coffee in addition to nausea and vomiting, which resulted in decreased caffeine consumption."	7.72	Changes in caffeine consumption as a signal of pregnancy. ( Lawson, CC; LeMasters, GK; Wilson, KA, 2004)
"One hundred and fifty-seven evaluable patients with advanced metastatic malignant melanoma were randomly assigned to receive either methyl-CCNU (MeCCNU) (200 mg/m2 orally every 6 weeks) (82 patients) or a combination of MeCCNU, chlorpromazine (50 mg/m2 im), and caffeine (600 mg/m2 sc) in the periumbilical area (75 patients)."	5.05	Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma. ( Cohen, MH; Schoenfeld, D; Wolter, J, 1980)
" Models accounted for women's age, BMI, employment, marital status, income, education, race, parity, prior losses, exercise and time-varying nausea/vomiting, caffeine, alcohol and smoking."	4.12	Prospectively assessed perceived stress associated with early pregnancy losses among women with history of pregnancy loss. ( Hinkle, SN; Kim, K; Mumford, SL; Plowden, TC; Purdue-Smithe, A; Schisterman, EF; Schliep, KC; Silver, RM; Sjaarda, LA; Stanford, JB, 2022)
"The aim of this study was to explore the relationships between nausea and vomiting in pregnancy and (a) fetal growth restriction; and (b) maternal caffeine metabolism and fetal growth restriction."	3.79	Does nausea and vomiting of pregnancy play a role in the association found between maternal caffeine intake and fetal growth restriction? ( Alwan, N; Boylan, SM; Cade, JE; Cooke, MS; Dolby, VA; Greenwood, DC; Hay, AW; Kirk, SF; Konje, JC; Potdar, N; Shires, S; Simpson, NA; Taub, N; Thomas, JD; Walker, JJ; White, KL; Wild, CP, 2013)
"This article provides an analysis of the use of artificial sweeteners, caffeine, and excess fluids in patients diagnosed with anorexia nervosa (AN)."	3.75	Caffeine, artificial sweetener, and fluid intake in anorexia nervosa. ( Crosby, RD; Crow, S; Doyle, P; Ertelt, TE; Fischer, S; Lancaster, K; Le Grange, D; Marino, JM; Mitchell, JE; Peterson, CB; Wonderlich, SA, 2009)
"Signals of early pregnancy included an aversion to coffee in addition to nausea and vomiting, which resulted in decreased caffeine consumption."	3.72	Changes in caffeine consumption as a signal of pregnancy. ( Lawson, CC; LeMasters, GK; Wilson, KA, 2004)
"Sumatriptan was significantly more effective than Cafergot at reducing the intensity of headache from severe or moderate to mild or none; 66% (145/220) of those treated with sumatriptan improved in this way by 2 h, compared with 48% (118/246) of those treated with Cafergot (p less than 0."	2.67	A randomized, double-blind comparison of sumatriptan and Cafergot in the acute treatment of migraine. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group. ( , 1991)
"Caffeine is a molecule free of serious adverse effects when consumed at low doses."	1.48	Severe Sympathomimetic Toxidrome in a French Soldier: How Caffeine Overdose Can Lead to Severe Consequences. ( Delacour, H; Dubost, C; Lahutte, B; Laitselart, P; Plantamura, J; Saguin, E, 2018)
"An analysis of calls to three poison centers for powdered caffeine found that exposures were uncommon, but did result in toxicity, and highlighted that the lack of clear dosing instructions on product packaging may place patients at risk of inadvertent overdose."	1.43	A Retrospective Study of Clinical Effects of Powdered Caffeine Exposures Reported to Three US Poison Control Centers. ( Beauchamp, GA; Crouch, BI; Hendrickson, RG; Horowitz, BZ; Johnson, AR; Valento, M, 2016)
"The headaches were treated with chlorpromazine with a good result."	1.30	[Intractable vomiting, convulsions and megaloblastic anemia: anamnesis, key to diagnosis]. ( de Torrenté, A; Humair, L; Schlaeppi, M, 1999)
"Caffeine was present in the serum of six infants, and three of the six infants had caffeine in their urine."	1.27	Neonatal withdrawal symptoms after chronic maternal ingestion of caffeine. ( Altman, RE; Kanto, WP; McGowan, JD, 1988)
"Migraine is one of the most common disorders seen in paediatric neurological practice."	1.26	Migraine and migraine equivalents in children. ( Brown, JK, 1977)

Research

Studies (26)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Abruption

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (38.46)	18.7374
1990's	4 (15.38)	18.2507
2000's	6 (23.08)	29.6817
2010's	5 (19.23)	24.3611
2020's	1 (3.85)	2.80

Authors	Studies
Schliep, KC	1
Hinkle, SN	1
Kim, K	1
Sjaarda, LA	1
Silver, RM	1
Stanford, JB	1
Purdue-Smithe, A	1
Plowden, TC	1
Schisterman, EF	1
Mumford, SL	1
Laitselart, P	1
Saguin, E	1
Plantamura, J	1
Lahutte, B	1
Delacour, H	1
Dubost, C	1
Takayama, M	1
Waters, B	1
Hara, K	1
Kashwagi, M	1
Matsusue, A	1
Ikematsu, N	1
Kubo, SI	1
Beauchamp, GA	1
Johnson, AR	1
Crouch, BI	1
Valento, M	1
Horowitz, BZ	1
Hendrickson, RG	1
Kromhout, HE	1
Landstra, AM	1
van Luin, M	1
van Setten, PA	1
Marino, JM	1
Ertelt, TE	1
Wonderlich, SA	1
Crosby, RD	1
Lancaster, K	1
Mitchell, JE	1
Fischer, S	1
Doyle, P	1
Le Grange, D	1
Peterson, CB	1
Crow, S	2
Boylan, SM	1
Greenwood, DC	1
Alwan, N	1
Cooke, MS	1
Dolby, VA	1
Hay, AW	1
Kirk, SF	1
Konje, JC	1
Potdar, N	1
Shires, S	1
Simpson, NA	1
Taub, N	1
Thomas, JD	1
Walker, JJ	1
White, KL	1
Wild, CP	1
Cade, JE	1
Iglesias-Lepine, ML	1
Epelde, F	1
Espinosa, J	1
Mariñosa, M	1
Lawson, CC	2
LeMasters, GK	2
Levin, LS	1
Liu, JH	1
JERIE, J	1
ZALOUDEK, M	1
NEYROUD, M	1
HARTWIG, J	1
PODLESCH, I	1
MEYER, M	1
BARTH, L	1
Wilson, KA	1
Reba-Harrelson, L	1
Von Holle, A	1
Thornton, LM	1
Klump, KL	1
Berrettini, WH	1
Brandt, H	1
Crawford, S	1
Fichter, MM	1
Goldman, D	1
Halmi, KA	1
Johnson, C	1
Kaplan, AS	1
Keel, P	1
LaVia, M	1
Mitchell, J	1
Plotnicov, K	1
Rotondo, A	1
Strober, M	1
Treasure, J	1
Woodside, DB	1
Kaye, WH	1
Bulik, CM	1
Cohen, MH	1
Schoenfeld, D	1
Wolter, J	1
Kolasa, KM	1
Weismiller, DG	1
Biederman, GB	1
Davey, VA	1
Schlaeppi, M	1
Humair, L	1
de Torrenté, A	1
Furneaux, EC	1
Langley-Evans, AJ	1
Langley-Evans, SC	1
Sullivan, JL	1
Brown, JK	1
McGowan, JD	1
Altman, RE	1
Kanto, WP	1
Plotnikoff, N	1
Will, F	1
Ditzler, W	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Effects of Aspirin in Gestation and Reproduction: A Multi-center, Controlled, Double-blind Randomized Trial.[NCT00467363]		1,228 participants (Actual)	Interventional	2007-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Partial or complete abruption (ie, premature separation of the placenta) (NCT00467363)
Timeframe: until delivery

Clinically Recognized Pregnancy

Early Pregnancy Loss (EPL)

Ectopic Pregnancy

Fetal Pregnancy Loss

hCG Recognized Pregnancy

Live Birth

Intervention	participants (Number)
Aspirin	7
Placebo	5

Intervention	pregnancy (Number)
Aspirin	374
Placebo	346

Intervention	pregnancy (Number)
Aspirin	28
Placebo	27

Intervention	pregnancy (Number)
Aspirin	3
Placebo	3

Intervention	pregnancy (Number)
Aspirin	4
Placebo	6

Intervention	pregnancy (Number)
Aspirin	394
Placebo	363

Live birth was obtained prospectively by maternal report and abstraction from medical records by trained staff . (NCT00467363)
Timeframe: after delivery

Molar Pregnancy

Preeclampsia

Pregnancy Losses Occurring Less Than 10 Weeks

Intervention	livebirths (Number)
Aspirin	309
Placebo	286

Intervention	pregnancy (Number)
Aspirin	0
Placebo	0

Intervention	participants (Number)
Aspirin	32
Placebo	30

Includes preembryonic and embryonic losses (exclusive of implantation failures) (NCT00467363)
Timeframe: less than 10-weeks

Article	Year
An autopsy case of caffeine intoxication related by energy drink. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence, 2016, Volume: 51, Issue:3 Topics: Autopsy; Caffeine; Energy Drinks; Humans; Male; Vomiting; Young Adult	2016
Nutrition during pregnancy. American family physician, 1997, Volume: 56, Issue:1 Topics: Caffeine; Constipation; Female; Humans; Lactose Intolerance; Nausea; Nutrition Assessment; Nutrition	1997
Nausea and vomiting of pregnancy: endocrine basis and contribution to pregnancy outcome. Obstetrical & gynecological survey, 2001, Volume: 56, Issue:12 Topics: Abortion, Spontaneous; Alcohol Drinking; Caffeine; Chorionic Gonadotropin; Congenital Abnormalities;	2001

Article	Year
Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma. Cancer treatment reports, 1980, Volume: 64, Issue:1 Topics: Caffeine; Chlorpromazine; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Melanoma; Nit	1980
A randomized, double-blind comparison of sumatriptan and Cafergot in the acute treatment of migraine. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group. European neurology, 1991, Volume: 31, Issue:5 Topics: Administration, Oral; Adult; Aged; Caffeine; Double-Blind Method; Drug Combinations; Electrocardiogr	1991

Article	Year
Prospectively assessed perceived stress associated with early pregnancy losses among women with history of pregnancy loss. Human reproduction (Oxford, England), 2022, 09-30, Volume: 37, Issue:10 Topics: Abortion, Spontaneous; Biomarkers; Caffeine; Child; Female; Humans; Nausea; Pregnancy; Stress, Psych	2022
Severe Sympathomimetic Toxidrome in a French Soldier: How Caffeine Overdose Can Lead to Severe Consequences. Military medicine, 2018, 01-01, Volume: 183, Issue:1-2 Topics: Administration, Oral; Adult; Caffeine; Central Nervous System Stimulants; Drug Overdose; Fluid Thera	2018
A Retrospective Study of Clinical Effects of Powdered Caffeine Exposures Reported to Three US Poison Control Centers. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:3 Topics: Adult; Caffeine; Central Nervous System Stimulants; Child; Combined Modality Therapy; Dietary Supple	2016
[Acute caffeine intoxication after intake of 'herbal energy capsules']. Nederlands tijdschrift voor geneeskunde, 2008, Jul-12, Volume: 152, Issue:28 Topics: Abdominal Pain; Adolescent; Caffeine; Central Nervous System Stimulants; Dietary Supplements; Drug O	2008
Caffeine, artificial sweetener, and fluid intake in anorexia nervosa. The International journal of eating disorders, 2009, Volume: 42, Issue:6 Topics: Adult; Anorexia Nervosa; Aspartame; Body Mass Index; Bulimia; Caffeine; Drinking; Exercise; Female;	2009
Does nausea and vomiting of pregnancy play a role in the association found between maternal caffeine intake and fetal growth restriction? Maternal and child health journal, 2013, Volume: 17, Issue:4 Topics: Adolescent; Adult; Caffeine; Female; Fetal Development; Fetal Growth Retardation; Gestational Age; H	2013
[Consumption of energy drinks with alcohol, hazardous mixture]. Medicina clinica, 2013, Aug-04, Volume: 141, Issue:3 Topics: Adolescent; Alcoholic Beverages; Caffeine; Catecholamines; Dose-Response Relationship, Drug; Drug Sy	2013
Pregnancy hormone metabolite patterns, pregnancy symptoms, and coffee consumption. American journal of epidemiology, 2002, Sep-01, Volume: 156, Issue:5 Topics: Adult; Caffeine; Chorionic Gonadotropin; Coffee; Estrone; Female; Humans; Nausea; Pregnancy; Pregnan	2002
[Use of caffeine and bromides in vomiting in pregnancy]. Ceskoslovenska gynekologie, 1953, Volume: 18, Issue:1 Topics: Bromides; Caffeine; Female; Humans; Pregnancy; Pregnancy Complications; Vomiting	1953
[Treatment of hypermesis gravidarum with bromides and caffeine with EEG control]. Ceskoslovenska gynekologie, 1953, Volume: 18, Issue:1 Topics: Bromides; Caffeine; Electroencephalography; Female; Humans; Pregnancy; Pregnancy Complications; Vomi	1953
[The treatment of uncontrollable vomiting in children by a combination of dramamine and vitamin B6]. Praxis, 1955, Jul-14, Volume: 44, Issue:28 Topics: Caffeine; Child; Dimenhydrinate; Female; Humans; Pregnancy; Vitamin B 6; Vomiting	1955
[Experiences with the antiemetic rodavan in prevention and therapy of postanesthesia vomiting]. Zentralblatt fur Chirurgie, 1958, Aug-09, Volume: 83, Issue:32 Topics: Antiemetics; Biomedical Research; Caffeine; Diphenhydramine; Surgical Procedures, Operative; Theophy	1958
[Prophylaxis and therapy of postoperative vomiting with the diphenhydramine derivative combination Rodavan; a clinical-statistical evaluation]. Der Anaesthesist, 1961, Volume: 10 Topics: Caffeine; Diphenhydramine; Postoperative Nausea and Vomiting; Surgical Procedures, Operative; Theoph	1961
Changes in caffeine consumption as a signal of pregnancy. Reproductive toxicology (Elmsford, N.Y.), 2004, Volume: 18, Issue:5 Topics: Adolescent; Adult; Asian People; Black or African American; Caffeine; Chorionic Gonadotropin; Coffee	2004
Features associated with diet pill use in individuals with eating disorders. Eating behaviors, 2008, Volume: 9, Issue:1 Topics: Adult; Alcohol Drinking; Anti-Obesity Agents; Body Mass Index; Caffeine; Cathartics; Emetics; Europe	2008
Alleviating nausea and emesis by Pavlovian conditioning. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1999, May-04, Volume: 160, Issue:9 Topics: Animals; Caffeine; Central Nervous System Stimulants; Conditioning, Classical; Dose-Response Relatio	1999
[Intractable vomiting, convulsions and megaloblastic anemia: anamnesis, key to diagnosis]. Schweizerische medizinische Wochenschrift, 1999, Jul-03, Volume: 129, Issue:26 Topics: Adult; Anemia, Megaloblastic; Barbiturates; Caffeine; Diagnosis, Differential; Drug Combinations; Er	1999
Caffeine poisioning in an infant. The Journal of pediatrics, 1977, Volume: 90, Issue:6 Topics: Caffeine; Central Nervous System; Diuresis; Female; Humans; Infant; Poisoning; Tachycardia; Vomiting	1977
Migraine and migraine equivalents in children. Developmental medicine and child neurology, 1977, Volume: 19, Issue:5 Topics: Caffeine; Capillary Permeability; Cerebrovascular Circulation; Child; Diagnosis, Differential; Epile	1977
Neonatal withdrawal symptoms after chronic maternal ingestion of caffeine. Southern medical journal, 1988, Volume: 81, Issue:9 Topics: Bradycardia; Caffeine; Female; Humans; Infant, Newborn; Male; Neonatal Abstinence Syndrome; Respirat	1988
Stimulant activity of pemoline and magnesium hydroxide. Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 181, Issue:2 Topics: Animals; Antacids; Ataxia; Caffeine; Cats; Central Nervous System Stimulants; Chlordiazepoxide; Chlo	1969

caffeine and Vomiting